| Interacting proteins: P27540 and Q15788 |
Pubmed |
SVM Score :0.0 |
| Examination of the role of SRC 1 in AhR / ARNT transactivation in ARNT deficient mutant Hepa 1 c 4 cells demonstrates that the AhR transactivation domain is sufficient for enhanced coactivation mediated by SRC 1 in the presence of a transactivation domain deleted ARNT protein . . ^^^ |
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| Interacting proteins: P27540 and Q15788 |
Pubmed |
SVM Score :0.0 |
| Recruitment of the NCoA / SRC 1 / p160 family of transcriptional coactivators by the aryl hydrocarbon receptor / aryl hydrocarbon receptor nuclear translocator complex . ^^^ In this report , we demonstrate that SRC 1 , NCoA 2 , and p / CIP are capable of independently enhancing TCDD dependent induction of a luciferase reporter gene by the AHR / ARNT dimer . ^^^ We demonstrate by coimmunoprecipitation and by a reporter gene assay that SRC 1 and NCoA 2 but not p / CIP are capable of interacting with ARNT in vivo after transient transfection into mammalian cells , while AHR is capable of interacting with all three coactivators . ^^^ We confirm the interactions of ARNT and AHR with SRC 1 with immunocytochemical techniques . ^^^ We demonstrate by yeast two hybrid , glutathione S transferase pulldown , and mammalian reporter gene assays that ARNT requires its helix 2 domain but not its transactivation domain to interact with SRC 1 . ^^^ |
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| Interacting proteins: P27540 and Q15788 |
Pubmed |
SVM Score :0.0 |
| In conclusion , CBP plays an important role as a mediator of HIF 1alpha / Arnt / CBP / SRC 1 complex formation , coordinating the temporally and hierarchically regulated intranuclear traffic of HIF 1alpha and associated cofactors in signal transduction in hypoxic cells . . ^^^ |
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| Interacting proteins: P27540 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27540 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
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