| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| A 7 , 917 bp fragment of DNA was cloned and shown to carry a 4 , 104 bp cluster of 5 pha genes , phaP , Q , R , B , and C . ^^^ |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| Avian retrovirus pp 32 DNA binding protein . 1 . ^^^ |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| Two cellular proteins , SET and pp 32 , also associated with viral DNA during early phase . ^^^ |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| Immunocytochemical investigations have revealed that LANP , vessel dilator , kaliuretic peptide and ANP localize to the nucleus and cytoplasm of human pancreatic adenocarcinomas , which is consistent with their ability to decrease DNA synthesis in the nucleus of this cancer mediated by the intracellular messenger cyclic GMP . ^^^ |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| Limited proteolysis of a high molecular mass complex containing SET ( also named putative HLA associated protein 2 or PHAPII ) , PHAPI ( pp 32 , leucine rich acidic nuclear protein ) and HMG 2 by GzmA liberates NM 23 H1 , a Mg2+ dependent DNase that causes single stranded breaks in nuclear DNA . ^^^ |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| Gel mobility shift assays and DNaseI footprinting experiments demonstrated the capability of the transcriptional repressor PhaR to bind to a DNA region +36 to +46 bp downstream of the phaP 3 start codon . ^^^ |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| Further experiments revealed that silencing of ANP32A and ANP32B inhibited AAV replication , while overexpression of all of the components of the TAF I / Set complex increased de novo AAV DNA synthesis in permissive cells . ^^^ |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| Three enzymatic domains exist ; the RNase H and DNA polymerase activities are located on the alpha subunit while the DNA endonuclease is located on the pp 32 moiety . ^^^ |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| By using molecularly cloned retroviral DNA and synthetic oligonucleotides to introduce initiator ATGs and codons corresponding to the authentic N termini , we constructed two bacterial expression clones ; one clone contains the entire pol gene , and the other contains the region encoding the pp 32 domain . ^^^ |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| Avian retrovirus pp 32 DNA endonuclease is phosphorylated on Ser in the carboxyl terminal region . ^^^ The avian retrovirus pp 32 DNA endonuclease and the beta polypeptide of the reverse transcriptase contain the same three phosphoserine ( p Ser ) tryptic peptides . ^^^ |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| This single point mutation in the NH 2 terminus of pp 32 prevented efficient integration of viral DNA , with no apparent effect on viral DNA synthesis per se . ^^^ |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| The pp 32 protein possesses DNA endonuclease activity and is produced from the precursor by two proteolytic cleavage events , one of which removes 4 . 1 kDa of protein from the C terminus . ^^^ Both possess DNA endonuclease activity and , like the pp 32 protein isolated from virions , can cleave near the junction of two tandem avian sarcoma leukosis virus long terminal repeats in double stranded supercoiled DNA substrates . ^^^ In the presence of Mg2+ , both p32pol and viral pp 32 cleave either strand of DNA 2 nucleotides 5 ' to the junction . . ^^^ |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| Site specific nicking at the avian retrovirus LTR circle junction by the viral pp 32 DNA endonuclease . ^^^ The avian retrovirus pp 32 DNA endonuclease prefers to nick supercoiled DNA containing long terminal repeat ( LTR ) circle junction sequences at one or the other of two sites , each which mapped two nucleotides back from the circle junction . ^^^ The majority of other LTR DNA sites nicked by pp 32 in the presence of Mg2+ were adjacent to or within the dinucleotide CA . . ^^^ |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| We studied the site specific nicking of supercoiled DNA that contains tandem copies of avian retrovirus LTR DNA in vitro by using purified avian myeloblastosis virus pp 32 endonuclease , Mg2+ , and viral DNA substrates containing different LTR circle junction sequences . ^^^ The results confirmed our previous observation that the pp 32 protein generates two nicks , one in either viral DNA strand , each 2 nucleotides from the circle junction site . ^^^ |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| Requirement of the avian retrovirus pp 32 DNA binding protein domain