| Interacting proteins: Q9UHA4 and P27361 |
Pubmed |
SVM Score :0.0 |
| A protein called MP 1 ( MEK Partner 1 ) was identified that bound specifically to MEK 1 and ERK 1 and facilitated their activation . ^^^ When overexpressed in cultured cells , MP 1 enhanced activation of ERK 1 and activation of a reporter driven by the transcription factor Elk 1 . ^^^ Expression of MP 1 in cells increased binding of ERK 1 to MEK 1 . ^^^ |
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| Interacting proteins: Q9UHA4 and P27361 |
Pubmed |
SVM Score :0.0 |
| Mapping of highly conserved , surface exposed residues on MP 1 and p 14 provided insight into the potential sites of binding of the signaling kinases MEK 1 and ERK 1 to this complex , as well as the areas potentially involved in other protein protein interactions . . ^^^ |
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| Interacting proteins: Q9UHA4 and P27361 |
Pubmed |
SVM Score :0.0 |
| To gain insight into the interactions of MP 1 with the ERK pathway , we analyzed the ability of MP 1 to bind to MEK 1 , ERK 1 , and to itself , and the regulation of these interactions . ^^^ An MP 1 mutant that lost MEK 1 binding no longer enhanced RasV 12 stimulated ERK 1 activity , and functioned as a dominant negative , consistent with the concept that MP 1 function depends on facilitating these oligomerizations . ^^^ |
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| Interacting proteins: Q9UHA4 and P27361 |
Pubmed |
SVM Score :0.0 |
| The adaptor protein p 14 is associated with the cytoplasmic face of late endosomes that is involved in cell surface receptor endocytosis and it also directly interacts with MP 1 , a scaffolding protein that binds the MAP kinase ERK 1 and its upstream kinase activator MEK 1 . ^^^ |
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| Interacting proteins: Q9UHA4 and P27361 |
Pubmed |
SVM Score :0.0 |
| Furthermore , using the human HG U133A GeneChip , positive expression levels of oncogenes or tumor related genes located at the regions of chromosomal breakpoints were identified , including AKT 1 , BMI 1 , CDK 6 , CTNNB 1 , E2F1 , GPNMB , GPRK 7 , KBRAS 2 , LDB 2 , LIMK 1 , MAPK 1 , MEL , MP 1 , MUC 18 , NRCAM , PBX 3 , RAB22A , RAB 38 , SNK , and STK 4 , indicating an association between chromosomal breakpoints and altered gene expression . ^^^ |
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| Interacting proteins: Q9UHA4 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
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