| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| The activation of JNK was maximal at 20 min whereas maximal activation of ERK 1 and ERK 2 was observed within 10 min . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| JNK activation was specific because related ERK 1 + 2 were not activated after con A . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Taken together , these data suggest that H2O2 activates ERK 1 , ERK 2 , p 46 JNK , and p 38 MAP kinases in PASMC . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Overexpressing ERK 1 , JNK , or p 38 led to severalfold increases in COX 2 promoter activity . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Coincident with activation of JNK , the amount of activated ERK 1 and ERK 2 decreased in etoposide treated parotid C 5 cells . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| A dominant negative mutant of ERK 1 but not of JNK decreased alpha 1 ( 1 ) gene promoter activation . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| In stromal cells NGF and GDNF stimulated phosphorylation of ERK 1 and JNK 1 . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| RESULTS : ERK 1 , JNK 1 , and p 38 MAPKs were transiently activated by LPS . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Inhibitors of MEK 1 and ERK 1 , but not of JNK or p 38 kinase , abrogated TNF inhibition of Osx mRNA and promoter activity . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| The levels of actin , p 42 and p 44 MAPK , JNK 1 , JNK 2 , p 38 , and PCNA were not substantially altered during this process . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| GalT 1 expression can also be induced by epidermal growth factor and dominant active Ras , JNK 1 , and ERK 1 . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| To unveil the upstream signaling events that lead to the potential transcriptional activation of genes , we studied the involvement of mitogen activated protein kinase , c Jun N terminal kinase 1 ( JNK 1 ) , and extracellular signal regulated kinase 1 and 2 cascades , which have been shown to mediate numerous types of extracellular signals . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Although extracellular signal regulated protein kinase 1 / 2 ( ERK1 / 2 ) , c Jun N terminal kinase 1 ( JNK 1 ) , and p 38 were activated after denudation , the activation of ERK 1 and p 38 was more rapid and prominent . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| The activities of HSP 70 and MAPKs ( c Jun N terminal kinase 1 ( JNK 1 ) , extracellular signal regulated kinase 1 ( ERK 1 ) , ERK 2 and p 38 ) were analyzed by Western blot at each time point . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| We determined immunoprecipitated kinase activity for PI 3 kinase and MAPK members ( Raf 1 , extracellular signal regulated kinase 1 [ ERK 1 ] , c Jun N terminal kinase 1 [ JNK 1 ] , and p 38 MAPK ) from either unfractionated splenocytes or purified donor CD4+ T cells . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Then , by affinity chromatographies and in vitro kinase assays with fusion proteins between glutathione S transferase and the transactivator domain of Spi B , two kinases were identified on their ability to interact and phosphorylate this domain ; the MAP kinase ERK 1 and the stress activated protein kinase JNK 1 . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Furthermore , transfection of Tpl 2 into COS 1 cells or Jurkat T cells . markedly activated the MAP kinases , ERK 1 and SAP kinase ( JNK ) , which are substrates for MEK 1 and SEK 1 , respectively . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| We determined whether physical exercise , a physiological stressor , and insulin , a metabolic stimulator and growth factor , activate the c jun NH 2 terminus kinase ( JNK ) , the p 38 kinase , and / or the extracellular regulatory kinases ( ERK ; p42MAPK and p44MAPK ) signaling pathways in rat skeletal muscle . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| To elucidate sPGN activated signal transduction pathways , stimulation of mitogen activated protein ( MAP ) kinases by sPGN was studied in mouse RAW264 . 7 macrophages . sPGN strongly activated extracellular signal regulated kinase ( ERK ) 1 and ERK 2 , moderately activated c Jun NH 2 terminal kinase ( JNK ) , and weakly activated p 38 MAP kinase , in contrast to LPS , which strongly activated all of these kinases , and phorbol 12 , 13 dibutyrate ( PDB ) , which strongly activated ERK 1 and ERK 2 but did not activate p 38 or JNK . sPGN and LPS induced activation of ERK 1 and ERK 2 , unlike PDB induced activation , was sensitive to inhibition by herbimycin A and insensitive to inhibition by increased intracellular cAMP . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| In summary , the BCR strongly activates ERK 2 and weakly activates ERK 1 , JNK , and p 38 , while CD 40 markedly stimulates the JNK and p 38 kinases . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Fluid shearing ( shear stress , 12 dynes / cm2 [ 1 dyne = 10 ( 5 ) N ] ) induced a transient and rapid activation of p21ras and preferentially activated c Jun NH 2 terminal kinases ( JNK 1 and JNK 2 ) over extracellular signal regulated kinases ( ERK 1 and ERK 2 ) . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| In this study Fas activated the stress responsive mitogen activated protein kinases , p 38 and JNK , within 2 h in Jurkat T lymphocytes but not the mitogen responsive kinase ERK 1 or pp70S6k . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| TNFalpha stimulation of endothelial cells induces transient phosphorylation of both ATF 2 and c JUN and induces marked activation of the c JUN N terminal kinase ( JNK 1 ) and p 38 but not extracellular signal regulated kinase ( ERK 1 ) . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| A series of 51 prostate cancers , including a subset ( n = 13 ) that had been previously treated by androgen ablation , was used to examine whether MKP 1 mRNA and protein expression correlated with that of ERK 1 , JNK 1 , bcl 2 , which confers resistance to apoptosis , and apoptotic index measured by in situ end labeling of fragmented DNA . ^^^ In a subset of tumors , MKP 1 expression was assessed by semiquantitative RT PCR and was compared with both ERK 1 and JNK 1 enzymatic activity . ^^^ There was coexpression of MKP 1 , ERK 1 , and JNK 1 proteins . ^^^ In addition , MKP 1 expression was inversely correlated to JNK 1 but not to ERK 1 enzymatic activity . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| The impact of these phosphorylation sites varied at different promoters and was dependent on whether Sap 1a was stimulated by ERK 1 or JNK 1 . ^^^ Additionally , a comparison of Sap 1a with another TCF , Elk 1 , revealed that these proteins behaved differently to stimulation by ERK 1 and JNK 1 . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Et 1 , but not LPA , was able to activate JNK 1 ; pharmacological analysis revealed that the same EtA receptor mediates DNA synthesis , ERK 1 and JNK 1 activation . ^^^ However , activation of JNK 1 required higher concentrations of Et 1 than was required for stimulation of ERK 1 or DNA synthesis . ^^^ Signalling to ERK 1 and JNK 1 was partly inhibited by pertussis toxin , suggesting that both pathways are regulated in part by Gi or G 0 proteins . ^^^ Activation of JNK 1 by Et 1 lagged behind ERK 1 activation but was not dependent on it because PD 98059 , an inhibitor of mitogen activated protein kinase ( or ERK ) kinase , was without effect on JNK 1 activation . ^^^ In contrast with recent studies , activation of protein kinase C ( PKC ) or Ca2+ fluxes inhibited activation of JNK 1 but not ERK 1 ; furthermore inhibition of PKC or sequestration of Ca2+ potentiated JNK 1 activation by Et 1 but not by anisomycin , and again had little effect on ERK 1 activation . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Western blotting revealed that these peaks coincided with Jun NH 2 terminal kinase ( JNK ) , extracellular signal regulated protein kinases , ERK 1 and ERK 2 , and p 38 MAP kinase . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Interestingly , the staurosporine activated kinase was immunoprecipitated by anti c Jun NH 2 terminal kinase ( JNK ) isoforms antibody , but not by anti JNK 1 specific antibody or anti ERK 1 antibody , raising the possibility that this kinase is a novel JNK isoform . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Activation of primary T cells by Tat protein involved integrin receptors and was associated with activation of mitogen activated protein kinases , including ERK 1 and JNK kinase . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| We identified a molecule , CEP 1347 ( KT 7515 ) , that rescues motoneurons undergoing apoptosis and investigated its effect on ERK 1 and JNK 1 activity . ^^^ During the first 24 hr ERK 1 activity was unchanged , whereas JNK 1 activity increased fourfold . ^^^ CEP 1347 did not alter ERK 1 activity but rapidly inhibited JNK 1 activation . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Transient expression of C3G in 293T cells induced JNK 1 activation without a significant effect on extracellular signal related kinase 1 ( ERK 1 ) , whereas mSos 1 activated equally both JNK 1 and ERK 1 . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| The pathway in which human MST 2 functions is not known ; however , it does not appear to involve either mitogen activated protein kinases such as Erk 1 and Erk 2 nor the stress activated protein kinases such as JNK and p 38 . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| As reported previously , the activities of ERK 1 and 2 were not affected by SB 203580 , but surprisingly , inhibition of native p 38 kinase activity correlates with up regulation of native JNK 1 activity in osmotically stressed cells . p 38 mRNA is induced by hypertonic stress and is attenuated with p 38 kinase inhibition . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| After rhG CSF induction , Janus N terminal kinases ( JNK 1 and 2 ) were simultaneously increased in the cytosol , up to 30 fold as measured by Western blotting ) , whereas ERK 1 and 2 accumulated maximally by 2 . 5 fold 1 hr after rhG CSF induction . c Jun was up regulated strongly by this cytokine at the translational level . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| CONCLUSIONS : Wounding of intestinal epithelial cells results in activation of Raf 1 , ERK 1 , ERK 2 , and JNK 1 MAPKs and subsequent cell proliferation in vitro . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Treatment of murine macrophages with LAMPf resulted in significant activation of MAPK family members extracellular signal regulated kinase 1 and 2 ( ERK1 / 2 ) , c Jun NH 2 terminal kinase ( JNK ) , and p 38 . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Western blot analysis using the antibody against JNK ( c jun N terminal kinase ) and ERK ( extracellular signal regulated kinase ) demonstrated that the level of phosphorylated JNK 1 , but not phosphorylated ERK 1 and ERK 2 , was reduced by 10 ( 5 ) M EGC . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| We found that all MAP kinases examined , ERK 1 , ERK 2 , p 38 , JNK 1 , and JNK 2 , were rapidly and transiently activated by erythropoietin ( Epo ) stimulation in SKT 6 cells , which can be induced to differentiate into hemoglobinized cells in response to Epo . ^^^ Furthermore , p 38 specific inhibitor SB 203580 but not MEK specific inhibitor PD 98059 significantly suppressed Epo induced differentiation and antisense oligonucleotides of p 38 , JNK 1 , and JNK 2 , but neither ERK 1 nor ERK 2 clearly inhibited Epo induced hemoglobinization . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Western blot analysis showed that treatment of macrophages with menadione rapidly induced phosphorylation of extracellular signal regulated kinases ( ERK 1 , ERK 2 ) and p 38 MAP kinase , but not c Jun N terminal kinase ( JNK ) . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Among signaling events displaying early response to IL 17 in chondrocytes were the mitogen activated protein ( MAP ) kinases ERK 1 , ERK 2 , JNK , and p 38 . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| To decipher the upstream signals for paclitaxel induced transcriptional activation and cell death , we studied the involvement of protein kinases that lead to the activation of AP 1 , specifically the c Jun NH 2 terminal kinase ( JNK 1 ) , p 38 , and the extracellular signal regulated kinase 1 ( ERK 1 ) . ^^^ Paclitaxel activated JNK , and to a lesser degree p 38 , but not ERK 1 . ^^^ Paclitaxel induced IL 8 promoter activation was inhibited by dominant inhibitory mutants of JNK , p 38 , and the super repressor form of IkappaBalpha , but not by dominant inhibitory forms of ERK 1 . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Importantly , the p 36 MBP kinase was immunologically different from MAPK superfamily molecules such as ERK 1 , JNK isoforms , and p 38 MAPK . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| In this study , we initially found that UV irradiation of HSCs activated JNK but not ERK 1 , 2 . ^^^ In conclusion , the current study combined with our previous report suggests that ERK 1 , 2 and JNK cascades regulate alphaI ( 1 ) collagen expression in HSCs through different regions of the 5 ' UPS of the gene . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Although it has the signature TEY activation motif of ERK 1 and ERK 2 , ERK 7 is not activated by extracellular stimuli that typically activate ERK 1 and ERK 2 or by common activators of c Jun N terminal kinase ( JNK ) and p 38 kinase . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Exogenous PlGF induced specific activation of the stress activated protein kinase ( SAPK ) pathways , c Jun N terminal kinase ( JNK ) and p 38 kinase , in primary term trophoblast with little to no induction of the extracellular signal regulated kinase ( ERK 1 and 2 ) pathways . ^^^ In contrast , PlGF induced significant ERK 1 and 2 activity in human umbilical vein endothelial cells but did not induce JNK or p 38 activity . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Furthermore , oncogenic stimuli , which may render the transformed cells tumorigenic and metastatic in vivo , activate , in a constitutive fashion , the extracellular regulated kinases ( Erk 1 and 2 ) classical mitogenic pathway and others such as the NH ( 2 ) Jun kinase ( Jnk ) . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| The use of PD 98059 , which inhibits activation of ERK 1 and 2 , and LY 294002 , an inhibitor of phosphatidylinositol 3 kinase , demonstrated that IGF 1 induced activation of JNK 1 is independent of ERK and phosphatidylinositol 3 kinase activation . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| In conclusion , these data indicate that IL 6 induced STAT 3 transactivation and Ser ( 727 ) phosphorylation is independent of ERK 1 or JNK 1 activity , but involves a gp 130 receptor signalling cascade that includes Vav , Rac 1 , MEKK and SEK 1 / MKK 4 as signal transduction components . . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Recently , glucose deprivation induced oxidative stress has been shown to cause cytotoxicity , activation of signal transduction ( i . e . , ERK 1 , ERK 2 , JNK , and Lyn kinase ) , and increased expression of genes associated with malignancy ( i . e . , bFGF and c Myc ) in MCF 7 / ADR human breast cancer cells . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Similarly , co expression of a dominant negative mutant of p38alpha , but not of ERK 1 , ERK 2 , JNK 1 , or JNK 2 , reduces basal and cadmium induced pE 1 luc activity . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| These may include the extracellular regulated protein kinases ( ERK 1 and ERK 2 ) , the c Jun N terminal kinases ( JNK 1 , JNK 2 , and JNK 3 ) , and one or more isoenzymes of protein kinase C . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| This cell death process was accompanied by strong activation of Akt , extracellular signal regulated kinase 1 ( ERK 1 ) and ERK 2 , p 38 , and c Jun N terminal ( JNK ) kinases . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Consistently , transfection with dominant negative mutants of ERK 1 and ERK 2 or a dominant negative mutant of JNK inhibited H2O2 induced apoptosis . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Extracellular signal regulated kinases 1 and 2 ( ERK 1 and ERK 2 ) , p 38 mitogen activated protein ( p 38 ) , and c Jun NH 2 terminal kinase or stress activated protein kinase ( SAPK / JNK ) were initially activated at 30 minutes , 10 minutes , and 5 minutes , respectively , after focal cerebral ischemia . ^^^ The immunohistochemical expressions of ERK 1 , ERK 2 , p 38 , and SAPK / JNK protein paralleled the Western blot analysis results . ^^^ Double labeled immunofluorescent staining demonstrated that the neurons and astrocytes expressed ERK 1 , ERK 2 , p 38 , and SAPK / JNK during the early time points after MCAO . ^^^ The current results demonstrate that brain damage after ischemia rapidly triggers time dependent ERK 1 , ERK 2 , p 38 , and SAPK / JNK phosphorylation , and reveals that neurons and astrocytes are involved in the activation of the MAPK pathway . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| While exposure of these cells to CGRP had no significant effect on ERK 1 or p 38 MAP kinases , JNK activity was stimulated by CGRP in a time and concentration dependent fashion . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| The mitogen activated protein kinases ( MAPKs ) ERK 1 and ERK 2 ( but not JNK ) were activated within 5 min after addition of 7beta hydroxycholesterol . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| To further investigate the mechanism of tumorigenesis by arenediazonium ions , we studied the effect of a representative arenediazonium ion on AP 1 activation and phosphorylation of the signal transduction proteins ERK 1 , ERK 2 , JNK , and p 38 kinase , both in vitro and in vivo . ^^^ Here , it was found that p methylbenzenediazonium ion ( 2a ) induced a 16 fold increase in the extent of AP 1 activation at micromolar concentrations , and that this increase coincided with phosphorylation of the signaling kinases ERK 1 and 2 and p 38 kinase , but not JNK , in JB 6 mouse epithelial cells . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| The inhibitory effects of VHR were also seen at the level of the mitogen activated kinases Erk 1 , Erk 2 , Jnk 1 , Jnk 2 , and on reporter genes that directly depend on these kinases , namely Elk , c Jun , and activator protein 1 . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Strain rapidly and time dependently activated focal adhesion kinase ( FAK ) , paxillin , ERK 1 and 2 , and p 38 on collagen . c Jun NH ( 2 ) terminal kinase ( JNK ) 1 and 2 exhibited delayed activation . ^^^ FAK inhibition by FAK 397 transfection blocked ERK 2 and JNK 1 activation by in vitro kinase assays , but pharmacological protein kinase C inhibition did not block ERK 1 or 2 activation by strain . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| LPS stimulation of peritoneal macrophages from these mice did not activate MEK 1 , ERK 1 , and ERK 2 but did activate JNK , p 38 MAPK , and NF kappaB . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Signaling pathways such as the MAP kinases , Erk 1 and 2 , p 38 and JNK , the PI 3 kinases and Ca2+ specific signals activated by growth factors or cellular stresses , converge on the Ets family of factors , controlling their activity , protein partnerships and specification of downstream target genes . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Moreover , kaurenes delayed the phosphorylation of p 38 , ERK 1 , and ERK 2 MAPKs , but not that of JNK , in response to lipopolysaccharide treatment of J 774 cells . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Maximum Pgp expression occurred in tumor spheroids with a high percentage of quiescent , Ki 67 negative cells , elevated glutathione levels , increased expression of the cyclin dependent kinase inhibitors p27Kip1 and p21WAF 1 as well as reduced ROS levels and minor activity of the mitogen activated kinase ( MAPK ) members c Jun amino terminal kinase ( JNK ) , extracellular signal regulated kinase ERK 1 , 2 , and p 38 MAPK . ^^^ Raising intracellular ROS by depletion of glutathione with buthionine sulfoximine ( BSO ) or glutamine starvation resulted in down regulation of Pgp and p27Kip1 , whereas ERK 1 , 2 and JNK were activated . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| SNB 19 cells that were transfected with dominant negative JNK , MEKK , and ERK 1 expression vectors showed reduced MMP 9 promoter activity . ^^^ Further , in the presence of a specific inhibitor of MEKK ( PD 098059 ) , the Matrigel invasion assay showed the invasiveness of dominant negative SNB 19 cells transfected with dominant negative JNK 1 or ERK 1 to be remarkably reduced . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Expression of dominant negative mutants of ERK 1 , MAPK / ERK activator 1 , or JNK 1 but not p 38 blocked phosphorylation of the substrate glutathione S transferase c Jun and inhibited VES induced apoptosis . ^^^ Collectively , these results imply a critical role for ERK 1 and JNK 1 but not p 38 in VES induced apoptosis of human MDA MB 435 breast cancer cells . . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| To investigate the involvement of the mitogen activated protein kinases ( MAPKs ) in c Jun mediated Mllerian duct ( MD ) differentiation , Western immunoblot with antibodies against c Jun N terminal kinase ( JNK ) , extracellular signal regulated kinases ( ERK 1 and 2 ) , p 38 , phosphorylated JNK ( p JNK ) , and p ERK were used to investigate these kinases in the left and right MDs ( LMD and RMD , respectively ) of female chicks . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Analysis of the activity of mitogen activated protein ( MAP ) kinases , which play important roles in transduction of the Ras signal , showed that malolactomycin D inhibits the activation of p 38 MAP kinase and Jun N terminal kinase ( JNK ) but not extracellular signal regulated kinase 1 or 2 ( ERK 1 or 2 ) . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Our results show that bromelain dose dependently blocks serovar Typhimurium induced ERK 1 , ERK 2 , and c Jun NH ( 2 ) terminal kinase ( JNK ) activation in Caco 2 cells . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Whereas ERK 1 and p 46 ( JNK ) activation were not significantly modified , the kinetics of both ERK 2 and p 54 ( JNK ) activation and inactivation were affected in splenocytes from old animals . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| A significant increase in the levels of MEK 1 , ERK 1 , p 38 MAPK , and JNK phosphorylation was observed in BeF ( 2 ) exposed macrophages . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Activation of MAP kinase signaling pathways ( p 38 , JNK 1 / 2 , ERK 1 / 2 , Elk 1 , MEK 1 / 2 , c Raf ) was evaluated by Western blotting using phospho specific antibodies . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| The first detected downstream activation of the mitogen activated protein kinases ERK 1 and ERK 2 , but not of JNK or p 38 , describes a novel target of CEACAM 1 mediated signaling and contributes to the understanding of how CEACAM 1 regulates cellular function . . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| We detected no activation of heat shock protein ( HSP ) 27 , 60 , 84 and 86 , osmotic stress protein 94 ( Osp 94 ) , IL 12 , extracellular signal regulated protein kinase 1 ( ERK 1 ) , p 38 mitogen activated protein ( MAP ) kinase ( p 38 ) , c Jun NH 2 terminal kinase ( JNK ) , signal transducer and activator of transcription 1 ( STAT 1 ) , CD 14 and caspase genes . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Human articular chondrocytes were found to respond to the 120 kd FN f and to adhesion blocking antibodies to the alpha2beta1 and alpha5beta1 integrins with increased phosphorylation of the extracellular signal regulated kinase 1 ( ERK 1 ) / ERK2 , c Jun N terminal kinase ( JNK ) , and p 38 MAP kinases . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Western blot analysis using MAP kinase phosphospecific antibodies showed that T . denticola strongly but transiently activated ERK 1 and ERK 2 , signals mediating cell proliferation , and JNK and p 38 , kinases mediating apoptosis . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| While the extracellular signal related kinases ( ERK1 / 2 ) and big MAPK 1 ( BMK 1 ) are primarily involved in growth and cytoprotective functions , Jun amino terminal kinases ( JNK ) and p 38 proteins play an important role in inflammatory and stress responses . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| In this study we evaluated how extracellular matrix oxidation could modulate the development of apoptosis as well as the activity of the transcription factor NF kappaB and that of the MAPK family members ERK 1 , 2 and JNK . ^^^ Western blot analysis revealed diminished levels of the phosphorylated form of ERK 1 , 2 in cells on oxidized matrix , while levels of phosphorylated JNK were increased . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| The levels of extracellular signal regulated kinase 1 and 2 ( Erk 1 / 2 ) , p 38 , c Jun N terminal protein kinase ( JNK ) and TNF alpha were estimated . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Finally , the mitogen activated protein kinases ( Erk 1 and 2 and Jnk ) were phosphorylated in flagellin treated T 84 cells , and inhibition of the p 38 and Erk pathways significantly decreased the IL 8 response induced by EPEC flagellin . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Intracellular signaling cascades , particularly those involving the mitogen activated protein ( MAP ) kinases , p 38 , ERK 1 , and JNK , have been shown to be activated by TGF betas in promoting cartilage specific gene expression . ^^^ Our results showed that TGF beta 1 treatment initiates and maintains chondrogenesis of MPCs through the differential chondro stimulatory activities of p 38 , ERK 1 , and to a lesser extent , JNK . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| We also show that IGF 1 stimulates the activation of ERK 1 and ERK 2 , but we could not detect any effect of IGF 1 on the phosphorylation of p 38 , JNK ( p 46 ) or JNK ( p 54 ) . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| RESULTS : The apoptotic effect was associated with the sustained activation of c Jun N terminal kinases ( JNK ) and the inhibition of extracellular signal regulated kinases 1 ( ERK 1 ) and 2 activities , suggesting that JNK plays a positive role in the death process . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Our results demonstrate that OxPAPC treatment activated in a time dependent fashion protein kinase C ( PKC ) , protein kinase A ( PKA ) , Raf / MEK1 , 2 / Erk 1 , 2 MAP kinase cascade , JNK MAP kinase and transient protein tyrosine phosphorylation in human pulmonary artery endothelial cells ( HPAEC ) , whereas nonoxidized PAPC was without effect . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : The stress responsive mitogen activated protein kinases ( MAPKs ) ( p 38 MAPK , c Jun NH 2 terminal kinase [ JNK 1 and JNK 2 ] , and extracellular signal regulated kinases [ ERK 1 and ERK 2 ] ) might be involved in angiotensin 2 ( AII ) induced ischemia reperfusion injury . ^^^ Western blotting was done on left ventricular tissue for AT1 / AT2 , p38 / phosphorylated p 38 ( p p 38 ) , phosphorylated ( p ) JNK 1 / 2 , phosphorylated ( p ) ERK 1 / 2 , and PKCepsilon proteins ; Northern blots for AT1 / AT2 mRNA ; and enzyme immunoassay for cGMP . ^^^ RESULTS : Compared with controls , ischemia reperfusion induced significant left ventricular dysfunction , decreased AT 2 protein and mRNA , increased p p 38 and p JNK 1 / 2 , did not change p ERK 1 / 2 or PKCepsilon , and decreased cGMP . ^^^ PD 123 , 319 improved left ventricular recovery after ischemia reperfusion , increased AT 2 protein and mRNA , mildly increased p p 38 , normalized p JNK 1 , did not change p ERK 1 / 2 , and increased PKCepsilon and cGMP . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Homocarnosine reduced OGD activation of ERK 1 , ERK 2 , JNK 1 , and JNK 2 by 40 % , 46 % , 55 % , and 30 % , respectively . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| These include adaptor molecules ( SOCS , Rho GTPase activating protein , RAB 35 ) , kinases ( MEK kinase 1 and 4 , PKC , MLCK , cyclin G associated kinase , EphA 1 , JNK kinase , MAP kinase 1 ) , phosphatases ( meprin , PTPK , protein phosphatase 2 subunit ) , and heat shock proteins ( Hsp 60 precursor ) . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Also , YS 51 induced the phosphorylation activity of JNK in a time dependent manner without affecting the phosphorylation activity of the extracellular signal regulated kinase 1 ( ERK 1 ) and p 38 MAP kinase . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| In this chapter , detailed protocols for analyzing the kinase activities of the key components of the MAPKs pathway MEK 1 , ERK 1 , JNK , and p 38 MAPK are described . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Deletion of both TNF receptors also potentiated RANKL induced c Jun N terminal kinase ( JNK ) , extracellular signal regulated kinase 1 and 2 ( ERK1 / 2 ) , and p 38 mitogen activated protein kinase ( MAPK ) activations in a dose and time dependent manner . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Thus , hypoxia concurrently triggered both JNK and ERK signaling , and with reoxygenation , ERK 1 activation and stem cell proliferation followed by neuronal progenitor cell differentiation and targeted migration to the site of pyramidal neuronal loss . . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation was not prevented by SB 203580 ( an inhibitor of SAPK2a / p38alpha and SAPK2b / p38beta2 ) and / or PD 184352 ( which inhibits the activation of ERK 1 and ERK 2 ) , and was similar in fibroblasts lacking both SAPK3 / p38gamma and SAPK4 / p38delta or JNK 1 and JNK 2 . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Hyperthermia incubation resulted in a differential activation of p 38 mitogen activated protein kinase ( MAPK ) , extracellular regulated kinase 1 , 2 ( ERK 1 , 2 ) , and c jun N terminal kinase ( JNK ) immediately , 4 hr and 24 hr after treatment . ^^^ In contrast the JNK inhibitor SP 600125 and the ERK 1 , 2 inhibitor UO 126 resulted in increase of HIF 1alpha and P glycoprotein in the control as well as the hyperthermia treated samples , indicating negative regulation of intrinsic HIF 1alpha and P glycoprotein expression by ERK 1 , 2 and JNK signaling cascades . ^^^ In summary our data demonstrate that hyperthermia induced upregulation of P glycoprotein and HIF 1alpha is mediated by activation of p 38 , whereas ERK 1 , 2 and JNK are involved in repression of P glycoprotein and HIF 1alpha under control conditions . . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Although IH induced the activation of ERK 1 , ERK 2 , JNK , PKC alpha , and PKC gamma , inhibitors of these kinases and of phosphatidylinositol 3 kinase did not block HIF 1 mediated reporter gene expression induced by IH , indicating that signaling via these kinases was not required . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| As we have shown previously , OTA activates mitogen activated protein kinases [ extracellular signal regulated kinase 1 and 2 ( ERK1 / 2 ) , c jun amino terminal kinase ( JNK ) , and extracellular regulated protein kinase 38 ( p 38 ) ] in proximal tubular cells ( opossum kidney and normal rat kidney epithelial ) . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| The effect of insulin on phosphorylation of both these sites required the activation of PI3K and the MAPKs ( mitogen activated protein kinases ) ERK1 / 2 ( extracellular signal regulated kinase 1 and 2 ) , but not the activation of mTOR ( mammalian target of rapamycin ) / p70S6 kinase , JNK ( c Jun N terminal kinase ) or p38MAPK . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of the transcription factor c Jun , a downstream target of JNK , was also undetected in contrast to p 38 MAPK and ERK 1 & 2 , which were clearly activated following anti IgE stimulation of the cells . ^^^ Additionally , inhibitors of the JNK pathway failed to prevent basophil mediator release and had no effect on the phosphorylation of p 38 MAPK or ERK 1 & 2 at concentrations which were specific for JNK blockade . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Electrical field treatment resulted in activation of extracellular regulated kinase 1 , 2 ( ERK 1 , 2 ) , p 38 , as well as c Jun NH 2 terminal kinase ( JNK ) . ^^^ The increase in capillary areas and VEGF expression as well as activation of JNK and ERK 1 , 2 was significantly inhibited in the presence of the free radical scavenger vitamin E underscoring the role of ROS in electrical field induced angiogenesis of ES cells . . