| Interacting proteins: Q07889 and P27361 |
Pubmed |
SVM Score :0.0 |
| In lymphohemopoietic cells , IL 13 , IL 4 , and insulin failed to induce increased tyrosine phosphorylation of Shc , or its association with grb 2 , modification of Sos 1 , or activation of erk 1 and erk 2 mitogen activated protein kinases , suggesting that p 170 mediates downstream pathways distinct from those mediated by IRS 1 . ^^^ |
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| Interacting proteins: Q07889 and P27361 |
Pubmed |
SVM Score :0.0 |
| Hence a kinase distinct from Erk 1 and Erk 2 , previously known to feedback phosphorylate Sos 1 and Raf 1 , is responsible for the phosphorylation of these molecules in the transformants . ^^^ |
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| Interacting proteins: Q07889 and P27361 |
Pubmed |
SVM Score :0.0 |
| METHODS : Sections of postnatal 5 day old and adult rat , and aged human retina , and cell cultures prepared from selected cell populations of young rat retina , were immunolabeled with specific antisera to FGFR ( FGFR 1 , 2 , 3 , and 4 ) or candidate signaling molecules [ phospholipase Cg 1 ( PLCg 1 ) , son of sevenless 1 and 2 ( SOS 1 , SOS 2 ) , extracellular signal regulated kinase 1 and 2 ( ERK1 / 2 ) , protein tyrosine phosphatase ( SH PTP 2 ) and SH 2 containing protein ( Shc ) ] , and with multiple retinal cell type specific antibodies . ^^^ |
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| Interacting proteins: Q07889 and P27361 |
Pubmed |
SVM Score :0.0 |
| Furthermore , treatment of PANC 1 cells with protein kinase C ( PKC ) inhibitors , GF 1 and Ro 31 8220 , completely abrogated NT induced ERK 1 and ERK 2 activation , and significantly attenuated NT induced c Raf 1 stimulation . ^^^ |
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| Interacting proteins: Q07889 and P27361 |
Pubmed |
SVM Score :0.0 |
| RESULTS : ( 1 ) Hypoosmolar WE medium phosphorylated p 38 , ERK 1 and 2 , and SAPK / JNK by 5 min . ( 2 ) Hypoosmolar WE medium activated NF kappaB at 60 min . ( 3 ) HGF phosphorylated all three MAPKs and activated NF kappaB with profiles similar to those of hypoosmotic stress . ( 4 ) Both PD 98059 and SB 202190 abrogated the activation of NF kappaB in HGF stimulated cells but not in hypoosmotically stressed cells . ^^^ CONCLUSION : ( 1 ) Both hypoosmotic cell swelling and HGF phosphorylate p 38 , ERK 1 and 2 , and SAPK / JNK , and ( 2 ) HGF , but not hypoosmotic stress , activates NF kappaB via p 38 and ERK 1 and 2 phosphorylation . ^^^ |
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| Interacting proteins: Q07889 and P27361 |
Pubmed |
SVM Score :0.0 |
| Stimulation with HGF led to activation of Met as well as to activation of PI 3 K , PKB / Akt , MEK , and the MAP kinases Erk 1 and 2 . ^^^ |
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| Interacting proteins: Q07889 and P27361 |
Pubmed |
SVM Score :0.0 |
| This action of HGF was apparently dependent on HGF mediated extracellular signal regulated kinase 1 and 2 ( Erk 1 / 2 ) phosphorylation and activation . ^^^ |
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| Interacting proteins: Q07889 and P27361 |
Pubmed |
SVM Score :0.0 |
| We demonstrate here that the C terminus of MUC 20 associates with the multifunctional docking site of Met without ligand activation , preventing Grb 2 recruitment to Met and thus attenuating hepatocyte growth factor ( HGF ) induced transient extracellular signal regulated kinase 1 and 2 activation . ^^^ |
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| Interacting proteins: Q07889 and P27361 |
Pubmed |
SVM Score :0.0 |
| Treatment of Huh 7 transfectants with EGF or HGF induced tyrosine phosphorylation of SIRPalpha 1 and its association with SHP 2 , which were accompanied by reduced ERK 1 activation . ^^^ |
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| Interacting proteins: Q07889 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
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