| Interacting proteins: P01241 and P27361 |
Pubmed |
SVM Score :0.0 |
| Insulin also elicited brief hyperphosphorylation of ERK 1 and 2 , an effect not seen in GH stimulated hepatocytes . ^^^ |
|
| Interacting proteins: P01241 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01241 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01241 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01241 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01241 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01241 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01241 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01241 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01241 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01241 and P27361 |
Pubmed |
SVM Score :0.0 |
| Previous studies have shown that the activation of p 44 and p 42 mitogen activated protein ( MAP ) kinases ( ERK 1 and ERK 2 ) by growth hormone ( GH ) and phorbol esters , but not by epidermal growth factor , in 3T3 F442A preadipocytes is dependent on protein kinase C ( PKC ) . ^^^ |
|
| Interacting proteins: P01241 and P27361 |
Pubmed |
SVM Score :0.0 |
| Herbimycin A and staurosporine inhibit JAK 2 and tyrosyl phosphorylation of all proteins stimulated by GH , whereas P 11 inhibits the GH dependent tyrosyl phosphorylation of only some proteins , including extracellular signal regulated kinases ERK 1 and 2 , but not JAK 2 . ^^^ |
|
| Interacting proteins: P01241 and P27361 |
Pubmed |
SVM Score :0.0 |
| GH treatment of Chinese hamster ovary cells stably transfected with the GH receptor ( CHOA cells ) led to rapid and transient activation of both STAT5a and ERK 1 and ERK 2 . ^^^ Transfection experiments with COS cells showed that kinase inactive ERK 1 decreased GH stimulation of STAT 5 regulated reporter gene expression . ^^^ |
|
| Interacting proteins: P01241 and P27361 |
Pubmed |
SVM Score :0.0 |
| We previously showed that IRS and GHR deficient 32D cells that stably express the rabbit GHR and rat IRS 1 ( 32D rbGHR IRS 1 ) exhibited markedly enhanced GH induced proliferation and MAP kinase ( ERK 1 and ERK 2 ) activation compared with cells expressing only the GHR ( 32D rbGHR ) . ^^^ Time course experiments revealed a similarly transient ( maximal at 15 min ) GH induced ERK 1 and ERK 2 activation in both 32D rbGHR and 32D rbGHR IRS 1 cells , but , consistent with our prior findings , substantially greater activation was seen in the IRS 1 containing cells . ^^^ This same pattern in both cells of IRS 1 dependent augmentation and IRS 1 independent wortmannin sensitivity was also observed for GH induced activation of Akt and MEK 1 ( using state specific antibody blotting for both ) , despite the lack of difference in GHR , JAK 2 , SHP 2 , p 85 , Akt , Ras , Raf 1 , MEK 1 , ERK 1 , or ERK 2 abundance between the two cells . ^^^ |
|