| Interacting proteins: O14745 and P26038 |
Pubmed |
SVM Score :0.0 |
| Identification of EBP 50 : A PDZ containing phosphoprotein that associates with members of the ezrin radixin moesin family . ^^^ Recombinant EBP 50 binds tightly to the N ERMADs of ezrin and moesin . ^^^ |
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| Interacting proteins: O14745 and P26038 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Immunofluorescence microscopy of adult rat eyes detected a polarized distribution of ERM ( ezrin , radixin , and moesin ) binding phosphoprotein of 50 kDa ( EBP 50 ) at the apical microvilli and synaptic associated protein of 97 kDa ( SAP 97 ) at the basolateral surface of RPE cells , which overlapped with ezrin . ^^^ |
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| Interacting proteins: O14745 and P26038 |
Pubmed |
SVM Score :0.0 |
| Ezrin and moesin are membrane cytoskeletal linking proteins that are involved in the regulation of the sodium hydrogen exchanger ( NHE 3 ) via interactions with another PDZ protein identified as sodium hydrogen exchanger regulatory factor ( EBP 50 , NHERF ) . ^^^ |
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| Interacting proteins: O14745 and P26038 |
Pubmed |
SVM Score :0.0 |
| Although apical moesin expression was present in null cells , it could not compensate for ezrin because ERM associated EBP 50 and the beta 2 adrenergic receptor failed to localize apically in the absence of Foxj 1 . ^^^ |
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| Interacting proteins: O14745 and P26038 |
Pubmed |
SVM Score :0.0 |
| RESULTS : CRALBP bound to a 54 kDa protein in RPE microsomes , which was identified as ERM ( ezrin , radixin , moesin ) binding phosphoprotein 50 ( EBP 50 ) , a PDZ domain protein , also known as sodium / hydrogen exchanger regulatory factory type 1 ( NHERF 1 ) . ^^^ |
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| Interacting proteins: O14745 and P26038 |
Pubmed |
SVM Score :0.0 |
| The EBP 50 moesin interaction involves a binding site regulated by direct masking on the FERM domain . ^^^ Members of the ezrin radixin moesin ( ERM ) protein family serve as regulated microfilament membrane crosslinking proteins that , upon activation , bind the scaffolding protein ERM phosphoprotein of 50 kDa ( EBP 50 ) . ^^^ Here we report a 3 . 5 A resolution diffraction analysis of a complex between the active moesin N terminal FERM domain and a 38 residue peptide from the C terminus of EBP 50 . ^^^ This crystallographic result , combined with sequence and structural comparisons , suggests that the C terminal 11 residues of EBP 50 binds as an alpha helix at the same site occupied in the dormant monomer by the last 11 residues of the inhibitory moesin C terminal tail . ^^^ Biochemical support for this interpretation derives from in vitro studies showing that appropriate mutations in both the EBP 50 tail peptide and the FERM domain reduce binding , and that a peptide representing just the C terminal 14 residues of EBP 50 also binds to moesin . ^^^ |
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| Interacting proteins: O14745 and P26038 |
Pubmed |
SVM Score :0.0 |
| The interaction of cellular retinaldehyde binding protein ( CRALBP ) with ERM ( ezrin , radixin , moesin ) binding phosphoprotein 50 ( EBP 50 ) in retinal pigment epithelium ( RPE ) microsomes has led to the hypothesis that a retinoid processing protein complex exists in apical RPE . ^^^ |
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| Interacting proteins: O14745 and P26038 |
Pubmed |
SVM Score :0.0 |
| The ERM ( ezrin radixin moesin ) proteins are believed to provide such links , with the N terminal halves associating with integral membrane proteins , either directly or indirectly through adapter molecules like EBP 50 ( ERM binding phosphoprotein , 50 kDa ) , and their C terminal halves associating with F actin . ^^^ Here we show that C terminal phosphorylation of full length , dormant ezrin and moesin by protein kinase C theta simultaneously unmasks both the F actin and EBP 50 binding sites . ^^^ |
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| Interacting proteins: O14745 and P26038 |
Pubmed |
SVM Score :0.0 |
| NHE RF , a regulatory cofactor for NHE ( Na ( + ) H ( + ) exchanger ) type 3 , interacts with ion transporters and receptors through its PDZ domains and with the MERM proteins ( merlin , ezrin , radixin and moesin ) via its carboxyl terminus . ^^^ |
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| Interacting proteins: O14745 and P26038 |
Pubmed |
SVM Score :0.0 |
| The carboxyl terminus of NHERF interacts with the FERM domain ( a domain shared by protein 4 . 1 , ezrin , radixin , and moesin ) of a family of actin binding proteins , ezrin radixin moesin . ^^^ |
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| Interacting proteins: O14745 and P26038 |
Pubmed |
SVM Score :0.0 |
| Using a myelinating explant culture system , we have observed that SCs reorganize and polarize microvillar components , such as the ezrin binding phosphoprotein 50 kD / regulatory cofactor of the sodium hydrogen exchanger isoform 3 ( NHERF 1 ) , actin , and the activated ezrin , radixin , and moesin family proteins before myelination in response to inductive signals . ^^^ |
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| Interacting proteins: O14745 and P26038 |
Pubmed |
SVM Score :0.0 |
| The sodium hydrogen exchanger regulatory factors ( NHERF 1 and NHERF 2 ) are a family of adaptor proteins characterized by the presence of two tandem PDZ protein interaction domains and a C terminal domain that binds the cytoskeleton proteins ezrin , radixin , moesin , and merlin . ^^^ |
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| Interacting proteins: O14745 and P26038 |
Pubmed |
SVM Score :0.0 |
| NHE RF binds to the related ERM proteins , moesin and radixin . ^^^ We have localized human NHE RF to actin rich structures such as membrane ruffles , microvilli , and filopodia in HeLa and COS 7 cells , where it co localizes with merlin and moesin . ^^^ |
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| Interacting proteins: O14745 and P26038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14745 and P26038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14745 and P26038 |
Pubmed |
SVM Score :0.0 |
| NA |
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