Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
Since methotrexate induced changes in deoxyuridine phosphorylase activity were time dependent , the reliability of the deoxyuridine suppression test and labeled deoxyuridine incorporation into DNA as measures of thymidylate synthetase ( EC 2 . 7 . 4 . 6 ) inhibition would also vary with time . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
A multienzyme complex containing at least DNA polymerase ( EC 2 . 7 . 7 . 7 ) , thymidine kinase ( EC 2 . 7 . 1 . 21 ) , dTMP kinase ( EC 2 . 7 . 4 . 9 ) nucleoside diphosphokinase ( EC 2 . 7 . 4 . 6 ) and thymidylate synthetase was separated from the corresponding free enzymes of DNA precursor synthesis by gel filtration of a gently lysed preparation of HPB ALL cells ( a human lymphoblastoid cell line ) . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
A GzmA activated DNase ( GAAD ) is in an ER associated complex containing pp 32 and the GzmA substrates SET , HMG 2 , and Ape 1 . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
Changes found in response to E ( 2 ) in multiply passaged cells , but not minimally passaged cells , included induction of growth arrest and DNA damage inducible protein 153 ( GADD 153 ) , and repression of Kirsten Ras 2B ( K Ras 2B ) , metastasis inhibition factor NM 23 and vascular endothelial growth factor . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
Reduced RNA and / or protein levels corresponding to the murine nm 23 1 and human nm 23 H1 complementary DNA clones have been correlated with high tumor metastatic potential in several rodent model systems and human breast carcinomas . ^^^ The pNM 23 H2S complementary DNA clone predicted a Mr 17 , 000 protein 88 % identical to nm 23 H1 . nm 23 H2 also shared a significant homology with nucleoside diphosphate kinases and a Drosophila developmental gene . ^^^ Southern blots containing BglII restricted genomic DNA , which exhibited an allelic restriction fragment length polymorphism for nm 23 H1 , contained nonallelic bands upon rehybridization to the nm 23 H2 probe . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
Somatic allelic deletion of nm 23 H1 was observed in human breast , renal , colorectal , and lung carcinoma DNA samples , as compared to DNA from matched normal tissues . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
We present a restriction fragment length polymorphism ( RFLP ) analysis of 29 benign and 30 malignant prostatic tumors , using polymorphic DNA probes to the putative tumor suppressor genes DCC ( Deleted in Colorectal Carcinoma ; chromosome 18q21 . 3 ) , nm 23 H1 ( 17q21 . 3 ) , APC ( Adenomatous Polyposis Coli ; 5q21 ) and p 53 ( 17p13 ) . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
The nm 23 H1 / NDPK A gene was also investigated on the DNA level to define possible genomic alterations . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
To evaluate the role of nm 23 H1 in ovarian carcinogenesis , we have analyzed this gene in 66 primary human ovarian carcinomas at both the DNA and RNA levels . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
METHODS : The metastatic human breast carcinoma cell line MDA MB 435 , clones transfected with a control pCMVBamneo vector , and clones transfected with pCMVBamneo vector containing nm 23 H1 complementary DNA ( the latter of which exhibited a substantial reduction in spontaneous metastatic potential in vivo ) were cultured within a reconstituted basement membrane . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
Both groups were similar according to age , sex , etiology , status of the underlying liver , tumor size , and other pathological characteristics of the neoplasm . nm 23 H1 mRNA levels were assessed in matched tumor and surrounding cirrhotic liver samples by Northern blot hybridization using a 900 base pair probe , which is a BamHI fragment of pnm 23 H1 recombinant complementary DNA clone encoding the nm 23 H1 human gene . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
To elucidate the regulatory mechanisms of nm 23 , we isolated , cloned and sequenced the presumptive regulatory DNA fragment spanning the 5 ' region of the human nm 23 H1 gene . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
A search for loss of heterozygosity ( LOH ) of the nm 23 gene after DNA extraction from frozen tissues and hybridization with nm 23 H1 cDNA specific probe was made in 10 endometrial carcinomas . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NM 23 H1 is composed of five exons , spanning a genomic DNA fragment of 10 kb . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
The potential mutation in the nm 23 H1 gene was examined in colorectal cancer using a reverse transcription polymerase chain reaction amplification followed by DNA sequencing analysis . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
The mechanism of nm 23 dependent sensitivity to cisplatin is unknown , but was correlated with increased formation of interstrand DNA cross links in nm 23 H1 transfected breast carcinoma cells . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
