| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| The results suggest that ( a ) granzyme A may be produced with putative different leader sequences from two different mRNAs ; ( b ) this may provide a model system for studying alternate splicing and the evolution of a complex enzymatic system in an organelle ; and ( c ) the genomic DNA reported will be useful for studying transcription regulations involved in controlling the specific expression pattern of this gene . . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| Induction of target cell DNA release by the cytotoxic T lymphocyte granule protease granzyme A . ^^^ This nuclear DNA releasing ( NDR ) activity is inhibited by serine esterase inhibitors that also inhibit the granule BLT esterase activity , and is specifically immunoabsorbed by antibodies to the CTL granule protease granzyme A . ^^^ Although fully lytic concentrations of purified LGL granule cytolysin alone failed to induce target cell DNA release , a combination of purified granzyme A and the cytolysin induces substantial DNA release . . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| Using an 11 kb subfragment of the cloned genomic DNA as a probe , we have identified the chromosomal position of human granzyme A on 5q11 q 12 . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| Granzyme A loading induces rapid cytolysis and a novel form of DNA damage independently of caspase activation . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| The cytotoxic T lymphocyte protease granzyme A induces caspase independent cell death in which DNA single strand nicking is observed instead of oligonucleosomal fragmentation . ^^^ Granzyme A is a specific tryptase that concentrates in the nucleus of targeted cells and synergistically enhances DNA fragmentation induced by the caspase activator granzyme B . ^^^ Here we show that granzyme A treatment of isolated nuclei enhances DNA accessibility to exogenous endonucleases . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| Intratumoral granzyme A activity was significantly increased in tumors injected with IL 2 plasmid : DMRIE / DOPE complexes , but not by an irrelevant plasmid DNA : DMRIE / DOPE control . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| Granzyme A and B deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potent in vivo anti tumor capacity . ^^^ Splenocytes and allogeneic CTL of granzyme A and / or B deficient mice were defective for induction of DNA fragmentation , but induced significant membrane damage and target cell death . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| Granzyme A activates an endoplasmic reticulum associated caspase independent nuclease to induce single stranded DNA nicks . ^^^ The cytotoxic T lymphocyte protease granzyme A ( GzmA ) initiates a novel caspase independent cell death pathway characterized by single stranded DNA nicking . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A . ^^^ Significant EL 4 DNA breakdown accompanying lysis was observed only with RBL that was transfected with both cytolysin and granzyme A . ^^^ These results support the granule exocytosis model for lymphocyte cytotoxicity and show that effector granzyme A plays a role in target cell DNA breakdown . . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| Complementary approaches with purified molecules or transfected cytolytic effector cells have suggested that both , granzyme A ( gzmA ) and granzyme B ( gzmB ) , similarly contribute to CTL mediatedand perforin ( perf ) dependent apoptotic nuclear damage ( DNA fragmentation ) in target cells . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| Cleaving the oxidative repair protein Ape 1 enhances cell death mediated by granzyme A . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| Granzyme A ( GzmA ) induces a caspase independent cell death pathway characterized by single stranded DNA nicks and other features of apoptosis . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| A special target of the granzyme A cell death pathway is an endoplasmic reticulum associated complex , called the SET complex , which contains three granzyme A substrates , the nucleosome assembly protein SET , the DNA bending protein HMG 2 , and the base excision repair endonuclease Ape 1 . ^^^ Cleavage of Ape 1 by granzyme A interferes with the ability of the target cell to repair itself . ^^^ Granzyme A induces single stranded DNA damage as well as rapid loss of cell membrane integrity and mitochondrial transmembrane potential through unknown mechanisms . ^^^ Granzyme A destroys the nuclear envelope by targeting lamins and opens up DNA for degradation by targeting histones . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| Granzyme A ( GzmA ) triggers cell death with apoptotic features by targeting the endoplasmic reticulum associated SET complex , which contains the GzmA activated DNase NM 23 H1 , its inhibitor SET , and Ape 1 . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| Granzyme A , which causes single stranded DNA damage , targets the double strand break repair protein Ku 70 . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| The exonuclease TREX 1 is in the SET complex and acts in concert with NM 23 H1 to degrade DNA during granzyme A mediated cell death . ^^^ Single stranded DNA damage is initiated when the endonuclease NM 23 H1 becomes activated to nick DNA after granzyme A cleaves its inhibitor , SET . ^^^ Silencing NM 23 H1 or TREX 1 inhibits DNA damage and death of cells treated with perforin ( PFN ) and granzyme A , but not of cells treated with perforin and granzyme B ( GzmB ) . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| A 270 to 420 kDa endoplasmic reticulum associated complex ( SET complex ) containing the nucleosome assembly protein SET , the tumor suppressor pp 32 , and the base excision repair enzyme APE can induce single stranded DNA damage in isolated nuclei in a granzyme A dependent manner . ^^^ HMG 2 , like SET and APE , is a physiologically relevant granzyme A substrate in targeted cells . ^^^ Granzyme A cleavage and functional disruption of key nuclear substrates , including HMG 2 , SET , APE , lamins , and histones , are likely to cripple the cellular repair response to promote cell death in this novel caspase independent death pathway . . ^^^ The cytotoxic T lymphocyte protease granzyme A induces caspase independent cell death in which DNA single stranded nicking is observed instead of oligonucleosomal fragmentation . ^^^ Granzyme A cleavage after Lys 65 in the midst of HMG box A destroys HMG 2 mediated DNA binding and bending functions . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| In confluent cultures of HF cells , subject to density dependent inhibition of growth , hEGF was able to stimulate DNA synthesis more effectively than fresh calf serum . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| We used the N terminal amino acid sequence of dihydrolipoamide dehydrogenase from Haloferax volcanii , to design and synthesize two oligonucleotide probes that were used to identify and clone a 4 . 3 kilobase pair ( kbp ) fragment from MboI restriction endonuclease digestion of Hf . volcanii genomic DNA . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| Infection of normal human diploid fibroblasts ( HF ) with the DNA tumor virus simian virus 40 ( SV ) leads to an extension of lifespan and concomitant increase in the levels of the viral large tumor antigen ( T antigen ) and the cellular protein p 53 . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| The involvement of DNA polymerases alpha , beta , and delta in DNA repair synthesis induced by N methyl N ' nitro N nitrosoguanidine ( MNNG ) was investigated in human fibroblasts ( HF ) . ^^^ In intact cells , MNNG induced DNA repair synthesis was inhibited 57 % by 50 micrograms of aphidicolin / mL and was not significantly inhibited by microinjecting anti ( DNA polymerase alpha ) antibodies into HF nuclei . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| The effect of monocytes ( M ) and monocyte derived macrophages ( MdM ) on cytomegalovirus ( CMV ) replication in human fibroblasts ( HF ) was studied by one step growth experiments , plaque formation and dot hybridization with a labeled CMV DNA probe . ^^^ A reduction of CMV DNA inhibition was observed upon incubation of the infected HF cells with MdM separated from the infected cells by a membrane . ^^^ Addition of tumor necrosis factor ( TNF ) antibody to CMV infected HF incubated with MdM either in direct contact or separated by a membrane from the infected cells reduced the inhibition of CMV DNA production . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| Marek ' s disease virus DNA isolated from the nuclear fraction of infected chicken embryo fibroblasts and sucrose purified particles was electrophoresed on 3 per cent polyacrylamide gels and was compared in its electrophoretical behaviour with isolated pseudorabies and herpes simplex DNA , strain HF . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| The virus specific DNA polymerase was synthesized in cells infected with the u . v . irradiated HF strain of HSV . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| DNA isolated from highly purified virions of herpes simplex virus type 1 ( HF strain ) was denatured by centrifugation in alkaline sucrose gradients . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| Unscheduled DNA repair synthesis was measured autoradiographically in cultured rainbow trout gonad ( RTG ) and human fibroblast ( HF ) cells following exposure to aflatoxin B 1 ( AFB 1 ) , 3 , 4 benzopyrene ( BP ) , 1 , 2 , 5 , 6 dibenzanthracene ( DBA ) , 1 , 2 benzanthracene ( BA ) and pyrene ( PY ) activated with S 9 prepared from rainbow trout liver . ^^^ S 9 from rainbow trout injected with Arochlor 1254 or an oil extract was compared with S 9 from Fischer rats injected with Arochlor 1254 for the ability to activate AFB 1 and cause DNA repair in RTG and HF cells . ^^^ All three types of S 9 activated AFB 1 , but the measured DNA repair response was greater in the HF cells . ^^^ Marginal but statistically significant amounts of DNA repair were elicited in HF and RTG cells exposed to rainbow trout S 9 activated BA and DBA , but no response was detected following PY exposure . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| The presence of receptors for DNA and RNA viruses , known to induce cytopathic effects in target cells , always occurred in normal HF and HC / SV40 cells as well as in their derived clones , whereas differences were observed in the expression of influenza A and Sindbis virus receptors . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| Hypertrophy of interscapular BAT after 16 wk on the HF diet was accompanied by increases in protein and DNA content , indicating growth of functional tissue . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| The reactivity of peripheral blood mononuclear cells ( PBMC ) from 40 hydatid patients to hydatid fluid ( HF ) and to two hydatid fractions ( pH5PPT and pH5SUP ) was evaluated by the incorporation of 3H methylthymidine into DNA . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| There is little information in the literature regarding the use of hydrofluoric acid ( HF ) for DNA hydrolysis and we have therefore undertaken a systematic study of this process . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| The length of time necessary for replication of an average molecule of viral DNA was found to be indistinguishable in HF and TC 7 cells . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| Human fibroblasts ( HF ) were transformed in vitro with origin defective SV 40 DNA ( ori ) using the calcium phosphate co precipitation technique . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| A comparison of in vitro DNA repair activity showed HF greater than CHO greater than Ul H = Ul F following exposure to MNNG and 4NQO . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| Unscheduled DNA repair synthesis ( UDS ) was measured autoradiographically in HF , CHO , RTG , RTO , CH and FHM cells given a 3 h exposure to MNNG , 4NQO , NA2AAF and AFB 1 . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| Tissue concentrations of DNA ( milligrams / gram of tissue ) were lower ( P < . 03 ) in HF than in LF only for jejunum , ileum , and liver . ^^^ Contents of DNA and protein ( milligrams ) did not differ between LF and HF for intestinal segments or liver . ^^^ The number of crypt cell nuclei that were labeled with BrdU ( indicating DNA synthesis and thus cell proliferation ) was increased ( P < . 03 ) in HF relative to LF for jejunum and colon . ^^^ The number of epithelial cells exhibiting DNA fragmentation ( indicating programmed cell death ) was greater ( P < . 07 ) in the HF than in the LF group for jejunum and ileum . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| Amplification of a 375 bp internal DNA fragment of hpaA by PCR demonstrated the presence of the gene in Hp and in two closely related gastric Helicobacters , H . nemestrinae ( Hn ) and H . acinonyx ( Hx ) , but not in the more distantly related H . felis ( Hf ) and H . mustelae ( Hm ) . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| The metal center ( Ti , Mo , Zr , Hf ) strongly influences the nature and extent of interactions between metallocene dichlorides Cp2MCl2 and DNA subunits . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| The amount of HF associated HHV 6 DNA was measured using limiting dilution PCR assay ; it was significantly increased during 4 day infection in the case of variant A but not variant B . ^^^ The yield of virus from infected HFs was demonstrated only for variant A by the serial propagation of virus from HFs to PBMCs and by the increase in cell free HHV 6 DNA in HF culture supernatant . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| Azeptin dose dependently suppressed both DNA and protein synthesis in human gingival fibroblasts ( HF ) and also suppressed blastogenesis of human peripheral blood lymphocytes ( PBL ) . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| In transient expression assays , introduction of IE 1 encoding plasmid DNA alone into Vero or HF cells produced the typical total redistribution of PML into a uniform nuclear diffuse pattern together with the IE 1 protein , whereas introduction of IE 2 encoding plasmid DNA alone resulted in stable colocalization of the IE 2 protein with PML in the PODs . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| This strain , Hf . volcanii DS 52 , has no detectable DNA recombination , is more sensitive to DNA damage by UV light and ethylmethane sulfonate , and has a slower growth rate than the wild type . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| Introduction of the gene for T antigen encoded by the DNA virus SV 40 extends the life span of HF and increases the frequency of immortalization ; however , immortalization requires both T dependent and T independent functions . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| METHODS AND RESULTS : We have designed algorithms for analyzing ambulatory ECG recordings and measuring HRV without human intervention , using robust methods for obtaining time domain measures ( mean and SD of heart rate ) , frequency domain measures ( power in the bands of 0 . 001 to 0 . 01 Hz [ VLF ] , 0 . 01 to 0 . 15 Hz [ LF ] , and 0 . 15 to 0 . 5 Hz [ HF ] and total spectral power [ TP ] over all three of these bands ) , and measures based on nonlinear dynamics ( approximate entropy [ ApEn ] , a measure of complexity , and detrended fluctuation analysis [ DFA ] , a measure of long term correlations ) . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| DNA content was significantly increased in HF vessels ( +100 % ) and was not modified in LF vessels . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| A milder DNA hydrolyzing agent , HF in pyridine , was substituted to HCOOH for the quantitative release of FapyGua from DNA . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| Cytoplasmic extracts from early passage ( young ) , late passage ( senescent ) normal human fibroblast ( HF ) cultures and immortalized human cell lines ( HeLa , HT 1080 , and MANCA ) were analyzed for their ability to support semiconservative DNA synthesis in an in vitro SV 40 ori DNA replication system . ^^^ Young HF extracts supplemented with RPA alone are able to support significant replicative activity but not senescent extracts which require both RPA and DNA pol alpha cat for any detectable activity . ^^^ In the HF cells , levels of DNA pol alpha cat and PCNA are higher ( per mg protein ) in the low passage than in the senescent cells . ^^^ Taken together , these results indicate that the low to undetectable activity of young HF extracts in this system is due mainly to reduced intracellular levels of RPA , while the senescent HF extracts are relatively deficient in DNA polymerase alpha and probably some other essential replication factors , as well as RPA . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| In HCMV ( Towne ) infected HF cells at 24 to 48 h , IE 2 also accumulated in newly formed viral DNA replication compartments containing the polymerase processivity factor ( UL 44 ) , the single stranded DNA binding protein ( SSB ; UL 57 ) , the UL 112 113 accessory protein , and newly incorporated bromodeoxyuridine ( BrdU ) . ^^^ Double labeling of the HCMV ( CR 208 ) infected HF cells demonstrated that formation of viral DNA replication compartments initiates within granular structures that bud from the periphery of some of the PODs and subsequently coalesce into larger structures that are flanked by PODs . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| Structures and energetics of complexes between guanine . . . cytosine Watson Crick ( GCWC ) DNA base pair and various metal cations were investigated by an ab initio Hartree Fock ( HF ) study in the absence of basis set superposition error . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| No significant differences in intake of macronutrients or assessed micronutrients , measured DNA base damage products , or plasma vitamin C were found between the HF and LF dietary treatments . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| C1q suppressed the DNA synthesis of HF in response to platelet derived growth factor ( PDGF ) with an IC ( 50 ) of 20 microg / ml , and blocked 78 % of the cycling cells in G ( 1 ) phase . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| The results showed that the values of high frequency power ( HF ) component , low frequency power ( LF ) component and ApEn in animals with bilateral vagi intact were the highest , but the LF / HF ratio was the lowest ; unilateral vagotomy decreased ApEn , right vagotomy increased LF / HF ratio but left vagotomy did not ; the LF / HF ratio increased while ApEn decreased significantly in animals with bilateral vagotomy . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| This study investigated the possible variance of gene expression profile between human osteoblasts ( HO ) and human fibroblasts ( HF ) in vitro , using DNA microarray technology . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| DNA binding of tonicity responsive enhancer binding protein ( TonEBP , a transcriptional regulator of AR ) paralleled AR mRNA , declining > 50 % in late HF ( P < 0 . 025 vs . control ) . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| Female mice were impregnated through artificial insemination by introducing sperm carrying pRC / RSV hF 8 BD , which contained human F 8 BD ( B domain deleted ) cDNA ( hF 8 BD c DNA ) , into the uteri . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| CONCLUSIONS : These structure function correlations confirm the hypothesis that transition to HF occurs by fibrosis and myocyte degeneration partially compensated by hypertrophy involving DNA synthesis and transcription . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| There was also a negative correlation between ApEn and LF / HF ( r = 0 . 406 and r = 0 . 357 , respectively ) . alpha 2 did not correlate with any spectral or non linear measures of HRV . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| A combination of MS analysis of the peptide nucleosides obtained after hydrolysis by HF and their fragmentation by MS / MS revealed that Lys 209 of MboI was crosslinked to the MboI recognition site at the position of the adenine , demonstrating that the region around Lys 209 is involved in specific binding of MboI to its DNA substrate . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| It is shown that the HF stability of the hydrogen bonded DNA base pairs originates mainly from electrostatic interactions . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| Polymorphism of 11 microsatellite DNA loci was analysed in Polish Red ( PR ) , Hereford and Holstein Friesian ( HF ) cattle raised in Poland and genetic distance among these breeds was determined . ^^^ At the 11 loci ( TGLA 227 , BM 2113 , TGLA 53 , ETH 10 , SPS 115 , TGLA 126 , TGLA 122 , INRA 23 , ETH 3 , ETH 225 and BM 1824 ) analysed with automated DNA sizing technology , a total of 213 alleles were identified : 76 in PR , 76 in HF , and 61 in Hereford . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| But during progressive exercise , caffeine intake resulted in a greater decrease of HF power as well as HR APEN . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| However , no significant increase of B 19 DNA level in the infected HF and HUVEC cultures was detectable through the entire incubation period of 6 days . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| Clenbuterol and metoprolol groups had decreased myocardial apoptosis and DNA damage markers and increased DNA repair markers versus HF rats ( all p < 0 . 01 ) . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| HF was found to promote apoptosis of B CLL cells , as shown by time and dose dependent stimulation of phosphatidylserine externalization and DNA fragmentation , by disruption of the mitochondrial transmembrane potential , caspase 3 activation and cleavage of the caspase substrate PARP 1 . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| Several time and frequency domain linear and nonlinear FHR indices were computed in these segments , namely mean FHR , very low frequency ( VLF ) , low frequency ( LF ) , high frequency ( HF ) , approximate entropy ( ApEn ) and sample entropy ( SampEn ) . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| The PCR and DNA analysis showed that the interspecies embryos contained human genomic DNA specific for the individual DNA profile of the HG or HF donor cells used for SCNT . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Although oxidative stress mediated by reactive oxygen species plays an important role in the pathogenesis of heart failure ( HF ) , good clinical markers for reactive oxygen species in patients with HF have not been established . 8 Hydroxy 2 ' deoxyguanosine ( 8 OHdG ) is formed from deoxyguanosine in DNA by hydroxyl free radicals and might serve as a sensitive biomarker of intracellular oxidative stress in vivo . ^^^ CONCLUSION : These data suggest oxidative DNA damage is increased in patients with DCM according to the severity of HF . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| We report here the preparation and systematic screening of a differential complementary DNA bank , in which we detected three distinct messenger RNA transcripts ( CTLA 1 , CTLA 2 and CTLA 3 ) present in various cytotoxic T cells but not ( or less so ) in a range of non cytotoxic lymphoid cells . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| In gzmAxB / mice , Tc / NK mediated target cell DNA fragmentation was not observed , even after extended incubation periods ( 10 h ) , but was normal in gzmA deficient and only impaired in gzmB deficient mice in short term ( 2 4 h ) , but not long term ( 4 10 h ) , nucleolytic assays . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| Limited proteolysis of a high molecular mass complex containing SET ( also named putative HLA associated protein 2 or PHAPII ) , PHAPI ( pp 32 , leucine rich acidic nuclear protein ) and HMG 2 by GzmA liberates NM 23 H1 , a Mg2+ dependent DNase that causes single stranded breaks in nuclear DNA . ^^^ |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12544 and P27695 |
Pubmed |
SVM Score :0.0 |
| NA |
|