| Interacting proteins: P27695 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| Here we show that CpG DNA activates the TLR / IL 1R signaling pathway via the molecules myeloid differentiation marker 88 ( MyD 88 ) and tumor necrosis factor receptor associated factor 6 ( TRAF 6 ) , leading to activation of kinases of the IkappaB kinase complex and the c jun NH ( 2 ) terminal kinases . ^^^ |
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| Interacting proteins: P27695 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| We also report the basic structure of the human TRAF 5 and TRAF 6 genes obtained by analysis of the genomic DNA database . ^^^ |
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| Interacting proteins: P27695 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| In contrast , overexpression of DN IRAK 1 or DN TRAF 6 only partially inhibited CpG DNA induced Cox 2 promoter activity and NF kappaB activation , indicating the presence of additional signaling modulators downstream of MyD 88 . ^^^ Conclusively , these results demonstrate that endosomal DNA processing and TLR9 / MyD88 dependent activation of NF kappaB and p 38 are required for transcriptional regulation of Cox 2 expression induced by CpG DNA , and suggest that interleukin 1 receptor associated kinase and / or TRAF 6 may be a diverging point for NF kappaB activation in response to CpG DNA in RAW264 . 7 cells . . ^^^ |
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| Interacting proteins: P27695 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| However , overexpression of DN IRAK 1 or DN TRAF 6 resulted in substantial , but not complete , inhibition of the CpG DNA induced COX 2 3 ' UTR luciferase activity . ^^^ Overexpression of DN TRAF 6 suppressed CpG DNA mediated activation of p 38 and JNK , but not ERK , explaining the partial inhibitory effects of DN TRAF 6 on CpG DNA induced COX 2 3 ' UTR luciferase activity . ^^^ Co expression of DN TRAF 6 and N17Ras completely inhibited CpG DNA induced COX 2 3 ' UTR luciferase activity , indicating the involvement of Ras in CpG DNA mediated ERK and COX 2 3 ' UTR regulation . ^^^ Collectively , our results suggest that MyD 88 and MAPKs play a key regulatory role in CpG DNA mediated cox 2 expression at the post transcriptional level and that TRAF 6 is a diverging point in the Toll like receptor 9 signaling pathway for CpG DNA mediated MAPK activation . . ^^^ |
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| Interacting proteins: P27695 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| This activity , in contrast to that mediated by kappaB DNA motifs that do not efficiently bind p 65 homodimers , is shown to be uniquely dependent upon signal transduction through the carboxyl terminus of TRAF 6 . ^^^ |
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| Interacting proteins: P27695 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| DNA chip analysis revealed upregulation of TNF alpha mRNA and a number of molecules involved in TNF signaling such as TRAF 6 , caspases 10 , and 7 in depsipeptide treated HL 60 cells , which prompted us to examine the involvement of the TNF / TNF receptor system in the anti leukemic effects of the drug . ^^^ |
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| Interacting proteins: P27695 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| Genes in the NF kappaB signaling pathway that had increased expression in EPA treated cells included the toll like receptor 4 ( Tlr 4 ) , adaptor proteins [ TNF receptor associated factor 6 ( Traf 6 ) , myeloid differentiation primary response gene 88 ] , signal transduction kinases ( NF kappaB inducing kinase , inhibitors of kappa light polypeptide gene enhancer isoforms ) , inhibitor protein ( 1 kappaB alpha chain ) , transcription factors ( nuclear factor of kappa light chain gene enhancer , ( p ) 105 and NF kappaB subunit p 100 ) , DNA binding proteins ( cAMP response element binding protein ) and response genes known to affect CP [ interleukin 6 ( IL 6 ) , inducible nitric oxide synthase ( iNOS ) , monocyte chemotactic protein 1 ] . ^^^ |
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| Interacting proteins: P27695 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| MATERIAL AND METHODS : Using denaturing high performance liquid chromatography ( dHPLC ) and DNA sequencing , all exons and exon intron boundaries of the TRAF 6 gene in probands of 95 IBD families were initially screened ; this material comprised 20 CD , 39 UC and 36 mixed families . ^^^ |
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| Interacting proteins: P27695 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P27695 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P27695 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P27695 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P27695 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P27695 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P27695 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P27695 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P27695 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P27695 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P27695 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P27695 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P27695 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P27695 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P27695 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P27695 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P27695 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P27695 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P27695 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| NA |
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