Transgenes that have the 750 bp awd upstream regulatory DNA fused to human nm 23 H2 cDNA but not to nm 23 H1 cDNA can rescue the imaginal disc phenotype and the zygotic lethality caused by homozygosis for an awd null mutation as efficiently as an awd transgene . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
Nevertheless , this study suggests that , in a fraction of cases , UCs could represent a distinct entity not involved in the malignant progression , associated with peculiar DNA anomalies , one possibly being that of the nm 23 H1 deletion . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
This study aimed to investigate whether immunohistochemical staining for nm 23 H1 protein in the primary tumour is correlated with tumour stage , tumour differentiation , DNA ploidy , cell proliferative index , p 53 status and patient survival time in colorectal cancer . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
METHODS : Southern blot , PCR / SSCP and DNA sequencing techniques were used in 33 gastric carcinomas to detect c met , EGFR , c erbB 2 , AKT 2 , c Ha ras , p 53 , p 16 and nm 23 H1 , for the presence of amplification , deletion , mutation and rearrangement . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
This analysis of 32 pairs of human squamous cell lung carcinomas and normal matched control DNA demonstrates that loss of heterozygosity ( LOH ) is infrequent at the nm 23 H1 locus , affecting only 2 of the 18 informative cases . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
The transactivation potential of Nm 23 H1 , a homolog of c myc transcription factor Nm 23 H2 / PuF was assessed in yeast as a fusion protein with the DNA binding domains ( DBDs ) of GAL 4 and LexA . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
OBJECTIVES : To explain the overall survival ( OS ) and disease free survival ( DFS ) in relation to nm 23 H1 protein , DNA ploidy and S phase fraction ( SPF ) in transitional cell carcinoma of the bladder . ^^^ Nm 23 H1 protein expression in immunohistological staining and DNA ploidy , S phase fraction by flow cytometric were performed . ^^^ RESULTS : The correlation between OS and staging , grading , DNA ploidy and S phase was significant ; whereas the overall survival and nm 23 H1 protein , was not significant . ^^^ There was no significant difference in age , sex , stage , grading , DNA ploidy and SPF distribution between patients with nm 23 H1 positive bladder cancer and those with nm 23 H1 negative tumours . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
Downregulation of intracellular nm 23 H1 prevents cisplatin induced DNA damage in oesophageal cancer cells : possible association with Na ( + ) , K ( + ) ATPase . ^^^ The present study was undertaken to investigate the association of nm 23 H1 expression with cisplatin induced DNA damage in OSCC using antisense nm 23 H1 transfectants . ^^^ Our data support the conclusion that reduced expression of intracellular nm 23 H1 in OSCC cells is associated with cisplatin resistance via the prevention of both nuclear and mitochondrial DNA damage and suggest that it may be related to Na ( + ) , K ( + ) ATPase activity , which is responsible for intracellular cisplatin accumulation . . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
We examined loss of heterozygosity ( LOH ) in the p 53 , APC , DCC , RB , and NM 23 H1 gene regions by polymerase chain reaction ( PCR ) LOH assay using an automated fluorescent DNA sequencer employing four microsatellite markers ( p 53 , APC , DCC , NM 23 H1 ) . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
A series of DNA primers specific for the specific fragments of nm 23 H1 and nm 23 H2 were designed and synthesized . ^^^ The specific fragments of nm 23 H1 ( 185 bp ) and nm 23 H2 ( 145 bp ) were amplified from human blood DNA by using polymerase chain reaction ( PCR ) . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
In contrast , NM 23 H2 , known as a transcriptional activator with a DNA cleavage function , cleaved within the 5 ' portions of both strands , revealing that NM 23 H1 and NM 23 H2 cleave at distinct sites of the 5 ' SHS and by different mechanisms . ^^^ These studies demonstrate for the first time that NM 23 H1 interacts both structurally and functionally with DNA . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
Furthermore , we show that Nm 23 H1 activates transcription when fused to the Gal 4 DNA binding domain and is coexpressed with a luciferase reporter construct containing the Gal 4 binding sites upstream of a basal promoter . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
We report here the mouse nm 23 M3 and nm 23 M4 complementary DNA sequences and the genomic cloning , characterization and tissue expression pattern of the nm 23 M2 , nm 23 M3 and nm 23 M4 genes , in comparison with their human and rat orthologs and with the human nm 23 H1 and mouse nm 23 M1 genes . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
