| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that Elk 1 , a protein closely related to p62TCF in function , is a nuclear target of two members of the MAP kinase family , ERK 1 and ERK 2 . ^^^ |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| Here we show that overexpression of extracellular signal regulated kinase 1 ( ERK 1 ) cDNA , encoding p44mapk , results in the activation of Elk 1 , the serum response factor accessory protein . ^^^ |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| Elk 1 ( also called p62TCF ) , a transcription factor involved in the induction of the expression from the c fos promoter through the promoter ' s serum response element , is known to be activated as a result of phosphorylation by the MAP kinases ERK 1 and ERK 2 . ^^^ |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| Under such conditions Elk 1 could be phosphorylated by the mitogen activated protein kinases ( MAPKs ) ERK 1 and ERK 2 . ^^^ |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| Additionally , a comparison of Sap 1a with another TCF , Elk 1 , revealed that these proteins behaved differently to stimulation by ERK 1 and JNK 1 . ^^^ |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| Inhibition of PKA also reduced the ability of NGF and cAMP , but not EGF , to activate the transcription factor Elk 1 , reduced the induction of both immediate early and late genes after NGF treatment , and blocked the nuclear translocation of ERK 1 induced by NGF . ^^^ |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| When overexpressed in cultured cells , MP 1 enhanced activation of ERK 1 and activation of a reporter driven by the transcription factor Elk 1 . ^^^ |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| TPA induced activation of the SRE was partially inhibited by dominant negative c Raf , ERK 1 , or ERK 2 , and constitutively active mutants of PKC alpha and PKC epsilon activated the transactivation domain of Elk 1 . ^^^ |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| Using the Jurkat T lymphocyte cell line , we found that a stably expressed Gi protein coupled receptor ( the delta opioid receptor ( DOR 1 ) ) stimulates MEK 1 and extracellular signal regulated kinases 1 and 2 ( ERK 1 and ERK 2 ) and transcriptional activity by an ERK target , Elk 1 , via a mechanism requiring a PTX sensitive Gi protein . ^^^ |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| By Western blot analysis , the phosphorylation of ERK 1 / 2 and of the downstream transcription factor Elk 1 were measured , and the activities of the ERKs were tested by in gel phosphorylation . ^^^ |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| Furthermore , tyrosine phosphorylation of FAK and phosphotyrosine kinase ( Pyk ) 2 ; serine phosphorylation of c Raf , MEK 1 , and Elk 1 ; and tyrosine threonine phosphorylation of Erk 1 and 2 were time dependently activated in the presence of GDNF . ^^^ More specifically , the Ras inhibitor manumycin inhibited phosphorylation of c Raf , MEK 1 , Erk 1 and 2 , and Elk 1 , but not that of FAK . ^^^ |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the results demonstrated a convergence of nutrient and growth factor mediated signaling pathways on Elk 1 activation through induction of Ras / mitogen activated protein kinase ERK 1 and 2 . ^^^ |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| On bryo 1 treatment , the activity of ERK 2 ( p 42 ) rapidly increased , with ERK 1 ( p 44 ) protein levels remaining constant . p44 / 42 immunoprecipitates from lysates of bryo 1 treated cells had increased their ability to phosphorylate the transcription factor Elk 1 . ^^^ |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| Amphetamine activates extracellular signal regulated kinase 1 and 2 ( ERK1 / 2 ) resulting in cAMP response element binding protein ( CREB ) and Elk 1 phosphorylation in striatal neurons . ^^^ |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| Activation of MAP kinase signaling pathways ( p 38 , JNK 1 / 2 , ERK 1 / 2 , Elk 1 , MEK 1 / 2 , c Raf ) was evaluated by Western blotting using phospho specific antibodies . ^^^ |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| Activation of group 1 metabotropic glutamate receptors ( mGluRs ) upregulates cAMP response element binding protein ( CREB ) and Elk 1 phosphorylation via extracellular signal regulated kinase 1 and 2 ( ERK1 / 2 ) in the striatum in vivo . ^^^ |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| This is further supported by the data showing that A beta causes phosphorylation of ERK 1 / ERK 2 , which , in turn , activates Elk 1 . ^^^ |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| C5b 9 activated ERK 1 , which in turn activated Elk 1 in myotubes . ^^^ |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| Here we show an activation of the extracellular signal regulated kinases ( ERK 1 and ERK 2 ) and the downstream nuclear targets Elk 1 and calcium / cAMP response element binding protein , in the hippocampus of cystathionine beta synthase deficient mice , a murine model of hyperhomocysteinemia . ^^^ |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| In addition , Nore1B is also required for KiRas GV 12 mediated ERK 1 activation and Elk 1 reporter activity in T cells . ^^^ |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|