| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.59534542 |
| METHODS AND RESULTS : To establish a causal relationship between ERK1 / 2 signaling and cardioprotection , we analyzed Erk 1 nullizygous gene targeted mice , Erk 2 heterozygous gene targeted mice , and transgenic mice with activated MEK 1 ERK1 / 2 signaling in the heart . 0.59534542^^^ |
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| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Since the only known targets of MAP kinase kinase 1 are Erk 1 and Erk 2 , these findings argue that MAP kinase function is required for the spindle assembly checkpoint in XTC cells . . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Following EGF stimulation of B82L cells expressing a kinase defective EGF receptor mutant ( K721M ) , we found that ERK 2 and ERK 1 MAP kinases , as well as MEK 1 and MEK 2 were all activated , and SHC became prominently tyrosine phosphorylated . ^^^ |
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| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| This hamster MAPKK ( MEK 1 isoform ) can reactivate recombinant p44mapk when immunoprecipitated from growth factor stimulated cells or when incubated with an active form of MAPKKK . ^^^ |
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| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Previously , we have observed that overexpression of either ERK 1 , MEK 1 , or a constitutively active truncated form of c Raf 1 ( BXB ) is insufficient to activate AP 1 in REF 52 fibroblasts . ^^^ We therefore examined whether overexpression of small t either alone or in conjunction with ERK 1 , MEK 1 , or BXB could activate AP 1 . ^^^ We found that coexpression of small t and either ERK 1 , MEK 1 , or BXB resulted in an increase in AP 1 activity , whereas expression of either small t or any of the kinases alone did not have any effect . ^^^ Coexpression of kinase deficient mutants of ERK 1 and ERK 2 inhibited the activation of AP 1 caused by expression of small t and either MEK 1 or BXB . ^^^ |
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| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| We now demonstrate that three recombinant MEKs ( MEK 1 , MEK 2 , MEK 3 ) show remarkably different activity toward recombinant ERK 1 and ERK 2 . ^^^ |
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| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Coinfection with Raf 1 activates Mek 1 > 150 fold , and coinfection with Raf 1 and Mek 1 activates Erk 1 approximately 90 fold . ^^^ |
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| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Interaction with SV 40 small tumor antigen ( small t ) compromised the ability of multimeric protein phosphatase 2A to inactivate the mitogen activated protein kinase ERK 1 and the mitogen activated protein kinase kinase MEK 1 . ^^^ |
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| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| MEK 1 is a dual specificity kinase that phosphorylates and activates the Erk / MAP kinases Erk 1 and Erk 2 by phosphorylating them on threonine and tyrosine . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Both MEK 1 and MEK 2 were expressed in Escherichia coli and shown to be able to activate recombinant human ERK 1 in vitro . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| A MAP kinase kinase ( MKK 1 or MEK 1 ) has been identified as a dual specificity protein kinase that is sufficient to phosphorylate MAP kinases p42mapk and p44mapk on the regulatory threonine and tyrosine residues . ^^^ |
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| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Active Raf 1 phosphorylates and activates the mitogen activated protein ( MAP ) kinase / extracellular signal regulated kinase kinase 1 ( MEK 1 ) , which in turn phosphorylates and activates the MAP kinases / extracellular signal regulated kinases , ERK 1 and ERK 2 . ^^^ We conclude that the MAP kinase signal transduction pathway consisting of Raf 1 , MEK 1 , and ERK 1 and ERK 2 functions in the stimulation IL 2 gene transcription in activated T lymphocytes . . ^^^ |
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| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Characterization of ERK 1 activation site mutants and the effect on recognition by MEK 1 and MEK 2 . ^^^ To discern MEK 1 and MEK 2 specificity for their substrate , extracellular signal regulated kinase ( ERK ) , site directed mutagenesis was performed on the amino acid residues flanking the regulatory phosphorylation sites of ERK 1 . ^^^ These ERK 1 mutants were analyzed for the ability to act as a substrate for MEK 1 and MEK 2 . ^^^ |
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| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Furthermore , transfection of Tpl 2 into COS 1 cells or Jurkat T cells . markedly activated the MAP kinases , ERK 1 and SAP kinase ( JNK ) , which are substrates for MEK 1 and SEK 1 , respectively . ^^^ |
