We describe the identification of eight novel mouse NATs associated with transcription factors ( Pax 6 , Pax 2 , Six 3 , Six 6 , Otx 2 , Crx , Rax and Vax 2 ) that play an important role in eye development and function . ^^^ |
CGIs in putative promoter regions of 34 genes ( ABHD 9 , BARHL 1 , CLIC 5 , CNNM 1 , COL2A1 , CPT1C , DDIT4L , DERL 3 , DHRS 3 , DPYS , EFEMP 2 , FAM62C , FAM78A , FLJ 33790 , GBX 2 , GPR 10 , GPRASP 1 , HOXA 9 , HOXD 11 , HOXD 12 , HOXD 13 , p14ARF , PAX 6 , PRDX 2 , PTPRG , RASD 1 , RAX , REC8L1 , SLC27A3 , TGFB 2 , TLX 2 , TMEM 22 , TMEM30B , and UNC5C ) were found to be methylated in at least 1 of 13 melanoma cell lines but not in two cultured normal melanocytes . ^^^ |