| Interacting proteins: Q13480 and P27361 |
Pubmed |
SVM Score :0.0 |
| Recently , several new members of this family have been identified including IRS 3 , IRS 4 , and growth factor receptor binding protein 2 associated binder 1 ( Gab 1 ) . 3T3 cell lines derived from IRS 1 deficient embryos exhibit a 70 80 % reduction in IGF 1 stimulated S phase entry and a parallel decrease in the induction of the immediate early genes c fos and egr 1 but unaltered activation of the mitogen activated protein kinases extracellular signal regulated kinase 1 and extracellular signal regulated kinase 2 . ^^^ |
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| Interacting proteins: Q13480 and P27361 |
Pubmed |
SVM Score :0.0 |
| Src family tyrosine kinases , phosphoinositide 3 kinase and Gab 1 regulate extracellular signal regulated kinase 1 activation induced by the type A endothelin 1 G protein coupled receptor . ^^^ Thus we determined whether Gab 1 regulated ET 1 induced ERK 1 activation . ^^^ Overexpression of wild type Gab 1 potentiated ET 1 induced activation of ERK 1 . ^^^ Structure function analyses of Gab 1 indicated that mutant forms of Gab 1 that do not bind the Src homology ( SH ) 2 domains of the p 85 adapter subunit of PI 3 kinase or the SH 2 domain containing protein tyrosine phosphatase 2 ( SHP 2 ) were impaired in their ability to potentiate ET 1 induced ERK 1 activation . ^^^ Taken together , our data indicate that PI 3 kinase and Src family tyrosine kinases regulate ET 1 induced Gab 1 tyrosine phosphorylation , which , in turn , induces ERK 1 activation via PI 3 kinase and SHP 2 dependent pathways . . ^^^ |
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| Interacting proteins: Q13480 and P27361 |
Pubmed |
SVM Score :0.0 |
| We found that overexpression of the c Met binding domain of Gab 1 disrupted serum induced Gab 1 ERK1 interaction and inhibited ERK 1 and Egr 1 nuclear accumulation . ^^^ |
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| Interacting proteins: Q13480 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
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