| Interacting proteins: P53370 and P27708 |
Pubmed |
SVM Score :0.0 |
| Addition of exogenous basic fibroblast growth factor ( bFGF ) ( 10 ng / ml ) stimulated CLM growth substantially more in the CAD than in the non CAD group , whereas bFGF neutralizing antibodies nearly abolished growth in both . ^^^ Endothelial cells isolated from non CAD coronary arteries exhibited in culture typical endothelial characteristics , including cobblestone appearance , staining for von Willebrand factor , CLM formation on Matrigel substrate , and sensitivity to bFGF and to bFGF neutralizing antibody . ^^^ |
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| Interacting proteins: P53370 and P27708 |
Pubmed |
SVM Score :0.0 |
| Cells transfected with bFGF encoding cDNA also exhibited a significant elevation in N ( phosphonacetyl ) L aspartate resistance , and CAD gene amplification . ^^^ |
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| Interacting proteins: P53370 and P27708 |
Pubmed |
SVM Score :0.0 |
| RESULTS : In vivo , intracoronary administration of bFGF increased the CBF by 33 + / 33 % and the CAD by 12 + / 5 % at baseline , but reduced the CBF by 45 + / 8 % and the CAD by 14 + / 6 % after 10 weeks of a high cholesterol diet . ^^^ |
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| Interacting proteins: P53370 and P27708 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : The purpose of this study was to test the hypothesis that there is a relation between collateral flow and intracoronary concentrations of basic fibroblast growth factor ( bFGF ) and vascular endothelial growth factor ( VEGF ) and that the combined concentrations of both growth factors and the extent of coronary artery disease ( CAD ) play a role as covariables in such an association . ^^^ CONCLUSIONS : In patients with CAD , there is an association between a directly measured index of collateral flow and intracoronary concentrations of bFGF and VEGF . ^^^ |
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| Interacting proteins: P53370 and P27708 |
Pubmed |
SVM Score :0.0 |
| Our results demonstrate that aberrant expression of the LMW FGF 2 and / or HMW FGF 2 isoforms differently modulates drug resistance and gene amplification properties in the NIH 3T3 and A 31 cell lines by differential amplification of the CAD gene . ^^^ |
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| Interacting proteins: P53370 and P27708 |
Pubmed |
SVM Score :0.0 |
| Since the individual FGF 2 mRNA and protein level are , to a large extent , triggered off by genetic background , the FGF 2 expression can not be referred to as an independent clinical marker for CAD . . ^^^ |
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| Interacting proteins: P53370 and P27708 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53370 and P27708 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53370 and P27708 |
Pubmed |
SVM Score :0.0 |
| NA |
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