| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.89696358 |
| These data indicate that ezrin and radixin can be functionally substituted , that moesin has some synergetic functional interaction with ezrin and radixin , and that these ERM family members are involved in cell cell and cell substrate adhesion , as well as microvilli formation . . 0.89696358^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The ERM ( Ezrin , Radixin , Moesin ) family members were colocalized with RhoA at all of these sites . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The ERM proteins ezrin , radixin , and moesin occur in particular cortical cytoskeletal structures . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Moesin is a member of a recently discovered family of closely related proteins that includes ezrin , radixin , and merlin . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| A novel moesin , ezrin , radixin like gene is a candidate for the neurofibromatosis 2 tumor suppressor . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| A novel moesin , ezrin , radixin like gene is a candidate for the neurofibromatosis 2 tumor suppressor . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Recent cloning of the murine and porcine radixin cDNAs revealed a protein highly homologous to ezrin and moesin . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| This superfamily of proteins includes ezrin , moesin , radixin , and talin , as well as several protein tyrosine phosphatases . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Recombinant radixin and moesin , ezrin related proteins , also bound RII in blot overlay . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The ERM proteins ezrin , radixin , and moesin are key players in membrane cytoskeleton interactions . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Ezrin , radixin , moesin and merlin form a subfamily of conserved proteins in the band 4 . 1 superfamily . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Moesin , ezrin , and radixin ( MER ) are components of the cortical actin cytoskeleton and membrane processes such as filopodia and microvilli . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The protein shares the domain structure of three homologous proteins : ezrin , radixin and moesin ( ERM ) . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Members of this ERM family of proteins include ezrin , radixin , and moesin . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The encoded protein , Merlin , is closely related to the Ezrin , Radixin , and Moesin family of membrane / cytoskeletal linker proteins . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The ERM protein ezrin , but not radixin or moesin , is markedly increased due to calpain inhibition . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| ERM ( ezrin , radixin and moesin ) proteins function as linkers between the actin cytoskeleton and the plasma membrane . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Moesin is a member of the ERM family consisting of ezrin , radixin , and moesin . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The Rho subfamily members regulate ERM ( ezrin , radixin and moesin ) dependent association of the actin cytoskeleton with the plasma membrane . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Levels of ezrin and moesin , proteins related to the NF 2 gene product , merlin , were unchanged in schwannoma cells compared to NHSC . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Labeling for actin binding proteins moesin and ezrin was negative in both the wt virus and the VLP . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Ezrin , radixin , moesin and merlin form a subfamily of conserved proteins in the band 4 . 1 superfamily . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| ERM ( ezrin , radixin , moesin ) proteins act as linkers between the plasma membrane and the actin cytoskeleton . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| These exons encode a FERM ( F , ezrin , radixin and moesin ) domain that may interact with integral membrane proteins . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Pez is a non transmembrane tyrosine phosphatase with homology to the FERM ( 4 . 1 , ezrin , radixin , moesin ) family of proteins . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| This assumption is based on the homology of the NF 2 protein to a group of band 4 . 1 related proteins , ezrin , radixin , and moesin . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The ERM proteins ( ezrin , radixin , and moesin ) function as membrane cytoskeletal linkers . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| This occurs through a previously unrecognized structural link between NHE 1 and the actin binding proteins ezrin , radixin , and moesin ( ERM ) . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Ezrin , radixin , and moesin constitute a family of proteins that link the plasma membrane to the actin cytoskeleton . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Moesin binds to a large range of proteins through its N terminal FERM ( band 4 . 1 , ezrin , radixin , moesin ) domain . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The NF 2 encoded protein , merlin , belongs to the ERM ( ezrin , radixin , and moesin ) family of cytoskeleton : membrane linkers . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Ezrin is a member of the ezrin , radixin , and moesin family . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The ERM ( ezrin , radixin and moesin ) family of proteins are linkers that tether actin microfilaments to the plasma membrane . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Ezrin , Radixin and Moesin ( ERM ) proteins are thought to constitute a bridge between the actin cytoskeleton and the plasma membrane ( PM ) . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The ERM proteins ( ezrin , radixin , moesin ) together with merlin comprise a subgroup of the band 4 . 1 superfamily . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The Nf 2 encoded protein , merlin , is related to the ERM ( ezrin , radixin , and moesin ) family of membrane : cytoskeleton associated proteins . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| In this region , ezrin , radixin , and moesin show 60 65 % identity , as compared with the 86 % identity in the whole FERM domain . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Detailed biochemical analysis showed an association of moesin and in a later stage ezrin with ICAM 3 upon crosslinking in HBMEC . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The NF 2 tumor suppressor protein , merlin , is related to the ERM ( ezrin , radixin , and moesin ) family of membrane / F actin linkers . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Cytoskeleton proteins and their associated proteins ezrin , moesin , actinin 4 , desmoplakin , and fascin were also detected . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Ezrin , Radixin , and Moesin ( the ERM proteins ) supply regulated linkage between membrane proteins and the actin cytoskeleton . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Actin linking proteins ezrin , moesin , RhoA , and RhoGDI were conveyed into Fas enriched rafts in drug treated leukemic cells . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Ezrin is a member of ezrin , radixin , moesin ( ERM ) protein family that links F actin to membranes . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| We have recently shown that advanced glycation products ( AGEs ) bind to the ERM ( ezrin , radixin , moesin ) family of proteins . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| ERM proteins ( ezrin , radixin , and moesin ) have recently been identified as a new class of AGE binding proteins . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The major actors in this connection are ezrin , radixin and moesin , a family of proteins with a high level of homology . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Here , we observed that band 4 . 1 , ezrin and moesin , members of the band 4 . 1 superfamily , are also able to open stable holes in liposomes . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| A gene family consisting of ezrin , radixin and moesin . ^^^ Sequence analysis has demonstrated that this protein is a mouse homologue of human moesin ( 98 . 3 % identity ) and that it shares 71 . 7 % and 80 . 1 % identity with ezrin and radixin , respectively . ^^^ Translation experiments in vitro combined with immunoblot analyses led us to conclude that there is a gene family consisting of ezrin , radixin and moesin . ^^^ We conclude that at least one of the members of the ezrin radixin moesin family is concentrated at specific regions where actin filaments are densely associated with plasma membranes . . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Moesin : a member of the protein 4 . 1 talin ezrin family of proteins . ^^^ Furthermore , our data indicate that moesin is identical to the 77 kDa band that copurifies with ezrin in its isolation from human placenta [ Bretscher , A . ( 1989 ) J . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| These proteins , including ezrin , radixin , and moesin , probably function as molecular linking proteins , connecting the cytoskeleton to the cell membrane . ^^^ On the grounds of the homology to the ezrin , radixin , and moesin proteins and on the basis of its predicted secondary structure , the NF 2 protein is also thought to act as a cytoskeleton cell membrane linking protein . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The ERM family members , ezrin , radixin , and moesin , localizing just beneath the plasma membranes , are thought to be involved in the actin filament / plasma membrane association . ^^^ Immunoprecipitation with various anti CD 44 mAbs showed that ezrin and radixin , as well as moesin , are associated with CD 44 , not only in BHK cells , but also in mouse L fibroblasts . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Analysis of a cortical cytoskeletal structure : a role for ezrin radixin moesin ( ERM proteins ) in the marginal band of chicken erythrocytes . ^^^ In recent years , two proteins with a high degree of homology to ezrin were identified : moesin and radixin , together comprising the ERM protein family . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The protein moesin is a member of a gene family consisting of talin , ezrin , radixin , protein 4 . 1 . , and merlin . ^^^ As a prominent feature , moesin as strongly expressed in endothelium of vessels in contrast to radixin and ezrin . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Moesin , ezrin , and p 205 are actin binding proteins associated with neutrophil plasma membranes . ^^^ The 78 and 81 kDa polypeptides were identified as moesin and ezrin , respectively , by co migration on sodium dodecyl sulfate polyacrylamide gel electrophoresis and immunoprecipitation with antibodies specific for moesin and ezrin . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Using specific cDNA probes we have studied the expression of the mRNAs encoding ezrin and moesin , two members of a class of proteins that connect the microvillar cytoskeleton to the plasma membrane , during the process of enterocyte maturation that occurs both in the embryonic and in the adult small intestine , along the crypt villus axis . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Although there was no evidence for distinct hotspots , all mutations occurred in the first 13 exons , the region of homology with the filopodial proteins moesin , ezrin , and radixin . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The 80 kDa protein was identified as ezrin and the 77 and 72 kDa proteins as gastric forms of proteins structurally related to ezrin , such as radixin and moesin . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The recently isolated gene for neurofibromatosis type 2 ( NF 2 ) encodes a 595 amino acid protein , named merlin , which is related to the cytoskeleton associated proteins moesin , ezrin and radixin . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Although the entire merlin ezrin radixin moesin ( MERM ) homology domain of merlin was found to be essential for binding to all five proteins , the MERM homology domains of ezrin and moesin did not bind to any of the five proteins . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Previously , we have cloned a candidate for the 595 amino acid neurofibromatosis type 2 tumor suppressor called NF 2 or Merlin , with striking sequence similarity in its N terminal half to an F actin binding protein family called TERM , which includes talin , ezrin , radixin , and moesin ( Trofatter , J . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The region corresponding to the COOH terminal actin binding site in ezrin is highly conserved in moesin , actin capping protein radixin and EM 10 protein of E . multilocularis , but not in merlin / schwannomin . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Ezrin is concentrated in the apical microvilli of a wide variety of epithelial cells whereas moesin is found primarily in endothelial cells . ^^^ Ezrin and moesin are two cytoskeletal proteins originally purified from human placenta that are 74 % identical in overall protein sequence . ^^^ To determine if ezrin and moesin share similar distributions in vivo , we studied their localizations with respect to F actin in tissue sections . ^^^ Surprisingly , ezrin and moesin exhibited very different cellular distributions . ^^^ All polarized cell types with abundant microvilli contained one or both proteins , suggesting that ezrin and moesin perform related functions . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Heterotypic and homotypic associations between ezrin and moesin , two putative membrane cytoskeletal linking proteins . ^^^ Ezrin and moesin are components of actin rich cell surface structures that are thought to function as membrane cytoskeletal linking proteins . ^^^ Here we show that a stable complex of ezrin and moesin can be isolated from cultured cells by immunoprecipitation with specific antibodies . ^^^ In addition to the heterotypic association of ezrin and moesin , homotypic binding of ezrin to ezrin and of moesin to moesin was also demonstrated in vitro . ^^^ These results suggest mechanisms by which ezrin and moesin might participate in dynamic aspects of cortical cytoskeletal structure . . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Comparison of the closely related sequences of human , murine and porcine moesin , ezrin and radixin with a protein from Echinococcus multilocularis , an evolutionarily quite distant human parasite , reveals several highly invariant domains in the aminoterminal and carboxyterminal regions . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Moesin , like ezrin , colocalizes with actin in the cortical cytoskeleton in cultured cells , but its expression is more variable . ^^^ Within this superfamily are three members , ezrin , radixin and moesin , that show approx . 75 % overall sequence identity . ^^^ A comparison of the domain structure and intracellular localization of ezrin and moesin in cultured cells is reported here . ^^^ Limited proteolytic digestion of ezrin or moesin yields a relatively stable 32 kDa domain derived from the amino terminal region that is homologous to the protease resistant membrane binding domain of erythrocyte band 4 . 1 . ^^^ We have generated polyclonal antibodies that discriminate between ezrin and moesin , and do not react with radixin . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The Merlin gene product belongs to a family of proteins which include moesin , ezrin and radixin , involved in linking the cytoskeleton to the cell membrane . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| One of these cDNAs encodes radixin , a protein belonging to the band 4 . 1 family of proteins and highly related to ezrin and moesin . ^^^ In addition the generation of antibodies specific for either radixin , ezrin or moesin allowed us to show that a previously described tumor transplantation antigen is indeed ezrin , thus implicating this protein in the determination of the biological phenotype of certain tumors . . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Soluble ezrin purified from placenta exists as stable monomers and elongated dimers with masked C terminal ezrin radixin moesin association domains . ^^^ Since radixin and moesin , the two other members of the closely related ERM protein family , both contain N and C ERMADs , the results we have documented and models proposed for ezrin are likely to apply to radixin and moesin as well . . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The gene for NF 2 , a syndrome typically associated with vestibular schwannomas and meningiomas , is homologous with a family of genes whose members appear to play an important role in bridging the cell membrane with the intracellular cytoskeleton , including moesin , ezrin , radixin , and protein 4 . 1 . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The NF 2 gene is homologous to a family of genes whose products , including moesin , ezrin , radixin and protein 4 . 1 , appear to have an important role in bridging the cell membrane and the intracellular cytoskeletion . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The ERM protein ezrin , radixin , moesin localize to a variety of cortical structures , where they may participate in connecting the cytoskeleton to components of the plasma membrane . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| It bears striking similarity to the ERM proteins , ezrin , radixin and moesin , members of the protein 4 . 1 superfamily that link proteins in the cytoskeleton and the plasma membrane . ^^^ Merlin does not localize to the same structures as either ezrin or moesin in human meningioma cells , suggesting a function distinct from these ERMs . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Regulation mechanism of ERM ( ezrin / radixin / moesin ) protein / plasma membrane association : possible involvement of phosphatidylinositol turnover and Rho dependent signaling pathway . ^^^ The ERM proteins , ezrin , radixin , and moesin , are involved in the actin filament / plasma membrane interaction as cross linkers . ^^^ To examine the CD44 / ERM protein interaction in vitro , we produced mouse ezrin , radixin , moesin , and the glutathione S transferase ( GST ) / CD44 cytoplasmic domain fusion protein ( GST CD44cyt ) by means of recombinant baculovirus infection , and constructed an in vitro assay for the binding between ERM proteins and the cytoplasmic domain of CD 44 . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The data revealed that three types of cytoskeletal proteins are present in virions at different concentrations relative to the molar level of Gag : actin ( approximately 10 to 15 % ) , ezrin and moesin ( approximately 2 % ) , and cofilin ( approximately 2 to 10 % ) . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| We studied the immunohistochemical localization of CD 44 , hyaluronate receptor , and the ezrin radixin moesin ( ERM ) family , actin binding proteins , in bone cells using confocal laser scanning microscopy and transmission electron microscopy to clarify the mechanism of the organization of their cytoskeletons . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| ERM ( ezrin / radixin / moesin ) family : from cytoskeleton to signal transduction . ^^^ The ERM family consists of three closely related proteins , ezrin , radixin , and moesin , that are thought to work as cross linkers between plasma membranes and actin based cytoskeletons . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Ezrin , radixin and moesin are possible auto immune antigens in rheumatoid arthritis . ^^^ It was found that three cytoplasmic molecules with molecular weights of 80 , 000 , 81 , 000 and 77 , 000 were immunoreactive and they were identified as ezrin ( E ) , radixin ( R ) , and moesin ( M ) , respectively , by partial amino acid sequencing . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| As to the functioning sites of Rho , Rho regulates formation of stress fibers and focal adhesions in many types of cultured cells , whereas we have shown that the association sites of actin filaments with the plasma membrane controlled by the ERM ( Ezrin , Radixin , Moesin ) family are the functioning sites of Rho in MDCK cells stably expressing myc RhoA . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Merlin is structurally related to ezrin , radixin and moesin , which are also expressed in the CNS , as demonstrated by Western blotting . ^^^ The pattern of merlin expression , however , is distinct from that of ezrin , which has been previously described , and that of moesin , in which immunohistochemistry with an anti moesin antibody showed expression in endothelial cells , glia and neurons in a membranous or diffuse cytoplasmic pattern . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Among the released proteins , we identified , in addition to annexin 2 itself , the cortical cytoskeletal proteins alpha actinin , ezrin and moesin , and membrane associated actin . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| We have previously identified the 78 , 80 , and 81 kD proteins as moesin , radixin , and ezrin , respectively . ^^^ Thus , it appears that F actin blot overlays provide an efficient assay for simultaneous monitoring of a subset of F actin binding proteins , including p30a , ponticulin , moesin , radixin , ezrin , p 205 , and drebrin . . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Specific binding of HIV 1 envelope protein gp 120 to the structural membrane proteins ezrin and moesin . ^^^ Two of seven prominent proteins eluted from the gp 120 affinity column specifically bound gp 120 in Western blot overlay experiments and were identified by subsequent immunoblotting and microsequencing as ezrin and moesin , members of the ERM ( ezrin , radixin , moesin ) family of cellular structural membrane proteins . ^^^ Antibodies to ezrin and moesin specifically recognized the eluted gp 120 binding proteins confirming their identification . ^^^ Ezrin and moesin are structural proteins binding to the cellular membrane and to several cytoskeletal and transmembrane proteins . ^^^ Our results suggest that ezrin and moesin might play a role as gp160 / gp120 binding proteins during the uptake , the assembly or the budding of HIV . . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The NF 2 gene encodes a tumor suppressor protein , schwannomin ( or merlin ) , with sequence homology to erythrocyte band 4 . 1 , talin , ezrin , moesin and radixin . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Rho and rac dependent assembly of focal adhesion complexes and actin filaments in permeabilized fibroblasts : an essential role for ezrin / radixin / moesin proteins . ^^^ Using recombinant proteins , we show that moesin and its close relatives ezrin and radixin can reconstitute stress fiber assembly , cortical actin polymerization and focal complex formation in response to activation of Rho and Rac . . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Identification of EBP 50 : A PDZ containing phosphoprotein that associates with members of the ezrin radixin moesin family . ^^^ Members of the ezrin radixin moesin ( ERM ) family of membrane cytoskeletal linking proteins have NH 2 and COOH terminal domains that associate with the plasma membrane and the actin cytoskeleton , respectively . ^^^ To search for ERM binding partners potentially involved in membrane association , tissue lysates were subjected to affinity chromatography on the immobilized NH 2 terminal domains of ezrin and moesin , which comprise the ezrin radixin moesin association domain ( N ERMAD ) . ^^^ Recombinant EBP 50 binds tightly to the N ERMADs of ezrin and moesin . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| When compared with normoxic cells , hypoxic keratinocytes exhibited increased expression and redistribution of the lamellipodia associated proteins ( ezrin , radixin , and moesin ) . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| In addition , the role of the merlin related ERM family members ( ezrin , radixin , and moesin ) remains unclear in these tumors . ^^^ We therefore studied expression of NF 2 encoded merlin as well as ezrin , radixin , and moesin in 22 vestibular and peripheral schwannomas that had been evaluated for NF 2 mutations and chromosome 22q loss . ^^^ Western blotting with antibodies directed against ezrin , radixin , and moesin , however , showed expression of these proteins in all schwannomas . ^^^ These data indicate that the specific loss of merlin is universal to schwannomas and is not linked to loss of ezrin , radixin , or moesin expression . . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The ERM proteins ( ezrin , radixin , and moesin ) are a group of band 4 . 1 related proteins that are proposed to function as membrane / cytoskeletal linkers . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Rho kinase phosphorylates COOH terminal threonines of ezrin / radixin / moesin ( ERM ) proteins and regulates their head to tail association . ^^^ The ezrin / radixin / moesin ( ERM ) proteins are involved in actin filament / plasma membrane interaction that is regulated by Rho . ^^^ Next , to detect Rho kinase dependent phosphorylation of ERM proteins in vivo , we raised a mAb that recognized the T 564 phosphorylated radixin as well as ezrin and moesin phosphorylated at the corresponding threonine residue ( T 567 and T 558 , respectively ) . ^^^ Immunoblotting of serum starved Swiss 3T3 cells with this mAb revealed that after LPA stimulation ERM proteins were rapidly phosphorylated at T 567 ( ezrin ) , T 564 ( radixin ) , and T 558 ( moesin ) in a Rho dependent manner and then dephosphorylated within 2 min . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The Neurofibromatosis 2 gene product , merlin , has striking similarity to ezrin , radixin , and moesin ( ERM ) , members of the protein 4 . 1 family which have been demonstrated to connect proteins in the plasma membrane to the cytoskeletal components . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Schwannomin itself lacks the actin binding sites found in ezrin , radixin and moesin , suggesting that signalling to the actin cytoskeleton occurs via actin binding sites on betaII spectrin . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| We found that in MDCK epithelial cells , MBS accumulated at the tetradecanoylphorbol 13 acetate ( TPA ) induced membrane ruffling area , where moesin , a member of the ERM ( ezrin , radixin , and moesin ) family , was localized . ^^^ Recombinant MBS interacted with the amino terminal domains of moesin and ezrin . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The encoded protein , merlin , is closely related to ezrin , radixin , and moesin , which are members of the band 4 . 1 family of membrane / cytoskeletal linker proteins . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Merlin , the product of the Neurofibromatosis type 2 ( NF 2 ) tumor suppressor gene , is a member of the protein 4 . 1 superfamily that is most closely related to ezrin , radixin , and moesin ( ERM ) . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The ERM ( ezrin , radixin and moesin ) family members , located just beneath the plasma membranes , are thought to be involved in the association of action filaments with the plasma membrane . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Moesin , one of the ERM ( ezrin ; radixin ; moesin ) family members , is directly associated with the cytoplasmic domain of CD 44 , which is now thought to be related to the metastatic potential of tumor cells . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The neurofibromatosis type 2 ( NF 2 ) tumor suppressor gene encodes merlin , a protein with homology to the cell membrane / F actin linking proteins , moesin , ezrin and radixin . ^^^ As is true for ezrin , moesin and radixin , the N and C terminal domains of merlin type 1 bind to each other . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Ezrin , radixin and moesin ( ERM proteins ) link cell adhesion molecules to the cytoskeleton , modulate cell morphology and cell growth and are involved in Rho mediated signal transduction . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| A 17 amino acid sequence was identified of which amino acids 2 17 matched exactly a portion of moesin , a membrane cytoskeletal linking protein and member of the ERM ( ezrin / radixin / moesin ) family . ^^^ Intestinal brush borders of mice and rats expressed ezrin but not moesin . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The protein encoded by the NF 2 gene has striking similarities to ezrin , radixin and moesin ( ERM ) proteins which link membrane proteins to the cytoskeleton . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The actin binding protein moesin , which belongs to the ERM family of ezrin , radixin and moesin , redistributes to the distal portion of uropods and physically interacts with ICAM 3 , CD 44 and CD 43 , thus acting as a physical link between the membrane molecules and the actin cytoskeleton . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Rho associated kinase ( Rho kinase ) , which is activated by the small GTPase Rho , regulates formation of stress fibers and focal adhesions , myosin fiber organization , and neurite retraction through the phosphorylation of cytoskeletal proteins , including myosin light chain , the ERM family proteins ( ezrin , radixin , and moesin ) and adducin . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Disruption of dynamic cell surface architecture of NIH3T3 fibroblasts by the N terminal domains of moesin and ezrin : in vivo imaging with GFP fusion proteins . ^^^ Lamellipodia , filopodia , microspikes and retraction fibers are characteristic features of a dynamic and continuously changing cell surface architecture and moesin , ezrin and radixin are thought to function in these microextensions as reversible links between plasma membrane proteins and actin microfilaments . ^^^ These are devoid of actin , endogenous moesin , ezrin and radixin , but contain the GFP labeled domain . ^^^ While a large proportion of endogenous proteins can be extracted with non ionic detergents as in untransfected control cells , > 90 % of N moesin and > 60 % of N ezrin and N radixin remain insoluble . ^^^ The data suggest that , in the absence of the carboxy terminal domain , N moesin , ezrin and radixin interact tightly with the plasma membrane and interfere with normal functions of endogeneous proteins mainly during retraction . . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Ezrin belongs to a family of plasma membrane cytoskeleton linking , actin binding proteins ( Ezrin radixin Moesin family ) involved in signal transduction , growth control , cell cell adhesion , and microvilli formation . ^^^ Distinct from its other family members , moesin and radixin , which are predominantly expressed in glomerular endothelial and mesangial areas , ezrin protein ( by immunohistochemistry ) was specifically and exclusively modulated during podocyte injury and regeneration . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Normal development of mice and unimpaired cell adhesion / cell motility / actin based cytoskeleton without compensatory up regulation of ezrin or radixin in moesin gene knockout . ^^^ Ezrin / radixin / moesin ( ERM ) proteins are general cross linkers between the plasma membrane and actin filaments . ^^^ In the tissues of the mutant mice , moesin completely disappeared without affecting the expression levels or subcellular distribution of ezrin and radixin . ^^^ Also , in platelets , fibroblasts , and mast cells isolated from moesin deficient mice , targeted disruption of the moesin gene did not affect their ERM dependent functions , i . e . platelet aggregation , stress fiber / focal contact formation of fibroblasts , and microvillar formation of mast cells , without compensatory up regulation of ezrin or radixin . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The ERM ( ezrin radixin moesin ) proteins are believed to provide such links , with the N terminal halves associating with integral membrane proteins , either directly or indirectly through adapter molecules like EBP 50 ( ERM binding phosphoprotein , 50 kDa ) , and their C terminal halves associating with F actin . ^^^ Here we show that C terminal phosphorylation of full length , dormant ezrin and moesin by protein kinase C theta simultaneously unmasks both the F actin and EBP 50 binding sites . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The ERM proteins , ezrin , radixin , and moesin , act as linkers between the plasma membrane and actin cytoskeleton . ^^^ The genomic structures of ezrin and moesin are highly conserved , suggesting their recent divergence . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Moesin , the major ERM protein of lymphocytes and platelets , differs from ezrin in its insensitivity to calpain . ^^^ The ERM proteins , ezrin , radixin and moesin , provide regulated linkage of the cytoskeleton with the plasma membrane , particularly in cell surface projections . ^^^ Ezrin and moesin were found co expressed , and radixin was not detected , in human blood lymphocytes , monocytes and neutrophils . ^^^ A striking difference was discovered : sensitivity of ezrin and resistance of moesin ( and radixin ) to calpain . ^^^ In intact stimulated lymphocytes , ezrin was cleaved , while moesin was not , strongly suggesting that differential sensitivity to calpain contributes to specialized functions of these proteins . . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Merlin , which shares significant homology with the actin associated proteins ezrin , radixin and moesin ( ERM proteins ) , inhibits cell growth when overexpressed in cell lines . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The band 4 . 1 domain was first identified in the red blood cell protein band 4 . 1 , and subsequently in ezrin , radixin , and moesin ( ERM proteins ) and other proteins , including tumor suppressor merlin / schwannomin , talin , unconventional myosins VIIa and 10 , and protein tyrosine phosphatases . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Ezrin , radixin and moesin ( ERM ) are homologous proteins , which are linkers between plasma membrane components and the actin containing cytoskeleton . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| CD 43 interacts with moesin and ezrin and regulates its redistribution to the uropods of T lymphocytes at the cell cell contacts . ^^^ Immunofluorescence analysis showed that all three ezrin radixin moesin ( ERM ) actin binding proteins localized in the uropod of both human T lymphoblasts stimulated with anti CD 43 MoAb and tumor infiltrating T lymphocytes . ^^^ Radixin localized at the uropod neck , whereas ezrin and moesin colocalized with CD 43 in the uropod . ^^^ Biochemical analyses showed that ezrin and moesin coimmunoprecipitated with CD 43 in T lymphoblasts . ^^^ The interaction of moesin and ezrin with CD 43 was specifically mediated by the cytoplasmic domain of CD 43 , as shown by precipitation of both ERM proteins with a GST fusion protein containing the CD 43 cytoplasmic tail . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Ezrin , radixin and moesin , collectively known as the ERM proteins , are a group of closely related membrane cytoskeleton linkers that regulate cell adhesion and cortical morphogenesis . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| We show in this study that the membrane cytoskeleton linker , ezrin , a member of the ERM ( ezrin , radixin , moesin ) family , plays an active role in the process of Shigella uptake . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Concomitant with TPA induced CD 44 cleavage , TPA treatment induces redistribution of CD 44 and ERM proteins ( ezrin , radixin , and moesin ) to newly generated membrane ruffling areas . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The protein encoded by the NF 2 gene has a similarity to ezrin , radixin and moesin ( ERM ) proteins that link membrane proteins to the cytoskeleton . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| When activated , ERM ( ezrin , radixin , moesin ) proteins are recruited to the plasma membrane , with concomitant carboxy terminal threonine phosphorylation , where they crosslink actin filaments to the plasma membrane to form microvilli ( reviewed in [ 1 ] [ 2 ] [ 3 ] [ 4 ] [ 5 ] ) . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Merlin , the neurofibromatosis 2 tumor suppressor protein , has two major isoforms with alternate C termini and is related to the ERM ( ezrin , radixin , moesin ) proteins . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Confocal and immunoelectron microscopy analysis in cultured cells reveal that PA 2 . 26 is concentrated in actin rich microvilli and plasma membrane projections , such as filopodia , lamellipodia and ruffles , where it colocalizes with members of the ERM ( ezrin , radixin , moesin ) family protein . ^^^ Ezrin and moesin , but not radixin , can be coimmunoprecipitated together with PA2 . 26 from cell lysates . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The ERM protein family members ezrin , radixin , and moesin are cytoskeletal effector proteins linking actin to membrane bound proteins at the cell surface . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Ezrin , a member of the ezrin / radixin / moesin ( ERM ) family , localizes to microvilli of epithelia in vivo , where it bridges actin filaments and plasma membrane proteins . ^^^ In the adult rat RPE , only ezrin ( no moesin or radixin ) was detected at high levels by immunofluorescence and immunoelectron microscopy at microvilli and basal infoldings . ^^^ Transfection of ezrin cDNA into the RPE J cell line , which has only trace amounts of ezrin and moesin , sparse and stubby apical microvilli , and no basal infoldings , induced maturation of microvilli and the formation of basal infoldings without changing moesin expression levels . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Involvement of ezrin / moesin in de novo actin assembly on phagosomal membranes . ^^^ Peripheral membrane proteins are crucial components of this actin assembly machinery , and we demonstrate a role for ezrin and / or moesin in this process . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The Neurofibromatosis 2 tumor suppressor gene encodes Merlin , a member of the Protein 4 . 1 superfamily most closely related to Ezrin , Radixin and Moesin . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Polarization and interaction of adhesion molecules P selectin glycoprotein ligand 1 and intercellular adhesion molecule 3 with moesin and ezrin in myeloid cells . ^^^ Bands of 78 and 81 kd were identified as moesin and ezrin by Western blot analysis . ^^^ These results suggest that the redistribution of PSGL 1 and its association with intracellular molecules , including the ezrin radixin moesin actin binding proteins , regulate functions mediated by PSGL 1 in leukocytes stimulated by chemoattractants . . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Radixin is a member of the ERM ( ezrin / radixin / moesin ) family of cytoskeletal linkers . ^^^ The 3 ' UTR of moesin , but not ezrin , was also conserved , suggesting an essential , and possibly specific , regulatory function . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Yeast two hybrid screening of a mouse brain cDNA library identified radixin , a member of the ERM family of three closely related proteins ( ezrin , radixin , and moesin ) , as a protein that interacted with Galpha ( 13 ) . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The subgroup of protein tyrosine phosphatases that contain an N terminal ezrin , radixin and moesin homology ( ERM ) domain and a C terminal catalytic domain is represented by three enzymes in Jurkat T cells , PTPH 1 , PTP MEG 1 and PTP 36 . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The NF 2 gene product , merlin ( or schwannomin ) , is a member of the protein 4 . 1 family of membrane associated proteins , which also includes ezrin , radixin and moesin . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| In vitro binding assays identified the C terminal `` 4 . 1 , ezrin , radixin , moesin ' ' ( FERM ) like domain of myosin VIIA as the interacting domain . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Under these conditions the CD 44 proteins recruit ERM proteins for example , ezrin or moesin to their cytoplasmic tails , thereby producing links to the cytoskeleton . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| One possibility is the phosphorylation of a 78 kDa mast cell protein , two fragments of which are homologous to moesin , a member of the ezrin , radixin , moesin family . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : ERM ( ezrin , radixin , and moesin ) proteins function as membrane cytoskeletal linkers , and are known to be localized at filopodia and microvilli like structures . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Both processes are inhibited by the ROCK inhibitor Y 27632 , which also inhibits association of ezrin with the cytoskeleton , and phosphorylation of T 567 , conserved between ezrin and its relatives radixin and moesin . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The ezrin , radixin , and moesin protein family members , which are present underneath the apical plasma membrane , potentially act to link the cytoskeleton and membrane proteins . ^^^ We have also analyzed the protein pattern and mRNA expression of ezrin and moesin in RL 95 2 cells versus HEC 1 A cells . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The product of the neurofibromatosis type 2 ( NF 2 ) tumor suppressor gene , merlin , is closely related to the ezrin radixin moesin ( ERM ) family , a group of proteins believed to link the cytoskeleton to the plasma membrane . ^^^ Merlin lacks an actin binding domain conserved among ezrin , radixin and moesin . ^^^ Because merlin , ezrin and moesin are co expressed in Schwann cells , and all homodimerize , we have examined whether merlin and ezrin dimerize with one another . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Radixin is a member of the ERM ( ezrin / radixin / moesin ) protein family that is proposed to function as a membrane cytoskeletal linker . ^^^ Similarly , moesin and ezrin mRNA levels were reduced in lung adenocarcinoma . ^^^ Ezrin was localized in the apical surface of non neoplastic bronchiolar and alveolar epithelial cells and , in contrast to radixin and moesin , the majority of tumor cells retained expression of ezrin . ^^^ Although structurally related to radixin and moesin , ezrin may have a distinct function in tumor cell invasion . . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| NHE RF , a regulatory cofactor for NHE ( Na ( + ) H ( + ) exchanger ) type 3 , interacts with ion transporters and receptors through its PDZ domains and with the MERM proteins ( merlin , ezrin , radixin and moesin ) via its carboxyl terminus . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Homology analysis indicates that merlin is most closely related to members of the protein 4 . 1 superfamily especially ezrin , radixin and moesin , the ERM proteins . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Nodes of Ranvier form in association with ezrin radixin moesin ( ERM ) positive Schwann cell processes . ^^^ As the ezrin radixin moesin ( ERM ) proteins are expressed in the microvilli of many epithelial cells , we have examined the expression and distribution of these proteins in Schwann cells and neurons in vitro and in vivo . ^^^ Cultured Schwann cells express high levels of all three proteins and the ezrin binding protein 50 , whereas neurons express much lower , although detectable , levels of radixin and moesin . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The ERM proteins , ezrin , radixin , and moesin , regulate cell motility by linking cortical F actin to the plasma membrane in different cell types . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| In addition , we discuss the discovery of a pair of intriguing domains , the Myosin Tail Homology 4 ( MyTH 4 ) and FERM ( band 4 . 1 , Ezrin , Radixin , Moesin ) domains , that are present in the tails of otherwise very different myosins as well as a plant kinesin like protein . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The neurofibromatosis 2 ( NF 2 ) gene encodes merlin , an ezrin radixin moesin ( ERM ) related protein that functions as a tumor suppressor . ^^^ At low cell density , merlin is phosphorylated , growth permissive , and exists in a complex with ezrin , moesin , and CD 44 . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The highly homologous ERM ( ezrin / radixin / moesin ) proteins , molecular cross linkers which connect the cell membrane with the underlying cytoskeleton , have molecular weights of 81 , 80 and 78 kDa respectively . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The neurofibromatosis 2 protein product merlin , named for its relatedness to the ezrin , radixin and moesin ( ERM ) family of proteins , is a tumour suppressor whose absence results in the occurrence of multiple tumours of the nervous system , particularly schwannomas and meningiomas . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Talin resembles ERM ( ezrin , radixin , moesin ) proteins in possessing an N terminal FERM ( band four point one , ezrin , radixin , moesin ) domain . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Because moesin was shown to be highly expressed in growth cones and moesin / radixin suppression led to impaired structure and function of this key element in brain development , we tested the ERM family , ezrin , radixin , and moesin , in fetal Down syndrome ( DS ) cortex at the early second trimester . ^^^ Moesin was shown to be significantly and manifold reduced in fetal DS brain , whereas reduction of ezrin and radixin did not reach statistical significance . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Thus , talin contains two integrin binding sites , one in the homologous FERM ( band four point one , ezrin , radixin , moesin ) domain and another near its C terminus . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The terminal portion of the Janus kinases ( Jaks ) contains a divergent FERM ( Four point one , Ezrin , Radixin , Moesin ) homology domain comprising 19 conserved hydrophobic regions . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The protein 4 . 1 , ezrin , radixin , moesin ( FERM ) domain of Drosophila Coracle , a cytoplasmic component of the septate junction , provides functions essential for embryonic development and imaginal cell proliferation . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The FERM PTPs are a group of proteins that have FERM ( Band 4 . 1 , ezrin , radixin , moesin homology ) domains at or near their N termini , and PTP ( protein tyrosine phosphatase ) domains at their C termini . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The cytoplasmic tail of L selectin interacts with members of the Ezrin Radixin Moesin ( ERM ) family of proteins : cell activation dependent binding of Moesin but not Ezrin . ^^^ By using this approach , members of the Ezrin Radixin Moesin family of proteins were found to interact specifically with the cytoplasmic tail of L selectin . ^^^ Furthermore , the PKC inhibitor Ro 31 8220 significantly reduced the interaction of moesin , but not ezrin , with L selectin . ^^^ Alanine mutations of membrane proximal basic amino acid residues in the cytoplasmic domain of L selectin identified arginine 357 as a critical residue for both ezrin and moesin interaction . ^^^ Based on these findings , although moesin and ezrin bind to a similar region of the cytoplasmic tail of L selectin , moesin binding is dependent on PKC activation , which suggests that ezrin and moesin are regulated differently in lymphocytes . . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Immunofluorescence microscopy of adult rat eyes detected a polarized distribution of ERM ( ezrin , radixin , and moesin ) binding phosphoprotein of 50 kDa ( EBP 50 ) at the apical microvilli and synaptic associated protein of 97 kDa ( SAP 97 ) at the basolateral surface of RPE cells , which overlapped with ezrin . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| To this end , we have studied the presence of ezrin , radixin , and moesin ( ERM proteins ) in the rat hippocampus and in primary cultured astrocytes , applying immunoperoxidase , immunofluorescence , and immunogold techniques . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| On the basis of some evidence suggesting P glycoprotein actin cytoskeleton interaction , this study investigated the association of P glycoprotein with ezrin , radixin , and moesin , a class of proteins that cross link actin filaments with plasma membrane in a human cell line of lymphoid origin and that have been shown to link other ion pump related proteins . ^^^ To this purpose , a multidrug resistant variant of CCRF CEM cells ( CEM VBL 100 ) was used as a model to investigate the following : ( 1 ) the cellular localizations of P glycoprotein and ezrin , radixin , and moesin and their molecular associations ; and ( 2 ) the effects of ezrin , radixin , and moesin antisense oligonucleotides on multidrug resistance and P glycoprotein function . ^^^ The results showed that : ( 1 ) P glycoprotein colocalized and coimmunoprecipitated with ezrin , radixin , and moesin ; and ( 2 ) treatment with antisense oligonucleotides for ezrin , radixin , and moesin restored drug susceptibility consistently with inhibition of both drug efflux and actin P glycoprotein association and induction of cellular redistribution of P glycoprotein . ^^^ These data suggest that P glycoprotein association with the actin cytoskeleton through ezrin , radixin , and moesin is key in conferring to human lymphoid cells a multidrug resistance phenotype . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The Nf 2 tumor suppressor gene product merlin is related to the membrane cytoskeleton linker proteins of the band 4 . 1 superfamily , including ezrin , radixin , and moesin ( ERMs ) . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The cause of the disease has been traced to mutations in the gene coding for a protein that is alternately called merlin or schwannomin and is a member of the ERM family ( ezrin , radixin and moesin ) . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| These protrusions , like microvilli , are highly enriched in ezrin and moesin , two members of the ERM ( ezrin / radixin / moesin ) family , whereas vinculin and paxillin are absent . ^^^ We thus propose that following pilus mediated adhesion , capsulated N . meningitidis recruit ERM binding transmembrane proteins , as well as ezrin and moesin , and that both Rho and Cdc 42 are critical for the subsequent cytoskeletal modifications responsible for the formation of microvilli like cellular protrusions and bacterial internalization . . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The ezrin / radixin / moesin ( ERM ) proteins are regulated microfilament membrane linking proteins . ^^^ Previous tissue localization studies have revealed that the three related proteins show distinct tissue distributions , with ezrin being found predominantly in polarized epithelial cells , whereas moesin is enriched in endothelial cells and lymphocytes . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| We have reconstituted actin assembly using a defined membrane surface , the latex bead phagosome ( LBP ) , and shown that the PI ( 4 , 5 ) P ( 2 ) binding proteins ezrin and / or moesin were essential for this process ( ) . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Ezrin and moesin , human proteins that functionally link the cytoskeleton to the plasma membrane , were identified as Sic binding proteins by affinity chromatography and matrix assisted laser desorption / ionization time of flight mass spectrometry analysis . ^^^ Sic colocalized with ezrin inside epithelial cells and bound to the F actin binding site region located in the carboxyl terminus of ezrin and moesin . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The intracellular domain of L 1 bound to ezrin , a member of the ezrin , radixin , and moesin ( ERM ) family of membrane cytoskeleton linking proteins , at a site overlapping that for AP 2 , a clathrin adaptor . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Dynamic interaction of VCAM 1 and ICAM 1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes . ^^^ Ezrin , radixin , and moesin ( ERM ) regulate cortical morphogenesis and cell adhesion by connecting membrane adhesion receptors to the actin based cytoskeleton . ^^^ We have studied the interaction of moesin and ezrin with the vascular cell adhesion molecule ( VCAM ) 1 during leukocyte adhesion and transendothelial migration ( TEM ) . ^^^ VCAM 1 interacted directly with moesin and ezrin in vitro , and all of these molecules colocalized at the apical surface of endothelium . ^^^ During leukocyte adhesion in static or under flow conditions , VCAM 1 , ICAM 1 , and activated moesin and ezrin clustered in an endothelial actin rich docking structure that anchored and partially embraced the leukocyte containing other cytoskeletal components such as alpha actinin , vinculin , and VASP . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Ezrin and moesin expression within the developing human cerebrum and tuberous sclerosis associated cortical tubers . ^^^ The ERM ( ezrin , radixin , and moesin ) proteins belong to the band 4 . 1 superfamily of membrane cytoskeleton linking proteins which bind to the actin cytoskeleton via their C terminal sequences and bind ERM binding membrane proteins ( ERMBMPs ) . ^^^ We investigated the immunohistochemical expression of two of the ERM proteins ( ezrin and moesin ) in developing human cerebral cortex and in cortical tubers from patients with tuberous sclerosis ( TSC ) , to assess possible consequences of TSC gene product malfunction or inactivation in the developing brain in relation to ERM protein expression . ^^^ Ezrin is abundantly expressed within radial glia and migrating cells in the intermediate zone in the prenatal human cerebrum , while moesin is primarily expressed in vascular endothelial cells in developing and adult human brain and scattered microglia in adult brain . ^^^ In addition , both ezrin and moesin are abundantly co expressed with hamartin and tuberin within a population of abnormal cells in TSC associated cortical tubers . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| We also found that Na ( + ) , K ( + ) ATPase seemed to be colocalized with ERM proteins phosphorylated at T 567 ( ezrin ) , T 564 ( radixin ) , and T 558 ( moesin ) in cells microinjected with RhoA ( Val 14 ) . . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Differential expression and distribution of ezrin , radixin and moesin in human natural killer cells . ^^^ In this study the expression and subcellular distribution of ezrin , radixin and moesin , a family of proteins that connect actin filaments to many membrane structures , were evaluated in human NK cells . ^^^ Only ezrin changed its distribution following IL 2 activation and all three ezrin , moesin and radixin were polarized on uropods of adherent natural killer cells . ^^^ Ezrin and radixin co localized with the perforin granules at the intimate sites of contact between NK and the target cells , while moesin remains uniformly distributed on the membrane of NK cells . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| This association is mediated by the actin linking proteins moesin and ezrin , which directly interact with Syk in an ITAM dependent manner . ^^^ These data unveil a new functional role for the ERMs ( ezrin / radixin / moesin ) as adaptor molecules in the interactions of adhesion receptors and intracellular tyrosine kinases and show that PSGL 1 is a signaling molecule in leukocytes . . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Ezrin and moesin co localise with ICAM 1 in brain endothelial cells but are not directly associated . ^^^ The ERM proteins ezrin and moesin were found to strongly co localise with both ICAM 1 and F actin in brain microvascular endothelial cells suggesting a potential role in mediating ICAM 1 signalling . ^^^ Cross linking of ICAM 1 demonstrated ICAM 1 clustering which no longer associated with ezrin or moesin . ^^^ Together these data suggest that ICAM 1 is not directly associated with ezrin and moesin in brain microvascular endothelial cells . . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Ezrin is a member of the ERM ( ezrin , radixin , moesin ) family of proteins that cross link the actin cytoskeleton to the plasma membrane and also may function in signaling cascades that regulate the assembly of actin stress fibers . ^^^ Structural comparison among the dormant moesin FERM domain structure and the three known active FERM domain structures ( radixin , moesin , and now ezrin ) allows the clear definition of regions that undergo structural changes during activation . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| First , we highlight results from our in vitro analysis of the role of the cytoskeletal ezrin , radixin , moesin adapter proteins in the exclusion of CD 43 from the well defined T cell receptor ( TCR ) and integrin rich zones of the synapse . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| CD 43 movement was found to depend on ezrin and moesin , members of the ERM family , which serve to link CD 43 and other cargo molecules to the actin cytoskeleton . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The three dimensional structure contains , starting from the N terminus , FERM ( 4 . 1 , ezrin , radixin , moesin ) , SH 2 ( Src homology region 2 ) , tyrosine kinase like , and tyrosine kinase domains . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| ERM ( ezrin , radixin , moesin ) proteins have been proposed to link transmembrane proteins to the actin cytoskeleton in the apical domain , suggesting a structural role in epithelial cells , and they have been implicated in signalling pathways . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The FERM ( four point one , ezrin , radixin , and moesin ) domain of talin engages integrins via a novel variant of the canonical phosphotyrosine binding ( PTB ) domain NPxY ligand interaction that may be a prototype for FERM domain recognition of transmembrane receptors . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Its short intracellular domain contains a conserved motif ( GNP motif ) capable of binding protein 4 . 1 domains [ FERM domains ( four point one , ezrin , radixin , moesin ) ] . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| In this paper we show by sequence analysis through mass spectrometry as well as by immunoblotting that pasin 2 is identical to moesin , a member of the FERM ( protein 4 . 1 , ezrin , radixin , moesin ) protein family , all members of which have been shown to serve as cytoskeletal adaptor molecules . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The amino terminal domains of the ezrin , radixin , and moesin ( ERM ) proteins bind advanced glycation end products , an interaction that may play a role in the development of diabetic complications . ^^^ NH 2 terminal and internal sequencing identified the proteins as the NH 2 terminal domains of ezrin , radixin , and moesin ( ERM proteins ) . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| PTPL 1 is the largest known cytoplasmic protein tyrosine phosphatase ( PTP ) containing a FERM ( four point 1 , ezrin , radixin and moesin ) domain . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Host proteins located internally in the virus ( actin , moesin , and ezrin ) and membrane associated host proteins ( major histocompatibility complex classes 1 and 2 ) remained associated with the treated virions . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| METHODS AND RESULTS : Mass spectrometry of 3 proteins in the size range of our phosphoprotein resulted in the identification of ezrin / villin2 , moesin , and PDZ domain containing 1 ( PDZ dc 1 ) . ^^^ Ezrin and moesin are membrane cytoskeletal linking proteins that are involved in the regulation of the sodium hydrogen exchanger ( NHE 3 ) via interactions with another PDZ protein identified as sodium hydrogen exchanger regulatory factor ( EBP 50 , NHERF ) . ^^^ Ezrin , moesin , and PDZ dc 1 protein levels were not increased following short term VE . ^^^ Two dimensional electrophoresis of our phosphorylated BBM proteins , followed by MALDI / MS analysis resulted in the identification of a protein mixture containing ezrin / moesin , alkaline phosphatase , and an unknown protein . ^^^ Based on Western and immunoprecipitation data for ezrin , moesin , and PDZ dc 1 we believe that it is unlikely that our phosphoprotein is any of these 3 proteins . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Using a myelinating explant culture system , we have observed that SCs reorganize and polarize microvillar components , such as the ezrin binding phosphoprotein 50 kD / regulatory cofactor of the sodium hydrogen exchanger isoform 3 ( NHERF 1 ) , actin , and the activated ezrin , radixin , and moesin family proteins before myelination in response to inductive signals . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Recent findings in hippocampal cell culture show that members of the ERM family of proteins ( ezrin , radixin , and moesin ) can also serve as MCLs between L 1 and actin in neurons . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Phosphoinositides , ezrin / moesin , and rac 1 regulate fusion of rhodopsin transport carriers in retinal photoreceptors . ^^^ Proteomic analysis of RTCs accumulated upon Ppl treatment showed a significant decrease in phosphatidylinositol 4 , 5 bisphosphate binding proteins ezrin and / or moesin . ^^^ By confocal microscopy , ezrin / moesin and rac 1 colocalized with rab 8 on RTCs at the sites of their fusion with the plasma membrane ; however , this distribution was lost upon Ppl treatment . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Functional activities and cellular localization of the ezrin , radixin , moesin ( ERM ) and RING zinc finger domains in MIR . ^^^ Myosin regulatory light chain interacting protein ( MIR ) belongs to the ezrin , radixin , moesin ( ERM ) family of proteins involved in membrane cytoskeleton interactions and cell dynamics . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Differential expression of ezrin / radixin / moesin ( ERM ) and ERM associated adhesion molecules in the blastocyst and uterus suggests their functions during implantation . ^^^ In the present investigation , we examined the possibility for a potential cross talk between the blastocyst and uterus involving the ezrin / radixin / moesin ( ERM ) proteins and ERM associated cytoskeletal cross linker proteins CD 43 , CD 44 , ICAM 1 , and ICAM 2 . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| In the peripheral nervous system , they are covered by Schwann cells microvilli , where three homologous cytoskeletal associated proteins , ezrin , radixin and moesin ( ERM proteins ) have been found , to be enriched . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| ERM ( ezrin , radixin , moesin ) family members link polarized proteins with cytoskeletal actin . ^^^ However , in differentiated cells , ezrin and moesin were selectively localized to apical membranes of ciliated airway cells and were absent from secretory cells . ^^^ Interestingly , Foxj 1 expression was also required for localization of apical ezrin , but not moesin . ^^^ Although apical moesin expression was present in null cells , it could not compensate for ezrin because ERM associated EBP 50 and the beta 2 adrenergic receptor failed to localize apically in the absence of Foxj 1 . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The other complex contains ezrin , periplakin , periaxin and desmoyokin ( and so is called the EPPD complex ) , usually together with moesin , spectrin ( s ) and plectin . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Kindlerin displays a putative FERM ( four point one ezrin radixin moesin ) domain that is closely related to the sequences in talin that interact with integrin beta subunit cytoplasmic domains . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Surprisingly , the proteolytic patterns of desmin , talin , vinculin , focal adhesion kinase ( FAK ) and ezrin , radixin , moesin ( ERM ) proteins are the same in calpastatin overexpressing myoblasts as compared to control cells . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Two DNA binding proteins , ezrin and moesin , known as plasma membrane actin linkers , were identified by one and two dimensional South Western blots and matrix assisted laser desorption and ionization mass spectrometry . ^^^ Ezrin and moesin are functionally associated with a number of transmembrane receptors such as the EGF , CD 44 or ICAM 1 receptor . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the expression level of membranous RhoA and phosphorylation of the target proteins of Rho kinase , the ERM ( ezrin , radixin , moesin ) family members , was significantly greater in L NAME treated rats than in control rats . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| RESULTS : CRALBP bound to a 54 kDa protein in RPE microsomes , which was identified as ERM ( ezrin , radixin , moesin ) binding phosphoprotein 50 ( EBP 50 ) , a PDZ domain protein , also known as sodium / hydrogen exchanger regulatory factory type 1 ( NHERF 1 ) . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Kin 5 is most closely related to Osm 3 , a Caenorhabditis elegans kinesin 2 ; Osm 3 and Kin 5 have a 56 % identity , which rises to 60 . 4 % in the motor domain and a 45 % identity in a 60 amino acid region of the C terminal FERM ( 4 . 1 , Ezrin , Radixin , Moesin ) domain , not present in Kin 1 or Kin 2 , which we hypothesize to be a critical domain either for dimerization or for cargo recognition in ICT . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Here , we show that addition of ET 1 to normal lung fibroblasts induces expression of proteins that contribute to a contractile phenotype , including alpha smooth muscle actin ( alpha SMA ) , ezrin , moesin , and paxillin . ^^^ Blockade of the Akt / phosphoinositide 3 kinase ( PI 3 kinase ) pathway with LY 294002 and wortmannin prevents the ability of ET 1 to induce alpha SMA , ezrin , paxillin , and moesin and to promote matrix contraction . ^^^ Systemic sclerosis lung fibroblasts show increased ability to contract a collagen matrix and elevated expression of the procontractile proteins alpha SMA , ezrin , paxillin , and moesin , which are greatly reduced by antagonizing endogenous ET 1 signaling . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| These results suggest that LyGDI functions in the cell membrane to afford spatial regulation of Rho family GTPase signaling through ezrin radixin moesin ( ERM ) proteins during metastasis . . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Ezrin , a widespread protein involved in cell migration , morphogenesis and cell adhesion , belongs to a large family of proteins known as ERM ( ezrin , radixin , moesin ) . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| To understand the function of moe in the RPE , we cloned the moe locus and show that it encodes a novel FERM ( for 4 . 1 protein , ezrin , radixin , moesin ) domain containing protein . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Nuclear ERM ( ezrin , radixin , moesin ) proteins : regulation by cell density and nuclear import . ^^^ The highly conserved ERM ( ezrin radixin moesin ) family of proteins function as molecular linkers between the actin cytoskeleton and transmembrane receptors . ^^^ We now provide unequivocal evidence that full length endogenous ezrin and moesin also localise to the nucleus in two independent mammalian cell lines . ^^^ The nuclear localisation of endogenous ezrin and moesin is regulated by cell density and is resistant to detergent extraction , suggesting tight association with nuclear structures . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The major integrin binding site lies within the talin FERM ( four point one , ezrin , radixin , moesin ) domain , and binding occurs via a variant of the classical PTB domain ( phosphotyrosine binding domain ) NPxY interaction . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Mutagenesis of the ezrin radixin moesin binding domain of L selectin tail affects shedding , microvillar positioning , and leukocyte tethering . ^^^ We have previously identified ezrin and moesin as novel binding partners of the 17 amino acid L selectin tail , but the biological role of this interaction is not known . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Although numerous studies in cell culture point to the crucial role of Ezrin , Radixin and Moesin ( ERM ) proteins in the actin membrane link , genetic approaches in mice have not yet revealed their activity during development . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Ezrin / radixin / moesin proteins are high affinity targets for ADP ribosylation by Pseudomonas aeruginosa ExoS . ^^^ Matrix assisted laser desorption ionization mass spectroscopy identified this protein as moesin , a member of the ezrin / radixin / moesin ( ERM ) family of proteins . ^^^ Moesin homologs ezrin and radixin were also ADP ribosylated , indicating the ERMs collectively represent high affinity targets of ExoS . ^^^ Type 3 delivered ExoS ADP ribosylated moesin and ezrin ( and / or radixin ) in cultured HeLa cells . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Herein , we report that Crk associates with ERM family proteins ( including ezrin , radixin , and moesin ) , activates RhoA , and promotes cell motility toward hyaluronic acid . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The interaction of cellular retinaldehyde binding protein ( CRALBP ) with ERM ( ezrin , radixin , moesin ) binding phosphoprotein 50 ( EBP 50 ) in retinal pigment epithelium ( RPE ) microsomes has led to the hypothesis that a retinoid processing protein complex exists in apical RPE . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| A second function of NHE 1 as a structural anchor for actin filaments through its direct binding of the ezrin , radixin , and moesin ( ERM ) family of actin binding proteins was recently identified . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Ezrin is a member of the Ezrin , Radixin , Moesin ( ERM ) proteins family that are proposed to act as linkers between the cytoskeleton and plasma membrane . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Merlin , the neurofibromatosis 2 tumor suppressor protein , is related to the ERM ( ezrin , radixin , moesin ) proteins and , like its family members , is thought to play a role in plasma membrane cytoskeletal interactions . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Each protein has a kinase domain and a catalytically inactive pseudo kinase domain , and they each bind cytokine receptors through amino terminal FERM ( Band 4 . 1 , ezrin , radixin , moesin ) domains . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The closely related ERM proteins ( ezrin , radixin , and moesin ) act as linkers between the cell membrane and cytoskeleton , and have also been implicated as active actin reorganizers . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| We have found that ezrin , a member of the ezrin , radixin and moesin ( ERM ) family that functions as a key membrane cytoskeleton linker , accumulates at Listeria protrusions . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Acid secreting parietal cells are characterized by abundant expression of ezrin ( Vil 2 ) , one of ezrin / radixin / moesin proteins , which generally cross link actin filaments with plasma membrane proteins . ^^^ Ezrin protein levels in Vil 2 ( kd / kd ) stomachs decreased to < 5 % of the wild type levels without compensatory up regulation of radixin or moesin . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The expression levels of RhoA in the membrane fraction and phosphorylated ERM family ( ezrin , radixin , and moesin ) in the NTS were greater in SHR than in WKY rats . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| In multiple experimental systems , ezrin ( ERM , Radixin , Moesin ) has been identified as being important in the metastatic behavior of pancreatic and other cancers . ^^^ We investigated the prognostic significance of aberrant expression of 14 3 3sigma and the ERM proteins ( Ezrin , radixin , Moesin ) in a series of invasive periampullary adenocarcinomas including 300 infiltrating pancreatic adenocarcinomas , 54 ampullary adenocarcinomas , and 33 noninvasive intraductal papillary mucinous neoplasms from patients who underwent pancreaticoduodenal resection at The Johns Hopkins Hospital , Baltimore , MD , between 1991 and 2003 . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| No interaction was observed between layilin and ezrin or layilin and moesin . ^^^ These findings expand the known binding partners of layilin to include other members of the talin / band 4 . 1 / ERM ( ezrin , radixin , and moesin ) family of cytoskeletal membrane linker molecules . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The carboxyl terminus of NHERF interacts with the FERM domain ( a domain shared by protein 4 . 1 , ezrin , radixin , and moesin ) of a family of actin binding proteins , ezrin radixin moesin . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| A novel 4 . 1 ezrin radixin moesin ( FERM ) containing protein , ' Willin ' . ^^^ The 4 . 1 superfamily of proteins contain a 4 . 1 Ezrin Radixin Moesin ( FERM ) domain and are described as linking the cytoskeleton with the plasma membrane . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Research in several areas , including unconventional myosins and deafness genes , has converged recently on a group of myosins whose tails contain myosin tail homology 4 ( MyTH 4 ) and band 4 . 1 , ezrin , radixin , moesin ( FERM ) domains . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The DAL 1 / 41B gene ( differentially expressed in adenocarcinoma of the lung ) , located in the chromosome 18p11 . 3 region , belongs to the protein family 4 . 1 ( membrane associated proteins ) , which includes the product of the NF 2 gene ( merlin ) , and the proteins , ezrin , radixin , and moesin . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Interferon gamma induced STAT 1 mediated membrane retention of NHE 1 and associated proteins ezrin , radixin and moesin in HT 29 cells . ^^^ This study evaluated the effect of interferon gamma ( IFN gamma ) upon the function and expression of type 1 Na ( + ) / H+ exchanger ( NHE 1 ) in human intestinal epithelial HT 29 cells , namely that concerning the abundance of surface NHE 1 and NHE 1 binding to the ezrin , radixin and moesin ( ERM ) family of proteins . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The ERM ( ezrin , radixin , moesin ) proteins function as cross linkers between cell membrane and cytoskeleton by binding to membrane proteins via their N terminal domain and to F actin via their C terminal domain . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Mutational and immunohistochemical analysis of ezrin , radixin , moesin ( ERM ) molecules in epilepsy associated glioneuronal lesions . ^^^ Ezrin , radixin and moesin ( ERM / band 4 . 1 proteins ) genes represent downstream effectors of the PI3K pathway , are involved in cytoskeleton membrane interference , cell growth , migration and differentiation , and harbor tumor suppressor motifs . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The band 4 . 1 proteins are cytoskeletal proteins , harboring a conserved FERM domain highly homologous to the N terminal FERM domain of ezrin , radixin , moesin , and merlin . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Proteomic analysis with MALDI TOF MS revealed an additional eight abundant membrane associated proteins that redistributed out of the microvillus enriched membrane during captopril treatment : megalin , myosin 2 A , clathrin , aminopeptidase N , DPPIV , ezrin , moesin , and vacuolar H ( + ) ATPase subunit beta ( 2 ) . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Ezrin , a member of the ezrin / radixin / moesin ( ERM ) family , seems to be involved in the formation and stabilization of the apical microvilli . ^^^ When , in the oncogenic Raf 1 transfected mouse hepatic cell line , epithelial to mesenchymal transition ( EMT ) indicated as down regulation of E cadherin and up regulation of Snail occurred , loss of microvilli and down regulation of ezrin but not radixin and moesin were also observed . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| It was shown recently that AGE bind to the ERM ( ezrin , radixin , and moesin ) family of membrane cytoskeletal linker proteins in renal homogenates . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Ezrin / radixin / moesin proteins are phosphorylated by TNF alpha and modulate permeability increases in human pulmonary microvascular endothelial cells . ^^^ Ezrin , radixin , and moesin ( ERM ) regulate many cell processes that often require a conformational change of these proteins as a result of phosphorylation on a conserved threonine residue near the C terminus . ^^^ |
|
| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Normal urothelium and pTa G 2 , pT 1 G3 , and > or=pT3 G 3 tissues were obtained from the operating room and , after macrodissection , subjected to 2D PAGE and to SELDI TOF MS ProteinChip . 2D PAGE gels expressed significantly different protein patterns for pTa G 2 and pT 3 G3 tumors . pT 1 G3 tumors showed expression profiles similar to those of the invasive tumors , with upregulation of galectin 3 , gelsolin , villin 2 , moesin , and annexin 6 . ^^^ |
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| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Altered expression of the actin and / or tubulin binding proteins gelsolin , moesin , ezrin , tropomyosin , CAP G , HSP 27 , HSP 70 , TCP 1 , and stathmin were associated with in vivo VCR resistance . ^^^ |
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| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The sodium hydrogen exchanger regulatory factors ( NHERF 1 and NHERF 2 ) are a family of adaptor proteins characterized by the presence of two tandem PDZ protein interaction domains and a C terminal domain that binds the cytoskeleton proteins ezrin , radixin , moesin , and merlin . ^^^ |
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| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Merlin and Expanded are members of the FERM ( Four point one , Ezrin , Radixin , Moesin ) domain superfamily , which consists of membrane associated cytoplasmic proteins that interact with transmembrane proteins and may function as adapters that link to protein complexes and / or the cytoskeleton . ^^^ |
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| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| This consists of ezrin , radixin , and moesin and connects the CD 44 receptor with the cytoskeleton . ^^^ To assess the role of ezrin and moesinfor ovarian carcinoma progression , we analyzed ovarian carcinoma samples from 105 patients for expression of ezrin and moesin by immunohistochemistry and correlated these data with several clinicopathological parameters . ^^^ To elucidate the functional importance of ezrin and moesin , their expression was inhibited in SKOV 3 cells by RNA interference . ^^^ Ezrin and moesin were strongly expressed in 49 and 48 % of ovarian carcinoma samples , respectively , and their presence correlated with reduced overall survival in univariate analysis ( ezrin , p=0 . 0189 ; moesin , p=0 . 0351 ) . ^^^ In SKOV 3 cells , siRNA against ezrin but not moesin inhibited in vitro invasion . ^^^ |
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| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| The three ERM proteins ( Ezrin , Radixin and Moesin ) form a conserved family required in many developmental processes involving regulation of the cytoskeleton . ^^^ |
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| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Additionally to the family defining phox homology ( PX ) domain , SNX 17 is the only member with a truncated FERM ( 4 . 1 , ezrin , radixin , and moesin ) domain and a unique C terminal region ( together designated as FC unit ) . ^^^ |
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| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| Bacteria adhering to endothelial cells actively recruit ezrin , moesin , and ezrin binding adhesion molecules . ^^^ Overexpression of exogenous ezrin or moesin is sufficient to rescue the formation of docking structures on and leukocyte migration through infected endothelial monolayers . ^^^ Ezrin and moesin thus appear as pivotal endothelial proteins required for leukocyte diapedesis that are titrated away by N . meningitidis . ^^^ |
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| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| It contains an N terminal extension of over 400 residues , and a tail consisting of four IQ motifs and two MyTH4 / FERM ( myosin tail homology 4 / band 4 . 1 , ezrin , radixin , and moesin ) tandem domains that are separated by a long region containing an SH 3 ( src homology 3 ) domain . ^^^ |
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| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| We show that Btsz binds to the Ezrin Radixin Moesin protein Moesin , an F actin binding protein that is localized apically and is recruited in the AJR in a btsz dependent manner . ^^^ |
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| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| We report two previously unrecognized actions of NIK : regulation of lamellipodium formation by growth factors and phosphorylation of the ERM proteins ezrin , radixin , and moesin . ^^^ |
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| Interacting proteins: P26038 and P15311 |
Pubmed |
SVM Score :0.0 |
| In addition , we confirmed the increase of Rho kinase activity in the brain stem in ovariectomized rats , and the increase was attenuated by intracisternal infusion of Y 27632 via the phosphorylated ezrin , radixin , and moesin ( ERM ) family , which are Rho kinase target proteins . ^^^ |
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