| Interacting proteins: P28562 and P27361 |
Pubmed |
SVM Score :0.0 |
| Increases in ERK 1 activity through treatment of cells with sodium vanadate ( SV ) , an inhibitor of the dual specificity MAP kinase phosphatase 1 ( PAC 1 ) , resulted in increased phosphorylation of the heat shock transcription factor 1 ( HSF 1 ) in unheated cells , delayed the activation of HSF 1 by heat shock , and inhibited the induction of hsp 70 by heat shock . ^^^ |
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| Interacting proteins: P28562 and P27361 |
Pubmed |
SVM Score :0.0 |
| Inactivation of growth factor regulated mitogen activated protein ( MAP ) kinases ( ERK 1 and ERK 2 ) has been proposed to occur in part through dephosphorylation by the dual specificity MAP kinase phosphatase 1 ( MKP 1 ) , an immediate early gene that is induced by mitogenic signaling . ^^^ |
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| Interacting proteins: P28562 and P27361 |
Pubmed |
SVM Score :0.0 |
| Reduced MAP kinase phosphatase 1 degradation after p42 / p44MAPK dependent phosphorylation . ^^^ |
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| Interacting proteins: P28562 and P27361 |
Pubmed |
SVM Score :0.0 |
| MKP 1 mRNA and MAP kinase ( ERK 1 and 2 ) protein expression was assessed in 164 human epithelial tumors of diverse tissue origin by in situ hybridization and immunohistochemistry . ^^^ MKP 1 , ERK 1 , and ERK 2 were co expressed in most tumors examined . ^^^ In a subset of 15 tumors , ERK 1 enzymatic activity as well as structural alterations that might be responsible for loss of function of MKP 1 during tumor progression , were examined . ^^^ ERK 1 enzymatic activity was found to be elevated despite MKP 1 overexpression . ^^^ |
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| Interacting proteins: P28562 and P27361 |
Pubmed |
SVM Score :0.0 |
| Whereas p 44 MAPK does not appear to phosphorylate NHE 1 in vitro , we found that inhibition of the p42 / p44 MAPK signaling by expression of a dominant negative form of p 44 MAPK , by expression of the MAP kinase phosphatase MKP 1 , or by inhibition of MAPK kinase 1 ( MKK 1 ) with the PD 98059 compound reduced by 50 60 % NHE 1 activation in response to growth factors . ^^^ |
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| Interacting proteins: P28562 and P27361 |
Pubmed |
SVM Score :0.0 |
| A series of 51 prostate cancers , including a subset ( n = 13 ) that had been previously treated by androgen ablation , was used to examine whether MKP 1 mRNA and protein expression correlated with that of ERK 1 , JNK 1 , bcl 2 , which confers resistance to apoptosis , and apoptotic index measured by in situ end labeling of fragmented DNA . ^^^ In a subset of tumors , MKP 1 expression was assessed by semiquantitative RT PCR and was compared with both ERK 1 and JNK 1 enzymatic activity . ^^^ There was coexpression of MKP 1 , ERK 1 , and JNK 1 proteins . ^^^ In addition , MKP 1 expression was inversely correlated to JNK 1 but not to ERK 1 enzymatic activity . ^^^ |
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| Interacting proteins: P28562 and P27361 |
Pubmed |
SVM Score :0.0 |
| Since cycloheximide did not potentiate MEK activity but abrogated the expression of mitogen activated protein kinase phosphatase ( MKP 1 ) normally seen in response to EGF and LPA , we speculated that the level of MKP 1 expression may be an important regulator of ERK 1 activity in Rat 1 cells . ^^^ Activation of PKC played little part in growth factor stimulated MKP 1 expression , but LPA and EGF induced MKP 1 expression was blocked by buffering [ Ca2+ ] 1 , leading to a potentiation of the sustained phase of ERK 1 activation without potentiating MEK activity . ^^^ In this way , ERK dependent and independent signals may regulate MKP 1 expression , the magnitude of sustained ERK 1 activity , and therefore gene expression . . ^^^ |
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| Interacting proteins: P28562 and P27361 |
Pubmed |
SVM Score :0.0 |
| The decreased phagocytosis of L . monocytogenes as a result of the MKP 1 overexpression in J 774 macrophages suggests that the activation of the MAP kinase ( s ) ERK 1 and / or ERK 2 is an essential requirement for the uptake of L . monocytogenes by J 774 macrophages . . ^^^ |
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| Interacting proteins: P28562 and P27361 |
Pubmed |
SVM Score :0.0 |
| Hyperosmotic MKP 1 mRNA induction was preceded by a transient activation of the MAP kinases Erk 1 , Erk 2 , and JNK 2 , which were not prerequisite for MKP 1 mRNA accumulation . ^^^ |
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| Interacting proteins: P28562 and P27361 |
Pubmed |
SVM Score :0.0 |
| Expression of JNK 1 , ERK 1 , p38 / RK and MKP 1 proteins was investigated by immunohistochemistry and expression of MKP 1 mRNA by in situ hybridisation in 50 cases of high grade prostatic intraepithelial neoplasia ( PIN ) , thought to represent the precursor of prostate cancer . ^^^ |
