| Interacting proteins: P48431 and P26367 |
Pubmed |
SVM Score :1.1230994 |
| We demonstrate that Pax 6 initiates lens development by forming a molecular complex with SOX 2 on the lens specific enhancer elements , e . g . , the delta crystallin minimal enhancer DC 5 . 1.1230994^^^ However , Pax 6 binds cooperatively with SOX 2 to the DC 5 sequence , resulting in formation of a high mobility form of ternary complex in vitro , which correlates with the enhancer activation in vivo . 1.1172098^^^ |
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| Interacting proteins: P48431 and P26367 |
Pubmed |
SVM Score :0.0 |
| Together these experiments show that the chicken delta crystallin enhancers show lens preference in transgenic mice despite the absence of delta crystallin in this species and add retinoic acid nuclear receptors to the growing list of transcription factors ( including Pax 6 , Sox 2 , and delta EF 3 ) that directly or indirectly contribute to the high expression of the delta 1 crystallin gene in the lens . . ^^^ |
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| Interacting proteins: P48431 and P26367 |
Pubmed |
SVM Score :0.0 |
| This phenotype partially overlaps with those reported for gene targeting of Prox 1 and Sox 1 ; however , expression of these genes is grossly normal , as is expression of Eya 1 , Eya 2 , Pax 6 , and Sox 2 . ^^^ |
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| Interacting proteins: P48431 and P26367 |
Pubmed |
SVM Score :0.0 |
| The formation of the lens pre placode appears to be unaffected in heterozygotes , as deduced from the number of cells , the mitotic index , the amount of apoptosis and the expression of SOX 2 and Pax 6 in the pre placode . ^^^ |
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| Interacting proteins: P48431 and P26367 |
Pubmed |
SVM Score :0.0 |
| This analysis establishes a role for Fgfr signaling in lens induction and defines a genetic pathway in which Fgfr and Bmp 7 signaling converge on Pax 6 expression in the lens placode with the Foxe 3 and Sox 2 genes lying downstream . . ^^^ |
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| Interacting proteins: P48431 and P26367 |
Pubmed |
SVM Score :0.0 |
| In early development , Pax 6 , Sox 2 and Six 3 are expressed in the head ectoderm , while L maf , Prox 1 and crystallin genes are expressed at a later stage in the lens placode in a more restricted fashion . ^^^ |
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| Interacting proteins: P48431 and P26367 |
Pubmed |
SVM Score :0.0 |
| Distinct roles of SOX 2 , Pax 6 and Maf transcription factors in the regulation of lens specific delta 1 crystallin enhancer . ^^^ It has been indicated that the SOX 2 , Pax 6 and Maf proteins are the major regulators of lens cell differentiation . ^^^ RESULTS : We defined the major binding sites of SOX 2 , Pax 6 and Maf transcription factors in the delta 1 crystallin enhancer and assessed the effect of mutations at these sites in the cultured lens epithelial cells and in developing lenses of transgenic mouse embryos . ^^^ |
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| Interacting proteins: P48431 and P26367 |
Pubmed |
SVM Score :0.0 |
| The defects in lens placode development correlate with delayed and insufficient expression of Foxe 3 , which is also required for lens development , while Maf , Sox 2 , Six 3 and PAX 6 levels are not significantly affected . ^^^ |
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| Interacting proteins: P48431 and P26367 |
Pubmed |
SVM Score :0.0 |
| The proximal half of the LE 9 sequence contains three plausible sites of HMG domain recognition , and HMG domain containing transcription factors Sox 2 and Sox 3 activated LE 9 synergistically with Pax 6 . ^^^ Furthermore , Pax 6 and Sox 2 proteins formed a complex when they were expressed together . ^^^ Based on these findings , we propose a model in which Pax 6 protein directly and positively regulates its own gene expression , and Sox 2 and Sox 3 proteins interact with Pax 6 protein , resulting in modification of the transcriptional activation by Pax 6 protein . . ^^^ |
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| Interacting proteins: P48431 and P26367 |
Pubmed |
SVM Score :0.0 |
| Here we show among various growth factors injected in an intact eye , a single injection of FGF 2 specifically caused morphological changes of the iris characteristic of lens regeneration , induced expression of transcription factor genes Pax 6 , Sox 2 and MafB , as well as endogenous Fgf 2 in both dorsal and ventral halves , and provoked second lens development only from the dorsal iris . ^^^ |
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| Interacting proteins: P48431 and P26367 |
Pubmed |
SVM Score :0.0 |
