| Interacting proteins: P27540 and P03372 |
Pubmed |
SVM Score :0.72571123 |
| Previous studies suggest that inhibitory cross talk between the estrogen receptor and the Ahr / Arnt complex may occur and that Hsp 90 Ahr complex formation is important for Ahr mediated signal transduction . 0.72571123^^^ |
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| Interacting proteins: P27540 and P03372 |
Pubmed |
SVM Score :0.0 |
| Here we show that ARNT ( aryl hydrocarbon receptor nuclear translocator ) , the obligatory heterodimerization partner for the aryl hydrocarbon receptor and hypoxia inducible factor 1alpha , functions as a potent coactivator of ERalpha and ERbeta dependent transcription . ^^^ |
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| Interacting proteins: P27540 and P03372 |
Pubmed |
SVM Score :0.0 |
| Restoration of Ah responsiveness was investigated by co transfecting Hs578T cells with pRNH11c or pMCAT5 . 12 and plasmids that express the ER ( hER ) , Ah receptor ( AhR ) and AhR nuclear translocator ( Arnt ) proteins . ^^^ |
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| Interacting proteins: P27540 and P03372 |
Pubmed |
SVM Score :0.0 |
| Aryl hydrocarbon receptor ( AhR ) levels , but not AhR nuclear translocator protein ( ARNT ) levels were highly dependent on cell type ; AhR was high and ER independent in MDA , and low and ER linked in T47D . ^^^ |
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| Interacting proteins: P27540 and P03372 |
Pubmed |
SVM Score :0.0 |
| We then examined a second possible mechanism , i . e . direct inhibition of ER alpha binding to estrogen response elements ( EREs ) by the AHR / AHR nuclear translocator ( ARNT ) complex . ^^^ We propose that at least part of the mechanism by which the AHR / ARNT complex inhibits estrogen action is by competitively inhibiting ER alpha binding to imperfect ERE sites , adjacent to or overlapping XREs . . ^^^ |
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| Interacting proteins: P27540 and P03372 |
Pubmed |
SVM Score :0.0 |
| In contrast , the AHR nuclear translocator protein ( ARNT ) did not interact with COUP TF , ERRalpha 1 , or ERalpha . ^^^ Purified ERalpha did not bind the consensus XRE , but COUP TFI bound the consensus XRE , suggesting a role for COUP TF as a AHR / ARNT competitor for XRE binding . ^^^ |
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| Interacting proteins: P27540 and P03372 |
Pubmed |
SVM Score :0.0 |
| Aryl hydrocarbon ( Ah ) nonresponsiveness in estrogen receptor negative MDA MB 231 cells is associated with expression of a variant arnt protein . ^^^ |
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| Interacting proteins: P27540 and P03372 |
Pubmed |
SVM Score :0.0 |
| We previously showed that estrogen receptor ( ER ) negative breast cancer cell lines expressed a splice variant of ARNT that was associated with Ah nonresponsiveness . ^^^ When the patient group was split into quartiles by increasing splice variant ratios , there was an inverse relationship of ER status to ARNT splice variant ratios ( P = 0 . 01 , chi ( 2 ) ) . ^^^ In multivariate analysis for relapse free and overall survival , ARNT splice variant ratio was the strongest independent factor and , although inversely related to ER , remained a separate risk factor . ^^^ Association of ARNT splice variants with estrogen receptor negative breast cancer , poor induction of vascular endothelial growth factor under hypoxia , and poor prognosis . ^^^ |
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| Interacting proteins: P27540 and P03372 |
Pubmed |
SVM Score :0.0 |
| Here we show that the agonist activated AhR / Arnt heterodimer directly associates with oestrogen receptors ER alpha and ER beta . ^^^ Our findings suggest a novel mechanism by which ER mediated oestrogen signalling is modulated by a co regulatory like function of activated AhR / Arnt , giving rise to adverse oestrogen related actions of dioxin type environmental contaminants . . ^^^ |
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| Interacting proteins: P27540 and P03372 |
Pubmed |
SVM Score :0.0 |
| ER alpha AHR ARNT protein protein interactions mediate estradiol dependent transrepression of dioxin inducible gene transcription . ^^^ In this study , we demonstrate that a significant component of TCDD inducible Cyp1a1 transcription is the result of recruitment of estrogen receptor ( ER ) alpha by AHR / ARNT as a transcriptional co repressor . ^^^ Both AHR and ARNT were capable of interacting directly with ER alpha , as ascertained by glutathione S transferase pull down . 17Beta estradiol repressed TCDD activated Cyp1a1 and Cyp1b1 gene transcription in MCF 7 cells in the presence of cycloheximide , as determined by reverse transcription / real time PCR . ^^^ |
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| Interacting proteins: P27540 and P03372 |
Pubmed |
SVM Score :0.0 |
| In the low FBS concentration medium with dioxin , AhR and ERa expression were increased with the proliferation of Caov 3 cells ; CYP1A1 and ARNT were stable . ^^^ Dioxin and estrogen linked genes ( AhR , ERalpha , ERbeta , CYP1A1 and ARNT ) expressed were determined with the RT PCR method . ^^^ |
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| Interacting proteins: P27540 and P03372 |
Pubmed |
SVM Score :0.0 |
| Because an unplanned subgroup analysis in CALGB 9344 indicated a significant benefit of paclitaxel in patients with estrogen receptor ( ER ) negative disease but not ER positive disease , the initial tAnGo trial design called for enrollment of patients with ER negative disease . ^^^ The tAnGo trial entry criteria were recently amended to allow any ER status , given experience suggesting that clinical benefit of taxane containing regimens in ER positive disease may emerge over a time frame longer than that required to detect benefit in ER negative disease . ^^^ |
|
| Interacting proteins: P27540 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27540 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27540 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27540 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27540 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27540 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27540 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27540 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27540 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27540 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27540 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27540 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27540 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27540 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27540 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27540 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27540 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27540 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27540 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|