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| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| To address these questions , we have utilized a constitutively active version of the immediate upstream activator of both ERK 1 and ERK 2 , mitogen activated / extracellular signal regulated kinase 1 ( MEK 1 ) , to activate ERK signaling selectively in the absence of other TCR activated signaling pathways . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Pretreatment with PD 98059 ( MEK 1 inhibitor ) partially ( 80 % ) blocked EGF mediated ERK 1 activation and had similar effects on EGF stimulation of each ribosomal S 6 kinase ( RSK ) . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Although [ Asp 218 ] and [ Asp 218 , Asp 222 ] Mek immunoprecipitated from clonal cell lines could phosphorylate kinase inactive Erk 1 equally well in vitro , the endogenous MAP kinase activity was 5 7 fold greater in [ Asp 218 ] Mek 1 infected clonal lines , and did not correlate with the degree of transformation . ^^^ Analysis of the Erk 1 pathway revealed Raf 1 activation , which correlated qualitatively with the MAP kinase activity seen in the [ Asp 218 ] and [ Asp 218 , Asp 222 ] Mek 1 infected clonal cell lines . ^^^ |
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| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Thus , in NIH3T3 fibroblasts expressing NGF receptors ( NIH3T3 / trk cells ) we found that cAMP potentiates NGF stimulated ERK 1 and MEK 1 activities , whereas in NIH3T3 fibroblasts expressing insulin receptors ( NIH3T3 / IR cells ) we saw no effect of cAMP on the activation of insulin stimulated ERK 1 and MEK 1 . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| HeLa cell infection with L . monocytogenes EGD resulted in a rapid , but transient , phosphorylation of the MAP kinases erk 1 and erk 2 , a transient phosphorylation of the MAP kinase kinase MEK 1 , and a transient activation of the MAP kinase kinase kinase Raf . ^^^ |
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| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| A two plasmid bacterial expression system was employed to express active forms of the following MEK and MAP kinase family members : ERK 1 , ERK 2 , alpha SAPK , and p 38 and their upstream activators , MEK 1 , 2 , 3 , and 4 . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Stable expression of constitutively active MEK 1 ( CA MEK 1 ) in epithelial MDCK C 7 cells led to an increased basal and serum stimulated ERK 1 and ERK 2 phosphorylation as well as ERK 2 activation when compared with mock transfected cells . ^^^ In both mock transfected and CA MEK 1 transfected MDCK C 7 cells , basal and serum stimulated ERK 1 and ERK 2 phosphorylation was almost abolished by the synthetic MEK inhibitor PD 098059 . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| A beta ( 1 40 ) induced phosphorylation of p 44 and p 42 MAP kinases ( Erk 1 and Erk 2 ) at tyrosine 204 , and PD 98059 , a MEK 1 inhibitor , inhibited A beta ( 1 40 ) induced CREB phosphorylation at serine 133 . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Interfering with MEK 1 , which is an upstream activator of ERK 1 , either with PD 098059 , which prevents the activation of MEK 1 , or with a dominant negative expression construct , reduced 92 kDa gelatinolysis and MMP 9 promoter activity respectively . c Raf 1 is an upstream activator of MEK 1 and a kinase deficient c Raf 1 expression construct decreased the activity of a promoter driven by either the MMP 9 promoter or three tandem AP 1 repeats . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| These results indicate that p21ras and MEK 1 are required for IFN gamma induced ERK 1 and ERK 2 activation . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Immune complex kinase assays indicated that the constitutive ERK 1 activity in RKO cells was largely a result of an activated MEK 1 . ^^^ Further , treatment of RKO cells with a specific inhibitor ( PD 098059 ) of MEK 1 activation , which diminished ERK 1 activity , reduced the amount of urokinase specifically bound to the cell surface and this was associated with reduced laminin degradation . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| MAPK expression was determined in five human tumors and five normal tissues ( adjacent non neoplastic liver ) by Western blotting using specific antisera raised against four MAPK pathway intermediates : Erk 1 , Erk 2 ( extracellular signal regulated kinases ) , Mek 1 and Mek 2 ( mitogen activated protein kinase kinases ) . ^^^ There was a significant increase in Erk 1 , Erk 2 , Mek 1 and Mek 2 expression in particulate and cytosolic fractions prepared from tumor specimens as compared with the adjacent normal control tissues . ^^^ |
