Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.56426772
Absence of association between HPV DNA , TP 53 codon 72 polymorphism , and risk of oesophageal cancer in a high risk area of China . 0.56426772^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.92665321
The tumor suppressor p 53 binding protein 1 ( 53BP1 ) binds to the DNA binding domain of p 53 and enhances p 53 mediated transcriptional activation . 53BP1 contains two breast cancer susceptibility gene 1 COOH terminus ( BRCT ) motifs , which are present in several proteins involved in DNA repair and / or DNA damage signaling pathways . 0.92665321^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Neither constitutional DNA nor DNA extracted from a retinoblastoma of the left eye of the patient contained the TP 53 mutation , suggesting that the TP 53 mutation in the osteosarcoma cells may represent a tumor promoting mutation , which confers a selective growth advantage . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Molecular analysis demonstrated no gross differences in the retinoblastoma gene or the TP 53 gene between constitutional and tumor DNA . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The ability of the oncogene products of DNA tumor viruses to induce DNA synthesis in quiescent cells is thought to depend on their capacity to bind to cellular proteins such as the retinoblastoma suppressor protein Rb and the tumor suppressor p 53 , thereby abolishing the growth arresting properties of these proteins . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Through the use of 17 DNA probes cloned from 7 rat genes , A2M , ATP1A1 , ATP1A2 , ATP1A3 , B2M , GSTP , and SMST ; 5 mouse genes , Ncam , Ngfg , Pim 1 , Tcp 1 , and Trp 53 ; and 5 human genes , MBP , MYB , NEFM , SCN2A , and TCRGC 1 , 17 structural genes including 15 newly assigned genes and 11 related DNA fragments were assigned to particular rat chromosomes . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
PURPOSE : To determine genetic alterations at chromosomes 13 and 17 in colorectal tumors , we have studied several loci on these chromosomes , with special focus on the RB 1 and TP 53 genes at both the level of DNA sequence and the level of gene expression . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Using single strand conformation polymorphism analysis of PCR products , we looked for TP 53 mutations in DNA of patients with Fanconi anemia , an autosomal recessive disease characterized by increased predisposition to neoplasia . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NRAS , MYCN , CSFIR , MYB , MYC , ABL , HRASI , TP 53 , and ERBB 2 did not reveal any consistent alterations in tumour DNA . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
In genomic DNAs from seven colon cancer cell samples , a 405 base pair DNA fragment containing exon 5 , intron 5 , and exon 6 of the TP 53 gene was amplified by polymerase chain reaction and analyzed for mutations . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The phosphoprotein p 53 seems to be implicated in various processes connected with cell transformation and in particular with the regulation of cell cycle and probably DNA replication . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Here we report that cellular tumor antigen p 53 may also participate in cellular DNA replication and another origin of DNA replication was cloned as a possible p 53 binding sequence . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The results show that d 10 large T is capable of binding to SV 40 DNA , to cellular DNA and to the cellular phosphoprotein p 53 as well as wild type large T . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
PATIENTS AND METHODS : We screened DNA samples from 47 patients with upper respiratory system squamous cell carcinomas for the presence of TP 53 mutations . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
In adults , loss of heterozygosity for DNA on 17p has been shown in high grade anaplastic astrocytomas ( AAs ) and glioblastomas multiforme ( GMs ) , and mutation of the TP 53 tumor suppressor gene has been reported in all grades of astrocytomas . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
After anionic resin removal of proteins , PCR amplification of TP 53 gene exons 5 / 6 and SSCP analysis , an abnormal SSCP band shift was observed in suspected tumour cells , compared with microdissected stromal cells used as an internal control , while ( 1 ) a crude preparation of tissue DNA carrying the tumour did not show any abnormality and ( 2 ) immunostaining by a set of monoclonal antibodies against TP 53 protein remained negative . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Human papillomavirus DNA and TP 53 mutations in lung cancers from butchers . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Detection of TP 53 gene mutation in human meningiomas : a study using immunohistochemistry , polymerase chain reaction / single strand conformation polymorphism and DNA sequencing techniques on paraffin embedded samples . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Mutations in the CDKN 2 and p 53 ( also known as TP 53 ) genes were analyzed by single strand conformation polymorphism and DNA sequencing . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Both pre and post treatment specimens from these 25 patients were analysed for mutation of the conserved regions of the TP 53 gene ( exons 5 8 ) , using constant denaturant gel electrophoresis ( CDGE ) followed by DNA sequencing . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Specific DNA probes for HLA class 1 , beta 2 microglobulin , beta actin , HLA class 2 , and p 53 ( also known as TP 53 ) were used in Northern blot analysis of the steady state level of messenger RNAs ( mRNAs ) and for `` run on ' ' transcription analysis . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
GADD 45 ( growth arrest and DNA damage ) is a DNA damage inducible gene regulated in part by the tumor suppressor p 53 . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Mus domesticus DNA probes for the tumor suppressor protein 53 ( Tp 53 ) and thymidine kinase 1 ( Tk 1 ) genetic loci were used to identify clones representing these loci in a Peromyscus leucopus ( white footed mouse ) cosmid library . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Tumor suppressor p 53 induction and DNA damage in hippocampal granule cells after adrenalectomy . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor p 53 protein possesses activities typical of eukaryotic transcriptional activators ; p 53 binds to specific DNA sequences and stimulates transcription of the target genes . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
TP 53 allele loss , mutations and expression in malignant melanoma . p 53 alterations at the DNA , mRNA and protein levels were studied in tumour metastases sampled from 30 patients with malignant melanoma . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
TP 53 mutations were also detected in 50 % of the cell lines by analysis of single strand conformation polymorphism ( SSCP ) and DNA sequencing of exons 4 through 9 . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The Tp 53 gene was mapped by FISH to Syrian hamster chromosome 9 bands qb2 . 2 > 2 . 3 using a genomic DNA probe with a high degree of sequence identity to the human Tp 53 gene . . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor p 53 is a cell cycle checkpoint protein that contributes to the preservation of genetic stability by mediating either a G 1 arrest or apoptosis in response to DNA damage . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Confirmation and characterization of TP 53 gene mutation at the DNA level would help to precisely define the role of this gene in the development of these tumors . . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Using single strand conformational polymorphism analysis followed by single strand DNA sequencing , genomic DNA extracted from whole blood was analyzed for the presence of TP 53 mutations for six living ADCC patients . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The TP 53 protein is proving to be central to cell cycle control after exposure to DNA damage , and every week a new feature of its role in the regulation of cell division is described . ^^^ There has been an explosion of reports about the function of the TP 53 protein in particular , it seems to have a central role in the monitoring of some types of DNA damage . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Tumor DNA was analyzed for possible TP 53 gene mutations in exons 5 , 7 , and 8 by constant denaturing gel electrophoresis . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Increased levels of the tumor suppressor p 53 due to DNA damage may result in either blockage of the cell cycle at G 1 or apoptosis . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
It has recently been shown that the tumor suppressor p 53 mediates a signal transduction pathway that responds to DNA damage by arresting cells in the late G 1 period of the cell cycle . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Transfection in both cell lines of vectors expressing wild type p 53 produced only clones with rearrangements of the transfected TP 53 complementary DNA . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor p 53 possesses characteristics of a transcription factor ; it binds to specific DNA sequences and activates transcription from various promoters . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The DNA samples were subjected to mutation analysis of four of the conserved domains in the TP 53 gene , using PCR followed by constant denaturant gel electrophoresis ( CDGE ) . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
In a series of 14 colorectal adenocarcinomas , the following genetic alterations were characterized : loss of heterozygosity on chromosomes 17 p , 1 p , 18 q , 5 q and 22 q , point mutations on TP 53 and K RAS genes , change in DNA index . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Heterozygous loss of the TP 53 gene on chromosome arm 17p in colorectal carcinomas was strongly associated with DNA aneuploidy ( P < 0 . 0001 ) . ^^^ DNA near diploid ( ND ) carcinomas and DNA aneuploid ( AN ) tumours with DNA index > or = 1 . 1 and < 1 . 3 had similar frequencies of TP 53 gene loss ( 49 % and 42 % , respectively ) , whereas AN tumours with DNA index > or = 1 . 3 had a significantly higher frequency of TP 53 gene loss ( 85 % ) ( P < 0 . 0001 and P < 0 . 0001 , respectively ) . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
We have investigated the effect of chemotherapeutic and DNA damaging agents on binding of the tumor suppressor phosphoprotein p 53 to its consensus DNA sequence . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Using single strand conformation polymorphism analysis of PCR products , we looked for TP 53 mutations in DNA of patients with AT . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
DNA derived from medulloblastoma biopsies was analyzed to determine if deletions of the 17p region , mutations of the TP 53 gene , or amplification of the c myc , N myc , EGFR ( epidermal growth factor receptor ) , or MDM 2 ( murine double minute 2 ) genes was indicative of a poor prognosis . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Allelic loss at the TP 53 locus was determined with polymorphic markers by comparing normal and tumour DNA . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor p 53 plays a role in mediating a G 1 arrest ( for example , in response to DNA damage ) , in the cellular commitment to apoptosis and in suppression of transformation . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The major types of genetic abnormalities that are frequently observed in breast tumors are amplification of protooncogenes ( MYC , ERBB 2 ) and DNA from chromosome band 11q13 ; mutation of TP 53 ; and loss of heterozygosity from chromosomes and chromosome arms 1 , 3p , 6q , 7q , 8p , 11 , 13q , 16q , 17 , 18q , and 22q . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Allelotypes ( TP 53 , AFM051xd10 and alu i 1 ) in normal DNA and in DNA from paraffin embedded tumours of a patient with a p 53 germ line mutation were compared in order to demonstrate LOH . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
In this study , we tested this hypothesis by examining whether the activity of TRs is modulated by the tumor suppressor p 53 . p 53 is a nuclear protein that regulates gene expression via sequence specific DNA binding and / or direct protein protein interaction . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Twenty nine samples from 28 cases of vulvar squamous cell carcinoma , of which 13 fulfilled the criteria of the bowenoid subtype ( mean age 45 years , range 31 68 ) and 16 of the usual subtype of invasive squamous cell carcinoma ( ISCC ) ( mean age 67 . 5 years , range 34 83 ) were investigated for human papillomavirus ( HPV ) DNA , TP 53 alterations , and mdm 2 and bcl 2 gene product deregulation . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor p 53 contributes to maintaining genome stability by inducing a cell cycle arrest or apoptosis in response to conditions that generate DNA damage . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
To assess the pathogenetic significance of TP 53 gene alterations in NSCLC , 24 paired samples of primary NSCLC and the corresponding normal lung tissue were analysed for mutations of the TP 53 gene ( exons 5 8 ) using exon specific PCR , single strand conformation polymorphism PCR ( SSCP PCR ) and direct DNA sequencing ; for p 53 protein accumulation by immunohistochemistry and for 17p allelic loss using restriction fragment length polymorphism ( RFLP ) probes on Southern blots and amplified fragment length polymorphism PCR . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The proto oncogene myc , which inhibits adipocyte differentiation , abrogates C / EBPalpha activation of gadd 45 . gadd 45 is known to be a target of the tumor suppressor p 53 in a G 1 checkpoint activated by DNA damage . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
CONCLUSIONS : A significantly higher proportion of p 53 overexpressing tumors are DNA aneuploid , indicating that mutations in the TP 53 gene constitute a sign of genetic instability , which might be of importance in malignant transformation . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Comparative synchronous fluorescence spectrophotometry and 32P postlabeling analysis of PAH DNA adducts in human lung and the relationship to TP 53 mutations . ^^^ We found a weak association between total PAH DNA adduct levels in lung tissue and TP 53 mutations . . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The MyD 118 encoded protein was observed to be remarkably similar to the protein encoded by Gadd 45 , a growth arrest and DNA damage induced gene , regulated in part by the tumor suppressor p 53 . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Apoptotic signaling caused an early accumulation of the tumor suppressor p 53 prior to DNA fragmentation . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The same tissue sections that were used for CGH were analyzed by means of DNA ploidy measurements and immunohistochemical staining to quantify proliferative activity and p21 / WAF 1 and TP 53 expression . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
