| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| Another 16 HLA B specificities corresponded one by one to 16 distinct EC groups , and two subtypes of HLA Bw 75 , B 27 , and Bw 48 were also identified enabling the accurate typing of 22 HLA B alleles at the DNA level . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| A `` novel ' ' DNA binding factor recognizing the CCAAT motif seems to be important for locus specific expression of HLA A mRNA , whereas a different factor which binds to a Sp 1 like sequence is crucial for normal HLA B mRNA expression . ^^^ This observation is further supported by experiments which demonstrated that the locus specific suppression of exogenously introduced TK chloramphenicol acetyltransferase DNA constructs , containing the `` putative ' ' HLA locus specific DNA core regulatory sequence , is regulated in a locus specific manner when introduced into these HLA A and HLA B deficient human colorectal cell lines . . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| The two DNA probes , M20A and R5A , were derived from previously cloned cosmids and are located 38 and 110 kilobases ( kb ) centromeric to HLA B , respectively . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| In an assessment of the technique in 53 unrelated HLA A and HLA B matched patient donor pairs , 42 pairs gave the same results with PCR fingerprinting as with DNA RFLP analysis . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| Serological typing data were reported by individual transplant laboratories . 29 of 107 transplants ( 27 % ) that were reported as HLA A , B , DR compatible and 76 of 273 ( 28 % ) transplants that were reported as HLA B , DR compatible according to serological typing were found to be HLA DR mismatched by DNA typing . ^^^ The one year transplant success rate for DNA matched HLA , A , B , DR grafts was 87 % compared with 69 % for mismatched grafts ( p less than 0 . 02 ) ; the corresponding success rate for DNA matched HLA B , DR grafts was 85 % compared with 72 % for mismatched grafts ( p less than 0 . 01 ) . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| TagI HLA B and DRB RFLP analysis can be performed on DNA from chorionic villi biopsies obtained in the 8th week of pregnancy . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| Using HLA locus specific DNA probes , the level of HLA A and HLA B specific mRNAs were found to be underrepresented in six of these cell lines when compared to an epithelial cell line derived from a normal lactating breast . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| Genomic DNA from 46 B27+ ankylosing spondylitis , Reiter ' s syndrome , or normal individuals was digested with Taq 1 and probed , in Southern blots , with the HLA B locus specific probe , EI 7 . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| DNA polymorphisms associated with HLA B like genes and evidence for a duplication of B 40 genes detected with an HLA B specific DNA probe . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| Diagnosis of classical steroid 21 hydroxylase deficiency using an HLA B locus specific DNA probe . ^^^ Restriction fragment length polymorphisms seen after digestion of genomic DNA with MspI and TaqI with the HLA B locus specific DNA probe , pHLA 1 . 1 , were examined in 7 nuclear families with classical steroid 21 hydroxylase deficiency . ^^^ The HLA B locus specific DNA probe , pHLA 1 . 1 , can be used for diagnosis and genotyping of individuals from families with 21 hydroxylase deficiency . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| This fragment , JY150 / C5 , hybridized with two genomic bands in DNA from human HLA homozygotes presumably the HLA B locus gene and a closely related gene . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| Use of DNA probes from the 5 ' flanking region of the HLA B gene to examine polymorphism at the HLA B locus . ^^^ Two DNA probes isolated from the region 5 ' to the HLA B gene are described . ^^^ Both probes are used to show a high level of DNA sequence homology between the 5 ' flanking region of HLA B and HLA C . . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| These libraries were made with DNA from three different cell lines expressing HLA B 27 : MRWC ( HLA B 27 , 14 ) , obtained from an AS patient ; KCA ( HLA B 27 , w 44 ) , obtained from a known normal individual ; and MVL ( HLA B 27 , 27 ) , a homozygous consanguineous cell line of unknown origin . ^^^ To increase the number of clones coding for the HLA B locus , partial libraries were made using a complete Eco RI digestion of genomic DNA in the lambda vector 607 . ^^^ DNA from those clones positive for HLA B 27 by transfection was subcloned into the Xba 1 site of M13mp18 and the DNA sequence for exons 2 through 4 ( encoding domains alpha 1 , alpha 2 , and alpha 3 ) was determined by the dideoxy technique by using synthetic oligonucleotide primers or the M 13 primer . