| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :1.466386 |
| These results demonstrate that calnexin and calreticulin can form a stable interaction with correctly folded tPA ; however , such interactions are not required for the synthesis of enzymically active tPA . . 1.466386^^^ |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| The effects of Ro 44 9883 , a new specific antagonist of platelet glycoprotein IIb IIIa receptor , on thrombus formation and reocclusion after thrombolysis induced by tissue type plasminogen activator ( t PA ) were compared with those of vapiprost , a thromboxane ( TX ) A 2 receptor antagonist , using a photochemically induced thrombosis model in the guinea pig femoral artery . ^^^ |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| Effects of heparin , aspirin and a synthetic platelet glycoprotein IIb IIIa receptor antagonist ( Ro 43 5054 ) on coronary artery reperfusion and reocclusion after thrombolysis with tissue type plasminogen activator in the dog . ^^^ In addition to recombinant tissue type plasminogen activator ( 30 micrograms / kg . min during 60 min ) , the dogs received 1 ) saline , 2 ) heparin 200 U / kg + 50 U / kg . hr i . v . , 3 ) aspirin 10 mg / kg i . v . , 4 ) heparin+aspirin , 5 ) Ro 43 5054 ( 3 micrograms / kg . min ) and 6 ) heparin+Ro 43 5054 . ^^^ |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| We examined the effect of a specific thrombin inhibitor , Ro 46 6240 , alone and combined with an antagonist of the platelet GP IIb / IIIa , Ro 44 9883 , on the response to tissue type plasminogen activator in a canine model of thrombolysis . ^^^ Ro 46 6240 administered before tissue type plasminogen activator induced a dose dependent prolongation of the activated partial thromboplastin time and prothrombin time . ^^^ At the dose used , Ro 44 9883 alone abolished platelet aggregation ex vivo but failed to modify the response to tissue type plasminogen activator or the excretion of 2 , 3 dinor TXB 2 after reperfusion ( 51 + / 6 ng / mg creatinine , n = 3 ) . ^^^ |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| Pharmacokinetics and pharmacodynamics of sibrafiban ( Ro 48 3657 ) , an orally active IIb / IIIa antagonist , administered alone or in combination with heparin , aspirin , and recombinant tissue type plasminogen activator in beagles . ^^^ This study characterized the pharmacokinetics ( PK ) and pharmacodynamics ( PD ) of sibrafiban ( Ro 48 3657 ) in the presence of aspirin , heparin , and recombinant tissue type plasminogen activator ( rt PA ) in beagles . ^^^ |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| When fusion of the L 6 cells is inhibited with either a high serum concentration or TGF beta or TPA , the nucleolar staining by anticalreticulin antibodies is diminished , although the presence of calreticulin in the endoplasmic reticulum remains unchanged . ^^^ |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| However , only all trans RA , Ro 12 7310 and Ro 13 7410 inhibited the formation of 20 : 4 metabolites in TPA stimulated M . ^^^ |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| The role of reactive oxygen ( RO ) in the promotion of neoplastic transformation of JB 6 mouse epidermal cells by 12 O tetradecanoylphorbol 13 acetate ( TPA ) was investigated using inhibitors of RO itself or RO generating systems of seven different types . ^^^ |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| Suppression could be restored by monocytes or PMN , both of which produced RO in response to TPA or zymosan . ^^^ |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| The presence of indomethacin ( 1 microgram / ml ) or Ro 20 5720 ( 10 micrograms / ml ) in TPA activated cell cultures , unlike PHA stimulated cultures , did not result in augmentation of 3H thymidine incorporation by cells from elderly individuals . ^^^ |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| The synthetic retinoid ( RO 15 1570 ) inhibited in vitro invasiveness of SW 620 cells , however , TPA treatment or addition of exogenous TGA did not inhibit invasiveness of these cells . ^^^ |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| In addition , we found that the protein kinase C inhibitor Ro 31 7549 blocked Fos lacZ expression induced by TPA but had little or no effect on that elicited by high calcium levels . ^^^ |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| Ro 31 8220 antagonized ( IC 50 , 1 . 