In a report from a meeting at Bethesda in 1993 , the following areas were outlined for collaborative study : the correlation ( if any ) of phenotypes with specific mutation ; age specific penetrance ; cumulative cancer incidence ; gender differences in tumour development in carriers ; the effects of DNA damaging agents on individuals with a TP 53 mutation ; the frequency of TP 53 germline mutations in cohorts of patients with rare childhood tumours ( eg adrenocortical carcinoma ) ; and the psychosocial aspects of predictive TP 53 testing . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Sensitive detection of loss of heterozygosity in the TP 53 gene in pancreatic adenocarcinoma by fluorescence based single strand conformation polymorphism analysis using blunt end DNA fragments . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The aims of the study were 1 ) to test whether numerical # 17 aberrations are involved in functional TP 53 loss in locally confined colorectal carcinomas ; 2 ) to search for correlations between aberrant p 53 expression and # 17 aberrations with DNA ploidy and histopathology ; and 3 ) to test the prognostic significance of these factors . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor p 53 gene plays a key role in controlling the cell cycle checkpoint and in apoptosis following the exposure of normal cells to DNA damage . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The cyclin dependent kinase ( Cdk ) inhibitor p 21 is induced by the tumor suppressor p 53 and is required for the G 1 S block in cells with DNA damage . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor p 53 protein is a transcription factor that plays a central role in the cellular response to DNA damage , and it can cause either G 1 arrest or apoptosis . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
We have investigated this possibility by examining DNA from 40 cases of endometriosis for clonal status , alterations in TP 53 and RASK , and allelic losses at candidate ovarian tumor suppressor loci on chromosome arms 6q , 9p , l1q , 17p , l7q , and 22q . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Tumor suppressor p 53 is a nuclear protein that is induced by DNA damage and is involved in G 1 and G 2 phase control of the cell cycle . p21WAF1 / CIP1 / SDI1 ( p 21 ) , a cyclin dependent kinase inhibitor , is a downstream target and effector of p 53 to induce G 1 arrest . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
We screened for mutations in the TP 53 gene by a combination of denaturing gradient gel electrophoresis and DNA sequencing in ten cases of adenocarcinoma arising in Barrett ' s mucosa . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
We studied a series of pediatric ependymoma specimens ( 16 intracranial and 2 spinal ) for loss of 17p and 22q DNA sequences and for mutation of the TP 53 and NF 2 genes . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumour suppressor gene product TP 53 is clearly a component in several biochemical pathways , including transcription , DNA repair , genomic stability , cell cycle control and apoptosis , that are central to human carcinogenesis . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
We studied lymphocyte DNA from 104 women with ovarian carcinoma , 15 with borderline tumours and 16 with benign tumours , using a previously reported PCR RFLP technique . 96 of the ovarian carcinoma cases had been previously examined for mutations in TP 53 and / or for overexpression of the TP 53 protein . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor p 53 protein induces apoptosis in response to various kinds of DNA damage in normal cells , but it is still unclear whether or not apoptosis induced by DNA damage correlates with the p 53 status in tumor cells . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The role of the tumor suppressor p 53 in repair of ultraviolet light ( UV ) induced DNA damage was evaluated using a host cell reactivation ( HCR ) assay . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
We also studied TP 53 mutations in tumour DNA from 51 of the same individuals and found mutations in 14 % . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Tumor suppressor p 53 protein acts as a checkpoint factor following DNA damage . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
If shortening of telomeres reaches a certain critical level , it is recognized as DNA damage by the cell ' s `` guardian of the genome ' ' , the tumor suppressor p 53 . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
IR induced G 1 arrest has been shown to depend on the presence of the tumor suppressor p 53 , which acts as a transcriptional activator of several genes . p 53 also plays a role in the induction of apoptosis in response to DNA damage , and this pathway can be activated by both transcription dependent and independent mechanisms . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Induction of tumor suppressor p 53 and DNA fragmentation in organotypic hippocampal cultures following excitotoxin treatment . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
DNA conformation is an important determinant of sequence specific DNA binding by tumor suppressor p 53 . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor p 53 exerts antiproliferation effects through its ability to function as a sequence specific DNA binding transcription factor . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The effect of different TP 53 mutations on the chromosomal stability of a human colonic adenoma derived cell line with endogenous wild type TP 53 activity , before and after DNA damage . ^^^ To investigate whether loss of TP 53 dependent checkpoints also predisposed the cells to accumulate persistent chromosomal aberrations after DNA damage , cells were exposed to 5 Gy gamma radiation . ^^^ These findings suggest that loss of TP 53 activity and / or acquisition of specific TP 53 mutations can increase chromosomal instability and resistance to low level DNA damage in human colonic adenoma cells . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
This short report describes the detection of mutations of the TP 53 tumour suppressor gene in sporadic ovarian carcinomas using archival paraffin embedded tissues and automated fluorescent DNA sequencing . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
After DNA extraction , polymerase chain reaction amplification was performed to investigate alteration ( i . e . , loss of heterozygosity [ LOH ] ) of the APC ( adenomatous polyposis coli ) , DCC ( deleted in colorectal carcinoma ) , and p 53 ( also known as TP 53 ) genes . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor gene TP 53 is implicated in the regulation of normal cell growth and division , DNA repair and apoptosis . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Analysis of the structure of the TP 53 gene exons was performed with the polymerase chain reaction single strand conformation polymorphism ( PCR SSCP ) method and with direct sequencing of amplified DNA . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
One gene intensely studied , p 21 , has been linked to the G 1 arrest mechanism and may , like TP 53 , be involved in some aspect of DNA repair . ^^^ The outcome of TP 53 activation for cell survival is equally complex and relies much upon cellular context and the type of DNA damaging agent employed . ^^^ Although TP 53 may participate in sensing DNA damage , additional components are likely to be required . ^^^ The finding that certain G 2 checkpoint abrogators preferentially synergize with DNA damaging agents in cells with defective TP 53 provides a potential pharmacological route through which TP 53 defective cells might be targeted for destruction . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Firstly , TP 53 arrests cell cycle progression in response to the types of DNA damage most commonly detected in cells undergoing tumour progression . ^^^ Analysis of the arrest kinetics after ionizing radiation shows that TP 53 activates a prolonged arrest response in cells with irreparable DNA damage and that high efficiency cell elimination is achieved by a process that can be activated over multiple cell cycles . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor p 53 has two DNA binding domains : a central sequence specific domain and a C terminal sequence independent domain . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor p 53 is a major regulator in the response of human cells to DNA damage . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor p 53 can exert its anti oncogenic activity in part by inducing apoptosis in cells that have sustained damage to their DNA . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
We therefore sequenced exons 1alpha and 2 of CDKN2A using lymphocyte DNA isolated from index cases from 67 families with cancers at multiple sites , where the patterns of cancer did not resemble those attributable to known genes such as hMLH 1 , hMLH 2 , BRCA 1 , BRCA 2 , TP 53 or other cancer susceptibility genes . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Nearly 95 % of TP 53 perturbations affect codons included within exons 5 8 which encode for almost the entire DNA binding domain . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Moreover , using denaturing gradient gel electrophoresis and DNA sequencing , we detected the presence of a double germline mutation in exon 7 of the TP 53 gene . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
TP 53 gene mutations also correlated significantly with allelic loss at TP 53 locus ( P = 0 . 024 ) , absence of estrogen ( P = 0 . 045 ) and progesterone receptors ( P = 0 . 001 ) , DNA nondiploidy ( P = 0 . 002 ) , and high S phase fraction values ( P = 0 . 002 ) . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
By using genomic DNA , we sequenced PCR products of the coding exons and most introns of the TP 53 gene , finding genetic changes in 30 % of the blast crisis samples and 12 % in chronic phase . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Detection of TP 53 mutation , loss of heterozygosity and DNA content in fine needle aspirates of breast carcinoma . ^^^ Tumours were screened for p 53 protein overexpression and TP 53 mutations ( exons 5 8 ) using immunocytochemistry , polymerase chain reaction single strand conformation polymorphism ( PCR SSCP ) and DNA sequencing analyses , and finally using fluorescence in situ hybridization ( FISH ) analysis . ^^^ Finally , DNA static image analysis performed on 29 cases showed aneuploidy in 26 cases , which included all TP 53 mutated cases . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Among the transcriptional activation domains that can stimulate viral DNA replication are acidic domains such as those derived from herpes simplex virus VP 16 and the tumor suppressor p 53 . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor p 53 is a nuclear phosphoprotein in which DNA binding activity is increased on exposure to DNA damaging agents such as UV or gamma radiation by unknown mechanisms . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
In this study we investigated the incidence of mutations and loss of heterozygosity ( LOH ) of the TP 53 gene in DNA samples from paired tumor and adjacent normal tissue from 90 patients with untreated squamous cell carcinoma of the head and neck . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor p 53 and its target the CDK inhibitor p 21 ( Cip1 / Waf1 ) are key components of the cellular response to DNA damage . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
It is tempting to assume that viruses such as EBV , as well as regulator genes that normally monitor the human genome for damaged DNA , such as TP 53 , might be involved in the postulated hindrance of the apoptotic pathway , leading to the genesis of classical HRS cells . . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Tumor suppressor p 53 can participate in transcriptional induction of the GADD 45 promoter in the absence of direct DNA binding . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Mutations in residues of TP 53 that directly contact DNA predict poor outcome in human primary breast cancer . ^^^ The tumour suppressor gene TP 53 is frequently mutated in breast tumours , and the majority of the mutations are clustered within the core domain , the region involved in DNA binding . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
TP 53 DNA contact mutations are selectively associated with allelic loss and have a strong clinical impact in head and neck cancer . ^^^ These data indicate that in HNSCC , TP 53 DNA contact mutations confer a strong selection pressure to eliminate wild type alleles , and that they result in an accelerated tumour progression and reduced therapeutic responsiveness . . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Because of this unusual familial clustering of tumors and a positive history of brain tumors and other cancers in several maternal relatives , we analyzed DNA isolated from both PNETs and the ovarian carcinoma as well as constitutional ( leukocyte ) DNA from the whole family for mutation of the TP 53 tumor suppressor gene . ^^^ The same mutation was present in one TP 53 allele in the constitutional DNA of the mother and the children , indicating that the mother had transmitted a TP 53 germline mutation to both of her children . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The major role played by mutations in the initiation of carcinogenesis is evidenced by the existence of genetic syndromes associated to hypersensitivity to genotoxic agents , defects in DNA repair capacity , anomalies in the expression of certain genes ( including the tumor suppressor p 53 gene , etc . ) and an elevated predisposition to cancer . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
We have used microdissection of paraffin embedded histological sections and polymerase chain reaction ( PCR ) based direct DNA sequencing for 54 transitional cell carcinoma ( TCC ) of the bladder , to examine critically the association between TP 53 nuclear accumulation determined by immunohistochemistry and the presence of TP 53 mutations , and to examine their relationship to tumour stage and grade , as well as patient survival . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Here we report that exposure of macrophages to lipopolysaccharide / interferon gamma or lipophilic cAMP analogs such as dibutyryl cAMP or 8 bromo cAMP for 15 h attenuated DNA fragmentation and accumulation of the tumor suppressor p 53 in response to the chemotherapeutic agents cisplatin and etoposide , compared to cells that received chemotherapeutic agents only . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The TP 53 status has been analysed at the DNA level in tumours from 45 ovarian cancer patients randomized to treatment with paclitaxel and cisplatin or cyclophosphamide and cisplatin . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Apoptotic cell death in RAW 264 . 7 macrophages and several other systems as a result of inducible NO synthase activation comprises upregulation of the tumor suppressor p 53 , activation of caspases , chromatin condensation , and DNA fragmentation . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Families with germline missense mutations in the core DNA binding domain showed a more highly penetrant cancer phenotype than families with other TP 53 mutations or no mutation . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The profile of distribution of these mutations in the TP 53 gene is of interest to establish correlation between the exposure to carcinogens responsible for DNA mutations . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Because Trp 53 ( the mouse homolog of human TP 53 ) is located with Tk 1 on chromosome 11 and is critical in regulating cellular responses following exposure to DNA damaging agents , we wanted to determine if these mouse lymphoma cells harbor mutations in Trp 53 . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
DNA of the critical Tp 53 exons 5 8 was amplified and run on horizontal polyacrylamide gels under defined temperature conditions ( TGGE ) to yield specific gel shifts and sets of homo and heteroduplexes in case of mutation . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Addition of extracellular ATP ( 300 microM to 5 mM ) to cultured rat mesangial cells for 90 min caused a 5 . 8 fold increase in DNA fragmentation ( terminal deoxynucleotidyl transferase assay ) and a 4 . 2 fold increase in protein levels of the tumor suppressor p 53 , which is thought to regulate apoptosis . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Semirational design of active tumor suppressor p 53 DNA binding domain with enhanced stability . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