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| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| In the present study , we found that electroporation of antibodies against MEK 1 or ERK 1 abolished vascular smooth muscle cell proliferation in response to either platelet derived growth factor or angiotensin 2 . ^^^ Our results indicate that : 1 ) STAT proteins play an essential role in angiotensin 2 induced vascular smooth muscle cell proliferation , 2 ) JAK 2 plays an essential role in the tyrosine phosphorylation of Raf 1 , and 3 ) convergent mitogenic signaling cascades involving the cytosolic kinases JAK 2 , MEK 1 , and ERK 1 mediate vascular smooth muscle cell proliferation in response to both growth factor and G protein coupled receptors . . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Inhibition of PDGF induced ERK 1 activity by the addition of a selective inhibitor of MEK 1 ( MAP kinase kinase / ERK kinase 1 ) activation , PD 98059 , or transfection with a dominant negative ERK 1 ( dnERK ) was correlated with growth arrest . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Morphine enhanced the cellular levels of ERK 1 ( 44 kDa ) , ERK 2 ( 42 kDa ) , a 54 kDa ERK , MEK 1 ( 45 kDa ) , and MEKK ( 78 kDa ) . ^^^ |
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| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Overexpression of wild type ERK 1 and ERK 2 or activation of endogenous ERKs using activated MEK 1 ( mitogen activated protein kinase kinase or ERK kinase ) overexpression stimulated HDC promoter activity in a dose dependent fashion . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| We confirm activation of the MAPK family members extracellular signal regulated kinases 1 and 2 ( ERK 1 and ERK 2 ) , p 38 , and Jun N terminal kinase / stress activated protein kinase ( JNK / SAPK ) , as well as activation of the immediate upstream MAPK activators MAPK / ERK kinases 1 and 4 ( MEK 1 and MEK 4 ) . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| In tumor , extracellular regulated kinases ( ERKs ) ERK 1 , ERK 2 , and mitogen activated ERK regulated kinase 1 ( MEK 1 ) were elevated by three to fourfold as compared with adjacent nontumorigenic normal liver . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| However , the known cytoplasmic substrates for MEK 1 , ERK 1 , and ERK 2 are not required for this process . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| In this study , we report the first evidence indicating that kinases MEK 1 ( MAP kinase / Erk kinase ) and ERK 1 ( extracellular signal regulated kinase ) act as intermediates in the cascade of events that regulate NF kappa B and AP 1 activation upon HIV 1 binding to cell surface CD 4 . ^^^ We found that CEM cells transfected with dominant negative forms of MEK 1 or ERK 1 do not display NF kappa B activation after HIV 1 binding to CD 4 . ^^^ Although the different cell lines studied expressed similar amounts of CD 4 and p 56 ( lck ) , HIV 1 replication and HIV 1 induced apoptosis were slightly delayed in cells expressing dominant negative forms of MEK 1 or ERK 1 compared with parental CEM cells and cells expressing a constitutively active mutant form of MEK 1 or wild type ERK 1 . ^^^ In light of recently published data , we propose that a positive signal initiated following oligomerization of CD 4 by the virus is likely to involve a recruitment of active forms of p 56 ( lck ) , Raf 1 , MEK 1 , and ERK 1 , before AP 1 and NF kappa B activation . . ^^^ |
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| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Activation of Raf 1 and MEK 1 , upstream kinases of ERK 1 , was shown by increased Raf 1 kinase activity in anti Raf 1 immunoprecipitates of OLG treated with C5b 9 and ERK 1 activity that can be inhibited by PD 098 , 059 , a specific MEK 1 inhibitor . ^^^ |
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| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| The selective MAPK / extracellular signal regulated kinase 1 ( MEK 1 ) inhibitor PD 98059 blocked both IL 1beta and TNF alpha but not IL 6 production by RAW 264 . 7 cells in response to LAMPf . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| The Mek 1 dual specificity protein kinase phosphorylates and activates the mitogen activated protein kinases Erk 1 and Erk 2 in response to mitogenic stimulation . ^^^ However , elevated Mek ER activity attenuated subsequent stimulation of Erk 1 and Erk 2 by serum . 4 OH tamoxifen stimulation of Mek ER expressing fibroblasts also resulted in up regulation of cyclin D 1 expression and down regulation of p 27 ( Kip 1 ) expression , establishing a direct link between Mek 1 and the cell cycle machinery . . ^^^ |
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| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Our previous results have demonstrated that Shc , Erk 1 and Mek 1 mRNAs are up regulated during nerve regeneration , whereas PKA which inhibits the Ras Erk pathway via Raf 1 was down regulated . ^^^ |
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| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| The MEK 1 proline rich insert is required for efficient activation of the mitogen activated protein kinases ERK 1 and ERK 2 in mammalian cells . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Addition of heptachlor to human CEM x 174 lymphocytic cells reduced the cellular levels of MAP kinase ( MAPK , mitogen activated protein kinase ) cascade proteins , including ERK 1 ( a 44 kDa MAPK ) , ERK 2 ( a 42 kDa MAPK ) , a 85 kDa and a 54 kDa MAP kinase , MEK 1 ( a 45 kDa ERK kinase ) and MEKK ( a 78 kDa MEK kinase ) . ^^^ |