0 microM ) the effect of the activator of protein kinase C , 12 O tetradecanoylphorbol 13 acetate ( TPA ) , on histamine stimulated aminopyrine accumulation . ^^^ |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| In differentiating keratinocytes incubated in medium containing 10 % serum and high calcium ( approximately 0 . 5 mM ) , Ro 31 7549 blocked the inhibitory effect of the phorbol ester 12 0 tetradecanoyl 13 acetate ( TPA ) ( a PKC activator ) on keratinocyte DNA synthesis at 24 h [ 50 % maximal response concentration ( EC 50 ) = 1 microM ] , consistent with inhibition of PKC mediated differentiation . ^^^ The potencies of these effects of Ro 31 7549 are comparable to that reported for inhibition of TPA induced platelet 47 kD protein phosphorylation [ 50 % inhibitory concentration ( IC 50 ) = 4 . 4 microM ] . ^^^ This antiproliferative effect of TPA was largely reversed by 0 . 1 microM Ro 31 7549 . ^^^ |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| The protein kinase C inhibitor , Ro 31 8220 , abolished TPA and agonist stimulation of [ 3H ] PBut production . 7 . ^^^ |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| The inhibitory effect of TPA on follicle growth was partially prevented by preincubation with the selective PKC inhibitor H 7 , and almost completely prevented by preincubation with the more potent PKC inhibitor Ro 31 7549 . ^^^ |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| The induction of the CYP2H1 gene by phenobarbital was not altered by treating cells with the specific inhibitors for protein kinase C ( GF 109203X and Ro 31 8220 ) or prolonged exposure to 12 O tetradecanoyl phorbol 13 acetate ( TPA ) or treatment with the specific inhibitors for tyrosine kinase ( genistein and tyrphostin A 25 ) . ^^^ |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| In addition , Ro 31 7549 inhibited the enhancement of carbachol and ( K+ ) evoked release after pretreatment with 12 O tetradecanoylphorbol 13 acetate ( TPA ; 100 nM ) for 8 min , with IC 50 values of 0 . 7 and 2 . 4 microM , respectively . ^^^ |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| The inactive phorbol ester 4 alpha TPA did not reduce daunomycin accumulation , and the PKC inhibitor , Ro 31 8220 , reversed the TPA effect . ^^^ Linear , short term daunomycin accumulation was reduced by pretreatment with TPA , an effect that could be reversed by Ro 31 8220 . ^^^ |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| The use of the method is demonstrated with examples of 10 different tigliane and daphnane esters ( TPA , DOPP , DOPPA , Sap A , Sap B , Sap C , Sap D , Thy A , Ro and Rx ) . ^^^ |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| In untreated control cells , the carbachol mediated increase in cytosolic CaM content was mimicked by TPA and blocked by pretreatment with the selective protein kinase C inhibitor Ro 31 8220 at 10 microM . ^^^ In the 72 h TPA treated cells , however , the ability of TPA to increase cytosolic CaM levels was significantly reduced , and the action of carbachol was no longer blocked by Ro 31 8220 . ^^^ The potential dissociation of carbachol and protein kinase C in eliciting increases in cytosolic CaM content was a function of prolonged TPA treatment and not differentiation per se because carbachol mediated increases in cytosolic CaM levels were inhibited by Ro 31 8220 in retinoic acid differentiated SK N SH cells . ^^^ |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| The ability of TPA to enhance NA release and to cause the translocation and phosphorylation of MARCKS was inhibited by the PKC inhibitor Ro 31 8220 ( 10 microM ) . ^^^ |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| The TPA induced ICAM 1 expression was reduced by the protein kinase C inhibitor Ro 31 8425 ( 1 to 10 microM ) , but not by the tyrosine kinase inhibitor genistein ( 185 microM ) . ^^^ |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| Stimulation of cells for 1 h with LPS caused activation of nuclear factor ( NF ) kB in the nuclei as detected by the formation of a NF kB specific DNA protein complex ; this effect was inhibited by genestein , D 609 , propranolol , or Ro 31 8220 or by PKCeta antisense oligonucleotides , but not by long term TPA treatment . ^^^ |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| The data