| Interacting proteins: Q16828 and P27361 |
Pubmed |
SVM Score :0.0 |
| Low level expression of MKP 3 blocks totally epidermal growth factor stimulated ERK 1 , whereas stress induced activation of p 54 SAPKbeta and p 38 MAP kinases is inhibited only partially under identical conditions . ^^^ ERK 1 activation by oncogenic p 21 ( ras ) was , however , blocked totally by co expression of MKP 3 . ^^^ |
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| Interacting proteins: Q16828 and P27361 |
Pubmed |
SVM Score :0.0 |
| This evidence suggests that constitutive activation of MAPK 1 synergistically induced by frequent mutation of KRAS 2 and the loss of function of DUSP 6 plays key roles in pancreatic carcinogenesis and progression . ^^^ By profiling of gene expressions associated with downregulation of MAPK 1 induced by exogenous overexpression of DUSP 6 in pancreatic cancer cells , we found that AURKA / STK15 , the gene encoding Aurora A kinase , which plays key roles in cellular mitosis , was among the downregulated genes along with its related genes , which included AURKB , TPX 2 and CENPA . ^^^ |
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| Interacting proteins: Q16828 and P27361 |
Pubmed |
SVM Score :0.0 |
| We now show that MKP 3 enzymatic specificity is paralleled by tight binding to both ERK 1 and ERK 2 while , in contrast , little or no interaction with either c Jun N terminal kinase / stress activated protein kinase ( JNK / SAPK ) or p 38 MAP kinases was detected . ^^^ Further study revealed that the N terminal noncatalytic domain of MKP 3 ( MKP 3DeltaC ) binds both ERK 1 and ERK 2 , while the C terminal MKP 3 catalytic core ( MKP 3DeltaN ) fails to precipitate either of these MAP kinases . ^^^ A chimera consisting of the N terminal half of MKP 3 with the C terminal catalytic core of M 3 6 also bound tightly to ERK 1 but not to JNK3 / SAPKbeta . ^^^ Also , a chimera of the M 3 6 N terminus with the MKP 3 catalytic core which fails to bind ERK elicits non selective inactivation of ERK 1 and JNK3 / SAPKbeta . ^^^ |
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| Interacting proteins: Q16828 and P27361 |
Pubmed |
SVM Score :0.0 |
| We have recently cloned MKP 3 as a novel dual specificity phosphatase displaying selectivity towards inactivation of the ERK 1 and ERK 2 MAP kinases . ^^^ |
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| Interacting proteins: Q16828 and P27361 |
Pubmed |
SVM Score :0.0 |
| The activity of MAPK 1 and MAPK 3 is regulated by dual specificity phosphatases : MKP 1 and MKP 3 . ^^^ |
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| Interacting proteins: Q16828 and P27361 |
Pubmed |
SVM Score :0.0 |
| Here , we describe a novel posttranslational mechanism for regulating MKP 3 / Pyst1 / DUSP6 , a member of the MKP family that is highly specific for extracellular signal regulated kinase 1 and 2 ( ERK1 / 2 ) inactivation . ^^^ |
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| Interacting proteins: Q16828 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
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