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| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we show that PKC activation of the cytoplasmic kinase cascade ( Raf 1 kinase , MAP kinase kinase [ MEK 1 ] , and extracellular signal regulated kinase [ ERK 1 ] ) by o HA culminated in the nuclear translocation of ERK 1 . ^^^ |
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| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| A protein called MP 1 ( MEK Partner 1 ) was identified that bound specifically to MEK 1 and ERK 1 and facilitated their activation . ^^^ Expression of MP 1 in cells increased binding of ERK 1 to MEK 1 . ^^^ |
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| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Induction of MMP 13 expression was inhibited by treatment of fibroblasts with a specific p 38 inhibitor , SB 203580 , whereas blocking the ERK 1 , 2 pathway ( Raf / MEK1 , 2 / ERK1 , 2 ) by PD 98059 , a selective inhibitor of MEK 1 , 2 activation potently augmented MMP 13 expression . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| OA elicited enhancement of MMP 1 mRNA abundance was also strongly prevented by two chemical MAPK inhibitors : PD 98059 , a specific inhibitor of the activation of ERK 1 , 2 kinases MEK 1 , 2 ; and SB 203580 , a selective inhibitor of p 38 activity . ^^^ |
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| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| The ability of these fractions to activate MEK 1 was confirmed by examining the phosphorylation of myelin basic protein , a known substrate for ERKs , in the presence of functional MEK 1 and ERK 1 . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| In a previous study , we have demonstrated that a constitutively active form of MEK 1 activates Erk 1 and Erk 2 kinases , which phosphorylate co transfected NF M in NIH 3T3 cells . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Using the Jurkat T lymphocyte cell line , we found that a stably expressed Gi protein coupled receptor ( the delta opioid receptor ( DOR 1 ) ) stimulates MEK 1 and extracellular signal regulated kinases 1 and 2 ( ERK 1 and ERK 2 ) and transcriptional activity by an ERK target , Elk 1 , via a mechanism requiring a PTX sensitive Gi protein . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Growth stimulation was inhibited by bisindolylmaleimide 1 , indicating a role for protein kinase C in the signaling cascade that involved the mitogen activated protein kinase members MEK 1 , 2 , ERK 1 , 2 , and c Jun N terminal kinase . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| When ectopically expressed , the serine / threonine kinase Mos can induce oncogenic transformation of somatic cells by direct phosphorylation of MAP kinase / ERK kinase ( MEK 1 ) , activating the mitogen activated protein kinases ERK 1 and ERK 2 . ^^^ |
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| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| IFN gamma also rapidly and transiently activates extracellular signal regulated kinase 1 , 2 ( ERK 1 , 2 ) and blocking ERK 1 , 2 pathway ( Raf / MEK1 , 2 / ERK1 , 2 ) by specific MEK 1 , 2 inhibitor PD 98059 partially ( by 50 % ) prevents Ser 727 phosphorylation of STAT 1 and suppression of MMP 13 expression by IFN gamma . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Unlike ERK 1 and ERK 2 , ERK1b failed to interact with MEK 1 as judged from its nuclear localization in resting cells overexpressing ERK1b together with MEK 1 or by lack of coimmunoprecipitation of the two proteins . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Activated MAP kinases ( ERK 1 and ERK 2 ) were detected in deltaRaf : ER transformed cells , and their presence was dependent upon a functional MEK 1 protein . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| The activation of Erk 1 was insensitive to ODQ but completely blocked by the Mek 1 inhibitor PD 98059 . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| In healthy subjects , within 30 min , insulin significantly increased MAP kinase [ isoforms p 42 ( MAPK ) and p 44 ( MAPK ) ( ERK 1 and ERK 2 ) ] phosphorylation ( 141 + / 2 % , P < 0 . 05 ) and activity ( 177 + / 5 % , P < 0 . 05 ) , and the activity of its upstream activator MEK 1 ( 161 + / 16 % , P < 0 . 05 ) . ^^^ |
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| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| In addition , specific activation of ERK 1 , 2 by adenovirus mediated expression of constitutively active MEK 1 in dermal fibroblasts results in marked reduction in decorin mRNA abundance and production . ^^^ Co transfections of human decorin promoter 5 ' deletion constructs with constitutively active MEK 1 expression vector identified the region 278 to 188 as essential for ERK 1 , 2 mediated down regulation of decorin promoter activity . ^^^ |