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| A DNA probe specific for the HLA B locus has been isolated from a broadly cross reactive HLA class 1 genomic clone . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| We have isolated a cDNA clone for one of the HLA B locus alloantigens by hybridization with a 30 nucleotide long DNA probe . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| Four human complement genes , which have previously been mapped between HLA D and HLA B on chromosome 6 , have now been aligned on a 98 kilobase ( kb ) section of the chromosome on the basis of four overlapping cosmid clones of genomic DNA . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| Here , using molecular clones of HTLV and human major histocompatibility antigen DNA , we have shown homology between the envelope gene region of HTLV and the region of an HLA B locus gene which codes for the extracellular portion of a class 1 histocompatibility antigen . . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| Unrelated bone marrow donor recipient pairs were assessed retrospectively for matching of the HLA B , C region ( beta block ) and HLA DR , DQ region ( delta block ) of the major histocompatibility complex ( MHC ) using a new DNA based method referred to as MHC block typing . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| We compared the cloned region between TNF and HLA B with the region in close proximity to HLA A using sequence analysis and DNA hybridization . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| Definition of a new HLA B 7 subtype ( B * 0704 ) by isoelectric focusing , family studies and DNA sequence analysis . ^^^ Cloning and sequencing of full length clones of complementary DNA showed that the new allele ( B * 0704 ) differs from B * 0702 , the common allele encoding HLA B 7 , by three nucleotide substitutions within the codon for residue 156 of the mature heavy chain . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| Comparison of the A 2 and non A 2 haplotypes at the DNA level showed that they were identical at HLA B , DR , and DQ loci . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| Low resolution DNA typing of the HLA B 5 cross reactive group by nested PCR SSP . ^^^ We have established a DNA typing system for the HLA B 5 serologically cross reactive group ( CREG ) by means of a two step PCR amplification with nested sequence specific primers ( nPCR SSP ) . ^^^ Two different primer combinations allow group specific amplification of all HLA B 5 CREG alleles and other related HLA class 1 alleles from genomic DNA . ^^^ Extension of this approach should allow rapid DNA typing of all serologically defined HLA B specificities by nPCR SSP . . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| Genomic DNA from 35 homozygous cell lines from the 10th International Histocompatibility Workshop and from eight heterozygous panel members was amplified using two primers designed to specifically amplify the HLA B locus . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| Comprehensive , serologically equivalent DNA typing for HLA B by PCR using sequence specific primers ( PCR SSP ) . ^^^ DNA samples from 57 International Histocompatibility Workshop reference cell lines and 160 control individuals have been typed by the HLA B PCR SSP technique . 3 / 57 cell line types and 12 / 160 normal control individuals types were discrepant with the reported serological types . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| Recombination rates within the class 2 region ( defined here as DRB 1 to DPB 1 ) and class 3 region ( defined here as HLA B to DRB 1 ) regions were 0 . 74 % and 0 . 94 % , respectively , both of which are within an expected range given the standard of 1 % recombination rate per megabase of DNA per meiosis . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| Low resolution DNA typing for HLA B using sequence specific primers in allele or group specific ARMS / PCR . ^^^ We describe here a polymerase chain reaction ( PCR ) system , based on the principle of the amplification refractory mutation system ( ARMS ) , for low resolution DNA typing of the HLA B gene . ^^^ A low resolution primer panel has been designed , based on published HLA B gene nucleotide sequences , consisting of 34 sequence specific primers ( SSP ) in 24 PCR reactions which cover all known HLA B alleles , to give allele specific or group specific amplification of DNA fragments of defined size ( 344 784bp ) . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| DNA typing of HLA B gene in Takayasu ' s arteritis . ^^^ Sixty four patients with Takayasu ' s arteritis and 156 healthy individuals in the Japanese population were examined for HLA B specificity at the DNA level by DNA typing using polymerase chain reaction ( PCR ) / sequence specific oligonucleotide probe ( SSOP ) analysis and by subsequent sequencing analysis . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| In one family , the crossover was shown to have occurred in the 20 kb stretch of DNA bounded by the two markers ( P3B and P 5 ) between which no evidence of linkage disequilibrium was found , a region which constitutes of only about 1 % of the distance between HLA A and HLA B . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| Serotyping of the HLA antigens , DNA typing of HLA B and HLA class 2 loci , study of polymorphic DNA markers of chromosome 6 , and cytogenetic analysis demonstrated paternal ID , involving at least a 25 centiMorgan portion of the chromosome pair that encompasses the MHC . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| Our results suggest that the constancy of the DNA of the HLA B , DR , DQ regions may extend to the DP region and that the extent of such fixity varies , perhaps as the result of ethnic variability of the population studied . . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| DNA typing for HLA DQA 1 and HLA DQB 1 antigens was performed in addition to serological typing of HLA A , HLA B , HLA C , and HLA DR antigens . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| HLA B locus DNA typing : detection of B * 7801 and seven additional alleles by BW 6 specific exon 2 amplification . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| We also identified a long repetitive DNA element in the region between HLA B and HLA E . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| New methods matching for blocks of DNA around HLA B and around HLA DR / DQ are available that are sensitive and identify additional mismatches that are not apparent using conventional typing methods . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| Transfection of both HLA B 35 and human beta 2 microglobulin genomic DNA into mouse P 815 cells led to high expression of HLA B molecules ; yet , expression of the TU 165 epitope was not observed . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| A statistical study of DNA sequences of alleles at the highly polymorphic class 1 MHC loci of humans , HLA A and HLA B , showed evidence of both large scale recombination events ( involving recombination of exons 1 2 of one allele with exons 3 8 of another ) and small scale recombination events ( involving apparent exchange of short DNA segments ) . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| Allelic heterogeneity of HLA B 35 subtypes in different populations as assessed by DNA typing . ^^^ In the present work a rapid DNA typing procedure was used to investigate the distribution of the various HLA B 35 alleles in different populations . ^^^ The amplified DNA was then hybridized to a panel of sequence specific oligonucleotide ( SSO ) probes designed to recognize the polymorphic residues in previously reported HLA B 35 subtypes . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| We have developed a simple , rapid and reliable method for specifically amplifying and cloning full length HLA B genes from genomic DNA . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| We have established a ligation based typing method to detect HLA B * 27 alleles at the DNA level . ^^^ The method requires amplification of exon 2 of the HLA B locus from genomic DNA by the polymerase catalyzed chain reaction ( PCR ) using group specific primers . ^^^ An aliquot of the PCR amplification product , heat stable ligase and a pair of oligonucleotide probes , designed to hybridize adjacently to HLA B * 27 specific sequences of the amplified DNA are subsequently thermocycled . ^^^ We conclude that ligation based typing is a reliable tool for the DNA based detection of HLA B * 27 alleles . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| We have examined 56 unrelated individuals from Malaysian aborigines for their DNA polymorphism of the HLA B gene by sequence specific oligonucleotide probe ( SSO ) method . ^^^ To determine the nucleotide sequences of ECB 1513 , a DNA fragment spanning from the beginning of exon 1 to the middle of exon 4 of the HLA B gene was amplified by polymerase chain reaction ( PCR ) from two ECB 1513 positive individuals , and the PCR products were cloned and sequenced . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| We have characterized , by DNA sequencing , the human alleles of a new highly informative ( CA ) n repeat localized approximately 20 kb centromeric to the HLA B gene . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| The DNA typing of HLA B gene and class 2 genes ( DRB 1 , DQA 1 , DPB 1 ) showed positive associations of the disease with HLA B 52 , B39 . 2 , DRB 1 * 1502 and DPB 1 * 0901 , confirming in part the serologic observations . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| To elucidate the detailed gene organization of the human leukocyte antigen ( HLA ) class 1 region on chromosome 6 , seven contiguous cosmid genomic clones covering the 237 kb segment around the HLA B and C loci were subjected to DNA sequencing by the shotgun strategy to give a single contig of 236 , 822 bp from the MICA gene ( 58 . 2 kb centromeric of HLA B ) to 90 . 8 kb telomeric of HLA C . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| In conclusion , there is a remarkable conservation of intronic sequences within related HLA B alleles , which probably reflects a common origin and perhaps a selective force avoiding DNA changes . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| Of the serologically concordant samples , 5 samples typed for HLA A and 7 samples typed for HLA B received DNA and serology types differing in their level of resolution . ^^^ One sample typed for HLA A and 3 samples typed for HLA B by DNA methods gave different results from their serologic assignments . ^^^ Of the samples exhibiting disparities among the different serologic typing laboratories , the DNA defined types of 7 samples typed for HLA A and 18 samples typed for HLA B were consistent with at least one of the serologic assignments . ^^^ The DNA types for the remaining 3 HLA B typed samples did not agree with the serologic assignments and their alleles were subsequently sequenced . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| DNA sequencing was used to identify HLA B 15 alleles associated with each serologic type and to examine the diversity within the B 15 antigen family . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| Clarification of HLA B serologically ambiguous types by automated DNA sequencing . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| As a source of DNA , we used cosmids centromeric of HLA B that had been mapped previously with conventional restriction digestion and fingerprinting and previously characterized yeast artificial chromosomes subcloned into cosmids and mapped with multiple complete digest methodologies . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| Comparison of serological and DNA PCR SSP typing results for HLA A and HLA B in 421 Black individuals : a Collaborative Transplant Study report . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| Polymerase chain reaction ( PCR ) readily identified HLA B DNA in transgenic trophoblastic cells but specific mRNA was of low abundance , being detectable by reverse transcriptase PCR but not by Northern blot hybridization . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| DNA typing for HLA A and HLA B identifies disparities between patients and unrelated donors matched by HLA A and HLA B serology and HLA DRB 1 . ^^^ To identify the extent and pattern of allelic disparities at HLA A and HLA B loci , 128 patients and 484 potential URD were evaluated by DNA typing . ^^^ DNA typing for HLA A , HLA B , and HLA DRB 1 was performed at Memorial Sloan Kettering Cancer Center . ^^^ By original typing ( serology for HLA A and HLA B ; DNA typing for DRB 1 ) 187 , 164 , and 133 URD were 6 / 6 , 5 / 6 , and 4 / 6 matches , respectively . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| Finally , the precise knowledge of these non coding regions could be important for developing DNA base typing strategies for the HLA B alleles . . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| There was no association between HLA B DNA haplotypes and the disease . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| DNA was extracted from frozen brain tissue and the highly polymorphic second and third exons of the HLA A and HLA B genes were independently PCR amplified using specific primers . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| To examine whether gene conversion occurs between two homologous loci of HLA A and HLA B , DNA sequences were compared and the differences or the numbers of substitutions per site at synonymous and nonsynonymous sites were calculated in the coding region and in the non coding region . ( 1 ) Totally differences at synonymous sites in introns and coding regions are small as compared with the differences in the 5 ' flanking region . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| Diversity in the HLA B 22 group was investigated in the Korean population using PCR SSOP and DNA sequencing analyses . