| Interacting proteins: P27708 and P20226 |
Pubmed |
SVM Score :0.0 |
| The CREB CAD interacts with the general transcription factor TFIID through one or more of the TATA binding protein associated factors ( TAFs ) , one of which is TAF 110 . ^^^ |
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| Interacting proteins: P27708 and P20226 |
Pubmed |
SVM Score :0.0 |
| CREB stimulates transcription through a constitutive activation domain ( CAD ) , which interacts with the promoter recognition factor TFIID , and through a kinase inducible domain ( KID ) , when Ser 133 is phosphorylated . ^^^ |
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| Interacting proteins: P27708 and P20226 |
Pubmed |
SVM Score :0.0 |
| Here , we show that the entire CREB activation domain or the CAD enhanced recruitment of a complex containing TFIID , TFIIB , and RNA polymerase 2 to a linked promoter . ^^^ Our results support a model for transcription activation in which the interaction between the CREB CAD and hTAFII 130 of TFIID promotes the recruitment of a polymerase complex to the promoter . . ^^^ |
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| Interacting proteins: P27708 and P20226 |
Pubmed |
SVM Score :0.0 |
| Enhancement of transcription activation by dTAF ( 2 ) 110 in mammalian cells required interaction with both the CAD and TFIID and was inhibited by mutation of core hydrophobic residues in the CAD . ^^^ |
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| Interacting proteins: P27708 and P20226 |
Pubmed |
SVM Score :0.0 |
| The CAD interacts with and recruits the promoter recognition factor TFIID through an interaction with a specific TATA binding protein associated factor ( TAF ) , dTAFII110 / hTAFII 135 . ^^^ A model for the activation of transcription by phosphorylated CREB is proposed , in which the polymerase is recruited by interaction of the CAD with TFIID and the recruited polymerase is activated further by phosphorylation of the KID in CREB . . ^^^ |
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