| Immunohistochemistry confirmed PBX 1 over expression and its cytoplasmic sequestration in ductal cells of obese subjects , associated with pronounced islet neogenesis ( cytokeratin 19 / chromogranin A double labeling ) . cDNA microarray analysis also showed up regulation of other genes implicated in islet regeneration , including betacellulin , laminin , TGFa , NeuroD 1 , Pax 6 , substantiating the role of the islet neogenesis pathway in human obesity . . ^^^ |