| Interacting proteins: P58304 and P26367 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P58304 and P26367 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P58304 and P26367 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P58304 and P26367 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P58304 and P26367 |
Pubmed |
SVM Score :0.0 |
| The genetic linkages of the murine ocular retardation mutation with the Chx 10 gene and the murine small eye mutation with the Pax 6 gene has demonstrated the importance of Paired class homeobox genes in the development of the mammalian retina . ^^^ |
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| Interacting proteins: P58304 and P26367 |
Pubmed |
SVM Score :0.0 |
| No significant changes were observed in the number of other retinal neurons , including those that express RA 4 ( ganglion cells ) , pax 6 ( ganglion cells and amacrine cells ) , and chx 10 ( bipolar cells ) . ^^^ |
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| Interacting proteins: P58304 and P26367 |
Pubmed |
SVM Score :0.0 |
| Furthermore , cells in the ciliary epithelium and retinal margin coexpressed the homeodomain transcription factors Pax 6 and Chx 10 , similar to multipotent progenitors of embryonic retina . ^^^ Expression of PCNA , Pax 6 , and Chx 10 in cells at the retinal margin was maintained in adult birds . ^^^ |
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| Interacting proteins: P58304 and P26367 |
Pubmed |
SVM Score :0.0 |
| We identified clones encoding homeodomain ( HD ) transcription factors Pax 6 , Rx , and Chx 10 and a novel paired like HD protein , RINX . ^^^ |
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| Interacting proteins: P58304 and P26367 |
Pubmed |
SVM Score :0.0 |
| In addition to activating expression of RPE specific genes , the extraocular mesenchyme inhibits the expression of the neural retina specific transcription factor Chx 10 and downregulates the eye specific transcription factors Pax 6 and Optx 2 . ^^^ |
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| Interacting proteins: P58304 and P26367 |
Pubmed |
SVM Score :0.0 |
| Surprisingly , GST pull down assays revealed that the homeodomains of such diverse proteins as Chx 10 , Six 3 , Lhx 2 , En 1 , Prep 1 , Prox 1 , and HoxB 1 could all bind to Pax 6 , and several of these enhanced Pax 6 mediated transactivation upon coexpression . ^^^ |
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| Interacting proteins: P58304 and P26367 |
Pubmed |
SVM Score :0.0 |
| In response to acute damage , numerous Mller glia re entered the cell cycle , and shortly thereafter , expressed CASH 1 , Pax 6 and Chx 10 , transcription factors expressed by embryonic retinal progenitors . ^^^ Some of these newly formed cells differentiated into retinal neurons , a few formed Mller glia , and most remained undifferentiated , with continued expression of Pax 6 and Chx 10 . ^^^ |
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| Interacting proteins: P58304 and P26367 |
Pubmed |
SVM Score :0.0 |
| A total of 84 / 122 of the MAC cases were screened for mutations in the coding regions of PAX 6 , CHX 10 , and SIX 3 . ^^^ |
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| Interacting proteins: P58304 and P26367 |
Pubmed |
SVM Score :0.0 |
| Pax 6 , Prox 1 , and Chx 10 homeobox gene expression correlates with phenotypic fate of retinal precursor cells . ^^^ PURPOSE : To study the expression patterns of the homeobox genes Pax 6 , Prox 1 , and Chx 10 during chick retinal development in vivo and in vitro . ^^^ In situ hybridization was carried out on tissue sections using digoxigenin labeled sense and antisense RNA probes that recognize chicken Pax 6 and Prox 1 ( whose sequences were already available ) , and chicken Chx 10 ( which was cloned and sequenced as part of this study ) . ^^^ CONCLUSIONS : These results suggest that the differentiated fate of retinal precursor cells may be influenced by Pax 6 , Prox 1 , or Chx 10 , this hypothesis is now being tested using dissociated chick embryo retinal cell cultures . . ^^^ |