TP 53 DNA was investigated by Southern blot and PCR SSCP analysis , and TP 53 expression was investigated by Northern blot analysis and immunocytochemistry . ^^^ Restriction enzyme analysis of TP 53 DNA in patient 1 showed alteration of fragments including exon 1 and intron 1 , and , in both patients , a specific loss of TP 53 DNA . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
These new markers include DNA ploidy , S phase , certain monoclonal antibodies , the p 53 ( alias TP 53 ) tumor suppressor gene , the retinoblastoma ( Rb ) gene , cell adhesion molecules , and angiogenesis . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
TP 53 gene mutations in plasma DNA of cancer patients . ^^^ We investigated the presence of TP 53 gene mutations in plasma DNA of breast and small cell lung cancer patients . ^^^ Tumor and plasma DNA of 25 patients were studied by PCR SSCP and direct sequencing , through exons 5 , 6 , 7 , and 8 , of TP 53 . ^^^ Mutations of the TP 53 gene are seen in plasma DNA of cancer patients , and may prove to be a useful new tool in the management of these patients . . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
To investigate the clinical relevance of LOH of BRCA 1 ( 17q21 ) , TP 53 ( 17p13 ) and TCRD ( 14q11 ) in endometrial cancer , polymerase chain reaction ( PCR ) based fluorescent DNA technology for the detection of microsatellite polymorphisms was applied . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Association of p 53 accumulation with TP 53 mutations , loss of heterozygosity at 17p13 , and DNA ploidy status in 273 colorectal carcinomas . ^^^ TP 53 mutations were significantly associated with DNA aneuploidy ( P < 0 . 00001 ) , and a nonrandom distribution of TP 53 gene alterations among diploid ( DI = 1 ) , hyperdiploid ( 1 . 0 < DI < 1 . 3 ) , and highly aneuploid ( DI > 1 . 3 ) tumors indicates that DNA hyperdiploid tumors constitute a separate developmental entity different from tumors with gross aneuploidy . . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The authors evaluated the TP 53 and KRAS 2 genes for mutations in sporadic endometrial carcinomas with microsatellite instability ( MSI ) and matched MSI negative controls to determine whether defective DNA mismatch repair impacts the patterns of mutations in two genes known to be involved in endometrial tumorigenesis . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Here we examine the mechanism through which DNA damaging agents result in a G 1 arrest that depends on the tumor suppressor p 53 and its transcriptional target p 21 . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Polymerase chain reaction ( PCR ) amplification was performed with the polymorphic DNA markers TP 53 ( 17p13 . 1 / p53 gene ) and D17S579 ( 17q / BRCA1 gene ) . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The inflammatory mediator nitric oxide ( NO * ) promotes apoptotic cell death based on morphological evidence , accumulation of the tumor suppressor p 53 , caspase 3 activation , and DNA fragmentation in RAW 264 . 7 macrophages . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
TP 53 is not required for the constitutive or induced repair of DNA damage produced by ionizing radiation at the G1 / S phase border . ^^^ In contrast , cells irradiated with UV radiation at the G1 / S phase border show an induction of TP 53 protein and halt DNA synthesis , but do not induce the VLRP . ^^^ Our results show that TP 53 is not required for the constitutive or induced repair of DNA damage induced by ionizing radiation . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor p 53 plays a key role in inducing G 1 arrest and apoptosis following DNA damage . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Wild type BRCA 1 protein binds to a number of cellular proteins , including DNA repair protein Rad 51 , tumor suppressor p 53 , RNA polymerase 2 holoenzyme , RNA helicase A , CtBP interacting protein , c myc , BRCA 1 associated RING domain protein ( BARD 1 ) , BRCA 2 protein , etc . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
We screened 81 ovarian tumours ( 30 BRCA 1 associated , 18 BRCA 2 associated , and 33 sporadic ) for somatic TP 53 mutations using both DNA analysis and immunostaining . ^^^ TP 53 mutations were significantly more frequent in tumours with mutations in BRCA 1 ( 70 % by immunostaining and 60 % by DNA analysis ) and BRCA 2 ( 67 % and 50 % ) compared to sporadic controls ( 39 % and 30 % ) ( P = 0 . 009 ) . ^^^ The poor differentiation of tumours with BRCA 1 and BRCA 2 mutations may be directly related to the role of these genes in DNA repair , and the need to overcome cell cycle checkpoints , often through loss of TP 53 . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor p 53 is a multifunctional protein that plays a critical role in modulating cellular responses upon DNA damage or other stresses . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
A radiosensitive variant , MOLT 4N1 , and a radioresistant variant , MOLT 4N2 , have been studied with respect to their radiosensitivity and its relationship to the levels of TP 53 protein ( formerly known as p 53 ) . 10 irradiation induces apoptosis in both cell lines with the following difference : The induction of apoptosis in MOLT 4N2 cells occurred later than in MOLT 4N1 cells as determined by the morphological changes and DNA fragmentation . ^^^ This accumulation of TP 53 protein preceded changes in DNA degradation and ladder formation and in nuclear morphology . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
C57BL / 10 mice transgenic for HLA A 2 were immunized with either a full length DNA construct of the tumor suppressor p 53 or with a minigene encoding the p 53 derived immunodominant peptide p 53 ( 264 ) LLGRNSFEV 272 ( L9V ) . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
In colorectal and cervical tumors , chromosomal copy number changes were correlated with nuclear DNA content , proliferative activity , expression levels of the tumor suppressor gene TP 53 , and the cyclin dependent kinase inhibitor p21 / WAF1 , as well as the presence of viral genomes . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Expression of MK is p 53 dependent and up regulated by tumor suppressor p 53 and by DNA damaging agents in mouse cells undergoing apoptosis . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor p 53 is a transcription factor implicated in neuronal death following various insults , including cerebral ischemia . p 53 is activated in response to cellular stress , e . g . hypoxia and DNA damage . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
We extended our development of the means to measure point mutations at the DNA level to the problem of detecting TP 53 gene variants in the area around tumors where mutant fractions are expected to be as low as one mutant per 1000 wild type ( WT ) sequences . ^^^ The TP 53 exon 8 sequence was amplified from genomic DNA samples under conditions of high polymerase fidelity using a fluorescein labeled primer . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
When testing the assay on DNA from cultured lung cancer cell lines and from paraffin embedded Dukes C colorectal carcinomas , significant TP 53 mutations were observed at high frequencies in 15 of 16 lung cancer cell lines ( 94 % ) and in 21 of 30 paraffin embedded tissue samples of Dukes C colorectal carcinomas ( 70 % ) . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Most of the oncogenic mutations in the tumor suppressor p 53 map to its DNA binding ( core ) domain . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Any or all of the following mechanisms may play a role : overexpression of viral E 6 and E 7 genes , often triggered by disruption of control elements upon integration of viral DNA into the cellular genome , activity of specific ( E 6 ? ) configurations in certain HPV variants , inactivation of TP 53 with decreased capacity for DNA repair and enhanced likelihood of accumulation of `` transforming ' ' mutations and viral integration at sites controlling function of cellular oncogenes and / or suppressor genes . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Preferential binding of tumor suppressor p 53 to positively or negatively supercoiled DNA involves the C terminal domain . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The DNA from breast cancers removed from 29 patients who were followed up for up to five years was analyzed for MSI and LOH using a panel of 24 markers located at chromosome 2 ( TPO , D2S131 , D2S144 , D2S171 , D2S177 , D2S119 , D2S123 , D2S147 and D2S136 ) , chromosome 11 ( C RAS , Int 2 , D11S940 , D11S912 ) , chromosome 13 ( D13S289 , D13S260 , D13S267 , D13S218 , D13S263 , D13S155 , and D13S162 ) , and chromosome 17 ( D17S513 , TP 53 , D17S855 , and D17S785 ) . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The possibility that the combination of vitamin D ( 3 ) compounds with radiation might promote cell death ( i . e . through a differentiation stimulus plus DNA damage ) was investigated by exposing both TP 53 ( formerly known as p 53 ) wild type and TP 53 mutated breast tumor cells to 1 , 25 ( OH ) ( 2 ) D ( 3 ) or EB 1089 for 48 h prior to irradiation . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The N terminal 168 residues of RPA 70 form a structurally distinct domain that stimulates DNA polymerase alpha activity , interacts with several transcriptional activators including tumor suppressor p 53 , and during the cell cycle it signals escape from the DNA damage induced G2 / M checkpoint . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Most of C 6 cells infected in vitro with rVV p 53 expressing the tumor suppressor p 53 protein showed apoptosis specific morphological changes in DAPI stained nuclei and DNA fragmentation pattern on gel electrophoresis ; infection with 10 induced low level of cell apoptosis . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Cytotoxicity as a result of a substantial NO formation is established to initiate apoptosis , characterized by upregulation of the tumor suppressor p 53 , changes in the expression of pro and anti apoptotic Bcl 2 family members , cytochrome c relocation , activation of caspases , chromatin condensation , and DNA fragmentation . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
These results suggest that deposited Thorotrast continuously damages DNA in liver cells in some way , resulting in A G transitions of the TP 53 gene . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor gene Trp 53 ( also known as p 53 ) is the most frequently mutated gene in human cancers . p 53 is induced in response to DNA damage and effects a G ( 1 ) cell cycle arrest . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Influence of promoter DNA topology on sequence specific DNA binding and transactivation by tumor suppressor p 53 . ^^^ Transcriptional activation by the tumor suppressor p 53 is regulated at multiple levels , including posttranslational modifications of the p 53 protein , interaction of p 53 with various regulatory proteins , or at the level of sequence specific DNA binding to the response elements in p 53 ' s target genes . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The status of the TP 53 alleles was followed at different stages by fluorescence in situ hybridization ( FISH ) and allele specific PCR ( ASPCR ) on total DNA , as well as flow sorted chromosomes taking advantage of a size difference between the two homologues of chromosome 17 that harbor TP 53 on 17p . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Single strand conformation polymorphism analysis and direct sequencing of polymerase chain reaction amplified DNA were used to establish two TP 53 mutations ( 7 . 4 % ) : a point mutation and a 63 bp duplication . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
EP 300 acetylation of TP 53 in response to DNA damage regulates its DNA binding and transcription functions . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Using a human lymphoblastoid cell line , we have analysed , following gamma irradiation ( 0 . 5 , 1 , 2 , 4 , 8 , 16 and 32 Gy , at 0 . 5 , 24 , 48 and 72 h after treatment ) , the correlation between proliferation , cell cycle analysis , apoptosis and micronuclei frequency with the expression of TP 53 , WAF 1 , DNA LIGASE 1 , PCNA , BAX , BLC 2 , BAK , DAD 1 , ICH 1 Long and Short forms mRNAs . ^^^ We have found that whereas TP 53 , BAK , ICH 1 Short form , and DAD 1 were expressed at constant levels , WAF 1 , PCNA , BAX were up regulated , ICH 1 Long form , DNA LIGASE 1 , and BCL 2 were down regulated . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
In the following study , we used comparative genomic hybridization ( CGH ) to screen for DNA copy number changes along all chromosomes in 37 gastric carcinomas , and fluorescence in situ hybridization ( FISH ) with the C MYC and TP 53 probes in 14 cases for comparison . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
A proposal for the integration of immunohistochemical staining and DNA based techniques for the determination of TP 53 mutations in human carcinomas . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Molecular analysis by single strand conformation polymorphism and DNA sequencing revealed that TP 53 gene mutations occurred in only 2 of 13 cholangiocarcinomas . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Through a strategy of direct cloning of TP 53 binding DNA sequences from human genome DNA , we have identified a novel TP 53 target gene , termed TP53TG5 ( TP 53 target gene 5 ) . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
No significant correlation was evidenced between the two telomere related parameters and cell population doubling time , DNA index or TP 53 gene status . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
In this report , we have demonstrated that the catalytic activity of topoisomerase IIalpha , as measured by decatenation of kinetoplast DNA and by relaxation of negatively supercoiled DNA , was stimulated approximately 2 3 fold by the tumor suppressor p 53 protein . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
TP 53 has been implicated in regulation of the cell cycle , DNA repair , and apoptosis . ^^^ Patients with TP 53 gene mutations in codons that directly contact DNA or with mutations in the zinc binding domain loop L 3 showed the lowest response to tamoxifen ( 18 % and 15 % response rates , respectively ) . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor p 53 plays a central role in sensing damaged DNA and orchestrating the consequent cellular responses . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
In the pattern of DNA damage responses which are influenced by ouabain we show that the G 2 cell cycle delay is prolonged and that early apoptosis events are upregulated in TP 53 wild type and TP 53 mutant cells . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Comparison of TP 53 mutations identified by oligonucleotide microarray and conventional DNA sequence analysis . ^^^ To assess the efficiency , sensitivity , and specificity of different methods , alterations of TP 53 were independently evaluated in 108 ovarian tumors by conventional DNA sequence analysis and oligonucleotide microarray ( p 53 GeneChip ) . ^^^ A total of 77 ovarian cancers were identified as having TP 53 mutations by one of the two approaches , 71 by microarray and 63 by gel based DNA sequence analysis . ^^^ Among the mutation analyses discordant by these methods for TP 53 sequence were 14 cases identified as mutated by microarray but not by conventional DNA sequence analysis and 6 cases identified as mutated by conventional DNA sequence analysis but not by microarray . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