DNA ploidy and S phase fraction , but not p 53 or NM 23 H1 expression , predict outcome in colorectal cancer patients . ^^^ PURPOSE : The aim of this study was to determine TP 53 and NM 23 H1 immunoreactivity , DNA ploidy , and S phase fraction ( SPF ) in a series of 160 patients undergoing resective surgery for primary operable colorectal cancer ( CRC ) and to establish whether these alterations have any clinical value in predicting CRC patients ' prognosis . ^^^ METHODS : TP 53 and NM 23 H1 expressions were evaluated on paraffin embedded tissue by immunohistochemistry and DNA ploidy and SPF on frozen tissue by flow cytometric analysis . ^^^ CONCLUSIONS : Our results indicate that DNA aneuploidy and high SPF are associated in CRC with a poor clinical 5 year outcome , while in contrast the prognostic role of TP 53 and NM 23 H1 expression is still to be clarified . . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
Limited proteolysis of a high molecular mass complex containing SET ( also named putative HLA associated protein 2 or PHAPII ) , PHAPI ( pp 32 , leucine rich acidic nuclear protein ) and HMG 2 by GzmA liberates NM 23 H1 , a Mg2+ dependent DNase that causes single stranded breaks in nuclear DNA . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
The aim of our study was to assess , in 160 patients undergoing surgery for colorectal cancer ( CRC ) , the expression of the Nm 23 H1 protein and to evaluate its possible associations with traditional clinicopathologic variables , with DNA ploidy and proliferative activity ( S phase fraction , SPF ) , and with disease free and overall survival of patients . ^^^ Nm 23 H1 expressions were evaluated on paraffin embedded tissue by immunohistochemistry ; DNA ploidy and SPF on frozen tissue by flow cytometric analysis . ^^^ No association was observed between Nm 23 H1 protein expression and clinicopathological variables , S phase fraction and DNA ploidy . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
DNA isolated from normal and tumour tissue was used for LOH analysis using a variable nucleotide tandem repeat ( VNTR ) marker located in the untranslated 5 ' region of the nm 23 H1 gene . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
Granzyme A ( GzmA ) triggers cell death with apoptotic features by targeting the endoplasmic reticulum associated SET complex , which contains the GzmA activated DNase NM 23 H1 , its inhibitor SET , and Ape 1 . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
Quantitative PCR ( Q PCR ) showed a substantial enrichment of the correlated oncosuppressor genes p 53 , WT 1 , ING 1 , and NM 23 H1 in the immunoprecipitated ( IP ) DNA . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
Downstream targets of Nm 23 H1 : gene expression profiling of CAL 27 cells using DNA microarray . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
The exonuclease TREX 1 is in the SET complex and acts in concert with NM 23 H1 to degrade DNA during granzyme A mediated cell death . ^^^ Single stranded DNA damage is initiated when the endonuclease NM 23 H1 becomes activated to nick DNA after granzyme A cleaves its inhibitor , SET . ^^^ NM 23 H1 and TREX 1 work in concert to degrade DNA . ^^^ Silencing NM 23 H1 or TREX 1 inhibits DNA damage and death of cells treated with perforin ( PFN ) and granzyme A , but not of cells treated with perforin and granzyme B ( GzmB ) . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
To ensure toxicologically the potential antiarrhythmic agent 3 carbethoxyamino 5 dimethylamino acetyl 10 , 11 dihydro dibenz [ b , f ] azepine hydrochloride ( Bonnecor , GS 015 , AWD 19 166 ) , the following preclinical studies have been made up to the present : Determination of the acute toxicity on mice and rats , toxicity test on the rat by repeated applications , study as to the action of GS 015 on the prenatal development of the rat , diverse toxicologic studies on reproduction , mutagenity tests by using the DNA repair test and the Ames test . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
The Awd structure suggests an allosteric mechanism of action of NDP kinase where DNA is the effector and the protein undergoes a major conformational change , possibly dissociating to dimers . . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
All of the human tumor cells were heterozygous for the nm 23 HI specific allelic DNA fragments , with no allelic deletions or gross alterations detected . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
Evaluation of NM 23 RNA levels , or DNA ploidy and T 138 surface antigen expression , which have been shown to correlate with metastatic potential , may hold important therapeutic implications . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
Loss of nm 23 and Alu DNA in human lung cancer propagated in nude mice . ^^^ Further restriction analysis revealed that only mouse DNA , but no human Alu DNA , was present in the tumor specimens which lacked the human nm 23 genes . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
