| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| The cDNA clones encode a polypeptide of 805 amino acids with a helix loop helix motif and with some similarity to a certain region designated PAS of Drosophila Per and Sim , and human Arnt protein . ^^^ |
|
| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| In addition to the BR / HLH domain , the N terminal domain of the Ah receptor has extensive sequence similarity to the human ARNT ( aryl hydrocarbon receptor nuclear translocator ) protein and two regulatory proteins of Drosophila , Sim and Per . ^^^ |
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| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| We show that both HIF 1 subunits are basic helix loop helix proteins containing a PAS domain , defined by its presence in the Drosophila Per and Sim proteins and in the mammalian ARNT and AHR proteins . ^^^ |
|
| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| DNA binding specificities and pairing rules of the Ah receptor , ARNT , and SIM proteins . ^^^ The Ah receptor ( AHR ) , the Ah receptor nuclear translocator protein ( ARNT ) , and single minded protein ( SIM ) are members of the basic helix loop helix PAS ( bHLH PAS ) family of regulatory proteins . ^^^ Further examination indicated that ARNT may have a relaxed partner specificity , since it was also capable of forming a heterodimer with SIM and recognizing the sequence GT ( G / A ) CGTG . ^^^ Comparison of this in vitro data with sites known to be bound in vivo suggests that the high affinity half site recognition sequences for the AHR , SIM , and ARNT are T ( C / T ) GC , GT ( G / A ) C ( 5 ' half sites ) , and GTG ( 3 ' half sites ) , respectively . . ^^^ |
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| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| Arnt is a nuclear basic helix loop helix ( bHLH ) transcription factor that , contiguous with the bHLH motif , contains a region of homology ( PAS ) with the Drosophila factors Per and Sim . ^^^ |
|
| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| We have examined interaction of Arnt with other PAS proteins Drosophila Per , Sim , and AhR by the coimmunoprecipitation method . ^^^ |
|
| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| The Ah receptor ( AHR ) is a ligand activated transcription factor that is structurally related to its dimerization partner , the Ah receptor nuclear translocator ( ARNT ) , and two Drosophila proteins , SIM and PER . ^^^ In addition , the AHR , ARNT , and SIM harbor a basic region helix loop helix motif in their N termini , whereas PER does not . ^^^ |
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| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| Recent cloning experiments have demonstrated that the AH receptor is structurally related to the Per , ARNT and Sim proteins . ^^^ Adjacent to the PAS domain in the AH receptor , ARNT and Sim proteins is a basic / helix loop helix ( bHLH ) domain that appears to mediate heterodimerization and sequence specific DNA binding properties . ^^^ |
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| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| Sim is a Drosophila developmental basic helix loop helix ( bHLH ) transcription factor containing a Per Arnt Sim ( PAS ) region of homology . ^^^ Dimerization with Arnt very efficiently disrupted Sim hsp 90 interaction , a process that required both the bHLH and PAS dimerization motifs of Arnt . ^^^ |
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| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| Arnt 2 interacted with AhR and mouse Sim as efficiently as Arnt , and the Arnt 2 AhR complex recognized and bound specifically the xenobiotic responsive element ( XRE ) sequence . ^^^ Finally , sequence comparison of the currently known bHLH / PAS proteins indicates a division into two phylogenetic groups : the Arnt group , containing Arnt , Arnt 2 , and Per , and the AhR group , consisting of AhR , Sim , and Hif 1alpha . . ^^^ |
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| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| The Ah receptor ( AHR ) and its DNA binding partner , the Ah receptor nuclear translocator ( ARNT ) , are basic helix loop helix proteins distinguished by their PER , AHR , ARNT , and SIM ( PAS ) homology regions . ^^^ |
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| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| The arylhydrocarbon receptor nuclear translocator ( ARNT ) is a member of the basic helix loop helix PAS family of heterodimeric transcription factors which includes the arylhydrocarbon receptor ( AHR ) , hypoxia inducible factor 1alpha ( HIF 1alpha ) and the Drosophila single minded protein ( Sim ) . ^^^ ARNT forms heterodimeric complexes with the arylhydrocarbon receptor , HIF 1alpha , Sim and the PAS protein Per . ^^^ |