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| Using the transmission disequilibrium test , we found significant evidence of linkage and allelic association across an interval defined by the markers tn 62 ( p = 1 . 0 10 10 ( 7 ) ) , HLA B ( p = 4 . 0 10 10 ( 7 ) ) , and HLA C ( p = 2 . 7 10 10 ( 9 ) ) , a region encompassed within a 285 kb genomic DNA fragment . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| We have developed and evaluated a test for HLA B * 27 based on PCR and DNA hybridization in microtiter plates . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| The probability of HLA C matching between patient and unrelated donor at the molecular level : estimations based on the linkage disequilibrium between DNA typed HLA B and HLA C alleles . ^^^ CONCLUSIONS : We conclude that , despite matching for both HLA B alleles by high resolution DNA typing and the presence of a strong LD between HLA B and HLA C loci , unrelated individuals are more likely to mismatch rather than match for one or both HLA C alleles . . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| HLA DR 2 subtypes , HLA B and MHC Class 1 chain related A ( MICA ) alleles were typed at the DNA level using the polymerase chain reaction single strand conformation polymorphism method . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| Sequence level polymorphisms of the HLA class 1 ( HLA A and HLA B ) genes were investigated in DNA samples of 50 Ainu living in Hidaka district , Hokkaido . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| Retrospective DNA typing by polymerase chain reaction using sequence specific primers ( PCR SSP ) has established the correspondence of this blank allele with the classical HLA B * 4001 allele . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| DNA sequencing of HLA B alleles in Mexican patients with Takayasu arteritis . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| DNA samples were genotyped by polymerase chain reaction / sequence specific primers ( HLA C ) , polymerase chain reaction / sequence specific primers ( HLA B ) , radioactive polymerase chain reaction ( MICA TM polymorphism in the transmembrane region ) , and polymerase chain reaction / restriction fragment length polymorphism ( protein S and octamer transcription factor 3 ) . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| To examine the genetic diversity in west Africa , class 1 HLA A and HLA B alleles of 92 unrelated individuals from two areas in the Cameroon , the capital Yaound and the village of Etoa , were identified by direct automated DNA sequencing of exons 2 and 3 of the HLA B locus alleles and sequence specific oligonucleotide probe ( SSOP ) and / or sequencing of the HLA A locus alleles . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| For alleles distinguished by both serological typing and the sequence of the peptide binding region , our estimates of S are comparable to those obtained by analysis of DNA sequences in showing that selection is strongest on HLA B and weaker on HLA A , HLA DRB 1 , and HLA DQA 1 . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| To further characterize HLA B * 15 in this population , B * 15 specific polymerase chain reaction ( PCR ) and sequence specific oligonucleotide probe ( SSOP ) hybridization analysis using 39 digoxigenin labeled probes were applied to DNA samples obtained from 237 B15 / B70 serologically positive unrelated individuals . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| Influence of HLA A , HLA B , and HLA DR matching on rejection of random corneal grafts using corneal tissue for retrospective DNA HLA typing . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| Novel DNA probe patterns for the HLA B * 07 allele were found using HLA B specific reverse sequence specific oligonucleotide probe ( SSOP ) and sequence specific primer ( SSP ) typing . ^^^ DNA sequencing demonstrated the presence of a new HLA B * 07 sequence variant encoding a single nucleotide substitution from a G to a T at nucleotide 539 in exon 3 . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| Patients and ethnically matched controls were HLA B genotyped from DNA using molecular based methods . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| METHODS : DNA samples from 81 Spanish patients with PsA and 110 healthy controls were examined by polymerase chain reaction ( PCR ) sequence specific primers to type HLA Cw and HLA DRB 1 , PCR sequence specific oligonucleotides to determine HLA B , and PCR restriction fragment length polymorphism for tumor necrosis factor alpha promoter polymorphisms at positions 238 and 308 . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| Complementary DNA sequence of the novel HLA B * 3704 allele . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| After DNA preparation , all samples were subjected to both PCR SSP ( sequence specific primers ) and PCR SSO ( sequence specific oligonucleotides ) typing procedures , designed for low resolution typing of the highly polymorphic HLA B locus . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| HLA B frequencies in 54 unrelated nasopharyngeal carcinoma ( NPC ) patients and 49 healthy random controls in Thailand were investigated by direct DNA sequencing . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| Among the 75 mismatched pairs , DNA typing of 63 pairs showed that 51 were mismatched at 1 HLA locus ( 18 HLA A , 11 HLA B , 22 HLA DRB 1 ) and 12 were mismatched at 2 or more loci . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| HLA A and HLA B alleles of a population from Kenya , Africa were examined by sequencing exon 2 and exon 3 DNA and typing using a Taxonomy based Sequence analysis ( TBSA ) method . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| To confirm this finding in another population , we performed HLA class 1 typing using the PCR SSP method and analyzed eight polymorphic markers distributed within 1100 kb around the HLA B gene using automated sequencer and subsequent automated fragment detection by fluorescent based technology with the DNA samples of 84 Iranian patients with BD and 87 healthy ethnically matched controls . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| Eighty samples of DNA carrying HLA B * 15 from 300 healthy unrelated individuals were tested . ^^^ Although limited conclusions can be drawn from this study because of the small number of DNA references used , the baseline data will be useful in the selection of common HLA B * 15 alleles when subtyping for unrelated donor transplantations . . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| METHODS : In 64 PSC patients and 183 normal controls of the same population ( Northern Italy ) , allelic polymorphisms at the DNA level were investigated in MHC region genes : HLA DRB 1 , HLA DQB 1 and HLA B , tumour necrosis factor A ( TNFA ) , and in CFTR gene , with polymerase chain reaction based methodologies . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| Transplants which had been reported to the Collaborative Transplant Study based on serological typing as matched for HLA A , B , DR or HLA B , DR were found to have a superior graft survival rate only if HLA DR compatibility was confirmed by DNA typing . . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| HLA B alleles were typed at low ( B 7 CREG alleles , i . e . , B * 7 , B * 54 , B * 55 , B * 56 , B * 40 , B * 42 ) or high resolution ( B * 27 alleles ) using polymerase chain reaction amplified DNA hybridized with sequence specific oligonucleotide probes . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| Class 1 HLA ( HLA B ) typing was performed by PCR amplification of genomic DNA . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| A novel HLA B * 55 allele , HLA B * 5514 , found in a DNA sample derived from a bone marrow donor . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| Paired normal and cancer genomic DNA was analyzed with DNA typing trays , including 57 subtypes of HLA A , 120 subtypes of HLA B , and 60 subtypes of HLA C . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| It takes only approximately 5 h from DNA extraction to the definition of HLA four digit alleles at the HLA A , HLA B , HLA C , and HLA DRB 1 loci for 96 samples when handled by a single typist . . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| HLA A and HLA B genes were typed by DNA sequencing in a mestizo population from Guadalajara , Jalisco , Mexico . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| DNA polymorphisms were looked for and several were shown to be more common in these subjects compared with controls ; these occur within genes of both the immune response [ human leucocyte antigen ( HLA ) DRB 1 , HLA B , transforming growth factor ( TGF ) beta 1 ] and those involved in several other cellular functions ( predominantly the cytoskeleton and cell adhesion ) . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| DNA from 129 patients and 76 healthy individuals were analyzed to determine the HLA B generic type as well as MICA 129 polymorphism . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| This method uses the highly polymorphic HLA B locus to discriminate the two HLA haplotypes in heterozygous individuals and its ideal location 1 . 4 Mbp telomeric to HLA DRB 1 and 1 . 2 Mbp centromeric to HLA A to capture 2 Mbp long genomic DNA . ^^^ Genomic DNA representing a single HLA B captured haplotype is genotyped for HLA A and HLA DRB 1 alleles and linkage to HLA B is established . ^^^ |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27695 and P30480 |
Pubmed |
SVM Score :0.0 |
| NA |
|