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| Interacting proteins: P58304 and P26367 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : The homeobox genes Pax 6 and Chx 10 are diffusely expressed in proliferating , undifferentiated retina neuroepithelial cells . ^^^ METHODS : Neural retinas from 5 day old chick embryos were dissociated , cultured at low density , and cotransfected with a plasmid expressing the green fluorescent protein ( GFP ) reporter gene , and a plasmid expressing Pax 6 , Chx 10 , Optx 2 , or the control gene lacZ . ^^^ RESULTS : Nonphotoreceptor neurons increased threefold with Chx 10 and almost sixfold with Pax 6 , compared with cells transfected with lacZ . ^^^ The frequency of GFP ( + ) cells immunoreactive with the ganglion cell specific antibody RA 4 was unchanged by Chx 10 , but was increased twofold by Pax 6 . ^^^ Conversely , Chx 10 and Pax 6 expression diminished the photoreceptor population to approximately 35 % and 15 % of control values , as determined by morphologic analysis , visinin immunocytochemistry , and peanut lectin binding . ^^^ |
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| Interacting proteins: P58304 and P26367 |
Pubmed |
SVM Score :0.0 |
| Although insulin or FGF 2 alone had no effect , the combination of insulin and FGF 2 caused Mller glia to coexpress transcription factors common to retinal progenitors ( Pax 6 and Chx 10 ) and initiated a wave of proliferation in Mller cells that began at the retinal margin and spread into peripheral regions of the retina . ^^^ Most of the newly formed cells remain undifferentiated , expressing Pax 6 and Chx 10 , whereas some differentiate into Mller glia , and a few differentiate into neurons that express the neuronal markers Hu or calretinin . ^^^ |
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| Interacting proteins: P58304 and P26367 |
Pubmed |
SVM Score :0.0 |
| Dlx 1 , Dlx 2 , Pax 6 , Brn3b , and Chx 10 homeobox gene expression defines the retinal ganglion and inner nuclear layers of the developing and adult mouse retina . ^^^ At E13 . 5 , the expression of four homeodomain proteins , DLX 2 , BRN3b , PAX 6 , and CHX 10 , define distinct yet overlapping domains in the retinal neuroepithelium . ^^^ In the adult , DLX 2 is coexpressed with BRN3b in ganglion cells ; PAX 6 in amacrine , horizontal , and ganglion cells ; and Chx 10 in some bipolar cells . ^^^ |
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| Interacting proteins: P58304 and P26367 |
Pubmed |
SVM Score :0.0 |
| METHODS : Expression of transcription factor genes , Crx , Pou4f2 , and Pax 6 , that mark specific cell types as they begin to differentiate was analyzed by RNA in situ hybridization of retina from wild type and Chx 10 null ocular retardation mice ( Chx 10 ( or J / or J ) ) . ^^^ |
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| Interacting proteins: P58304 and P26367 |
Pubmed |
SVM Score :0.0 |
| Retinal progenitor properties were identified by the capacity to proliferate and by the expression of the progenitor markers Nestin , Flk 1 , Chx 10 , Pax 6 and the radial glia marker BLBP . ^^^ |
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| Interacting proteins: P58304 and P26367 |
Pubmed |
SVM Score :0.0 |
| Assuming a founder effect in each of the families , we performed homozygosity mapping using polymorphic markers adjacent to human homologues of genes known to be associated with eye absence in various species , namely EYA 1 , EYA 2 , EYA 3 , SIX 4 , SIX 6 , PAX 6 and CHX 10 . ^^^ |
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| Interacting proteins: P58304 and P26367 |
Pubmed |
SVM Score :0.0 |
| The defects in optic vesicle development correlate with reduced expression of Chx 10 , which is also required for retina development ; Rx , Lhx 2 , and Pax 6 expression is not significantly affected . ^^^ |
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| Interacting proteins: P58304 and P26367 |
Pubmed |
SVM Score :0.0 |
| By mutation analyses and molecular modeling we now demonstrate that , surprisingly , the recognition helix for specific DNA binding of the homeodomains of Pax 6 and Chx 10 interacts with the C terminal RED subdomain of the paired domain of Pax 6 . ^^^ |
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| Interacting proteins: P58304 and P26367 |
Pubmed |
SVM Score :0.0 |
| Putative genes of anophthalmia and microphthalmia reported to date include PAX 6 ( Glaser T et al 1994 ) and CHX 10 ( Ferda Percin E et al 2000 ) . ^^^ |
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| Interacting proteins: P58304 and P26367 |
Pubmed |
SVM Score :0.0 |
| GF activated CB epithelial cells co express the retinal progenitor homeodomain transcription factors Pax 6 and Chx 10 . ^^^ |
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