further indicate that specific PKC isoenzymes that are inhibited by staurosporin or Ro 31 8220 do not take part in the desensitization process , while isoenzymes that are downregulated by TPA are involved . ^^^ |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| The PKC inhibitors ( staurosporine , calphostin C , Ro 31 8220 , or Go 6976 ) or long term 12 O tetradecanoylphorbol 13 acetate ( TPA ) treatment also resulted in inhibition of LPS induced NO release and iNOS expression . ^^^ |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| Western blots demonstrated expression of PKCalpha , betaI , epsilon , delta , and zeta in H9c2 cells ; PKC inhibitors ( staurosporine or Ro 31 8220 ) or down regulation of PKCalpha , betaI , epsilon , and delta by long term ( 24 h ) TPA treatment caused a partial blockade of the AVP induced response , whereas the A 23187 induced AA release was unaffected by down regulation of these isoforms . ^^^ |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| The pronounced inhibition of the TPA induced arachidonic acid release by the protein kinase C ( PKC ) inhibitors GF 109203X and Ro 31 82220 , respectively , and by the p 38 MAP kinase inhibitor SB 202190 suggests that the activation of the PLA2s by TPA is mediated via PKC and p 38 MAP kinase . . ^^^ |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| IKK activity was stimulated by either IL 1beta or TPA , and these effects were inhibited by Ro 31 8220 or tyrphostin 23 . ^^^ |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| PKC inhibitors ( staurosporine , Ro 31 8220 , calphostin C , or Go 6976 ) also inhibited TNF alpha induced response . 12 O Tetradecanoylphorbol 13 acetate ( TPA ) , a PKC activator , stimulated ICAM 1 expression , this effect was inhibited by genistein or tyrphostin 23 . ^^^ IKK activity was stimulated by both TNF alpha and TPA , and these effects were inhibited by Ro 31 8220 or tyrphostin 23 . ^^^ |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| Protein kinase C ( PKC ) inhibitors ( staurosporine or Ro 31 8220 ) also inhibited IFN gamma induced response . 12 O Tetradecanoylphorbol 13 acetate ( TPA ) , a PKC activator , stimulated ICAM 1 expression ; this effect was inhibited by tyrosine kinase or Src inhibitor . ^^^ |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| The TPA induced increase of H ( + ) secretion was sensitive to the cell permeable Ca ( 2+ ) chelator BAPTA / AM , Ro 31 8220 , and the CaMKII inhibitor KN 62 , but not to G 6976 . 6 . ^^^ |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| The protective effect of TPA on CYP2E1 dependent AA + Fe toxicity seemed to involve a PKC related survival mechanism , since PKC inhibitors such as Ro 31 8425 ( bisindolylmaleimide 10 hydrochloride ) or staurosporine abolished that protection , and activation of PKC by TPA was an early event that occurs prior to the developing toxicity . ^^^ |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND AND PURPOSE : We aimed to determine clinical and hemodynamic predictors of early reocclusion ( RO ) in stroke patients treated with intravenous tissue plasminogen activator ( tPA ) . ^^^ TCD monitoring of MCA recanalization ( RE ) and RO was performed during the first 2 hours after tPA bolus and repeated when clinical deterioration occurred < 24 hours after documented RE in absence of intracranial hemorrhage . ^^^ Age older than 75 years ( P=0 . 012 ) , previous antiplatelet treatment ( P=0 . 048 ) , baseline NIHSS score > 16 points ( P=0 . 009 ) , higher leukocytes count ( P=0 . 042 ) , beginning of RE < 60 minutes after tPA bolus ( P=0 . 039 ) , and ipsilateral severe carotid stenosis / occlusion ( P=0 . 001 ) were significantly associated with RO . ^^^ CONCLUSIONS : Stroke severity and ipsilateral severe carotid artery disease independently predict RO after tPA induced MCA RE . . ^^^ |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| The stimulating effect of high D glucose on t PA expression in HMC was prevented by treating the cells with different protein kinase C ( PKC ) inhibitors ( Ro 31 8220 , G 6976 ) , but could not be mimicked by the PKC activating phorbol ester PMA , indicating that this effect of high glucose is dependent on PKC activity , but not mediated through PKC activation . ^^^ |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00750 and P27797 |
Pubmed |
SVM Score :0.0 |
| NA |
|