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| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| To ensure that ERK activation was unnecessary for pVWF dependent platelet activation , we functionally inhibited ERK dependent signalling with PD 98059 , a potent and selective inhibitor of the MAP kinase kinase ( MEK 1 ) , which is the upstream kinase of ERK 1 and ERK 2 . ^^^ |
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| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| This same pattern in both cells of IRS 1 dependent augmentation and IRS 1 independent wortmannin sensitivity was also observed for GH induced activation of Akt and MEK 1 ( using state specific antibody blotting for both ) , despite the lack of difference in GHR , JAK 2 , SHP 2 , p 85 , Akt , Ras , Raf 1 , MEK 1 , ERK 1 , or ERK 2 abundance between the two cells . ^^^ |
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| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| RESULTS : The MEK 1 inhibitor PD 98059 decreased erk 1 and 2 phosphorylation and blocked actin reorganization in a dose dependent manner . ^^^ |
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| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Preincubation with the MAP kinase kinase ( MEK 1 ) inhibitors PD 98059 ( 20 ng / ml ) and U 0126 ( 250 nM ) , or the PI 3 K inhibitors wortmannin ( 100 nM ) and LY 294002 ( 50 microM ) repressed the activation of ERK 1 , ERK 2 , and Akt in association with CPPD crystal incubation , in the absence or presence of TNF alpha . ^^^ |
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| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Here we show that the corresponding sequences in human MEK 1 and MEK 2 are necessary and sufficient for the direct binding of the MAPKs ERK 1 and ERK 2 . ^^^ |
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| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Finally , mechanistic studies to examine the mechanism by which alpha 1 antitrypsin acts , showed that alpha 1 antitrypsin induced the rapid activation of p42MAPK and p44MAPK ( also known as ERK1 / 2 ) and that the specific MEK 1 inhibitor PD 98059 totally blocked alpha 1 antitrypsin ' s mitogenic effects . ^^^ |
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| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| This suggests that laminin and fibronectin induced MEK 1 activation and the downstream targets Erk 1 and Erk 2 are involved in NF M KSP tail domain phosphorylation . ^^^ |
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| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Like ERK 1 and ERK 2 , ERK 5 is expressed in neurons , and ERK 5 stimulation by epidermal growth factor is blocked by the MAP kinase / ERK kinase 1 ( MEK 1 ) inhibitors PD 98059 and U 0126 . ^^^ |
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| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| LPS stimulation of peritoneal macrophages from these mice did not activate MEK 1 , ERK 1 , and ERK 2 but did activate JNK , p 38 MAPK , and NF kappaB . ^^^ |
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| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| A gain of function approach was used to perturb the ERK pathway in the lenses of transgenic mice via expression of a constitutively active mutant of the mitogen activated protein kinase kinase 1 ( MEK 1 ( E ) ) , the direct upstream kinase of the ERK 1 and ERK 2 kinases , under the alphaA crystallin promoter . ^^^ |
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| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Results were compared with those in T cells in which ras MAPK signaling was inhibited with a soluble inhibitor of MAPK ERK 1 ( MEK 1 ) . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Specific activation of p38alpha by adenovirus delivered constitutively active MKK3b resulted in potent inhibition of the activity of ERK 1 , 2 and its upstream activator MEK 1 , 2 . ^^^ Furthermore , arsenite prevented phorbol ester induced phosphorylation of ERK 1 , 2 kinase MEK 1 , 2 , and this effect was dependent on p 38 mediated activation of protein phosphatase 1 ( PP 1 ) and PP2A . ^^^ These results provide evidence that activation of signaling cascade MKK 3 MKK3b > p38alpha blocks the ERK 1 , 2 pathway at the level of MEK 1 , 2 via PP 1 PP2A and inhibits the activation of MMP 1 gene expression . . ^^^ |
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| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Here , we show that both HCV genotype 1a and 3 core proteins activate MEK 1 and Erk1 / 2 MAP kinases and that the costitutive expression of the HCV core results in a high basal activity of Raf 1 and MAP / kinase / kinase , as determined by endogenous Raf 1 in vitro kinase assay and immunodetection of hyperphosphorylated Erk 1 and Erk 2 even after a serum starvation . ^^^ |
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| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Further analyses disclosed that transfection of dominant negative forms of raf 1 , MEK 1 , ERK 1 , ERK 2 , or wild type MEKK 1 all increased cystatin A promoter activity in normal human keratinocytes , whereas wild type raf 1 , ERK 1 , ERK 2 , or dominant negative forms of MEKK 1 , MKK 7 , or JNK 1 suppressed the promoter activity . ^^^ |