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| Interacting proteins: P28562 and P27361 |
Pubmed |
SVM Score :0.0 |
| We observed that the AT 2 receptor activates tyrosine phosphatase ( s ) such as mitogen activated protein ( MAP ) kinase phosphatase 1 ( MKP 1 ) and inactivates MAP kinase ( extracellular signal regulated kinase ( ERK 1 and ERK 2 ) ) , resulting in Bcl 2 dephosphorylation and up regulation of Bax . ^^^ |
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| Interacting proteins: P28562 and P27361 |
Pubmed |
SVM Score :0.0 |
| The above results demonstrate that activation of MAPK plays an important role in Ang 2 induced cardiomyocyte hypertrophic response in neonatal rat cardiomyocytes through MKP 1 mediated inactivation of p44MAPK and p42MAPK . cardiomyocyte hypertrophic response in neonatal rat cardiomyocytes through MKP 1 mediated inactivation of p44MAPK and p42MAPK . . ^^^ |
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| Interacting proteins: P28562 and P27361 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To investigate the effect of reinforcing kidney , replenishing Qi and blood activating prescription ( RKRQBAP ) on extracellular signal regulating kinase 1 ( ERK 1 ) and mitogen activated protein kinase phosphatase 1 ( MKP 1 ) of fetal rats with fetal growth restriction ( FGR ) . ^^^ The expression of ERK 1 and MKP 1 in brain and liver were measured by western blot . ^^^ The expression of ERK 1 in brain was much higher in CHM group than in L arg group ( P < 0 . 05 ) , the expression of MKP 1 was almost the same ( P > 0 . 05 ) ; Both of them in liver were higher in CHM group than in L arg group ( P < 0 . 01 ) . ^^^ CONCLUSION : The possible mechanism which the RKRQBAP cure FGR is to affect the expression of ERK 1 and MKP 1 and to promote growth related genes expression and restrain apoptosis . ^^^ |
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| Interacting proteins: P28562 and P27361 |
Pubmed |
SVM Score :0.0 |
| The numbers of tumor and diameter of each tumor in forestomach were counted ; the mice plasma malondialdehyde ( MDA ) were measured by TBARS assay ; TUNEL assay was used to analyze the apoptosis in forestomach neoplasia and the expression of MEK 1 , ERK 1 , MKP 1 protein in forestomach neoplasm were studied by Western Blotting assay . ^^^ The 75 % purity c 9 , t 11 CLA showed stronger inhibition ; CLA could also inhibit the expression of ERK 1 protein and promote the expression of MKP 1 protein , however no influence of CLA on MEK 1 protein was observed . ^^^ And the effect of CLA on the expression of ERK 1 and MKP 1 may be one of the mechanisms of the inhibition of CLA on the tumor . . ^^^ |
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| Interacting proteins: P28562 and P27361 |
Pubmed |
SVM Score :0.0 |
| The activity of MAPK 1 and MAPK 3 is regulated by dual specificity phosphatases : MKP 1 and MKP 3 . ^^^ |
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| Interacting proteins: P28562 and P27361 |
Pubmed |
SVM Score :0.0 |
| The expression of either an ERK inactivating phosphatase ( CL 100 ) , or a kinase defective ERK 1 , decreased the activity of a u PAR promoter driven CAT reporter in RKO cells . ^^^ |
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| Interacting proteins: P28562 and P27361 |
Pubmed |
SVM Score :0.0 |
| When several phosphoproteins were tested for recombinant HVH 1 , only MEK activated ERK 1 was dephosphorylated . ^^^ HVH 1 selectively dephosphorylated threonine and tyrosine residues but not serine residues of the activated ERK 1 . ^^^ Inactivation of ERK 1 by HVH 1 could be reversed by MEK , suggesting that HVH 1 dephosphorylates the same residues that are recognized and phosphorylated by MEK . ^^^ |
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| Interacting proteins: P28562 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P28562 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P28562 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P28562 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P28562 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P28562 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P28562 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28562 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28562 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28562 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28562 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28562 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28562 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28562 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28562 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28562 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28562 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
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