| Interacting proteins: P27169 and P10909 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27169 and P10909 |
Pubmed |
SVM Score :0.0 |
| Human serum paraoxonase ( PON 1 ) is closely associated with a specific HDL subfraction also containing apoA 1 and clusterin . ^^^ |
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| Interacting proteins: P27169 and P10909 |
Pubmed |
SVM Score :0.0 |
| There were no differences in the PON 1 55 and 192 polymorphisms or clusterin concentration between patients with CHD and control subjects . ^^^ |
|
| Interacting proteins: P27169 and P10909 |
Pubmed |
SVM Score :0.0 |
| Human paraoxonase ( PON 1 ) is a calcium dependent esterase exclusively bound to apolipoprotein A 1 and clusterin , containing high density lipoprotein ( HDL ) particles that hydrolyzes organophosphates and aryl esters . ^^^ |
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| Interacting proteins: P27169 and P10909 |
Pubmed |
SVM Score :0.0 |
| Profiles of PON 1 activity and ApoA 1 , ApoA 2 , ApoE , ApoJ , and cholesterol concentrations were obtained by use of various density gradients . ^^^ |
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| Interacting proteins: P27169 and P10909 |
Pubmed |
SVM Score :0.0 |
| Paraoxonase 1 ( PON 1 ) associates to specific high density lipoproteins ( HDLs ) those containing apolipoprotein A 1 ( apoA 1 ) and apolipoprotein J ( apoJ ) and is largely responsible for their antiatherogenic properties . ^^^ Serum and liver paraoxonase and arylesterase activities , serum triglyceride , total and HDL cholesterol concentrations , serum PON 1 , apoA 1 and apoJ contents and liver PON 1 mRNA levels were measured . ^^^ Serum PON 1 content was higher in female rats and decreased in both genders with CR , whereas apoA 1 and apoJ contents , which were higher in female rats too , decreased only in the former animals , accounting for the high PON 1 activity decrease observed in these animals . ^^^ In conclusion , the short term CR associated reduction of serum PON 1 activity and PON 1 , apoA 1 and apoJ levels points toward a reduced stability of HDL PON 1 complexes and / or HDL particle levels responsible for PON 1 transport and function in the blood . ^^^ |
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| Interacting proteins: P27169 and P10909 |
Pubmed |
SVM Score :0.0 |
| Aging impaired the serum lipid profile and increased lipid peroxidation , PON 1 activities , and the content of both PON 1 and apolipoprotein J in HDL , which suggests an HDL subfraction redistribution to protect LDL more effectively from oxidation . ^^^ |
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| Interacting proteins: P27169 and P10909 |
Pubmed |
SVM Score :0.0 |
| We have examined the effects of mildly oxidized LDL and atherosclerosis on the levels of two proteins associated with HDL ; apolipoprotein J ( apoJ ) , and paraoxonase ( PON ) . ^^^ On an atherogenic diet , PON activity decreased by 52 % , and apoJ levels increased 2 . 8 fold in fatty streak susceptible mice , C57BL / 6J ( BL / 6 ) , but not in fatty streak resistant mice , C3H / HeJ ( C3H ) . ^^^ Plasma PON activity was also significantly decreased , and apoJ levels were markedly increased in apolipoprotein E knockout mice on the chow diet , resulting in a 9 . 2 fold increase in the apoJ / PON ratio as compared to controls . ^^^ Furthermore , a dramatic increase in the apoJ / PON ratio ( over 100 fold ) was observed in LDL receptor knockout mice when they were fed a 0 . 15 % cholesterol enriched diet . ^^^ Injection of mildly oxidized LDL ( but not native LDL ) into BL / 6 mice ( but not in C3H mice ) on a chow diet resulted in a 59 % decrease in PON activity ( P < 0 . 01 ) and a 3 . 6 fold increase in apoJ levels ( P < 0 . 01 ) . ^^^ |
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| Interacting proteins: P27169 and P10909 |
Pubmed |
SVM Score :0.0 |
| Using immunolocalization techniques , we have shown that paraoxonase ( Pon ) , clusterin , and apolipoprotein ( apo ) A 1 accumulate in the artery wall during the development of atherosclerosis . ^^^ In normal aortas ( n = 6 ) there were low levels of extracellular Pon , clusterin , and apoA 1 , immunoreactivity . ^^^ With the progression of disease from fatty streaks ( n = 3 ) to advanced atherosclerosis ( n = 8 ) there was an increase in Pon , apoA 1 , and clusterin immunoreactivity , indicating the increasing presence of these proteins with disease progression . ^^^ The increase in Pon , clusterin , and apoA 1 during the development of atherosclerosis may therefore represent a protective response to the oxidative stress associated with the development of atherosclerosis . . ^^^ |
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| Interacting proteins: P27169 and P10909 |
Pubmed |
SVM Score :0.0 |
| Apolipoprotein J ( apoJ ) levels , rather than being decreased , were significantly ( P = 0 . 01 ) higher ( 36 % ) in Lcat ( / ) than in Lcat ( + / + ) mice , and the apo J / PON ratio was 3 fold greater in Lcat ( / ) than in Lcat ( + / + ) animals . ^^^ Apolipoprotein J ( apoJ ) levels , rather than being decreased , were significantly ( P = 0 . 01 ) higher ( 36 % ) in Lcat ( / ) than in Lcat ( + / + ) mice , and the apo J / PON ratio was 3 fold greater in Lcat ( / ) than in Lcat ( + / + ) animals . ^^^ |
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| Interacting proteins: P27169 and P10909 |
Pubmed |
SVM Score :0.0 |
| Treatment of HepG 2 cells with oxidized 1 palmitoyl 2 arachidonyl sn glycero 3 phosphoryl choline ( OX PAPC ) , or biologically active lipids present in mildly oxidized low density lipoprotein , increased apolipoprotein J ( apoJ ) , and decreased paraoxonase ( PON ) mRNA levels . ^^^ In vivo , OX PAPC injected into C57BL / 6J mice resulted in a marked reduction in PON activity and an increase in apoJ levels in plasma after 16 h . ^^^ Injection of OX PAPC into IL 6 deficient C57BL / 6J mice ( IL 6 / ) did not alter either PON activity or apoJ levels . ^^^ |
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| Interacting proteins: P27169 and P10909 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27169 and P10909 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27169 and P10909 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27169 and P10909 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27169 and P10909 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27169 and P10909 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27169 and P10909 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27169 and P10909 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27169 and P10909 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27169 and P10909 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27169 and P10909 |
Pubmed |
SVM Score :0.0 |
| NA |
|