for replication . ^^^ The NH 2 terminal amino acid sequence of the pp 32 DNA binding protein has been determined , thus establishing its precise coding region in the polymerase gene of Rous sarcoma virus . ^^^ Specific mutations were constructed in molecularly cloned Prague A DNA near the NH 2 and COOH termini of pp 32 and the effects were assayed by transfection on chick embryo fibroblasts . ^^^ |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| Partial phosphorylation in vivo of the avian retrovirus pp 32 DNA endonuclease . ^^^ Avian retrovirus pp 32 , a DNA endonuclease which is structurally related to the avian retrovirus DNA polymerase beta polypeptide , has been demonstrated to be partially phosphorylated in vivo . ^^^ However , pp 32 had one tryptic peptide which was preferentially labeled in comparison to the comigrating peptide found in beta digests , suggesting that phosphorylation may play a role in the processing of pp 32 from beta or in the regulation of its associated DNA endonuclease activity . . ^^^ |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| Antibodies against a synthetic peptide of the avian retrovirus pp 32 protein and the beta DNA polymerase subunit . ^^^ These studies confirm the correct reading frame predicted for the polymerase gene and establish a minimal NH 2 terminus for the pp 32 DNA binding protein , which was previously shown to be derived from the carboxyl terminus of the polymerase gene . . ^^^ |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| Avian retrovirus pp 32 DNA binding protein . ^^^ The avian retrovirus pp 32 protein possesses DNA endonuclease activity and unique DNA binding properties . ^^^ Single stranded DNA is only slightly preferred over double stranded DNA for pp 32 binding . ^^^ The pp 32 DNA binding sites on form 1 pBR 322 DNA which contained an insert of avian retrovirus long terminal repeat ( LTR ) DNA were determined . ^^^ Fragments containing viral LTR DNA sequences and plasmid DNA containing promoter sequences for the ampicillin and tetracycline genes , sequences for the `` left end ' ' inverted repeat of transposon 3 , and sequences encompassing the carboxyl terminus of the beta lactamase gene were preferentially retained on the filter by pp 32 . ^^^ |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| In order to determine the association between pp 32 expression and cell division , DNA synthesis was monitored by bromodeoxyuridine incorporation during prostate involution and regeneration . ^^^ |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| Assessment of Feulgen stained transfected and control lines of AT3 . 1 , a rat prostatic carcinoma cell line , using a computerized Cellular Image Analysis System ( BD CAS 200 ) showed that stable overexpression of human pp 32 in AT3 . 1 cells is accompanied by marked increases in the coefficient of variation of nuclear shape , nuclear size and chromatin textures but not in DNA content . ^^^ |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| A 270 to 420 kDa endoplasmic reticulum associated complex ( SET complex ) containing the nucleosome assembly protein SET , the tumor suppressor pp 32 , and the base excision repair enzyme APE can induce single stranded DNA damage in isolated nuclei in a granzyme A dependent manner . ^^^ |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| A GzmA activated DNase ( GAAD ) is in an ER associated complex containing pp 32 and the GzmA substrates SET , HMG 2 , and Ape 1 . ^^^ |
|
| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| In this study , we have identified pp 32 , which interacts with the DNA binding domain of ER alpha when the receptor is free , but not when it is bound to an estrogen response element . ^^^ Although pp 32 substantially enhances the association of the receptor with estrogen response element containing DNA , overexpression of pp 32 in MCF 7 cells decreases transcription of an estrogen responsive reporter plasmid . pp 32 Represses p 300 mediated acetylation of ER alpha and histones in vitro and inhibits acetylation of ER alpha in vivo . pp 32 Also binds to other nuclear receptors and inhibits thyroid hormone receptor beta mediated transcription . ^^^ |
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| Interacting proteins: P39687 and P27695 |
Pubmed |
SVM Score :0.0 |
| Recently , it was reported that the adenovirus DNA interacts with TAF 1 and pp 32 , another host acidic protein ( Y . ^^^ Although pp 32 had the potential ability to interact with protein 7 , pp 32 did not remodel the adenovirus DNA protein 7 complex in vitro . ^^^ |
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