| We analyzed the spatiotemporal pattern of expression of 15 transcription factors ( Six 1 , Six 4 , Eya 1 , Sox 3 , Sox 2 , Pax 6 , Pax 3 , Pax 2 , Pax 8 , Dlx 3 , Msx 1 , FoxI1c , Tbx 2 , Tbx 3 , Xiro 1 ) during placode development in Xenopus laevis from neural plate to late tail bud stages . ^^^ |
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| Interacting proteins: P48431 and P26367 |
Pubmed |
SVM Score :0.0 |
| These include Pax 6 , the Meis transcription factors , Six 3 , Mab21l1 , FoxE 3 , Prox 1 and Sox 2 . ^^^ |
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| Interacting proteins: P48431 and P26367 |
Pubmed |
SVM Score :0.0 |
| Interplay of Pax 6 and SOX 2 in lens development as a paradigm of genetic switch mechanisms for cell differentiation . ^^^ These factors have been identified as SOX1 / 2 / 3 ( Group B 1 SOX proteins , SOX 2 being the major player ) and Pax 6 , and have been shown to bind cooperatively to DC 5 and form a ternary complex having a robust potency for transcriptional activation . ^^^ Thus , the cooperative action of Pax 6 and SOX 2 initiates lens differentiation . ^^^ Thus , the regulation of SOX 2 ( and SOX1 / 3 ) and its partner factors , exemplified by Pax 6 , determines the spatio temporal order of the occurrence of cell differentiation . . ^^^ |
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| Interacting proteins: P48431 and P26367 |
Pubmed |
SVM Score :0.0 |
| Here , we review mechanisms of lens preferred expression of crystallin genes by employing synergism between developmentally regulated DNA binding transcription factors : Pax 6 , c Maf , MafA / L Maf , MafB , NRL , Sox 2 , Sox 1 , RARbeta / RXRbeta , RORalpha , Prox 1 , Six 3 , gammaFBP B and HSF 2 . ^^^ Pax 6 forms functional complexes with a number of transcription factors including the retinoblastoma protein , pRb , MafA , Mitf and Sox 2 . ^^^ |
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| Interacting proteins: P48431 and P26367 |
Pubmed |
SVM Score :0.0 |
| Raldh 2 ( / ) embryos exhibited neural induction ( activation ) as evidenced by expression of Sox 1 and Sox 2 along the neural plate , but differentiation of spinal cord neuroectodermal progenitor cells ( posterior transformation ) did not occur as demonstrated by a loss of Pax 6 and Olig 2 expression along the posterior neural plate . ^^^ |
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| Interacting proteins: P48431 and P26367 |
Pubmed |
SVM Score :0.0 |
| An overexpression of sox 2 , sox 10 , pax 6 , fzd , erbB 2 , and erbB 4 is found in nestin positive MSCs . ^^^ |
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| Interacting proteins: P48431 and P26367 |
Pubmed |
SVM Score :0.0 |
| DC 5 contains PAX 6 and SOX 2 binding sites , and its activity depends on the cooperative binding of these two transcription factors . ^^^ To test the idea that Pax 6 and Sox 2 , together with the DC 5 enhancer , could form a basic regulatory circuit functional in distantly related animals , we introduced the DC 5 fragment into Drosophila and studied its activation pattern and regulation . ^^^ However , regulation of the DC 5 enhancer is carried out not by Pax 6 , but by Pax 2 ( D Pax 2 ; shaven FlyBase ) in combination with the Sox 2 homologue SoxN . ^^^ |
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| Interacting proteins: P48431 and P26367 |
Pubmed |
SVM Score :0.0 |
| Agonistic and antagonistic action of AP 2 , Msx 2 , Pax 6 , Prox 1 AND Six 3 in the regulation of Sox 2 expression . ^^^ Taking our data together , AP 2 , Pax 6 and PROX 1 can activate the Sox 2 promoter . ^^^ |
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| Interacting proteins: P48431 and P26367 |
Pubmed |
SVM Score :0.0 |
| The proteins Pax 6 , Emx 2 , Sox 2 , 3 and Olig 1 were predominantly localized to dividing neural precursors while the factors Sox 1 , Ngn 1 , Dlx 1 , 5 , Olig 2 and Nkx2 . 2 were mainly expressed by neuronal precursors . ^^^ |
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| Interacting proteins: P48431 and P26367 |
Pubmed |
SVM Score :0.0 |
| Analysis of gene expression after knockdown of xMADML revealed significant alterations in the expression of some genes , including Pax 6 , xSix 3 , Sox 2 , and Sox 3 , suggesting that xMADML plays a role in regulating gene expression during development of the eye . ^^^ |
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| Interacting proteins: P48431 and P26367 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48431 and P26367 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48431 and P26367 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48431 and P26367 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48431 and P26367 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48431 and P26367 |
Pubmed |
SVM Score :0.0 |
| NA |
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