DNA was extracted , amplified with primers flanking polymorphic microsatellites linked to BRCA 1 ( D17S855 and D17S579 ) and TP 53 ( TP 53 and D17S786 ) , and analyzed for LOH at these microsatellites . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The adenovirus E1B 55 kDa protein binds to cellular tumor suppressor p 53 and inactivates its transcriptional transactivation function . p 53 transactivation activity is dependent upon its ability to bind to specific DNA sequences near the promoters of its target genes . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Direct DNA sequencing showed a point mutation which yielded to a stop codon at the amino acid 213 in exon 6 of the TP 53 gene . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The DNA of the cells was stained with propidium iodide ( red fluorescence ) whereas specific proteins ( estrogen receptor [ ER ] or tumor suppressor p 53 ) were detected immunocytochemically ( green fluorescence ) , each excited by an Ar ion laser . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
TP 53 deficient cells of human leukaemia HL 60 die by massive apoptosis after treatment by high ( 50 100 nmol / l ) doses of DNA damaging agent Idarubicin , regardless of the cell cycle phase , in which they are affected . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The mutant Trp 53 was abundant , its level was not affected by DNA damage and it bound DNA constitutively ; however , it showed defects in cell cycle regulation and apoptosis . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Alternatively , if TP 53 is wild type , then the increased levels of p 53 expression would enable the cells to become more susceptible to DNA damaging treatments such as cisplatin or gamma radiation . . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Through the induction of damages to DNA , NO stimulates the expression of enzymes and transcription factors involved in DNA repair and modulation of apoptosis , such as the tumor suppressor p 53 . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Fluorescently labeled DNA fragments of TP 53 exon 8 wild type and two mutants ( base pair number 14480 and 14525 ) are detected at two separate points of the same capillary . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
We have analyzed 56 SCCE cases from this area for TP 53 mutations by denaturing gradient gel electrophoresis ( DGGE , exons 5 8 ) and direct DNA sequencing . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
METHODS : DNA of the critical Tp 53 exons 5 8 was anaylzed by temperature gradients ( TGGE ) and sequence . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor p 53 plays a pivotal role in the cellular response to DNA damage as it controls DNA repair , cell cycle arrest and apoptosis . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
METHODS : DNA from eight carcinoma tissues and nine adenoma tissues from this reported case were examined for mutations in p 53 by single strand conformation polymorphism analysis , K ras by mutant allele specific analysis , and replication error or loss of heterozygosity of the TP 53 locus on chromosome # 17 . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
DNA obtained from archival tissues was examined using PCR based analyses for loss of heterozygosity and microsatellite alterations ( MAs ) at several chromosomal regions , TP 53 and K ras gene mutations , and frameshift mutations at minisatellite sequences at the coding regions of several genes ( TGF betaRII , IGFIIR , BAX , hMSH 6 , and hMSH 3 ) . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Microsatellite alterations and TP 53 mutations in plasma DNA of small cell lung cancer patients : follow up study and prognostic significance . ^^^ Furthermore , we looked for mutations of the TP 53 gene in tumor and plasma DNA . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
We present a cytogenetic and fluorescence in situ hybridization ( FISH ) study , using centromeric probes for chromosomes 3 , 7 , 11 , and 18 , TP 53 gene ( 17p13 ) , and RB 1 locus ( 13q14 ) DNA probes , in four cases of plasma cell leukemia ( PCL ) . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
MDM 2 inhibits p 300 mediated p 53 acetylation and activation by forming a ternary complex with the two proteins . p 300 acetylates and activates the tumor suppressor p 53 after DNA damage . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Normal constitutional and tumor DNA of the 14 patients with a positive cancer history , but negative family history , were analyzed for p16INK4a , TP 53 , and BRCA 2 mutations by single strand conformational variant ( SSCV ) analysis and direct sequencing . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor p 53 is a transcription factor which binds DNA through a structurally complex domain stabilized by a zinc atom . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
DNA was extracted from peripheral blood leukocytes , and genotyping was performed using a PCR based assay for the TP 53 codon 72 polymorphism and Southern blot analysis and PCR for allelic polymorphisms in the HRAS 1 minisatellite . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
To characterize phenotypic and genotypic changes in gastric cancer ( GC ) , DNA copy number aberrations ( CNAs ) were assessed in 53 tumors using comparative genomic hybridization ( CGH ) and correlated with clinicopathologic characteristics and status of TP 53 and replication error ( RER ) . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
We evaluated DNA from both primary and metastatic glioblastomas for genetic alterations commonly found in glioblastomas : TP 53 mutations , CDKN2A / p16 deletions , EGFR amplification , and allelic loss of chromosomes 1p , 10q and 19q . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Exposure of the lung to severe hyperoxia induces terminal transferase dUTP end labeling ( TUNEL ) indicative of DNA damage or apoptosis and increases expression of the tumor suppressor p 53 and of members of the Bcl 2 gene family . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor p 53 , a well studied stress response factor , has also been shown to play a role in DNA damage G 2 arrest , although in a manner that is probably independent of CHK 1 . p 53 , however , can be phosphorylated and regulated by both CHK 1 as well as another checkpoint kinase , hCds 1 ( also called CHK 2 ) . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Mechanisms to protect organisms from the consequences of DNA damage include the tumor suppressor p 53 pathway . p 53 protein binds specifically to a DNA consensus sequence to induce growth inhibitory genes or nonspecifically to damaged sites leading to DNA repair or apoptosis . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The TP 53 status of each of the cell lines was determined by single strand conformation polymorphism and DNA sequence analysis . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Here , we test the hypothesis that 5 aza CdR treatment is perceived as DNA damage , as assessed by the activation of the tumor suppressor p 53 . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
A similar result obtained with Trp 53 , an amino acid present at the C terminal side of AlcR , also indicated its involvement in the DNA recognition . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
RESULTS : An overall lack of G1 / S arrest and muted DNA fragmentation were consistent with the presence of TP 53 gene abnormalities . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Since the tumor suppressor TP 53 plays a central role in the regulation of the cellular response to DNA damage , our study explored the ability of ionizing radiation to change telomerase activity and telomere length in two closely related human lymphoblast cell lines with different TP 53 status . ^^^ Induction of telomerase activity by radiation does not generally appear to be controlled by the TP 53 dependent DNA damage response pathway . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
We examined 56 ESCC patients using single strand conformation polymorphism and DNA sequencing to assess the frequency and spectrum of TP 53 mutation and the association between allelic loss at microsatellite marker TP 53 and TP 53 mutations . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Dukes ' stage , tumor DNA ploidy status , and TP 53 genotype / phenotype were also examined for the same . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
CONCLUSIONS : Our findings provide novel evidence that loss of BRCA 1 function in human cells activates the p 53 DNA damage response pathway and that loss of this pathway , by somatic mutation of TP 53 , is a likely requirement for BRCA associated tumor development . . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
In this study we have investigated the effect of bile acids on the tumor suppressor p 53 using the human colon tumor cell line HCT 116 , which retains the wild type p 53 gene and functional p 53 signaling in response to DNA damage . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The DNA index was higher in tp 53 carcinomas compared to wtp 53 tumors , 1 . 97 + / 0 . 4 vs . 1 . 67 + / 0 . 1 , p = 0 . 05 . ^^^ Moreover , hypoxic cancers were more often immunohistologically positive for tp 53 protein and had a higher DNA index with the highest DNA index in tumors with both hypoxia and tp 53 protein expression . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The effects of ( 56 ) Fe particles and ( 137 ) Cs gamma radiation were compared in TK 6 and WTK 1 human lymphoblasts , two related cell lines which differ in TP 53 status and in the ability to rejoin DNA double strand breaks . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Molecular analysis of tumor DNA from the second recurrent tumor demonstrated the presence of the TP 53 mutation , which previously had been observed in the first recurrent tumor , but again no evidence of EGFR amplification . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor p 53 product has been shown to play an important role in preventing carcinogenesis by at least two different mechanisms , by evoking cell cycle arrest and eliciting DNA repair on one hand , or by eliminating damaged cells by induction of apoptosis on the other hand . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
In most of the families , LFS results from germline mutations of the tumor suppressor TP 53 gene encoding a transcriptional factor able to regulate cell cycle and apoptosis when DNA damage occurs . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
High thermostability and lack of cooperative DNA binding distinguish the p 63 core domain from the homologous tumor suppressor p 53 . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Thus , the cell and molecular biological data presented suggest that BBI is able to protect cells with functional TP 53 from UVB induced DNA damage . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
This response was heterogeneous , since cells that received the same dose had different staining intensities , suggesting that the induction of Trp 53 is not based simply on dose dependent responses to DNA damage . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
C cell hyperplasia foci were microdissected for DNA extraction to analyze the methylation pattern of androgen receptor alleles and microsatellite regions ( TP 53 , RB 1 , WT 1 , and NF 1 ) . ^^^ C cell hyperplasia foci showed heterogeneous DNA deletions revealed by loss of heterozygosity of TP 53 ( 12 of 20 ) , RB 1 ( 6 of 14 ) , and WT 1 ( 4 of 20 ) and hypodiploid G0 / G1 cells ( 14 of 20 ) , low cellular turnover ( MIB 1 index 4 . 5 % , in situ end labeling index 0 . 03 % ) , and significantly high nuclear area to DNA index ratio . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
We found a TP 53 heterozygous mutation in exon 7 in 1 of 47 primary tumors that yielded useable DNA , and in its recurrence 3 years later . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Analysis of TP 53 mutations in tumours from these regions has shown a high prevalence of mutations at A : T basepairs that may result from DNA damage caused by specific mutagens . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
For determination of TP 53 polymorphism , exon 4 of the TP 53 gene was amplified by PCR , and DNA was subsequently subjected to restriction enzyme digest . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
DNA extraction , PCR , and direct sequencing of exons 5 through 8 of the TP 53 gene were conducted following protocols optimized in our laboratory . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Promoter methylation of the DNA repair gene MGMT in astrocytomas is frequently associated with G : C > A : T mutations of the TP 53 tumor suppressor gene . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor p 53 plays a central role in the protection against DNA damage and other forms of physiological stress primarily by inducing cell cycle arrest or apoptosis . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The aim of this study was to examine any relation between DNA ploidy and previously detected TP 53 ( p 53 ) or p21WAF1 / CIP1 expression in 94 patients with muscle invasive transitional cell carcinoma of the urinary bladder and to associate these factors with survival . ^^^ We conclude that DNA aneuploidy may confer increased radiosensitivity in bladder cancer patients and that TP 53 accumulation may confer increased radiosensitivity , but its effect is detectable only in euploid tumours . . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Cells containing perturbations to DNA expressed the tumor suppressor p 53 . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
A role for c myc in DNA damage induced apoptosis in a human TP 53 mutant small cell lung cancer cell line . ^^^ Based on the role of p 53 in the control of apoptosis following DNA damage , the status of the TP 53 gene has been implicated as a major determinant of tumour responsiveness to cytotoxic therapies . ^^^ The cell line , in spite of TP 53 mutation , retained an efficient response to genotoxic stress as documented by cells ability to modulate the p 53 protein , arrest in the G 1 and G 2 phases of the cell cycle and its marked susceptibility to apoptosis following treatment with DNA damaging agents . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
We and others reported previously that the tumor suppressor p 53 down regulates spontaneous homologous recombination in chromosomally integrating plasmid substrates , but how p 53 affects homology dependent repair of DNA double strand breaks has not been established . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
To investigate whether the tumor suppressor p 53 protein , an indicator of DNA damage and cell stress , accumulates in the course of influenza virus induced murine pneumonia at the site of inflammation , female BALB / c mice were infected each with 5 10 10 ( 4 ) infectious units of influenza virus A , strain Puerto Rico ( PR ) 8 , by instillation into the nose and the pharynx . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The function and stability of the tumor suppressor p 53 are tightly controlled by the negative regulator mouse double minute 2 ( Mdm 2 ) , which binds to p 53 , blocking DNA binding and targeting p 53 for proteosome mediated degradation . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The DNA damage signal for Mdm 2 regulation , Trp 53 induction , and sunburn cell formation in vivo originates from actively transcribed genes . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
DNA samples isolated from 10 phenolphthalein induced thymic lymphomas were analyzed for loss of heterozygosity ( LOH ) at the Trp 53 locus and simple sequence length polymorphic ( SSLP ) loci . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
