| Interacting proteins: P35236 and P27361 |
Pubmed |
SVM Score :0.52589301 |
| Pull downs from Jurkat T cells using a recombinant GST LCPTP substrate trap protein , but not wild type LCPTP show a clear specific association with both ERK 1 and ERK 2 . 0.52589301^^^ |
|
| Interacting proteins: P35236 and P27361 |
Pubmed |
SVM Score :0.0 |
| Efforts to pinpoint the exact site of action and specificity of HePTP in the signaling cascade revealed that HePTP acts directly on the mitogen activated protein ( MAP ) kinases Erk 1 and 2 and consequently reduces the magnitude and duration of their catalytic activation in intact T cells . ^^^ |
|
| Interacting proteins: P35236 and P27361 |
Pubmed |
SVM Score :0.0 |
| The haematopoietic protein tyrosine phosphatase ( HePTP ) is a negative regulator of the MAP kinases Erk 1 , Erk 2 and p 38 . ^^^ |
|
| Interacting proteins: P35236 and P27361 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylated ERK 2 , but not ERK 1 , p 38 , or JNK 1 , efficiently bound to catalytically inactive HePTP mutants in which the active site cysteine ( HePTP C / S ) or the conserved aspartic acid residue ( HePTP D / A ) had been exchanged for serine and alanine , respectively . ^^^ |
|
| Interacting proteins: P35236 and P27361 |
Pubmed |
SVM Score :0.0 |
| LC PTP and LC PTPCS made complexes with ERK 1 , ERK 2 , and p38alpha , but not with the gain of function sevenmaker ERK 2 mutant ( D321N ) . ^^^ |
|
| Interacting proteins: P35236 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35236 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|