| Interacting proteins: P27695 and Q13177 |
Pubmed |
SVM Score :0.55470881 |
| In addition , the heat shock induced cleavage and activation of PAK 2 was found to be closely associated with both DNA fragmentation and activation of an ICE / CED 3 family cysteine protease termed caspase 3 in heat shock treated Hep 3B cells . 0.55470881^^^ |
|
| Interacting proteins: P27695 and Q13177 |
Pubmed |
SVM Score :0.5676158 |
| The cleavage and activation of PAK 2 was found to be closely associated with both DNA fragmentation and activation of an ICE / CED 3 family cysteine protease termed caspase 3 in hyperosmotically shocked cells . 0.5676158^^^ |
|
| Interacting proteins: P27695 and Q13177 |
Pubmed |
SVM Score :0.0 |
| In addition , UV irradiation also led to activation of CPP32 / caspase 3 , but not ICH 1L / caspase 2 and ICE / caspase 1 , in A 431 cells and the kinetics of activation of CPP32 / caspase 3 appeared to correlate well with that of DNA fragmentation and of cleavage / activation of PAK 2 , respectively . ^^^ |
|
| Interacting proteins: P27695 and Q13177 |
Pubmed |
SVM Score :0.0 |
| Caspase 3 cleaves several essential downstream substrates involved in the expression of the apoptotic phenotype in vitro , including gelsolin , PAK 2 , fodrin , nuclear lamins and the inhibitory subunit of DNA fragmentation factor . ^^^ |
|
| Interacting proteins: P27695 and Q13177 |
Pubmed |
SVM Score :0.0 |
| UV ( 80 J / m ( 2 ) ) and the DNA damaging drugs cytosine beta D arabinofuranoside ( AraC ) and cis platinum ( 2 ) diammine dichloride ( cisplatin ) also induce gamma PAK activation . ^^^ The activation of gamma PAK in response to IR or AraC is dependent on tyrosine kinase and phosphoinositide 3 kinase activity , as demonstrated by use of the inhibitors genistein and wortmannin ; in contrast activation of gamma PAK by cisplatin and UV is not affected significantly by these inhibitors , suggesting that gamma PAK can be activated by more than one pathway in response to different types of DNA damage . ^^^ |
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| Interacting proteins: P27695 and Q13177 |
Pubmed |
SVM Score :0.0 |
| A member of the family of p 21 activated protein kinases , gamma PAK , has cytostatic properties and is activated during apoptosis and in response to DNA damage . ^^^ |
|
| Interacting proteins: P27695 and Q13177 |
Pubmed |
SVM Score :0.0 |
| We report that genistein , an isoflavone compound with known inhibitory activities to protein tyrosine kinases ( PTKs ) and topoisomerase 2 ( topo 2 ) , can prevent UV irradiation induced apoptotic biochemical changes ( DNA fragmentation , caspase 3 activation , and cleavage / activation of PAK 2 ) in A 431 cells . ^^^ |
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| Interacting proteins: P27695 and Q13177 |
Pubmed |
SVM Score :0.0 |
| A member of the p 21 activated protein kinase ( PAK ) family , gamma PAK has cytostatic properties and is activated by cellular stresses such as hyperosmolarity or DNA damage . ^^^ |
|
| Interacting proteins: P27695 and Q13177 |
Pubmed |
SVM Score :0.0 |
| The p 21 activated protein kinase gamma PAK , also known as PAK 2 , has very different properties from the other two highly conserved isoforms of the PAK family , alpha PAK ( PAK 1 ) and beta PAK ( PAK 3 ) . gamma PAK has cytostatic activity , as shown by inhibition of cleavage of early frog embryos following microinjection of gamma PAK and by inhibition of growth when expressed in mammalian cells . gamma PAK is activated in response to a variety of stresses including radiation and chemically induced DNA damage , hyperosmolarity , addition of sphingosine , serum starvation , and contact inhibition . ^^^ |
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| Interacting proteins: P27695 and Q13177 |
Pubmed |
SVM Score :0.0 |
| We have recently shown that formation of the Myc / Max / DNA complex is inhibited by the stress responsive protein kinase Pak 2 signaling pathway through phosphorylation of Myc . ^^^ |
|
| Interacting proteins: P27695 and Q13177 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and Q13177 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and Q13177 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and Q13177 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and Q13177 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and Q13177 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and Q13177 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and Q13177 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and Q13177 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and Q13177 |
Pubmed |
SVM Score :0.0 |
| NA |
|