In order to evaluate TP 53 alterations as a potential marker for a non invasive diagnosis of recurrences or residuals and to determine whether tumor specific DNA exhibiting LOH or sequences harbouring a mutation , can be detected in body fluids , mutation screening was performed in urine , plasma and serum of patients with a mutated primary tumor . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumour suppressor gene TP 53 plays an important role in the regulation of DNA repair , and particularly of nucleotide excision repair . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Mutations in the TP 53 gene are associated with more than 50 % of human cancers , and 90 % of these affect p 53 DNA interactions , resulting in a partial or complete loss of transactivation functions . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor p 53 and its close relative p 73 are activated in response to DNA damage resulting in either cell cycle arrest or apoptosis . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The effect of the tumor suppressor gene TP 53 on repair of genomic DNA damage was examined in human urinary bladder transitional cell carcinoma ( TCC ) cell lines . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Furthermore , we found that Opn expression was upregulated by DNA damage induced Tp 53 activity and by adenovirus mediated transfer of the human TP 53 gene . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
For mutational studies , areas of tissue that contained malignant glioma were isolated by microdissection , and the DNA was subjected to polymerase chain reaction based amplification and sequencing of TP 53 exons 5 , 6 , 7 , and 8 . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor p 53 plays an important role in response to DNA damage , including DNA repair . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
In an attempt to correlate the TP 53 mutation pattern of squamous cell carcinomas of the esophagus ( ESCC ) and life style factors of patients from the high risk area Rio Grande do Sul , Brazil , 135 ESCC were analyzed , after prescreening by p 53 immunohistochemistry , by SSCP and DNA sequencing of TP 53 , exon 5 9 . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Both DNA binding and reporter transcriptional activity of NF kappaB , but not of TP 53 , were activated in HK 18 IR cells compared with the parental HK 18 cells ; this activation was observed both before and after a single dose of 5 Gy . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Germline DNA obtained from female subjects of similar age but without cancer was used to estimate the TP 53 and p 21 genotype frequencies in a control population . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The authors determined the nucleotide sequence of amplified DNA from exons 5 to 8 of the TP 53 gene in leukemic cells obtained from 17 children with ALL at the time of first bone marrow relapse . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Analysis of TP 53 germline mutations in pediatric tumor patients using DNA microarray based sequencing technology . ^^^ DNA samples were independently analyzed for TP 53 mutations by GeneChip and standard automated laser fluorescence ( ALF ) sequencing technology . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The arrayed primer extension based TP 53 gene test provides an accurate and efficient tool for DNA sequence analysis of this frequently mutated gene for both research and clinical applications . . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
RESULTS : Microsatellite instability was present in 21 % , DNA nondiploidy in 15 % , and mutations in the PTEN , KRAS , CTNNB1 / beta catenin , TP 53 , and CDKN2A genes were detected in 32 , 11 , 13 , 17 , and 0 % of the tumors , respectively . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Redox state of tumor suppressor p 53 regulates its sequence specific DNA binding in DNA damaged cells by cysteine 277 . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
DNA damage induced by camptothecin , which activates the tumor suppressor p 53 , was found to activate GSK3beta . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor gene , TP 53 , plays a major role in surveillance and repair of radiation induced DNA damage . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
This radioadaptive bystander effect was found to be preceded by early decreases in cellular levels of TP 53 protein , increase in intracellular ROS , and increase in the redox and DNA repair protein AP endonuclease ( APE ) . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Flavonoids are known to have DNA topoisomerase activity , a Tp 53 inducing activity that is confirmed in the assay . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Cytotoxicity because of substantial NO formation is established to initiate apoptosis , characterized by upregulation of the tumor suppressor p 53 , changes in the expression of pro and antiapoptotic Bcl 2 family members , cytochrome c relocation , activation of caspases , and DNA fragmentation . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Further , to elucidate the downstream effector pathway , we studied the 10 ray induced adaptive response in cultured mouse and human cells with different genetic background relevant to the DNA damage response pathway , such as deficiencies in TP 53 , DNA PKcs , ATM and FANCA genes . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
DNA was extracted from microdissected samples ( superficial and deep ) and used for microsatellite analysis of TP 53 and NF 1 by polymerase chain reaction denaturing gradient gel electrophoresis . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
DNA interstrand cross linking and TP 53 status as determinants of tumour cell sensitivity in vitro to the antibody directed enzyme prodrug therapy ZD 2767 . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
In the present study the clinical data , histology , proliferation rate , DNA ploidy status and the results of TP 53 mutation analysis and comparative genomic hybridization ( CGH ) of three typical cases of desmoplastic infantile astrocytoma and ganglioglioma are presented . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Using this method , A > G mutations in a p 53 ( TP 53 ) containing system , T > G , G > A , and C > A , mutations in the Ku gene ( XRCC 5 ) , and ATM , gene for a number of patient derived genomic DNA samples have been successfully screened . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
TP 53 overexpression ( > = 0 . 6 ng / mg protein ) was observed in 22 % of the tumors and correlated with nonendometrioid histology types ( P = 0 . 005 ) , poorly differentiated tumors ( P = 0 . 001 ) , higher FIGO grade ( P = 0 . 001 ) , DNA nondiploidy ( P = 0 . 002 ) , and high S phase fraction ( P = 0 . 03 ) . ^^^ TP 53 overexpression ( P = 0 . 04 ) , FIGO grade 3 vs . 1 + 2 ( P = 0 . 01 ) , higher age ( P = 0 . 02 ) , and DNA nondiploidy ( P < 0 . 001 ) showed significant correlation to shorter progression free survival in these patients . ^^^ In comparison to TP 53 overexpression and higher FIGO grades , DNA nonploidy status seems to be a better prognostic indicator to define a subset of early stage endometrial cancer patients who may benefit by adjuvant chemotherapy / radiotherapy . . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The correlation between inactivation of the TP 53 gene through mutation or the presence of high risk human papillomavirus ( HPV ) DNA and intrinsic paclitaxel sensitivity was studied in 27 gynaecological cancer cell lines . ^^^ TP 53 mutations were investigated with polymerase chain reaction single strand conformation polymorphism ( PCR SSCP ) and direct DNA sequencing . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Neural network predicts sequence of TP 53 gene based on DNA chip . ^^^ The trained neural network uses as input the fluorescence intensities of DNA hybridized to oligonucleotides on the surface of the chip and makes between zero and four errors in the predicted 1300 bp sequence when tested on wild type TP 53 sequence . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor p 53 downregulates homologous recombination independently of its transcriptional transactivation function and has been linked to enzymes of DNA recombination and replication . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
A major issue for the correct detection of TP 53 somatic mutations in primary tumors is often represented by the large amount of normal DNA , which can cause excessive dilution of the mutant allele , with consequent possible false negative results . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The results may suggest that at later times in organ development , DNA repair is more active , allowing some cells to escape radiation induced Trp 53 dependent apoptosis . ^^^ A diminished effect in the absence of functional Trp 53 is consistent with an influence of heat on inhibiting DNA repair , but with a diminished probability of apoptosis . . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The purpose of the study was to examine the TP 53 status of ameloblastomas using newly developed yeast functional assay whose accuracy and sensitivity has been proven to be higher than those of the previous DNA structure based methods such as single strand conformation polymorphism ( SSCP ) analysis . ^^^ METHODS : TP 53 status was analyzed by yeast functional assay and DNA sequencing in 12 cases of ameloblastoma which were diagnosed histologically and represented the clinical features of a benign tumor . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Tumor suppressor p 53 induces the cellular response to DNA damage mainly by regulating expression of its downstream target genes . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The inhibition of MyoD by DNA damage requires a functional c Abl tyrosine kinase ( encoded by Abl 1 ) , but occurs in cells deficient for p 53 ( transformation related protein 53 , encoded by Trp 53 ) or c Jun ( encoded by the oncogene Jun ) . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Many mutations in the human tumor suppressor p 53 affect the function of the protein by destabilizing the structure of its DNA binding domain . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor p 53 is critical in preventing cancer due to its ability to trigger proliferation arrest and cell death upon the occurrence of a variety of stresses , most notably , DNA damage and oncogenic stress . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor p 53 is required for the maintenance of genomic integrity following DNA damage . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Role of tumor suppressor p 53 domains in selective binding to supercoiled DNA . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Usually , the exon 4 of the TP 53 gene is amplified by polymerase chain reaction ( PCR ) on DNA extracted from blood and tumor tissues , then digested by AccII . ^^^ In the case of heterozygosity , the comparison of AccII profile from blood and tumor DNA PCR products allowed the identification of a potential LOH in the TP 53 locus . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Previously , we reported the presence of a novel Trp 53 dependent S phase checkpoint that suppresses pronuclear DNA synthesis in mouse zygotes fertilized with 10 irradiated sperm ( sperm irradiated zygotes ) ( Shimura et al . , Mol . ^^^ In the Trp 53 ( + / + ) genetic background , all of the sperm irradiated zygotes cleaved successfully to the two cell stage despite the fact that half of them carried a sub 2N amount of DNA . ^^^ In contrast , sperm irradiated Trp 53 ( / ) embryos lacking an S phase checkpoint exhibited an abnormal segregation of chromosomes at the first cleavage , even though they carried an apparently normal 2N amount of DNA . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The characterization of plasma DNA , based on similar alterations in tumor and plasma DNA , was achieved with six polymorphic markers ( D17S855 , D17S654 , D16S421 , TH ( 2 ) , D10S197 , and D9S161 ) and mutations in the TP 53 gene . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
PURPOSE : The aim of this study was to determine TP 53 and NM 23 H1 immunoreactivity , DNA ploidy , and S phase fraction ( SPF ) in a series of 160 patients undergoing resective surgery for primary operable colorectal cancer ( CRC ) and to establish whether these alterations have any clinical value in predicting CRC patients ' prognosis . ^^^ METHODS : TP 53 and NM 23 H1 expressions were evaluated on paraffin embedded tissue by immunohistochemistry and DNA ploidy and SPF on frozen tissue by flow cytometric analysis . ^^^ CONCLUSIONS : Our results indicate that DNA aneuploidy and high SPF are associated in CRC with a poor clinical 5 year outcome , while in contrast the prognostic role of TP 53 and NM 23 H1 expression is still to be clarified . . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
RESULTS : TP 53 gene mutations were detected in the tumor DNA of 30 patients , all of whom had the identical TP 53 mutation in their stools . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
In this study , we used the comet FISH assay to examine initial DNA damage and subsequent repair in the TP 53 gene region of RT 4 and RT 112 bladder carcinoma cells after 5 Gy gamma irradiation . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Complexity of the mechanisms of initiation and maintenance of DNA damage induced G 2 phase arrest and subsequent G 1 phase arrest : TP 53 dependent and TP 53 independent roles . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Cloning the TP 53 gene from tumor DNA followed by sequencing was performed in 14 heterozygotes with tumor mutation , and 9 of the mutations resided on the Arg 72 allele . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
DNA was extracted from all subjects ' normal oral mucosa and the polymerase chain reaction amplification ( PCR ) was performed for detection of the TP 53 genotypes . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The genes associated with bladder carcinogenesis include oncogenes ( such as H ras , FGFR 3 , erbB 2 , CCND 1 , mdm 2 ) , tumor suppressor genes ( such as INK4A / ARF , Rb , TP 53 , PTEN , TSC 1 , PTCH , DBCCR 1 ) , and DNA mismatch repair genes , etc . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Pin 1 is also a critical regulator of the tumor suppressor p 53 during DNA damage response . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Immunofluorescence image analysis was used to quantitate the DNA damage marker 8 oxoguanine , the tumor suppressor p 53 , the base excision repair polymerase beta , and apoptotic internucleosomal DNA fragmentation in ovarian surface epithelial cells isolated from the perimeter of ovulated follicles . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
In six cases , single strand conformation polymorphism analysis for mutations of the TP 53 gene in stromal blood vessels compared with adjacent tumor cells and subsequent DNA sequencing of the resulting DNA fragments were carried out . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The presence of HPV DNA as well as the TP 53 polymorphism at codon 72 of exon 4 were investigated in a series of 45 penile SCC . ^^^ The TP 53 Arg / Arg genotype does not appear to represent a risk factor for the development of genital SCC in men , and no correlation was found between the TP 53 polymorphism at codon 72 and the presence of HPV DNA . . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Mutations of TP 53 induce loss of DNA methylation and amplification of the TROP 1 gene . p 53 and DNA methylation play key roles in the maintenance of genome stability . ^^^ Taken together , these findings demonstrate that the inactivation of TP 53 induces loss of DNA methylation and DNA methylation dependent gene amplification . . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
