| Interacting proteins: Q9Y2U5 and P25963 |
Pubmed |
SVM Score :0.0 |
| We now show that MEKK 2 and MEKK 3 can in vivo activate IKK alpha and IKK beta , induce site specific IkappaBalpha phosphorylation , and , relatively modestly , activate an NF kappaB reporter gene . ^^^ |
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| Interacting proteins: Q9Y2U5 and P25963 |
Pubmed |
SVM Score :0.0 |
| MEKK 3 is involved in the formation of the IkappaBalpha : NF kappaB / IKK complex , whereas MEKK 2 participates in assembling the IkappaBbeta : NF kappaB / IKK complex ; these two distinct complexes regulate the proinflammatory cytokine induced biphasic NF kappaB activation . ^^^ |
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