A study on the relationship between clinicopathological findings of gastric cancer and its biological behavior such as DNA ploidy pattern and immunohistochemical staining of PCNA , laminin , p 53 and nm 23 ] . ^^^ The quantity of DNA ploidy and the expression of PCNA , laminin , p 53 and nm 23 by immunohistochemical stain were investigated using paraffin embedded specimens obtained from 135 gastric cancer patients , and were compared with clinicopathological findings . ^^^ Results : ( 1 ) The incidence of DNA high ploidy ( HP ) was significantly higher in such a case with infiltrating type ( INF ) and positive lymph node metastasis ( p+ ) compared with that of negative cases . ( 2 ) The high level of PCNA labeling index ( HLI ) , negative expression of laminin ( NEL ) and nm 23 ( NE 23 ) were more frequently observed in INF ; large tumor size , deep invasion and p+ , while positive p 53 was noted only in p+ cases . ( 3 ) The survival curve of HP , HLI , NEL , and NE 23 was significantly lower than that of the cases showing the reverse findings . ^^^ As a conclusion , it is suggested that the investigation of the DNA ploidy , PCNA , laminin , p 53 and nm 23 might be useful as a parameter of biological behavior for gastric cancer and the prognosis of gastrectomized patients . . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
Southern blot containing Bg1II digested human liver genomic DNA hybridized to the entire nm 23 H3b DNA and showed three bands at 10 . 5 , 7 . 9 and 4 . 0 kb . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
Nucleoside diphosphate kinase enzyme activity of NM 23 H2 / PuF is not required for its DNA binding and in vitro transcriptional functions . nm 23 genes encode proteins that participate in tumor metastasis regulation and in various fundamental cellular processes , although the mechanisms remain undefined . ^^^ To understand the significance of these two biochemical activities to NM 23 H2 function , we have investigated the relationship between the DNA binding and transcriptional activity of NM 23 H2 and its NDPK function . ^^^ These results indicate a lack of correlation between nucleoside diphosphate kinase activity of nm 23 H2 on the one hand , and its DNA binding and transcriptional activity on the other , suggesting that the nm 23 H2 gene encodes a bifunctional protein molecule . . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
DNA sequence analysis of recombinant PuF revealed perfect identity with the human nm 23 H2 nucleoside diphosphate kinase gene , a potential negative regulator of cancer metastasis . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
Evidence for nm 23 RNA overexpression , DNA amplification and mutation in aggressive childhood neuroblastomas . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
We have developed a method for detecting nm 23 H 1 and nm 23 H 2 RNA using the polymerase chain reaction , based on the amplification of complementary DNA copies of nm 23 H 1 and nm 23 H 2 RNA . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
In order to better understand the biological role ( s ) of nm 23 in non transformed cells , an nm 23 specific antibody was introduced into rat embryo fibroblasts and effects on DNA synthesis and cell cycle progression were analyzed . ^^^ Microinjection of the nm 23 antibody inhibited cell division with no apparent effect on DNA synthesis . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
The latter include evaluation of NM 23 RNA levels , or DNA ploidy and T 138 surface antigen expression , which have been shown to correlate with metastatic potential . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
Because cell motility plays an essential role in metastatic dissemination , we have studied whether tumor cells transfected with nm 23 complementary DNA have any alterations in their ability to migrate . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
To clarify the role of nm 23 in lung carcinoma , the genetic abnormalities of nucleoside diphosphate / kinase A / nm23 H 1 were investigated at the DNA and protein levels . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
We have evaluated and compared the expression of nm 23 NPD kinase protein using an immunohistochemical method and DNA ploidy evaluation with image analysis . ^^^ Results have shown an association between the parameters obtained for the nm 23 NPD kinase protein expression , and aneuploid DNA and neoplastic progression . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
Two of these , Asn 69 and Lys 135 , are not conserved between NM 23 variants differing in DNA binding potential , suggesting that DNA recognition resides partly in nonconserved amino acids . ^^^ In the context of the known crystal structure of NM 23 H2 , the DNA binding residues are located within distinct structural motifs in the monomer , which are exposed to the surface near the 2 fold axis of adjacent subunits in the hexamer . ^^^ These findings are explained by a model in which NM 23 H2 binds DNA with a combinatorial surface consisting of the `` outer ' ' face of the dimer . ^^^ Chemical crosslinking data support a dimeric DNA binding mode by NM 23 H2 . . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
With n myc we propose a candidate gene regulated by ROR alpha / RZR beta and Nm 23 , based on the finding that the respective DNA binding sites in the first intron are conserved in several mammalian species . . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