This work examined the importance of radiation induced and ligand induced EGFR ERK signaling for the regulation of DNA repair proteins XRCC 1 and ERCC 1 in prostate carcinoma cells , DU 145 ( TP 53 ( mut ) ) , displaying EGFR TGFA dependent autocrine growth and high MAPK ( ERK1 / 2 ) activity , and LNCaP ( TP 53 ( wt ) ) cells expressing low constitutive levels of ERK1 / 2 activity . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Putative colon cancer risk factors damage global DNA and TP 53 in primary human colon cells isolated from surgical samples . ^^^ This study describes a novel in vitro method in genetic toxicology that is based on detection of chemical induced DNA damage connected with altered migration of TP 53 in primary human colonocytes . ^^^ In these cells TP 53 was more sensitive than global DNA for genotoxicity induced by trans 2 hexenal and H ( 2 ) O ( 2 ) . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Cyclin G 1 is a transcriptional target of the tumor suppressor p 53 , and its expression is increased after DNA damage . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
We used SSCP and DNA sequencing to assess and compare frequencies of R72P ( TP 53 ) and 5 ' UTR203G > A , N372H , and K1132K ( BRCA 2 ) polymorphisms in healthy Chinese subjects at varying risk for esophageal squamous cell carcinoma ( ESCC ) and in ESCC patients . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Moreover , it has been shown that DNA retrieved from plasma can be successfully used for detection of TP 53 mutations , which gives hope for earlier more accurate detection of human cancers . . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
TP 53 DNA sequencing was also performed on the cell lines . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Moreover , the incidence of mutations of the KRAS 2 and TP 53 genes was lowest among the DNA near triploid subpopulations and highest among the near diploid ones . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Dual role of tumor suppressor p 53 in regulation of DNA replication and oncogene E 6 promoter activity of epidermodysplasia verruciformis associated human papillomavirus type 8 . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
After DNA damage cells may arrest in G ( 2 ) through TP 53 dependent and independent mechanisms , raising the question of the precise position of the arrest within G ( 2 ) . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Tumor suppressor p 53 dependent recruitment of nucleotide excision repair factors XPC and TFIIH to DNA damage . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
After HNE incubation , TP 53 migrated more efficiently into the comet tail than the global DNA , which suggests a higher susceptibility of the TP 53 gene to HNE . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Previous evidence has shown that apoptotic death of embryonic cortical neurons treated with the DNA damaging agent camptothecin is dependent upon the tumor suppressor p 53 , an upstream death mediator , and more distal death effectors such as caspases . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
If white patients were stratified according to the type and location of TP 53 mutations , patients with mutations affecting amino acids directly involved in DNA or Zn binding displayed a poor prognosis . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The concept that the tumor suppressor p 53 is a latent DNA binding protein that must become activated for sequence specific DNA binding recently has been challenged , although the `` activation ' ' phenomenon has been well established in in vitro DNA binding assays . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor p 53 transcriptionally transactivates cellular target genes that are implicated in growth control , apoptosis , and DNA repair . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The frequencies of aberrant methylation were : 64 % for thrombospondin 1 ( THBS 1 ) ; 30 % for tissue inhibitor of metalloproteinase 3 ( TIMP 3 ) ; 27 % for O 6 methylguanine DNA methyltransferase ( MGMT ) ; 25 % for p 73 ; 18 % for RB 1 ; 14 % for death associated protein kinase ( DAPK ) , p14ARF , p16INK4a and caspase 8 , and 0 % for TP 53 and glutathione S transferase P 1 ( GSTP 1 ) . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The common missense mutations in the TP 53 gene disrupt the ability of p 53 to bind to DNA and consequently to transactivate downstream genes . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
We speculate that PML bodies may interact directly with the TP 53 DNA sequence to regulate TP 53 gene expression . . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
MATERIAL AND METHODS : DNA sequencing of the TP 53 gene was performed in 46 patients with gastric carcinoma . ^^^ RESULTS : DNA sequencing of exons 5 9 of the TP 53 gene demonstrated a mutation in 31 % of patients . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Detection and assignment of TP 53 mutations in tumor DNA using peptide mass signature genotyping . ^^^ To explore the suitability of PMSG for tumor genotyping , 25 human squamous cell carcinomas of the head and neck , as well as a set of cell lines derived from those tumors , were analyzed for mutations in exons 5 to 8 of the TP 53 gene , the exons that encode the DNA binding domains of the p 53 protein . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
BACKGROUND : Several tumor suppressor genes such as p16INK4 , TP 53 , RB 1 y p21WAF1 are involved in cell cycle regulation in response to DNA damage and belong to the complex pathway that regulates cell proliferation and / or differentiation . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
DNA sequence profile of TP 53 gene mutations in childhood B cell non Hodgkin ' s lymphomas : prognostic implications . ^^^ OBJECTIVES : The TP 53 gene encodes a nuclear protein implicated in the regulation of the cell cycle , DNA repair , and apoptosis . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
DNA was studied for loss of heterozygosity ( LOH ) at 19p ( STK 11 ) , 5q ( APC ) , and 17p ( TP 53 ) ; mutations in beta catenin , APC , and K RAS ; and microsatellite instability . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Sequence analysis of the TP 53 gene and screening for defective DNA mismatch repair revealed no abnormalities . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
We screened exons 5 8 of TP 53 for mutations in DNA from tumor biopsies ( n = 44 ) and blood samples ( n = 42 ) from the same LC patients , and blood samples from a healthy , matched control group ( n = 40 ) , using polymerase chain reaction single strand conformation polymorphism ( PCR SSCP ) analysis and direct sequencing . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
We review how the tumor suppressor P 53 is involved in the complex response to IR to enforce the cell ' s fate to live by inducing the growth arrest coupled to DNA damage repair or to die by inducing irreversible growth arrest or apoptosis . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor p 53 exerts its versatile function to maintain the genomic integrity of a cell , and the life of cancerous cells with DNA damage is often terminated by induction of apoptosis . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Microarray analysis reveals that TP 53 and ATM mutant B CLLs share a defect in activating proapoptotic responses after DNA damage but are distinguished by major differences in activating prosurvival responses . ^^^ Using microarray analysis of ATM mutant , TP 53 mutant , and ATM / TP53 wild type B CLLs , we show that after exposure to DNA damage transcriptional responses are entirely dependent on ATM function . ^^^ Consequently , the greater severity of the TP 53 mutant B CLLs compared with ATM mutant B CLLs is consistent with the additive effect of defective apoptotic and elevated survival responses after DNA damage in these tumors . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Cytogenetics , DNA profiling , expression of basal , luminal , and neuroendocrine differentiation markers , and mutation analyses of the TP 53 and androgen receptor ( AR ) genes were performed . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Most of the cancer associated mutations in the tumor suppressor p 53 map to its DNA binding core domain . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The frequency of DNA deletions by homologous recombination at the pink eyed unstable ( p ( un ) ) locus is elevated in mice with mutations in ATM , Trp 53 , Gadd 45 , and WRN genes and after exposure to carcinogens . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Tumor suppressor p 53 controls cell cycle progression and apoptosis following DNA damage , thus minimizing carcinogenesis . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Brain tumors were associated with missense TP 53 mutations located in the DNA binding loop that contact the minor groove of DNA ( P = 0 . 01 ) , whereas adrenal gland carcinomas were associated with missense mutations located in the loops opposing the protein DNA contact surface ( P = 0 . 003 ) . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The cyclin dependent kinase inhibitor p 21 , a major transcriptional target of the tumor suppressor p 53 , plays a critical role in cell cycle arrest in G 1 and G 2 after DNA damage . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Cells respond to DNA damage through the stabilisation of the tumor suppressor p 53 , which maintains genomic fidelity through induction of a cell cycle arrest in order to allow repair or elimination of the damaged cell through apoptosis . ^^^ This study was carried out to determine if TNF alpha caused oxidative DNA damage in primary cultures of murine hepatocytes and whether any damage would result in the induction of the tumor suppressor p 53 and cell cycle arrest . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Quantification of activity of the DNA dependent kinase was performed by immunoprecipitation and phosphorylation of a TP 53 derived peptide . ^^^ This effect on the fidelity of DNA repair is TP 53 dependent and correlated with induction of DNA PK activity . . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
EXPERIMENTAL DESIGN : We examined the DNA methylation status of 12 tumor related genes ( NF 2 , RB 1 , p 14 ( ARF ) , p 16 ( INK4a ) , p 73 , TIMP 3 , MGMT , DAPK , THBS 1 , caspase 8 , TP 53 , and GSTP 1 ) in 44 sporadic and / or NF 2 associated schwannomas using methylation specific PCR . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Thus , in addition to these two genes , we determined the methylation status of the genes p16INK4a , glutathione S transferase P 1 ( GSTP 1 ) , O 6 methylguanine DNA methyltransferase ( MGMT ) , thrombospondin 1 ( THBS 1 ) , p14ARF , TP 53 , p 73 , and tissue inhibitor of metalloproteinase 3 ( TIMP 3 ) , in 18 brain metastases of solid tumors , with methylation specific PCR . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Hybridization of cDNA microarrays with DNA released from spermatozoa revealed a consistent hypersensitivity of certain genes to endogenous cleavage including TP 53 , VHL ( tumour suppressors ) , BRCA 1 ( breast cancer ) , NOS 1 ( neurotransmitter ) , PECAM 1 , FLT 1 ( angiogenesis ) and CDKN1C ( cell cycle / imprinted ) . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Using DNA based sequencing , we evaluated the TP 53 gene in all 44 patients . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
A new solid phase chemical cleavage of mismatch method ( CCM ) allowed rapid and efficient screening and analysis of the TP 53 gene in DNA samples extracted from tumors of 89 breast cancer patients . ^^^ Mutation analysis involved amplification of five different fragments of the TP 53 gene using DNA from the 89 tumor samples , then pairing of the 391 labeled PCR products and forming heteroduplexes . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Specifically , in the donors ' lymphocytes , biallelically expressed genes ( TP 53 and AML 1 ) and a repetitive noncoding DNA sequence associated with chromosome segregation ( CEN 17 ) showed loss of synchrony in allelic replication timing ( allele specific replication ) . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
In this study , we used isogenic fibroblasts derived from Trp 53 knockout mice to study radiation sensitivity , PLD repair , and repair of DNA double strand breaks ( DSBs ) . ^^^ In conclusion , our results show that loss of wild type Trp 53 leads to increased radioresistance with consequent reduction in PLD repair but with no effect on DNA DSB repair . . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Experimental Design : We followed up 102 consecutive Caucasian patients with advanced gastric adenocarcinoma for > 5 years and determined the status of the TP 53 codon 72 polymorphism in DNA samples extracted from archived gastric tissues . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
TP 53 mutations were analyzed in 35 human papillomavirus ( HPV ) type 16 DNA positive cancers of the oral cavity and oropharynx and in 35 HPV DNA negative cancers matched by subsite , country , sex , age , and tobacco and alcohol consumption . ^^^ Wild type TP 53 was found more frequently in cancer specimens that contained HPV 16 DNA than in those that did not . ^^^ All 14 HPV 16 DNA positive cancers in HPV 16 E6 antibody positive patients contained wild type TP 53 , compared with 50 % of corresponding HPV DNA negative cancers ( matched odds ratio , infinity ; 95 % confidence interval , 1 . 4 infinity ) . ^^^ In contrast , for HPV 16 DNA positive cancers in E 6 negative patients , wild type TP 53 frequency was similar to that in corresponding HPV DNA negative cancers ( matched odds ratio , 1 . 0 ; 95 % confidence interval , 0 . 2 5 . 4 ) . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
METHODS : Primary cultures of keratinocytes and fibroblasts were established from lesional and nonlesional skin biopsies of two subjects with DSAP . p 53 mutations were analysed by DNA sequencing of the conserved region of the TP 53 gene . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
TP 53 inducible genes play crucial roles from many biological aspects including cell cycle control , DNA repair , and apoptosis . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Comparison of BRCT domains of BRCA 1 and 53BP1 : a biophysical analysis . 53BP1 interacts with the DNA binding core domain of the tumor suppressor p 53 and enhances p 53 mediated transcriptional activation . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor p 53 regulates cellular responses to stress by serving in the nucleus to regulate transcription of genes involved in processes including cell cycle arrest , DNA repair , and apoptosis . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
This altered distribution of mutations across the p 53 DNA sequence more closely resembles the pattern observed in TP 53 from human skin tumors at sun exposed sites than that in the p 53 gene of mice treated with UV alone . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Mutations in the Trp 53 gene of UV irradiated Xpc mutant mice suggest a novel Xpc dependent DNA repair process . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Biopsy specimens were examined histologically , and genomic DNA extracted from frozen biopsies and lavage fluid was analysed for mutations in TP 53 exons 4 9 . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
A selective mutation in TP 53 ( AGG > AGT at codon 249 , Arg > Ser ) has been identified as a hotspot in HCCs from such areas , reflecting DNA damage caused by aflatoxin metabolites . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Telomerase positive Rad51d ( / ) Trp 53 ( / ) primary mouse embryonic fibroblasts ( MEFs ) exhibited telomeric DNA repeat shortening compared to Trp 53 ( / ) or wild type MEFs . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
