| Interacting proteins: Q14242 and P26038 |
Pubmed |
SVM Score :0.65237624 |
| Interaction of PSGL 1 with moesin was shown in HL 60 cell lysates by isolating a complex with glutathione S transferase fusions of the cytoplasmic domain of PSGL 1 . 0.65237624^^^ The adhesion molecules PSGL 1 and ICAM 3 were found to colocalize with the cytoskeletal protein moesin in the uropod of stimulated neutrophils . 0.60472106^^^ |
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| Interacting proteins: Q14242 and P26038 |
Pubmed |
SVM Score :0.63907833 |
| The PSGL 1 cytoplasmic domain interacted selectively with the ezrin / radixin / moesin ( ERM ) protein moesin , but not with other ERM proteins or several other cytoskeletal linker proteins . 0.63907833^^^ |
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| Interacting proteins: Q14242 and P26038 |
Pubmed |
SVM Score :0.0 |
| A juxta membrane amino acid sequence of P selectin glycoprotein ligand 1 is involved in moesin binding and ezrin / radixin / moesin directed targeting at the trailing edge of migrating lymphocytes . ^^^ Dynamic fluorescence videomicroscopy analyses of migrating lymphocytes demonstrated that PSGL 1 and moesin redistributed towards the cellular uropod at the trailing edge of these cells , where activated ezrin / radixin / moesin ( ERM ) proteins were located . ^^^ An eighteen amino acid sequence in the juxta membrane region of the PSGL 1 cytoplasmic tail was found to be critical for uropod targeting and moesin binding . ^^^ Substitution of S 336 , S 348 , and the basic cluster R337K338 by alanines within this region significantly impaired both moesin binding and PSGL 1 polarization . ^^^ These results underline the role of moesin in the subcellular redistribution of PSGL 1 in lymphoid cells and make evident the importance of specific serine residues within the cytoplasmic tail of PSGL 1 for this process . . ^^^ |
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| Interacting proteins: Q14242 and P26038 |
Pubmed |
SVM Score :0.0 |
| Treatment of cells with the Syk inhibitor piceatannol and overexpression of either a Syk dead kinase mutant or an ITAM mutated moesin abrogated PSGL 1 induced transcriptional activation . ^^^ These data unveil a new functional role for the ERMs ( ezrin / radixin / moesin ) as adaptor molecules in the interactions of adhesion receptors and intracellular tyrosine kinases and show that PSGL 1 is a signaling molecule in leukocytes . . ^^^ |
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| Interacting proteins: Q14242 and P26038 |
Pubmed |
SVM Score :0.0 |
| NA |
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