| Interacting proteins: P12544 and P26583 |
Pubmed |
SVM Score :0.0 |
| HMG 2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T lymphocyte protease granzyme A . ^^^ HMG 2 , like SET and APE , is a physiologically relevant granzyme A substrate in targeted cells . ^^^ Granzyme A cleavage after Lys 65 in the midst of HMG box A destroys HMG 2 mediated DNA binding and bending functions . ^^^ Granzyme A cleavage and functional disruption of key nuclear substrates , including HMG 2 , SET , APE , lamins , and histones , are likely to cripple the cellular repair response to promote cell death in this novel caspase independent death pathway . . ^^^ |
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| Interacting proteins: P12544 and P26583 |
Pubmed |
SVM Score :0.0 |
| A special target of the granzyme A cell death pathway is an endoplasmic reticulum associated complex , called the SET complex , which contains three granzyme A substrates , the nucleosome assembly protein SET , the DNA bending protein HMG 2 , and the base excision repair endonuclease Ape 1 . ^^^ |
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| Interacting proteins: P12544 and P26583 |
Pubmed |
SVM Score :0.0 |
| A GzmA activated DNase ( GAAD ) is in an ER associated complex containing pp 32 and the GzmA substrates SET , HMG 2 , and Ape 1 . ^^^ |
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| Interacting proteins: P12544 and P26583 |
Pubmed |
SVM Score :0.0 |
| Limited proteolysis of a high molecular mass complex containing SET ( also named putative HLA associated protein 2 or PHAPII ) , PHAPI ( pp 32 , leucine rich acidic nuclear protein ) and HMG 2 by GzmA liberates NM 23 H1 , a Mg2+ dependent DNase that causes single stranded breaks in nuclear DNA . ^^^ |
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