DNA sequencing , performed in 84 % of cases , revealed that TP 53 mutations were most frequent in gemistocytic astrocytomas ( 88 % ) , followed by fibrillary astrocytomas ( 53 % ) and oligoastrocytomas ( 44 % ) , but were infrequent ( 13 % ) in oligodendrogliomas . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Activation of the tumor suppressor p 53 by DNA damage induces either cell cycle arrest or apoptosis , but what determines the choice between cytostasis and death is not clear . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor gene Tp 53 was analyzed by polymerase chain reaction amplification of genomic DNA extracted from paraffin embedded tissue sections of rat lung tumors to compare mutations that occurred after inhalation exposures to plutonium dioxide , neptunium dioxide , or radon and radon progenies . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Abnormality of the DNA double strand break checkpoint / repair genes , ATM , BRCA 1 and TP 53 , in breast cancer is related to tumour grade . ^^^ The role of the DNA double strand break ( DSB ) checkpoint / repair genes , ATM , BRCA 1 and TP 53 , in sporadic breast cancer requires clarification , since ATM and BRCA 1 mutations are rare in sporadic tumours . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
MATERIAL AND METHODS : Tumor DNA from 29 patients with an ameloblastoma was examined for mutations in exons 5 to 8 of the tp 53 tumor suppressor gene using PCR , SSCP , and sequential analysis . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Mutations in the WRN or the TP 53 genes lead to spontaneous genetic instability , an elevated risk of tumor formation , and sensitivity to compounds that interfere with DNA replication , such as camptothecin and DNA interstrand cross linking drugs . ^^^ We investigated the hypothesis that WRN and TP 53 are involved in cellular responses to DNA replication blocking lesions by exposing WRN deficient and TP 53 mutant lymphoblastoid cell lines ( LCLs ) to 1 beta d arabinofuranosylcytosine ( AraC ) and bleomycin . ^^^ WRN and TP 53 operate in a shared DNA damage response pathway , since in cells in which TP 53 was inactivated by SV 40 transformation , no difference in AraC and bleomycin sensitivity was found regardless of WRN status . ^^^ In contrast to TP 53 mutant LCLs , WRN deficient cells showed unaffected cell cycle arrest after AraC and bleomycin exposure , which indicates that WRN is not involved in DNA damage activated cell cycle arrest . ^^^ Neither WRN nor TP 53 deficiency affected cellular recovery from exposure to AraC and bleomycin , which disagrees with a direct role in repair of these DNA lesions . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Another subset of 17 tumors ( 39 % ) displayed different and new features , characterized by recurrent gains of whole chromosomes 5 , 7 and 8 with few chromosome rearrangements , rare DNA amplifications and no TP 53 mutation . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
This gene encodes a nuclear phosphoprotein p 53 , which plays a key role in cell cycle arrest , induction of apoptosis , and DNA repair . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Otherwise , p 53 would not be active and there would be no selective pressure for TP 53 mutations . 1 make the argument that tumorigenic transformation is intrinsically associated with formation of DNA DSBs in every cell cycle leading to activation of DNA damage checkpoint pathways . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
A functional assay was developed in yeast to identify mutations induced by DNA damaging agents at the flounder TP 53 locus . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Therefore it was suggested that radiation induced DNA damage and TP 53 , ATM , or DNA PK mediated cellular responses occurring downstream thereof were not involved in the radiation induced apoptotic cell death in C3H mouse PRMs . . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Human tumor suppressor p 53 and DNA viruses . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor p 53 plays an important role in the regulation of cellular response to DNA damage . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Bi directional regulation between tyrosine kinase Etk / BMX and tumor suppressor p 53 in response to DNA damage . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The E287X TP 53 mutation segregated with the cancer phenotype in the family members from whom DNA samples were available . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
An increased inability to maintain the DNA damage induced G 2 checkpoint was observed in Fancc / ; Trp 53 / cells compared with Fancc / cells , indicating that Fancc and p 53 cooperated to maintain the G 2 checkpoint . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
DNA sequencing revealed TP 53 missense mutations in 4 ( 20 % ) of 20 cerebellar liponeurocytomas , a frequency higher than in medulloblastomas . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Hypermethylation of the DNA repair gene MGMT : association with TP 53 G : C to A : T transitions in a series of 469 nervous system tumors . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Polymerase chain reaction was used to amplify genomic DNA at specific loci on chromosome 7q31 ( D7S522 ) , 8p21 . 3 q11 . 1 ( D8S133 , D8S137 ) , 8p22 ( D8S261 ) , 10q23 ( D10S168 , D10S571 ) , 17p13 ( TP 53 ) , 16q23 . 2 ( D16S507 ) , 12q11 12 ( D12S264 ) , 17q ( D17S855 ) , 18p11 . 22 p 11 ( D18S53 ) , and 22q11 . 2 ( D22S264 ) . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Seven microsatellite polymorphic DNA markers ( TP 53 at 17p , D1S211 , and D1S162 at 1p32 , D17S1323 at 17q21 , D17S1330 at 17q25 , D5S346 at 5q , and D2S123 at 2p ) were utilized . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Our primary hypothesis was that the TP 53 mutation spectrum is influenced by polymorphisms in genes involved in DNA repair and apoptosis . ^^^ Functional polymorphisms in XPD ( Asp312Asn , rs 1799793 and Lys751Gln , rs 1052559 ) , a protein required for nucleotide excision repair and with roles in p 53 mediated apoptosis , were modestly associated with G : C > T : A mutations in TP 53 in lung tumors [ Asp / Asn312 + Asn / Asn312 and / or Lys / Gln751 + Gln / Gln751 versus Asp / Asp312 + Lys / Lys751 ; odds ratio ( OR ) 2 . 73 , 95 % confidence interval ( CI ) 0 . 98 7 . 61 ] , consistent with the role of this protein in repair of bulky carcinogen DNA adducts . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Here we report that BCL 6 suppresses the expression of the p 53 ( also known as tp 53 ) tumour suppressor gene and modulates DNA damage induced apoptotic responses in germinal centre B cells . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Mutation of tumor suppressor p 53 gene gains new function in regulation of DNA damage induced apoptotic response in tumor cells , which may lead to a poor response in cancer chemotherapy and radiotherapy . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Direct DNA sequencing of the most commonly mutated genes in sporadic endometrial cancer , PTEN , K RAS , TP 53 , and CTNNB 1 , was performed in addition to microsatellite instability ( MI ) studies . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Association of amino acid substitution polymorphisms in DNA repair genes TP 53 , POLI , REV 1 and LIG 4 with lung cancer risk . ^^^ An SNP , Arg72Pro , of the TP 53 gene encoding a DNA damage response protein showed the strongest association with squamous cell carcinoma risk ( OR Pro / Pro vs . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Promising approaches and molecular markers include gene expression profiles , DNA ploidy , loss of heterozygosity and chromosomal aberrations as detected by CGH and FISH ( 1q , 17p , 17q ) , as well as oncogenes / tumor suppressor genes and their proteins ( TP 53 , PTEN , c erbB 2 , N myc , c myc ) , growth factor and hormonal receptors ( PDGFRA , VEGF , EGFR , HER 2 , HER 4 , ErbB 2 , hTERT , TrkC ) , cell cycle genes ( p 27 ) and cell adhesion molecules , as well as factors potentially related to therapeutic resistance ( multi drug resistance , DNA topoisomerase IIalpha , metallothionein , P glycoprotein , tenascin ) . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Loss of heterozygosity ( LOH ) at BRCA 1 ( D17S579 , D17S855 ) and p 53 ( TP 53 , D17S786 ) in serum DNA was analyzed by PCR based method . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Potentially prognostic histopathological markers vary among different entities and consist of assessment of necroses , mitoses , differentiation , vascular proliferation , and growth pattern , whereas immunohistochemical features include proliferation markers ( Ki 67 , MIB 1 ) , expression of oncogenes / tumor suppressor genes and their proteins ( TP 53 , c erbB 2 ) , growth factor and hormonal receptors ( VEGF , EGFR , HER 2 , HER 4 , ErbB 2 ) , cell cycle genes ( p 27 , p14ARF ) and cell adhesion molecules , as well as factors potentially related to therapeutic resistance ( DNA topoisomerase IIalpha , metallothionein , P glycoprotein , tenascin ) . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
METHODS : Single strand conformational polymorphism analysis followed by DNA sequencing was used to screen for mutations in the sonic hedgehog pathway genes PTCH , SMOH , SUFUH and GLI 1 , in the TP 53 tumour suppressor gene , and in the proto oncogenes NRAS , KRAS , HRAS , BRAF and CTNNB 1 . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Sequence specific DNA binding is a major activity of the tumor suppressor p 53 and a prerequisite for the transactivating potential of the protein . p 53 interaction with target DNA is tightly regulated by various mechanisms , including binding of different components of the transcription machinery , post translational modifications , and interactions with other factors that modulate p 53 transactivation in a cell context and promoter specific manner . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
B cell chronic lymphocytic leukemia ( B CLL ) is a clinically variable disease where mutations in DNA damage response genes ATM or TP 53 affect the response to standard therapeutic agents . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Our recent findings indicate that tumor suppressor p 53 plays an important role in maintaining genetic stability in ESCs by eliminating DNA damaged ESCs from the replicative ESC pool . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
RESULTS : Immunohistochemistry showed an overexpression of p 53 in more than 80 % of tumoral cells ; furthermore , mutations of TP 53 were observed in two cases , involving the sequence specific DNA binding domain . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Low density DNA microarray for detection of most frequent TP 53 missense point mutations . ^^^ CONCLUSION : Our results demonstrate that a simple TP 53 microarray employing short ( 7 mer ) probes , used in combination with single or double tandem hybridization approach and a simple or multiplex target preparation method , can identify common TP 53 missense mutations from a variety of DNA sources with good specificity . . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Deletions in the DNA binding domain of the TP 53 gene in 5 src transformed chicken cells . ^^^ We have examined the chicken TP 53 tumor suppressor gene in 5 src transformed chicken tumor cells by reverse transcriptase polymerase chain reaction and deoxyribonucleic acid ( DNA ) sequencing . ^^^ Initially , we have detected frequent deletions of variable length in both DNA binding and oligomerization domains of the TP 53 in late as well as early in vitro passages of the chicken tumor cell line PR 9692 . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
We compared all but one ( whose DNA was of bad quality ) of the microsatellite unstable TP 53 mutation containing tumors ( 8 ) with a similarly sized group of microsatellite unstable tumors without TP 53 mutation ( 11 ) . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor p 53 is a transcription factor and is activated in response to DNA damage or oncogenic transformation through modification of its interaction with regulatory proteins . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Analyses have been done on sensitivity to DNA cross linking agents , loss of heterozygosity profile , TP 53 mutations , TP 53 polymorphisms and the presence of human papillomavirus . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Tumors were analyzed for the presence of TP 53 mutations by polymerase chain reaction single strand conformation polymorphism analysis and direct DNA sequencing . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Detection of TP 53 mutation using a portable surface plasmon resonance DNA based biosensor . ^^^ A DNA based surface plasmon resonance ( SPR ) biosensor has been developed for the detection of TP 53 mutation using the inexpensive and commercially available instrument , SPREETA SPR EVM BT , from Texas Instruments . ^^^ Finally , the sensor system was successfully applied to polymerase chain reaction ( PCR ) amplified real samples , DNA extracted from both normal , wild type , ( Jurkat ) and mutated ( Molt 4 ) , carrying the mutation at codon 248 of the TP 53 cell lines . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor p 53 functions as a transcriptional activator to induce cell cycle arrest and apoptosis in response to DNA damage . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
After DNA extraction samples were tested for the following markers : TP 53 , D16S423 , D16S310 , DS 163210 and D16S476 , and analyzed on ABI PRISM 3100 ( Applied Biosystems , Foster city CA ) . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The sensors were able to detect these mutations in both oligonucleotides and PCR products with normal and mutant TP 53 DNA , but the difference in hybridisation signal was small . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
An unselected series of 310 colorectal carcinomas , stratified according to microsatellite instability ( MSI ) and DNA ploidy , was examined for mutations and / or promoter hypermethylation of five components of the WNT signaling cascade [ APC , CTNNB 1 ( encoding beta catenin ) , AXIN 2 , TCF 4 , and WISP 3 ] and three genes indirectly affecting this pathway [ CDH 1 ( encoding E cadherin ) , PTEN , and TP 53 ] . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Tumor suppressor p 53 is a transcription factor that transactivates a wide range of genes , including those in DNA repair , cell cycle arrest , apoptosis and its own degradation . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
We present the development of HTRF technology as applied to the diagnosis of tumor suppressor gene p 53 ( TP 53 ) mutations , and its application to the analysis of genomic DNA from human tumoral samples . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
It is characterized by : ( 1 ) a sharp increase in incidence above age 50 ; ( 2 ) a characteristic pattern of chromosomal gain and , especially , loss , that is , of 5q14q33 , 7q32q35 , and 17p13 , translating into reduced expression of genes in these regions ; ( 3 ) a unique gene expression pattern including up regulation of genes involved in DNA repair ; ( 4 ) a high incidence of TP 53 deletions and / or mutations ; and ( 5 ) an overall unfavorable prognosis . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Complicons affecting Igh / Myc have been reported previously in lymphomas of mouse models simultaneously deficient in Tp 53 and in genes of the nonhomologous end joining DNA repair pathway . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