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| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Furthermore , tyrosine phosphorylation of FAK and phosphotyrosine kinase ( Pyk ) 2 ; serine phosphorylation of c Raf , MEK 1 , and Elk 1 ; and tyrosine threonine phosphorylation of Erk 1 and 2 were time dependently activated in the presence of GDNF . ^^^ More specifically , the Ras inhibitor manumycin inhibited phosphorylation of c Raf , MEK 1 , Erk 1 and 2 , and Elk 1 , but not that of FAK . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Indeed , MEK 1 and MEK 2 are the only known activators of ERK 1 and ERK 2 . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Use of selective inhibitors of signal transduction and the quantitation of the levels of phosphorylated MAPK / ERK activating kinase 1 ( MEK 1 ) , extracellular signal regulated kinase 1 ( ERK 1 ) , and p 38 mitogen activated protein kinase ( MAPK ) suggests that the effects of Cd ( 2+ ) are mediated by the p 21 ( ras ) dependent MAPK , but not the phosphoinositide 3 ( PI 3 ) kinase signalling pathway . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| A significant increase in the levels of MEK 1 , ERK 1 , p 38 MAPK , and JNK phosphorylation was observed in BeF ( 2 ) exposed macrophages . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| The MCF 7 cell line , considered a suitable model , was used in these studies to investigate the effects of ethanol on [ ( 3 ) H ] thymidine incorporation , cell number , and p44 / 42 MAPK activities in the presence or absence of a MAPK or extracellular signal regulated kinase ERK 1 , and ( MEK 1 ) inhibitor ( PD 098059 ) . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| In summary , MEK 1 , ERK 1 , the transcription factor c jun , and the cyclin dependent kinase inhibitor p 21 ( Waf1 / Cip1 ) play a part in VES induced differentiation of human MDA MB 435 breast cancer cells . . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Western blot and immunohistochemistry were used to measure the expression of MEK 1 , MEK 2 and ERK 1 , ERK 2 protein . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| PP2A is activated by a signaling pathway including PI 3gamma > Janus activated kinase 2 ( Jak 2 ) > MEK 1 > ERK 1 and 2 . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| The expression and phosphorylation of downstream targets of the EGFR , mitogen activating kinase kinase ( MEK 1 and 2 ) and extracellular signal regulated kinases 1 and 2 ( ERK 1 and 2 ) were not significantly affected . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that exposure of post confluent 3T3 L 1 preadipocytes to insulin , isobutylmethylxanthine ( MIX ) , dexamethasone ( DEX ) , and fetal bovine serum induces a rapid but transient activation of MEK 1 as indicated by extensive phosphorylation of ERK 1 and ERK 2 during the initial 2 h of adipogenesis . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| The numbers of tumor and diameter of each tumor in forestomach were counted ; the mice plasma malondialdehyde ( MDA ) were measured by TBARS assay ; TUNEL assay was used to analyze the apoptosis in forestomach neoplasia and the expression of MEK 1 , ERK 1 , MKP 1 protein in forestomach neoplasm were studied by Western Blotting assay . ^^^ The 75 % purity c 9 , t 11 CLA showed stronger inhibition ; CLA could also inhibit the expression of ERK 1 protein and promote the expression of MKP 1 protein , however no influence of CLA on MEK 1 protein was observed . ^^^ |
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| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Although we effectively blocked phosphorylation of MAPKs ERK 1 and ERK 2 using the selective MEK 1 inhibitor PD 98059 , no quantitative changes of mRNA or protein levels of claudin 1 , occludin and ZO 1 could be detected in all cell lines investigated . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| However , the reversibility of these cellular events , as well as the relative role of both MEK isoforms ( MEK 1 and MEK 2 ) and both ERK isoforms ( ERK 1 and ERK 2 ) during these processes , has not yet been investigated . ^^^ We now report that loss of constitutively active MEK 1 ( caMEK 1 ) and , thus , loss of active ERK1 / 2 in C7caMEK1 cells is associated with increased MEK 2 protein expression , reexpression of ERK 1 protein , and epithelial redifferentiation of these cells . ^^^ In contrast , loss of active MEK 1 ERK1 / 2 results in increased MEK 2 protein expression and reexpression of ERK 1 protein , concomitant with the restoration of epithelial phenotype and the ability to form cystic structures . . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Among the KRAS2 / BRAF wild type carcinomas , no mutations within pathway members MEK 1 , MEK 2 , ERK 1 , ERK 2 , RAP1B , or BAD were found . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Using in vitro assays , we show that platelet derived growth factor alpha ( PDGFA ) enhances medulloblastoma migration and increases downstream MAP2K1 ( MEK 1 ) , MAP2K2 ( MEK 2 ) , MAPK 1 ( p 42 MAPK ) and MAPK 3 ( p 44 MAPK ) phosphorylation in a dose dependent manner . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| The activities of ERK 1 and 2 are required for cell survival signaling using stable cell clones expressing MEK 1 . ^^^ The survival signals exerted by MEK 1 most likely result from the activation of ERK 1 and 2 . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Mek 1 and Erk 1 depletion also caused cell cycle arrest at G 2 , suggesting that these enzymes are required for the G2 / M transition , whereas the loss of Mek 2 or Erk 2 caused arrest at G1 . . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| We now show that in double positive thymocytes Vav 1 is required for TCR induced activation of the ERK 1 and ERK 2 kinases via a pathway involving the Ras GTPase , and B Raf , MEK 1 , and MEK 2 kinases . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NK ( 1 ) R mediated cell death was inhibited by a dominant negative form of arrestin 2 , Raf 1 , or Nur 77 , by MEK1 / 2 specific inhibitors , and by RNA interference directed against ERK 2 or MEK 2 but not ERK 1 or MEK 1 and against Nur 77 . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| In vitro kinase assays using the combined STAT 1 proteins as substrates from immunoprecipitation and glutathione S transferase pull down show that active ERK 1 , JNK 1 , p 38 kinase , MEK 1 and MSK 1 stimulated phosphorylation of STAT 1 ( Ser 727 ) indirectly through an unidentified factor or a downstream kinase . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Mapping of highly conserved , surface exposed residues on MP 1 and p 14 provided insight into the potential sites of binding of the signaling kinases MEK 1 and ERK 1 to this complex , as well as the areas potentially involved in other protein protein interactions . . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| In this chapter , detailed protocols for analyzing the kinase activities of the key components of the MAPKs pathway MEK 1 , ERK 1 , JNK , and p 38 MAPK are described . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Abolition of MEK 1 , 2 activity with PD 98059 , or ERK 1 , 2 small interfering RNA knockdown , was insufficient to induce apoptosis . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Blocking Erk 1 , 2 activity either with antisense oligonucleotides to Erk 1 , 2 mRNA sequences or by specifically inhibiting its upstream activating kinase MEK 1 , 2 markedly reduced neurofilament phosphorylation . ^^^ By contrast , inhibiting Erk 1 , 2 with U 0126 , a specific inhibitor of Mek 1 , 2 , had no appreciable effect on ionomycin induced calpain activation . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| The role of the extracellular signal regulated kinase ( ERK ) 1 and ERK 2 in the neutrophil chemotactic response remains to be identified since a previously used specific inhibitor of MEK 1 and MEK 2 , PD 98059 , that was used to provide evidence for a role of ERK 1 and ERK 2 in regulating chemotaxis , has recently been reported to also inhibit MEK 5 . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| The involvement of the Ras > Erk pathway in the protection of tumor cells from the apoptosis induced by IFNalpha is further demonstrated by both Ras inactivation by RASN 17 transfection and mitogen extracellular signal regulated kinase 1 ( Mek 1 ) inhibition by exposure to PD 098059 . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Disruption of protein protein interactions by treatment with high salt was required to facilitate immunoprecipitation of active ERK 1 and co precipitation of MEK 1 . ^^^ The large protein complex containing ERK 1 and MEK 1 was resolved by velocity sedimentation from fragments of microtubules ; however , it did not contain other scaffolding components known to bind ERK and MEK . ^^^ We conclude that there are two independent nerve growth factor regulated ' signalling particles ' with an estimated size of 60 75 S , one containing ERK 1 and MEK 1 and the other containing B Raf . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| To gain insight into the interactions of MP 1 with the ERK pathway , we analyzed the ability of MP 1 to bind to MEK 1 , ERK 1 , and to itself , and the regulation of these interactions . ^^^ An MP 1 mutant that lost MEK 1 binding no longer enhanced RasV 12 stimulated ERK 1 activity , and functioned as a dominant negative , consistent with the concept that MP 1 function depends on facilitating these oligomerizations . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| The involvement of the Ras > Erk pathway in the protection of tumour cells from the apoptosis induced by IFNalpha is further demonstrated by both Ras inactivation by RASN 17 transfection and mitogen extracellular signal regulated kinase 1 ( Mek 1 ) inhibition by exposure to PD 098059 . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Compared with normal tissues , the protein levels of ERK 1 ( integral optical density value 159 526+ / 65 760 vs 122 807+ / 65 515 , P = 0 . 001 ) , ERK 2 ( 168 471+ / 95 051 vs 120 469+ / 72 874 , P < 0 . 001 ) , ERK 3 ( 118 651+ / 71 513 vs 70 934+ / 68 058 , P < 0 . 