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| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| This protein is a member of a rapidly expanding family of gene products possessing basic helix loop helix ( bHLH ) and hydrophobic PAS ( designated a conserved region among PER , ARNT [ aryl hydrocarbon receptor nuclear translocator ] and SIM ) protein association domains . ^^^ |
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| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| A single Drosophila gene encoding a bHLH / PAS protein homologous to the vertebrate ARNT protein was isolated and may serve as a partner for both Trh and Sim . ^^^ |
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| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| Both proteins represent a novel class of basic helix loop helix ( bHLH ) containing transcription factors in that ( 1 ) activation of AHR requires the binding of ligand ( e . g . , 2 , 3 , 7 , 8 tetrachlorodibenzo p dioxin [ TCDD ] ) , ( 2 ) the xenobiotic responsive element ( XRE ) recognized by the AHR / ARNT heterodimer differs from the recognition sequence for nearly all other bHLH proteins , and ( 3 ) both proteins contain a PAS homology region , which in the Drosophila PER and SIM proteins functions as a dimerization domain . ^^^ |
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| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| Considering these results and that Arnt or Arnt 2 functions as a common partner in the formation of transcriptional regulators with other bHLH / PAS proteins such as AhR , HLF , and HIF 1alpha , the possibility arises that CBP / p300 is extensively involved as a coactivator in the transactivation process by bHLH / PAS ( a conserved sequence motif among Per , Arnt , and Sim ) heterodimer transcription factors through interaction with Arnt or Arnt2 . . ^^^ |
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| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| Arnt 2 is a member of the bHLH PAS ( Per , Ahr , Arnt , Sim ) family of transcription factors and shares the highest similarity with Arnt . ^^^ |
|
| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| In response to decreased cellular oxygen concentrations the basic helix loop helix ( bHLH ) / PAS ( Per , Arnt , Sim ) hypoxia inducible transcription factor , HIF 1alpha , mediates activation of networks of target genes involved in angiogenesis , erythropoiesis and glycolysis . ^^^ |
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| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| The mPer genes share a conserved PAS domain ( a dimerization domain found in Per , Arnt and Sim ) and show a circadian expression pattern in the suprachiasmatic nucleus . ^^^ |
|
| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| The protein chaperone heat shock protein 90 ( Hsp 90 ) is a major regulator of different transcription factors such as MyoD , a basic helix loop helix ( bHLH ) protein , and the bHLH Per aryl hydrocarbon nuclear translocator ( ARNT ) Sim ( PAS ) factors Sim and aryl hydrocarbon receptor ( Ahr ) . ^^^ |
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| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| The ARNT protein belongs to a subfamily of the `` basic region helix loop helix ' ' ( bHLH ) protein that shares an additional region of similarity called the PAS ( Per , ARNT , SIM ) domain . ^^^ |
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| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| PAS ( PER , ARNT , SIM ) proteins play important roles in adaptation to low atmospheric and cellular oxygen levels , exposure to certain environmental pollutants , and diurnal oscillations in light and temperature . ^^^ |
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| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| Furthermore , DAP 3 formed a complex with several other nuclear receptors and some basic helix loop helix / Per Arnt Sim proteins , as well as with heat shock protein 90 ( hsp 90 ) ( Arnt is the aryl hydrocarbon receptor nuclear translocator , and Per and Sim are the Drosophila proteins Period and Single minded ) . ^^^ |
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| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| By sequence analysis we have assigned these proteins to families defined by Atonal , Hairy Enhancer of Split , Hand , p 48 , Mesp , MYC / USF , and the bHLH Per , Arnt , Sim ( PAS ) domain . ^^^ |
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| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| These two subunits belong to the bHLH ( basic Helix Loop Helix ) PAS ( Per , Ahr / ARNT , Sim ) family . ^^^ |
|
| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| Cross talk between basic helix loop helix / per Arnt Sim homology transcription factors . ^^^ The basic helix loop helix / Per Arnt Sim homology ( bHLH / PAS ) protein family comprises a group of transcriptional regulators that often respond to a variety of developmental and environmental stimuli . ^^^ In cell lines engineered to stably express SIM 1 and SIM 2 , we show that both are nuclear proteins that constitutively complex with the general bHLH / PAS partner factor , ARNT . ^^^ We report that the murine SIM factors , in combination with ARNT , attenuate transcription from the hypoxia inducible erythropoietin ( EPO ) enhancer during hypoxia . ^^^ Such cross talk between coexpressed bHLH / PAS factors can occur through competition for ARNT , which we find evident in SIM repression of DR induced transcription from a xenobiotic response element reporter gene . ^^^ |
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| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| A protein containing a heme binding PAS ( PAS is from the protein names in which imperfect repeat sequences were first recognized : PER , ARNT , and SIM ) domain from Escherichia coli has been implied a direct oxygen sensor ( Ec DOS ) enzyme . ^^^ |
|
| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| The AHR and ARNT are members of the basic helix loop helix Per , ARNT , and Sim homology ( bHLH PAS ) family of transcription factors . ^^^ |
|
| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| VicK , an atypical PAS domain containing histidine kinase , can be autophosphorylated in vitro , and VicR functions in vitro as a phospho acceptor protein . ( PAS is an acronym formed from the names of the proteins in which the domains were first recognized : the Drosophila period clock protein [ PER ] , vertebrate aryl hydrocarbon receptor nuclear translocator [ ARNT ] , and Drosophila single minded protein [ SIM ] . ) PAS domains are commonly involved in sensing intracellular signals such as redox potential , which suggests that the signal for vic might also originate in the cytoplasm . ^^^ |
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| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| The aryl hydrocarbon receptor nuclear translocator ( ARNT ) is a member of the Per ARNT Sim ( PAS ) protein superfamily , transcription factors that mediate the cellular responses to various developmental signals and environmental conditions . ^^^ A beta class ( `` partner ' ' ) PAS protein , ARNT exhibits the capacity to form transcriptionally active heterodimers with several alpha class ( `` sensor ' ' ) proteins , including the aryl hydrocarbon receptors ( AHRs ) , the hypoxia inducible factors ( HIFs ) , and the Single minded ( Sim ) proteins . ^^^ |
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| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| PAS is an acronym formed from the names of the Drosophila period clock protein ( PER ) , vertebrate aryl hydrocarbon receptor nuclear translocator ( ARNT ) , and Drosophila single minded protein ( SIM ) . ^^^ |
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| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| The domain architecture of NifL is similar to that of some histidine protein kinases , with two N terminal PAS ( PER , ARNT , SIM ) domains , one of which contains an FAD cofactor that senses the redox status , and a C terminal domain containing conserved residues that constitutes the nucleotide binding domain of the GHKL ( gyrase , Hsp 90 , histidine kinase , MutL ) superfamily of ATPases . ^^^ |
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| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| Drosophila single minded , which acts as a positive master gene regulator in central nervous system midline formation in Drosophila , its two mouse homologs SIM 1 and SIM 2 , and the mammalian aryl hydrocarbon receptor ( AHR ) and aryl hydrocarbon receptor nuclear translocator ( ARNT ) proteins are members of the basic helix loop helix . ^^^ In the yeast two hybrid system , we demonstrate strong constitutive interaction of ARNT with SIM 1 and SIM 2 and fully ligand dependent interaction of ARNT with AHR . ^^^ Thus mouse SIM 1 and SIM 2 are novel heterodimerization partners for ARNT in vitro , and they may function both as positive and negative transcriptional regulators in vivo , during embryogenesis and in the adult organism . . ^^^ |
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| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| Similar to full length Sim 2 , Sim2s interacts with Arnt and to a lesser extent , Arnt 2 . ^^^ |
|
| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14190 and P27540 |
Pubmed |
SVM Score :0.0 |
| NA |
|