In addition , the loss of one copy of the TP 53 gene and identical IGH DNA clonal rearrangements were shown with FISH and polymerase chain reaction analysis respectively in the two types of leukemic cells . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The CHK 2 gene , whose product is a checkpoint kinase that plays a central role in DNA damage response and acts upstream of TP 53 , has been found to be mutated in a subset of Li Fraumeni syndrome without mutations of TP 53 and in some other sporadic human tumors , earmarking this serine / threonine kinase as a candidate tumor suppressor gene . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
TP 53 mutations and S phase fraction but not DNA ploidy are independent prognostic indicators in laryngeal squamous cell carcinoma . ^^^ To prospectively evaluate the prognostic significance of TP 53 , H , K , and N Ras mutations , DNA ploidy and S phase fraction ( SPF ) in patients affected by locally advanced laryngeal squamous cell carcinoma ( LSCC ) . ^^^ At Univariate analysis , the DNA aneuploidy , high SPF ( > 15 . 1 % ) , TP 53 mutations and , in particular , the mutations that occur in exons 5 and 8 were significantly related to quicker disease relapse and short OS . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
INTRODUCTION : The TP 53 binding protein ( 53BP1 ) has been shown to influence TP 53 mediated transcriptional activation , thus playing a pivotal role in DNA damage signalling . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Recently accumulating evidence suggest a role of the long patch DNA mismatch repair system in sensing cisplatin damaged DNA and in triggering cell death through a c Abl and p 73 dependent cascade ; two other important pathways have been unravelled that are the mitogen activated protein kinase cascade and the tumor suppressor p 53 . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
TP 53 mutation in plasma DNA , hepatitis B viral infection , and risk of hepatocellular carcinoma . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
We enlarged our study to assess the relationships of risk factors with TP 53 as well as epidermal growth factor receptor ( EGFR ) and murine double minute 2 ( MDM 2 ) gene amplification and expression and the germ line Leu84Phe polymorphism in the DNA repair protein O 6 methylguanine DNA methyltransferase ( MGMT ) . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
PROCEDURE : Primary ependymomas at diagnosis or relapse from 24 children were analyzed for p 53 pathway , using a functional assay in yeast , RT PCR , Western blot analysis , and / or immunohistochemistry for TP 53 mutation , p 14 ( ARF ) deletion and promoter hypermethylation , MDM 2 and PAX 5 expression , respectively . p 53 mediated response to radiation induced DNA damage was evaluated using Western blot and flow cytometry analysis in two ependymoma xenograft models , IGREP 37 and IGREP 83 , derived from primary anaplastic childhood ependymomas . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
A mutation in the TP 53 tumor suppressor gene at codon 249 ( TP 53 Ser249 mutation ) has been reported previously for hepatocellular carcinoma tumors and matched plasma DNA samples in individuals from areas with high aflatoxin exposure . ^^^ We examined whether the TP 53 Ser249 mutation could be observed in DNA found in plasma of young children ( ages 2 5 years ) from Guinea , west Africa , a region of high aflatoxin exposure . ^^^ Following PCR amplification of plasma derived DNA and detection using mass spectrometry , none of the samples were found to contain the TP 53 Ser249 mutation . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
We sequenced BRAF and KRAS , analyzed for microsatellite instability ( MSI ) and 18q loss of heterozygosity ( LOH ) , and performed immunohistochemistry for TP 53 , cyclooxygenase 2 ( COX 2 ) , MLH 1 , O 6 methylguanine DNA methyltransferase ( MGMT ) , p 16 ( CDKN2A ) , and fatty acid synthase ( FASN ) . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Consistent with other studies , overexpression / mutation of TP 53 and aneuploid DNA content were more frequently detected in secondary GBMs of Chinese adult patients . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
DNA extracted was examined for loss of heterozygosity ( LOH ) using 2 microsatellite markers and for TP 53 mutations at exons 5 to 8 . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Recently , TP 53 mutations have been detected in surrogate sources of genetic material such as free circulating DNA isolated from plasma . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Furthermore , we found several genes associated with DNA repair namely p53R2 , DDB 2 , XPC , PCNA , BTG 2 , and MSH 2 that were highly induced in TK 6 compared to WTK 1 and NH 32 . p53R2 , which is regulated by the tumor suppressor p 53 , is a small subunit of ribonucleotide reductase . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Additionally , we demonstrated that the role of SHP 2 in DNA damage induced cellular responses was independent of the tumor suppressor p 53 . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
In response to DNA damage , the tumor suppressor p 53 elicits a complex cellular response . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Polymerase chain reaction analysis of extracted DNA targeted five polymorphic DNA markers ( D3S1285 , D9S161 , D11S1316 , D13S290 , and TP 53 ) representing chromosome regions 3p14 , 9p21 , 11q23 , 13q12 . 1 and 17p13 , respectively . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
DNA samples from 218 HNPCC mutation positive patients from Australia and Poland were genotyped for the arginine to proline change at codon 72 in the TP 53 gene . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
DNA samples were extracted , and PCR RFLP was utilised for genotyping TP 53 codon 72 and WRN codon 1367 . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Quantitative analysis of plasma TP 53 249Ser mutated DNA by electrospray ionization mass spectrometry . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Five polymorphic DNA regions from TP 53 , RB 1 , WT 1 , and NF 1 were systematically studied by PCR denaturing gradient gel electrophoresis . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
SSCP followed by DNA sequencing revealed TP 53 mutations in 16 of 73 ( 22 % ) glioblastomas and PTEN mutations in 13 of 63 ( 21 % ) cases analyzed . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
One of the most important functions of the tumor suppressor p 53 protein is its sequence specific binding to DNA . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The mutations C742T , G746T , G747T in the TP 53 gene and G35T in the KRAS gene have been repeatedly found in sectors of human tumors by direct DNA sequencing . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
METHODS : Twenty previously analyzed DNA samples from lung tumors were examined under dummy laboratory codes for occurrence of mutations of the TP 53 gene . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
For designing DNA ligands , mismatched base pair positions favorable for detection of SNPs were also explored by use of hybridized DNAs coding a part of the human TP 53 gene . . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The recent structure of human replication protein A ( RPA ) bound to residues 38 58 of tumor suppressor p 53 exemplifies several important features of protein protein interactions involved in transcription and DNA repair . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Here , we present the development of the methodology to assign the genotype of TP 53 ( tumor protein p 53 ) codon 72 polymorphism and its application to analysis of genomic DNA from cell lines and from human colorectal samples . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Tumor suppressor p 53 is often activated in response to DNA damage or other forms of stress , leading to either cell cycle arrest or apoptosis . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor p 53 is a central player in apoptosis induction in response to oncogenic stimuli and DNA damage . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor p 53 plays a central role in the DNA damage response . p 53 enhances base excision repair ( BER ) , in part , through direct interaction with the repair complex . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Plasma DNA was assessed in the same way as tumor DNA , following identification of similar alterations in polymorphic markers and TP 53 gene mutations . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Tp 53 associated growth arrest and DNA damage repair gene expression is attenuated in mammary epithelial cells of rats fed whey proteins . ^^^ The present study examined the modulatory effects of dietary intake of whey protein hydrolysate ( WPH ) relative to casein ( CAS ) , on mammary epithelial cell resistance to endogenous DNA damage using Tp 53 gene expression and signaling as a read out , and on systemic proapoptotic and immune surveillance activity , in young adult female Sprague Dawley rats . ^^^ At postnatal day ( PND ) 50 , mammary glands of rats fed WPH had lower levels of activated Tp 53 and p 38 mitogen activated protein kinase proteins , and reduced transcript levels for Tp 53 associated DNA damage repair , growth arrest , and proapoptotic genes than those of CAS fed rats . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
DNA was obtained from 100 / 139 women . 17 / 36 familial cases had a BRCA 1 , BRCA 2 or TP 53 mutation . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
In this paper , we describe specific in situ hybridization of Ret , Abl 1 ( cAbl ) , and Trp 53 gene fragmentations on SCGE slides ( comet FISH assay ) in peripheral blood cells from C57BL / 6 and CBA / J mice as an indicator of radiation induced DNA damage . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Comparative mutational profiling for different genomic loci [ 1p36 ( CCM = cutaneous malignant melanoma ] , 3p26 ( OGGI = 8 oxoguanine DNA glycosylase ) , 5q23 ( APC , MCC = mutated in colorectal cancer ) , 9p21 ( p16 / CDKN2A = cyclin dependent kinase 2A ) , 10q23 ( PTEN = phosphatase and tensin homolog [ mutated in multiple advanced cancers 11 ) , 12p12 ( K ras 2 point mutation ) , 17p13 ( TP 53 ) , 18q25 ( DCC= deleted in colorectal cancer ) was carried out on each microdissected tissue target using microsatellite loss of heterozygosity determination or DNA sequencing . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
To study the cytogenetic mechanism for loss of TP 53 , metaphase and interphase FISH studies were conducted on 16 B CLL patients to investigate 17p10 to 17p12 , a chromosome region known to be rich in low copy DNA repeats . ^^^ Translocations or isochromosome formations at sites of low copy DNA repeats in 17p10 to 17p12 appear to be the mechanism for the loss of TP 53 in B CLL . . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
DNA sequence of mutation hot spots in TP 53 was determined in representative samples of each tumor . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Upon molecular investigation , BRAFT1799A was detected in DNA extracted from paraffin embedded material , whereas TP 53 was wild type . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
DNA was sequenced for TP 53 mutations . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
It includes integration of hepatitis B virus ( HBV ) DNA , R249S TP 53 ( tumor protein p 53 ) mutation in aflatoxin B 1 exposed patients , KRAS mutations related to vinyl chloride exposure , hepatocyte nuclear factor 1alpha ( HNF1alpha ) mutations associated to hepatocellular adenomas and adenomatosis polyposis coli ( APC ) germline mutations predisposing to hepatoblastomas . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The Cdc25C gene contains tumor suppressor p 53 binding sites and is demonstrated to contribute to the p 53 dependent cell cycle arrest upon DNA damage . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
DNA mismatch repair and TP 53 defects are early events in uterine carcinosarcoma tumorigenesis . ^^^ We studied the pattern and frequency of defective DNA mismatch repair and TP 53 alterations in the epithelial and mesenchymal components of 28 uterine carcinosarcomas . ^^^ Our results indicate that defective DNA mismatch repair and TP 53 defects are common early events in carcinosarcoma tumorigenesis . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
TP 53 and KRAS 2 mutations in plasma DNA of healthy subjects and subsequent cancer occurrence : a prospective study . ^^^ There was a nonsignificant trend for association between TP 53 mutations and bulky adducts in lymphocyte DNA ( OR , 2 . 78 ; 95 % CI , 0 . 64 12 . 17 ) . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Previous studies of the apoptotic response ( AR ) to radiation induced DNA damage of lymphoid cells from individuals carrying germline TP 53 mutations have demonstrated a defective AR compared with normal controls . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Tumor suppressor p 53 plays a critical role in cellular responses , such as cell cycle arrest and apoptosis following DNA damage . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
In addition , a growing number of other proteins have been implicated in centrosomal regulation of the DNA damage response , e . g . the tumor suppressor p 53 , the breast cancer susceptibility gene product BRCA 1 and mitotic regulators such as Aurora A , Nek 2 and the Polo like kinases Plk 1 and Plk 3 . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
The tumor suppressor p 53 plays a crucial role in the cellular response to DNA damage by transcriptional activation of numerous downstream genes . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Our data suggest that the CHEK 2 and TP 53 mutations can substitute each other in at least 25 % ( 21 / 84 ) of prostate cancers and that DNA damage signaling pathway plays an important role in prostate cancer tumorigenesis . . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Our data suggest that the sensitization to radiation results from NBS 1 siRNA mediated suppression of DNA repair and / or 10 ray induced cell survival signaling pathways through NFKB and XIAP . siRNA targeting appears to be a novel radiation sensitizing agent , particularly in human TP 53 mutant cancer cells . . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Ultraviolet B radiation induced skin cancer in mice defective in the Xpc , Trp 53 , and Apex ( HAP 1 ) genes : genotype specific effects on cancer predisposition and pathology of tumors . ^^^ The Trp 53 and Apex heterozygous conditions altered the skin tumor spectrum to more poorly differentiated forms in all Xpc genotypes . . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
By combining mutations in Xpc , Trp 53 and Apex we have obtained genetic evidence for a functional interaction between Apex and Trp 53 which probably involves the activation of the Trp 53 protein by Apex . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
Selected SNPs belong to the following genes : ADH1B , ALDH 2 , APEX , CDKN2A , COMT , CYP1A1 , CYP1A2 , CYP1B1 , CYP2A6 , CYP2C19 , CYP2C9 , CYP2E1 , CYP3A4 , DRD 2 , DRD 4 , EPHX 1 , ERCC 1 , ERCC 2 , ERCC 4 , ERCC 5 , GRPR , GSTA 4 , GSTM 3 , GSTP 1 , GSTT 2 , LIG 3 , MDM 2 , MGMT , MPO , NAT 1 , NAT 2 , NQO 1 , OGG 1 , PCNA , POLB , SLC6A3 , SOD 2 , TP 53 , XRCC 1 , XRCC 2 , XRCC 3 , and XRCC 9 . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
In order to make screening more effective , a commercially available TP 53 genotyping microarray from Asper Biotech has been constructed by arrayed primer extension ( APEX ) . ^^^ The present study is the first report that blindly evaluates the efficiency of the second generation APEX TP 53 genotype chip outside the Asper laboratory and compares it to temporal temperature gradient electrophoresis ( TTGE ) and sequencing of TP 53 for mutation detection in ovarian and breast cancer samples . ^^^ We conclude that the APEX TP 53 microarray is a robust , rapid , and comprehensive screening tool for sequence alterations in tumors . . ^^^
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27695 and P04637	Pubmed	SVM Score :0.0
NA