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Lingonberry extract blocked UVB induced phosphorylation of the mitogen activated protein kinase ( MAPK ) signaling members ERK 1 , ERK 2 , p 38 , and MEK1 / 2 but not JNK . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| LPS induced DcR 3 releases in IECs appeared to be via the activation of mitogen activated protein kinases ( MAPK ) such as extracellular signal regulated kinase 1 and 2 ( ERK1 / 2 ) and c Jun NH 2 terminal protein kinase ( JNK ) , and the transcription factor NF kappaB . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| DNA binding activity of NFAT , NFkappaB , and AP 1 transcription factors was determined by gel shift assay , and JNK , p 38 , and ERK 1 and ERK 2 activation was assessed by Western blot analysis of immunoprecipitates . ^^^ The CSA inhibited NFAT , NFkappaB , and p 38 and JNK activities ; however , ERK 1 and ERK 2 were not affected significantly . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Extracellular signal regulated kinase 2 ( ERK 2 ) pathway was found to be significantly activated greater than seven fold within 30 min ; however , there was little activation of ERK 1 and no activation of JNK or p 38 MAPK . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| CONCLUSIONS : RET directly phosphorylates tyrosine residues on FAK , ERK 1 / 2 , DOK 1 , the p 85 subunit of of phosphatidylinositol 3 ' kinase , JNK 1 and 2 , P 38 , and phospholipase gamma . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| The relative contribution of ERK 1 / 2 , p 38 , and JNK 1 / 2 and their interrelationships in hormonal regulation of muscle cell proliferation and differentiation remain to be established . . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Transfection with dominant negative mutants of MEK1 / 2 , ERK 1 , ERK 2 , p 38 , and JNK attenuated TNF alpha induced VCAM 1 expression . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| DNA damage and G2 / M arrest in Syrian hamster embryo cells during Malachite green exposure are associated with elevated phosphorylation of ERK 1 and JNK 1 . ^^^ Western blots of MG treated cells with phosphoactive antibodies showed elevated phosphorylation of ERK 1 and JNK 1 and no change in p 38 kinase . ^^^ The present study indicates that elevated phosphorylation of ERK 1 and JNK 1 and an increase in G2 / M phase and apoptotic cells seems to be the changes associated with MG exposure to SHE cells in primary culture . . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Prooxidants and chemical hypoxia activated ERK 1 , 2 , JNK and p 38 as well as PI 3 kinase . ^^^ The proxidant and CoCl 2 mediated upregulation of CT 1 was significantly inhibited in the presence of the ERK 1 , 2 antagonist UO 126 , the JNK antagonist SP 600125 , the p 38 antagonist SKF 86002 , the PI 3 kinase antagonist LY 294002 , the Jak 2 antagonist AG 490 as well as in the presence of free radical scavengers . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Furthermore , phosphorylation of extracellular regulated kinase 1 , 2 ( ERK 1 , 2 ) , p 38 , and c jun N terminal kinase ( c Jun NH 2 terminal kinase ( JNK ) ) was observed . ^^^ Cardiomyogenesis was inhibited by the p 38 inhibitor SB 203580 , the ERK 1 , 2 inhibitor UO 126 , and the JNK inhibitor SP 600125 . ^^^ Vasculogenesis / angiogenesis was blunted following inhibition of ERK 1 , 2 and JNK , whereas p 38 inhibition was ineffective . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Xenon preconditioning differently regulates p44 / 42 MAPK ( ERK 1 / 2 ) and p46 / 54 MAPK ( JNK 1 / 2 and 3 ) in vivo . ^^^ The role of ERK 1 / 2 and JNK 1 / 2 and 3 in Xe PC has yet not been determined . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| An acute increase in IVC intraluminal pressure failed to increase the phosphorylation of ERK 1 , JNK 2 , or any of the p 38 MAPKs in the diabetic obese Zucker rats . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Although stress induced activation of p 54 SAPKbeta , p 46 SAPKgamma ( JNK 1 ) or p 38 MAP kinases is abolished upon co transfection with increasing amounts of M3 / 6 plasmid , epidermal growth factor stimulated ERK 1 is remarkably insensitive even to the highest levels of M3 / 6 expression obtained . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| The changes in ERK 1 protein expression and activation were accompanied by a small rise in c jun NH 2 terminal kinase 1 ( JNK 1 ) protein expression but slightly decreased basal and anisomycin stimulated JNK 1 activity . ^^^ Differential expression and activation of ERK 1 , ERK 2 , and JNK 1 were accompanied by an inhibition of serum induced MDCK C7F cell proliferation . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| C5b 9 but not C5b6 induced activation of both ERK 1 and c jun NH 2 terminal kinases 1 ( JNK 1 ) in OLG . ^^^ The increased ERK 1 and JNK 1 activities are transient , reaching a maximum around 20 min following exposure to C5b 9 . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| CEP 1347 , also known as KT 7515 , a derivative of a natural product indolocarbazole , inhibited motor neuronal death in vitro , inhibited activation of the stress activated kinase JNK 1 ( c jun NH terminal kinase ) in cultured spinal motor neurons , but had no effect on the mitogen activated protein kinase ERK 1 in these cells . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Expression of JNK 1 , ERK 1 , p38 / RK and MKP 1 proteins was investigated by immunohistochemistry and expression of MKP 1 mRNA by in situ hybridisation in 50 cases of high grade prostatic intraepithelial neoplasia ( PIN ) , thought to represent the precursor of prostate cancer . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| In contrast , wild type Raf 1 , ERK 1 , ERK 2 , MEK 4 , or JNK 1 produced no change in activity and the dominant negative forms of these kinases failed to suppress TPA dependent transcription . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| A glutathione S transferase ( GST ) PTP SL fusion protein containing the KIM associated with ERK 1 and ERK 2 as well as with p38 / HOG , but not with the related JNK 1 kinase or with protein kinase A or C . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylated ERK 2 , but not ERK 1 , p 38 , or JNK 1 , efficiently bound to catalytically inactive HePTP mutants in which the active site cysteine ( HePTP C / S ) or the conserved aspartic acid residue ( HePTP D / A ) had been exchanged for serine and alanine , respectively . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Our immunohistochemical analysis showed that the cases with overexpression of Ras and MAPK proteins ( Ras p 21 , ERK 1 , JNK 1 , and p 38 ) had a progressive tendency towards invasive growth , advanced stage cancer , and decreased levels of ER alpha protein . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Further analyses disclosed that transfection of dominant negative forms of raf 1 , MEK 1 , ERK 1 , ERK 2 , or wild type MEKK 1 all increased cystatin A promoter activity in normal human keratinocytes , whereas wild type raf 1 , ERK 1 , ERK 2 , or dominant negative forms of MEKK 1 , MKK 7 , or JNK 1 suppressed the promoter activity . ^^^ |
|
| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| To further examine signaling pathways involved in TNF alpha expression , we determined that JNK 1 and 2 and p 38 , but not ERK 1 or 2 , were phosphorylated following toxin exposure . ^^^ |
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| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| All cell lines showed complete detectable DNA repair by 30 min after irradiation , and clearly delayed migration of BAX and active stress activated protein ( SAP ) kinases MAPK 1 ( also known as p 38 ) and MAPK 8 ( also known as JNK 1 ) to the mitochondria at 3 h . ^^^ |
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| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Addition of GM CSF , but not TNF alpha , increased phosphorylation of both Raf 1 and the mitogen activated protein kinases ( MAPKs ) JNK 1 and ERK 1 . ^^^ |
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| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| Activities of ERK 1 and 2 , Raf 1 , JNK 1 and 2 in yolk sac cells were analyzed by Western blot with primary antibodies specific to the phosphorylated kinases , respectively . ^^^ Key mitogen activated protein kinases serve as syllabic intermediates : increased activities of Jun amino terminal kinase ( JNK 1 and 2 ) and decreased activities of extracellular signal regulated kinase ( ERK 1 and 2 ) were observed during hyperglycemia induced embryopathy . ^^^ |
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| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| We have studied the ability of ERK 1 , 2 , JNK 1 , 2 and p 38 kinases to be regulated after serum deprivation in E1A + E1B 19 kDa and E1A + E1A + c Ha ras transformed rat embryo fibroblasts . ^^^ |
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| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| In vitro kinase assays using the combined STAT 1 proteins as substrates from immunoprecipitation and glutathione S transferase pull down show that active ERK 1 , JNK 1 , p 38 kinase , MEK 1 and MSK 1 stimulated phosphorylation of STAT 1 ( Ser 727 ) indirectly through an unidentified factor or a downstream kinase . ^^^ |
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| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To explore the expression of p 38 , ERK 1 ( extracellular signal regulated kinases 1 ) and JNK 1 ( c jun NH 2 terminal kinases 1 ) , subtribes of MAPK ( mitogen activated protein kinases ) , and their clinical implication in non small cell lung cancer ( NSCLC ) cells . ^^^ METHOD : Immunohistochemistry was used to detect the expression of p 38 , ERK 1 , JNK 1 , and ras in the resected specimens of non small cell lung cancer from 73 patients . ^^^ The relation between p 38 , ERK 1 , and JNK 1 and clinicopathological factors were analyzed by Mann Whitney u test , chi ( 2 ) test , and Fisher precise probability method . ^^^ Expression of JNK 1 was related with the tumor location ( P = 0 . 005 ) . ras expression was correlated with p 38 ( P = 0 . 003 ) and ERK 1 ( P = 0 . 012 ) . ^^^ CONCLUSION : Among the subtribes of MAPK , p 38 may be of use to assess lymph node metastasis and TNM staging , ERK 1 may be of use to evaluate histological type , lymph node metastasis and TNM staging , and JNK 1 to assess the tumor location . ras may increase the expression of p 38 and ERK 1 . p 38 , as well as some clinicpathological factors , including TNM staging , lymph node metastasis and tumor differentiation are prognostic factors of NSCLC . . ^^^ |
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| Interacting proteins: P45983 and P27361 |
Pubmed |
SVM Score :0.0 |
| In addition , the activity of GalT 5 promoter could be induced by epidermal growth factor , dominant active Ras , ERK 1 , JNK 1 , and constitutively active AKT . ^^^ |
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