001 ) , P 38 ( 104 776+ / 51 650 vs 82 930+ / 40 392 , P = 0 . 048 ) and MEK 1 ( 116 486+ / 45 725 vs 101 434+ / 49 387 , P = 0 . 027 ) were increased in gastric cancer tissues . ^^^ The immunohistochemistry demonstrated that ERK 1 , ERK 2 , ERK 3 , p 38 and MEK 1 proteins were mainly localized in cytoplasm . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Inhibition of the upstream ERK 1 , 2 activator MEK 1 , 2 with U 0126 prevented IL 1beta stimulated iNOS expression , while the p38MAPK inhibitor SB 03580 potentiated iNOS expression . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| The adaptor protein p 14 is associated with the cytoplasmic face of late endosomes that is involved in cell surface receptor endocytosis and it also directly interacts with MP 1 , a scaffolding protein that binds the MAP kinase ERK 1 and its upstream kinase activator MEK 1 . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Taken together , our data demonstrate that PKCiota is a critical lung cancer gene that activates a Rac 1 > Pak > Mek 1 , 2 > Erk 1 , 2 signaling pathway required for transformed growth . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Dictyostelium mek 1 ( ) ( MEK 1 null ) and erk 1 ( ) cells exhibit severe defects in cell polarization and directional movement , but the molecules responsible for the mek 1 ( ) and erk 1 ( ) chemotaxis defects are unknown . ^^^ Microarray analysis reveals that some genes are precociously expressed in mek 1 ( ) and erk 1 ( ) cells . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Furthermore , tPA induced rapid tyrosine phosphorylation on the beta subunit of LRP 1 , which was followed by the activation of Mek 1 and its downstream Erk 1 and 2 . ^^^ Blockade of Erk 1 / 2 activation by the Mek 1 inhibitor abolished MMP 9 induction by tPA in NRK 49F cells . ^^^ Conversely , overexpression of constitutively activated Mek 1 induced Erk 1 / 2 phosphorylation and MMP 9 expression . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Inhibitors of MEK 1 and ERK 1 , but not of JNK or p 38 kinase , abrogated TNF inhibition of Osx mRNA and promoter activity . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Cellular morphology , DNA fragmentation , nuclear condensation , total mitogen activated protein kinase / extracellular regulated protein kinase 1 ( ERK 1 ) , total ERK 1 protein , and phosphorylated ERK 1 protein products in cultured H9c2 myocardial cells were measured by actin immunofluorescence , agarose gel electrophoresis , nuclear condensation , and western blotting following stimulation with P . gingivalis spent growth medium or pre administration of U 0126 , a potent MEK 1 / 2 inhibitor . ^^^ Components of P . gingivalis spent culture medium not only resulted in increased total MEK 1 and ERK 1 protein products , but also caused increased cellular size , DNA fragmentation , and nuclear condensation in H9c2 cells . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| A similar repression was also observed in cells that contained a dominant , nonactive form of ERK 2 but not in cells where ERK 1 phosphorylation was inhibited via overexpression of a dominant negative mutant MEK 1 protein . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Mitogen activated protein ( MAP ) kinase kinases ( MKKs ) are dual specificity protein kinases which activate p42mapk and p44mapk by phosphorylation of regulatory tyrosine and threonine residues . cDNAs for two isotypes of MKK , MKK 1 and MKK 2 , have been isolated from several species . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Transformation of immortalized rat embryo fibroblasts by a ts isolate of Moloney murine sarcoma virus ( Mo MuSVts 110 ) constitutively activates MAP kinases ( ERK 1 and ERK 2 ) and MAP kinase kinases ( MKK 1 and MKK 2 ) only at the permissive temperature when 5 mos kinase is present and active . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Moreover , the use of a CCL 39 derived cell line that stably expresses an inducible chimera of the estrogen receptor fused to a constitutively active Raf 1 mutant ( DeltaRaf 1 : ER ) revealed that in absence of growth factors , activation of the Raf > MKK 1 > p42 / p44MAPK cascade is sufficient to fully induce cyclin D 1 . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| Whereas p 44 MAPK does not appear to phosphorylate NHE 1 in vitro , we found that inhibition of the p42 / p44 MAPK signaling by expression of a dominant negative form of p 44 MAPK , by expression of the MAP kinase phosphatase MKP 1 , or by inhibition of MAPK kinase 1 ( MKK 1 ) with the PD 98059 compound reduced by 50 60 % NHE 1 activation in response to growth factors . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| The mitogen activated protein ( MAP ) kinase pathway , which includes extracellular signal regulated protein kinases 1 and 2 ( ERK 1 , ERK 2 ) and MAP kinase kinases 1 and 2 ( MKK 1 , MKK 2 ) , is well known to be required for cell cycle progression from G 1 to S phase , but its role in somatic cell mitosis has not been clearly established . ^^^ |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|