| Interacting proteins: P26640 and P56192 |
Pubmed |
SVM Score :0.0 |
| The sequence of CysRS bears the canonical His Ile Gly His ( HIGH ) and Lys Met Ser Lys Ser ( KMSKS ) motifs characteristic of the group of enzymes containing a Rossmann fold ; furthermore , it shows striking homologies with MetRS ( an homodimer of 677 residues ) and to a lesser extent with Ile , Leu , and ValRS ( monomers of 939 , 860 , and 951 residues respectively ) . ^^^ |
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| Interacting proteins: P26640 and P56192 |
Pubmed |
SVM Score :0.0 |
| Out of the 18 known aaRS , only 9 referred to as class 1 synthetases ( GlnRS , TyrRS , MetRS , GluRS , ArgRS , ValRS , IleRS , LeuRS , TrpRS ) , display two short common consensus sequences ( ' HIGH ' and ' KMSKS ' ) which indicate , as observed in three crystal structures , the presence of a structural domain ( the Rossman fold ) that binds ATP . ^^^ |
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| Interacting proteins: P26640 and P56192 |
Pubmed |
SVM Score :0.0 |
| We therefore conclude that these lysines of MetRS and ValRS are directed toward the ATP binding site of these synthetases , more specifically at or close to the subsite for the gamma phosphate of ATP . ^^^ AP 3 PL labeled Lys 335 of MetRS and Lys 557 of ValRS belong to the consensus tRNA CCA binding Lys Met Ser Lys Ser sequence [ Hountondji , C . , Dessen , P . , & Blanquet , S . ( 1986 ) Biochimie 68 , 1071 1078 ] . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^ |
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| Interacting proteins: P26640 and P56192 |
Pubmed |
SVM Score :0.0 |
| The alignments also indicate that the class 1 synthetases may be partitioned into two subgroups : a ) MetRS , IleRS , LeuRS , ValRS , CysRS and ArgRS ; b ) GlnRS , GluRS , TyrRS and TrpRS . . ^^^ |
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