| Interacting proteins: Q15418 and P25963 |
Pubmed |
SVM Score :0.0 |
| IKKalpha / beta kinases and p 90 ( rsk 1 ) are involved in stimuli induced targeting of one or both of these IkappaBalpha sites . ^^^ |
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| Interacting proteins: Q15418 and P25963 |
Pubmed |
SVM Score :0.0 |
| In agreement with our previous finding that p 90 ( rsk 1 ) is essential for TPA induced activation of NF kappaB in Adenovirus 5E1 transformed Baby Rat Kidney cells , we now report that the MEK / ERK / p90 ( rsk 1 ) inhibitor U 0126 efficiently blocks TPA induced IkappaBalpha processing in these cells . ^^^ |
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| Interacting proteins: Q15418 and P25963 |
Pubmed |
SVM Score :0.0 |
| In addition , overexpression of the dominant inhibitory mutant ( S32A / S36A ) of IkappaBalpha inhibited PMA stimulated and RSK 1 enhanced megakaryocytic differentiation , indicating that NF kappaB mediates a signal for megakaryocytic differentiation downstream of RSK 1 . ^^^ |
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| Interacting proteins: Q15418 and P25963 |
Pubmed |
SVM Score :0.0 |
| The lower affinity of RSK 1 phosphorylated p 65 for its negative regulator , IkappaBalpha , decreases IkappaBalpha mediated nuclear export of shuttling forms of NF kappaB , thereby promoting the binding and action of NF kappaB on cognate kappaB enhancers . ^^^ |
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| Interacting proteins: Q15418 and P25963 |
Pubmed |
SVM Score :0.0 |
| We have investigated the potential function of the 90 kDa ribosomal S 6 kinase , or pp 90 ( rsk ) , as a signal inducible IkappaBalpha kinase . pp 90 ( rsk ) lies downstream of mitogen activated protein ( MAP ) kinase in the well characterized Ras Raf MEK MAP kinase pathway that is induced by various growth factors and phorbol ester . ^^^ We now show that pp 90 ( rsk ) , but not pp 70 ( S6K ) or MAP kinase , phosphorylates the regulatory N terminus of IkappaBalpha principally on serine 32 and triggers effective IkappaBalpha degradation in vitro . ^^^ When co expressed in vivo in COS cells , IkappaBalpha and pp 90 ( rsk ) readily assemble into a complex that is immunoprecipitated with antibodies specific for either partner . ^^^ |
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| Interacting proteins: Q15418 and P25963 |
Pubmed |
SVM Score :0.0 |
| Of the putative N terminal IkappaBalpha kinases , we demonstrated that the Ikappakappa complex , but not p 90 ( rsk ) , is activated by HIV infection and mediates HIV dependent NF kappaB activation . ^^^ |
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| Interacting proteins: Q15418 and P25963 |
Pubmed |
SVM Score :0.0 |
| By using Jurkat and primary human T lymphocytes , we demonstrate that the simultaneous activation of two second messengers of the TCR initiated signal transduction , protein kinase C ( PKC ) and calcineurin , results in the synergistic activation of the IkappaBalpha kinase ( IKK ) complex but not of another putative IkappaBalpha kinase , p 90 ( rsk ) . ^^^ We also demonstrate that the IKK complex , but not p 90 ( rsk ) , is responsible for the in vivo phosphorylation of IkappaBalpha mediated by the co activation of PKC and calcineurin . ^^^ |
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| Interacting proteins: Q15418 and P25963 |
Pubmed |
SVM Score :0.0 |
| However , in chlorate treated cells , the addition of heparin or purified HSPGs simultaneously with FGF 2 restored DNA synthesis , the sustained phosphorylation of p42 / 44 ( MAPK ) and p 90 ( RSK ) , and the degradation of IkappaBalpha and IkappaBbeta . ^^^ |
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| Interacting proteins: Q15418 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15418 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15418 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
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