| Interacting proteins: O75030 and P26367 |
Pubmed |
SVM Score :0.0 |
| In the mouse , only a few genes have been definitively associated with a small eye phenotype ; the paired box gene Pax 6 and the gene coding for the microphthalmia associated transcription factor ( Mitf ) . ^^^ |
|
| Interacting proteins: O75030 and P26367 |
Pubmed |
SVM Score :0.0 |
| The expression patterns of pax 6 and Mitf are complementary both in vivo in vitro . ^^^ Overexpression of Mitf inhibited expression of pax 6 in cultured rPECs . ^^^ These observations suggest that Mitf regulates pax 6 expression negatively . . ^^^ |
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| Interacting proteins: O75030 and P26367 |
Pubmed |
SVM Score :0.0 |
| Expression of PEC specific genes , mmp 115 , tyrosinase , and TRP 1 , was downregulated , but that of Mitf and pax 6 was upregulated in B / B PECs . ^^^ |
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| Interacting proteins: O75030 and P26367 |
Pubmed |
SVM Score :0.0 |
| The affected genes have been identified for a number of the recovered mutations including Cryga , Crygb , Cgyge , Pax 6 , Pax 2 , Mitf , Lim 2 , and Cx 50 . ^^^ |
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| Interacting proteins: O75030 and P26367 |
Pubmed |
SVM Score :0.0 |
| Pax 6 and microphthalmia transcription factor ( Mitf ) are required for proper eye development . ^^^ In the present study , we investigated the interaction between Pax 6 and Mitf . ^^^ In transient transfection expression experiments , we found that transactivating effects of Pax 6 and Mitf on their respective target promoters were strongly inhibited by co transfection of both transcription factors . ^^^ This repression was due to direct protein / protein interactions involving both Pax 6 DNA binding domains and the Mitf b HLH LZ domain . ^^^ These results suggest that Pax 6 / Mitf interactions may be critical for retinal pigmented epithelium development . . ^^^ |
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| Interacting proteins: O75030 and P26367 |
Pubmed |
SVM Score :0.0 |
| Pigmented cells at the retinal margin expressed mitf and pax 6 , transcription factors that are transiently expressed by the developing RPE . ^^^ |
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| Interacting proteins: O75030 and P26367 |
Pubmed |
SVM Score :0.0 |
| A combination of genetic mapping , complementation and molecular analysis revealed that 14 of these are mutations in genes previously identified to play a role in eye pathophysiology , namely Pax 6 , Mitf , Egfr and Pde6b . ^^^ |
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| Interacting proteins: O75030 and P26367 |
Pubmed |
SVM Score :0.0 |
| Pax 2 ; Pax 6 compound mutants display a dose dependent reduction in the expression of the melanocyte determinant Mitf , accompanied by transdifferentiation of retinal pigmented epithelium ( RPE ) into neuroretina ( NR ) in Pax 2 ( / ) ; Pax 6 ( + / ) embryos , which strongly resembles the phenotype of Mitf null mutants . ^^^ In Pax 2 ( / ) ; Pax 6 ( / ) OVs Mitf fails to be expressed and NR markers occupy the area that usually represents the Mitf ( + ) RPE domain . ^^^ Furthermore , both , Pax 2 and Pax 6 bind to and activate a MITF RPE promoter element in vitro , whereas prolonged expression of Pax 6 in the Pax 2 positive optic stalk leads to ectopic Mitf expression and RPE differentiation in vivo . ^^^ |
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| Interacting proteins: O75030 and P26367 |
Pubmed |
SVM Score :0.0 |
| In Mitf mutant mice , the presumptive RPE cells hyperproliferate , abnormally express the retinal transcriptional regulator Pax 6 , and form an ectopic neural retina . ^^^ In vitro , transcriptional regulation by Drosophila Mitf , like its mouse counterpart , is modified by the Eyeless ( Drosophila Pax 6 ) transcription factor . ^^^ |
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| Interacting proteins: O75030 and P26367 |
Pubmed |
SVM Score :0.0 |
| Here , we have outlined many recent findings that suggest that a limited number of transcription factors , including Otx 2 , Mitf and Pax 6 and a few signalling cascades , are the elements required for the onset of RPE specification in vertebrates . ^^^ |
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| Interacting proteins: O75030 and P26367 |
Pubmed |
SVM Score :0.0 |
| Loss of optic vesicle RA signaling does not effect expression of early determinants of retina at the optic vesicle stage ( Pax 6 , Six 3 , Rx , Mitf ) . ^^^ |
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| Interacting proteins: O75030 and P26367 |
Pubmed |
SVM Score :0.0 |
| Pax 6 forms functional complexes with a number of transcription factors including the retinoblastoma protein , pRb , MafA , Mitf and Sox 2 . ^^^ |
|
| Interacting proteins: O75030 and P26367 |
Pubmed |
SVM Score :0.0 |
| Moreover , the expression of Pax 6 was increased by Mitf siRNA ( to 143 . 5+ / 18 . 0 % ) ( P < 0 . 0005 ) , and induced dedifferentiation of the RPE cells . ^^^ |
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| Interacting proteins: O75030 and P26367 |
Pubmed |
SVM Score :0.0 |
| The expression of early ocular markers ( MITF , Pax 6 , Six 3 , Otx ) in migrated cells and in MNCs isolated from granulocyte colony stimulating factor ( G CSF ) and Flt 3 ligand ( FL ) mobilized and nonmobilized peripheral blood ( PB ) was analyzed by real time RT PCR . ^^^ |
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| Interacting proteins: O75030 and P26367 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75030 and P26367 |
Pubmed |
SVM Score :0.0 |
| NA |
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