Immunohistochemical analysis of proliferating cell nuclear antigen , p 53 protein and nm 23 protein , and nuclear DNA content in transitional cell carcinoma of the bladder . ^^^ In this study , the authors determined the prognostic significance of proliferating cell nuclear antigen ( PCNA ) , p 53 protein , and nm 23 protein , as well as nuclear DNA content in specimens with TCC of the bladder . ^^^ PCNA expression , p 53 protein and nm 23 protein immunoreactivities , and the parameters for nuclear DNA content such as 2c deviation index ( 2cDI ) and 5c exceeding rate ( 5cER ) were evaluated using a computer assisted image analyzer , and the results were compared with histologic findings and clinical outcome . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
Conventional transcription factors possess DNA binding and transactivation domains ; Nm 23 fusion proteins were used to address two questions . ^^^ First , if provided with a well characterized DNA binding domain , does Nm 23 possess a transactivation domain capable of stimulating transcription of an appropriate reporter . ^^^ Second , if provided with a potent transactivation domain , is the DNA binding of Nm 23 of sufficient specificity and affinity to direct the fusion protein to a CT dependent reporter . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
METHODS : Three neuroblastoma cell lines ( human LAN 5 , human SK N SH , and murine N1E 115 ) were used in these experiments ; cells from two of the lines ( SK N SH and N1E 115 ) were also studied after being stably transfected with a plasmid containing a full length DR nm 23 complementary DNA . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
Neither p 53 , nm 23 , DNA methyltransferase , activated ras , fibroblast growth factor 4 ( FGF 4 ) , or epidermal growth factor receptor ( EGFR ) mediated the acquisition of the metastatic or undifferentiated phenotype within the C 8161 human fusions . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
METHODS : Nineteen specimens ( 10 jugulotympanic and 9 carotid glomus tumors ) were investigated by quantitative DNA measurements and immunohistochemical assessment of proliferation markers ( PCNA , Ki 67 ) , oncogenes ( p 53 , nm 23 ) , different cell surface antigenes ( CD 44 4 / 5 and 6 , CD 54 , CD 106 ) , and bcl 2 as a marker for apoptosis . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
Many NM 23 proteins bind DNA . ^^^ The mechanism whereby NM 23 regulates gene expression is proposed to entail DNA binding and subsequent alterations in promoter DNA structure . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
The examinations included morphologic multifactorial tumor front grading , quantitative DNA analysis , and immunohistochemical assessment of proliferation markers ( i . e . proliferating cell nuclear antigen [ PCNA ] and MIB 1 ) and of oncogene products ( i . e . p 53 ; nm 23 ) . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
Cleavage of DNA by human NM 23 H2 / nucleoside diphosphate kinase involves formation of a covalent protein DNA complex . ^^^ The cleavage reaction requires only NM 23 H2 , DNA , Mg ( 2+ ) , and buffer , occurs in the absence of denaturing conditions , and can be reversed by EDTA . ^^^ Transfer of ( 32 ) P radioactivity from DNA to NM 23 H2 has been observed , and a covalent polypeptide DNA complex has been isolated and identified by Western blotting as NM 23 H2 . ^^^ Since covalent protein DNA complexes are known to serve the role of breaking and rejoining DNA strands , the present findings suggest that NM 23 H2 is involved in DNA structural transactions necessary for the activity of the c MYC promoter . . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
Melanoma cells transfected with wild type Rad , but not the S105N Rad , showed enhanced DNA synthesis in response to serum ; this effect was lost with coexpression of nm 23 . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
Immunohistochemical expression of p 53 , nm 23 HI , Ki 67 and DNA ploidy : correlation with lymph node status and other clinical pathologic parameters in breast cancer . ^^^ METHODS : Seventy one primary breast carcinoma specimens obtained by mastectomy or quadrantectomy were examined for the determination of the p 53 , nm 23 and Ki 67 expression , with immunohistochemistry , and the DNA content , with static cytometry . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
Operative specimens of three patients who underwent surgery for a paraganglioma of the nasal cavity ( one case ) or paranasal sinuses ( two cases ) were investigated by routine histology , quantitative DNA analysis , and immunohistochemical assessment of proliferation markers ( i . e . , Proliferating Cell Nuclear Antigen , PCNA ; Ki 67 MIB 1 ) , the expression of cell surface antigens , which reflect the tumor stroma interaction ( i . e . , CD 44 v0 . 4 / 5 and 6 , CD 54 , CD 106 ) , oncogene products ( nm 23 ; p 53 ) , and bcl 2 as a marker of apoptosis . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
Immunohistochemical examinations ( Ki 67 , p 53 , nm 23 ) and DNA cytophotometry in bladder cancer . ^^^ The aim of our study was to compare the potential of aggression of both superficial and invasive bladder tumours by means of the proliferation marker Ki 67 , the tumour suppressor gene p 53 , the non metastasizing protein nm 23 and the evaluation of DNA ploidy . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
Using DNA flow cytometry and immunohistochemical staining techniques we determined the DNA content and the level of co expression of seven tumor associated proteins : proliferating cellular nuclear antigen ( PCNA ) , epidermal growth factor receptor ( EGFr ) , p 53 , c erbB 2 , H ras , c myc , and nm 23 . ^^^ In conclusion , this study demonstrates that the DNA content and genetic markers c myc , c erbB 2 , EGFr , H ras , p 53 , PCNA , and nm 23 do not predict survival after potentially curative resection of hepatic metastases from CRC . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
Due to the analogies and correlations between nm 23 and p 53 , the role of nm 23 as a potential predictive factor of response to chemotherapy and in DNA repair is emphasized . . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
Ki 67 , p 53 , nm 23 , and DNA cytometry in bladder cancer : potential markers for detection of recurrence . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
This review includes K ras , p 53 , DCC , NM 23 and DNA mismatch repair genes . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
Twenty nine cases of oral melanomas were investigated for nm 23 and Ki 67 antigen expression , as well as for the fraction of tumour cells in S phase , using immunohistochemical techniques and DNA cytophotometry . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
In the last 10 years , a plethora of new markers ( proliferation markers and DNA alteration , P gp , p 53 , TLS CHOP , cyclins , survivin , TERT , PAX 3 PAX7 / FKHR , SYT SSX1 / 2 , VEGF , E cadherin and beta catenin , nm 23 , SKP 2 , p 27 , CD 40 ) has been studied with regard to their role in promoting progression ( in a laboratory setting ) and then determining prognosis and therapy ( in a clinical setting ) . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
Totally , 1557 twofold differentially expressed genes were screened out by 17 , 000 human genome complementary DNA microarrays between the two cell lines , including some important genes such as , nm 23 , c erbB 2 , and other unknown genes or expressed sequence tags with remarkable fold changes . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
In this analysis , 4 out of 5 members of the SET complex , SET , APE 1 , NM 23 and HMGB 2 , were highly expressed in invasive grade 3 tumors . ^^^ When combining all tumors , overexpression of Nm 23 ( p = 0 . 04 ) , Set ( p = 0 . 004 ) and Ape 1 ( p = 0 . 004 ) was associated with the clinical stage of the disease . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
DNA sequencing and restriction analysis demonstrated that all clones contain the NME 1 gene encoding the RNA of the ribonucleprotein particle RNase MRP . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
The highest frequencies for DNA sequence copy number gains were detected for SNRPN ( 61 % ) ; GNLY ( 44 % ) ; NME 1 ( 44 % ) ; DDX 15 , ABCB 1 ( MDR ) , ATM , LAMA 3 , MYBL 2 , ZNF 217 , and TNFRSF6B ( 39 % each ) ; and MSH 2 , TERC , SERPINE 1 , AFM137XA11 , IGF1R , and PTPN 1 ( 33 % each ) . ^^^
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
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Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
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Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
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Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
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Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
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Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
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Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
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Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
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Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
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Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
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Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
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Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
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Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
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Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
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Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
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Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15531 and P27695	Pubmed	SVM Score :0.0
NA