| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| The inhibitors 1 kappa B alpha and beta and pp 40 recognize either p 65 or the c rel protein . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Coexpression of 1 kappa B alpha completely abrogated p 65 , c Rel , or p 65 p50 induced gene activity . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Coexpression of IkappaBalpha , a c Rel inhibitor , inhibited the MEKK 1 induced transcriptional activity . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Furthermore , contrary to p 65 , c Rel appears to display little affinity for p 105 , p 100 and IkappaBalpha regulators . . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Using antibodies , we demonstrated that these complexes contain NFkappaB subunits NFkB 1 , NFkB 2 , RelA and c Rel . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| The reduction of ch IAP 1 expression in these cells correlated with the efficient regulation of c Rel by IkappaBalpha . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| It shows a stack of six IkappaBalpha ankyrin repeats facing the C terminal domains of the NF kappaB Rel homology regions . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Cytoplasmic sequestration of rel proteins by IkappaBalpha requires CRM 1 dependent nuclear export . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Super shift assays showed that the gel shifted complexes consisted of p 65 ( Rel A ) and p 50 ( NF kappaB 1 ) . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of IkappaBalpha was followed by Rel A ( p 65 ) nuclear translocation . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Growth sensitivity towards cycloheximide is also restored by the coexpression of the avian c Rel protein and its 1 kappa B alpha counterpart , p 40 , as Gal 4 fusion proteins . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Our previous work demonstrates that the Rel / NF kappa B family proteins c Rel , RelA ( p 65 ) , and NFKB 1 ( p 50 ) are involved in the complex that binds to the CD28RE . ^^^ We also showed that c Rel , but not NFKB 1 ( p 50 ) , can bind to the CD28RE and activate CD28RE driven transcription in cotransfection assays . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| We found that c rel alone activated the IL 2R alpha promoter only weakly but worked with the p 50 subunit of NF kappa B ( NFKB 1 ) to give a higher level of expression . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Avian 1 kappa B alpha is transcriptionally induced by c Rel and 5 Rel with different kinetics . ^^^ Avian 1 kappa B alpha is also upregulated in fibroblasts overexpressing c Rel and oncogenic variants of c Rel . c Rel , a carboxy terminally truncated variant of c Rel , and 5 Rel are all able to directly transactivate the expression of the avian 1 kappa B alpha gene . ^^^ However , c Rel was the most potent activator of this gene , and the induction of 1 kappa B alpha expression showed faster kinetics in cells overexpressing c Rel than in those overexpressing 5 Rel . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| I kappa B alpha mediated inhibition of nuclear transport and DNA binding by Rel proteins are separable functions : phosphorylation of C terminal serine residues of 1 kappa B alpha is specifically required for inhibition of DNA binding . 1 kappa B alpha inhibits both DNA binding and nuclear translocation of dimeric Rel complexes that contain either the RelA or c Rel proteins . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Analysis of NF kappa B mRNA in human umbilical vein endothelial cells revealed that nfkb 1 , nfkb 2 , and relA NF kappa B but not c rel were induced by tumor necrosis factor alpha and lipopolysaccharide , which also induce VCAM 1 . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Transfection of U 937 cells with NF kappa B family members demonstrated activation of AP 3 mediated transcription by rel A but little effect induced by NFKB 1 and c rel . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| The PEST like sequence of 1 kappa B alpha is responsible for inhibition of DNA binding but not for cytoplasmic retention of c Rel or RelA homodimers . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Recombinant NF kappa B subunits ( p 50 , p 65 , c Rel , p 52 , and 1 kappa B alpha ) and interferon regulatory factor 1 were produced from either Escherichia coli or baculovirus expression systems . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Human T cell leukemia virus type 1 Tax activation of NF kappa B / Rel involves phosphorylation and degradation of 1 kappa B alpha and RelA ( p 65 ) mediated induction of the c rel gene . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Recombinant 1 kappa B alpha inhibited kappa B motif binding by nuclear factor kappa B 1 , RelA , and c Rel as indicated by studies using UV radiation induced covalent cross linking to a bromodeoxyuridine substituted kappa B oligonucleotide . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| We showed that CD 28 costimulation accelerated the kinetics of nuclear translocation of c Rel ( and its phosphorylated form ) , p 50 ( NFKB 1 ) , and p 65 ( RelA ) . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| We performed radioimmunoprecipitation followed by serial immunoblots to show that , in the unstimulated Jurkat T cell line , the NF kappa B / Rel family proteins , p 80 c Rel , p 105 NF kappa B , p 65 NF kappa B , p 50 NF kappa B and p 36 1 kappa B alpha , can be detected as complexes using antisera against c Rel , p 105 NF kappa B or p 65 NF kappa B . p 36 1 kappa B alpha and p 105 , both known inhibitors of NF kappa B function , can physically associate with NF kappa B / Rel family members , but not with each other . ^^^ In vivo and in vitro phosphorylation experiments demonstrated that NF kappa B / Rel family members , including p 105 , c Rel , p 50 , p 65 ( for the first time for p 50 and p 65 ) and p 36 1 kappa B alpha are also phosphoproteins . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Our data suggest that 1 kappa B alpha is the down stream target of both CD 28 signaling and rapamycin ; a continued down regulation of 1 kappa B alpha by CD 28 costimulation leads to enhanced nuclear translocation of c Rel , which in turn causes a sustained up regulation of IL 2 gene expression . . ^^^ However , the levels of two other c Rel inhibitors , namely NFKB 1 ( p 105 ) and NFKB 2 ( p 100 ) , were not affected . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| The ability of 5 Rel to stabilize 1 kappa B alpha but poorly induce Ikba mRNA expression relative to c Rel may play a role in regulating gene expression , thereby leading to transformation . . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| In this study we demonstrate that constitutive phosphorylation and increased turnover of the regulatory 1 kappa B alpha protein in HTLV 1 infected MT 2 and C 8166 cells and Tax expressing 19D cells contribute to constitutive NF kappa B binding activity , which consists primarily of c Rel , p 52 ( NFKB 2 ) , and p 50 ( NFKB 1 ) . 1 kappa B alpha mRNA expression is also increased 7 to 20 fold in these cells , although the steady state level of 1 kappa B alpha protein is reduced in HTLV 1 infected and Tax expressing T cells . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Recombinant 1 kappa B alpha inhibited the DNA binding activity of c Rel p 65 ( RelA ) via association with either c Rel or p 65 ( RelA ) . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Some liberated dimers were retained in the cytoplasm , however , through binding to newly synthesized 1 kappa B alpha , a finding which strongly suggests ( 1 ) that the LPS induced signal causes dissociation of complexes rather than preventing their association and ( 2 ) that dissociation results from modification of 1 kappa B alpha and not of c rel or p 65 . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| The subunits of NF kappa B , NFKB 1 ( formerly p 50 ) and RelA ( formerly p 65 ) , belong to a growing family of transcription factors that share extensive similarity to the c rel proto oncogene product . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Experiments using MAD 3 1 kappa B , a specific inhibitor of NF kappa B , and antibodies directed against rel family members demonstrated that the induced binding activities contained p 50 and p 65 proteins but not c rel . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| The virally induced 90 to 100 kDa proteins have a distinct binding specificity for the PRDII domain and an AT rich sequence but do not cross react with NF kappa B subunit specific antisera directed against NFKB 1 ( p 105 or p 50 ) , NFKB 2 ( p 100 or p 52 ) , RelA ( p 65 ) , or c rel . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Only antibody to RelA ( p 65 ) , but not to NFKB 1 ( p 50 ) , NFKB 2 ( p50B ) , c Rel , or RelB was able to abolish binding , suggesting that RelA is a major component in these kappa B binding complexes . ^^^ Gel mobility shift analysis with in vitro translated and purified proteins indicated that whereas the kappa B element in the human immunodeficiency virus type 1 long terminal repeat bound to all members of the kappa B / Rel family examined , the IL 8 kappa B site bound only to RelA and to c Rel and NFKB 2 homodimers , but not to NFKB 1 homodimers or heterodimers of NFKB 1 RelA . ^^^ Cotransfection with various NF kappa B subunits indicated that RelA and c Rel , but neither NFKB 1 nor heterodimeric NFKB 1 RelA , was able to activate transcription from the IL 8 promoter . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| In cotransfection experiments , RelA ( p 65 ) and c Rel ( p 85 ) were identified as the main subunits responsible for the activation of the IL 1 beta NF kappa B site ; also , combinations of NFKB 1 ( p 50 ) and RelA ( p 65 ) or c Rel and RelA were strong transcriptional activators of reporter gene activity . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NF kappa B is composed of distinct subunits ; five independent genes , NFKB 1 ( p 105 ) , NFKB 2 ( p 100 ) , RelA ( p 65 ) , c rel and relB , that encode related proteins that bind to kappa B DNA elements have been isolated . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Transfection studies reveal that the 1 kappa B alpha mRNA and the encoded protein are potently induced by NF kappa B and by homodimers of p 65 and of c Rel . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Lipopolysaccharide induces phosphorylation of MAD 3 and activation of c Rel and related NF kappa B proteins in human monocytic THP 1 cells . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Interestingly , expression of RelA ( p 65 ) , c Rel , NF kappa B 1 ( p 105 ) , NF kappa B 2 ( p 100 ) , and NF kappa B 2 ( p 52 ) subunits increased 1 kappa B alpha protein levels from 3 to 30 fold , indicating that one mechanism to compensate for the increased expression of NF kappa B proto oncogenes was to increase the synthesis and / or stability of the regulatory 1 kappa B alpha protein . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| In comparison to the conventional GC box containing Sp 1 motif , the alpha V / kappa B motif also binds in vitro to c Rel and RelA but not to NFKB 1 . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Cultured fibroblasts derived from IkappaBalpha deficient embryos exhibit levels of NF kappaB 1 , NF kappaB 2 , RelA , c Rel , and IkappaBbeta similar to those of wild type fibroblasts . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Avian 1 kappa B alpha transcription is increased in response to both c Rel and 5 Rel . ^^^ These studies address the difference in c Rel and 5 Rel ' s ability to synergistically stimulate 1 kappa B alpha expression in conjunction with the AP 1 factors . . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| A dramatic increase in the intracellular levels of NF kappaB subunits c Rel and NF kappaB 2 p100 and a moderate increase in NF kappaB 2 p52 and RelA ( p 65 ) were detected in HIV 1 infected cells , whereas NF kappaB 1 p105 / p50 levels were not altered relative to the levels in uninfected cells . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Using primary murine CD4+ T cell cultures , elevated NF kappaB / Rel and c Rel / p50 binding activities were also observed at VT of 500 ng / ml from 1 to 72 hr concurrently with decreased IkappaBalpha levels . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| In the present study , precursor B lymphocytes were engineered to express a trans dominant form of 1 kappa B alpha that simultaneously impairs the c Rel and RelA transactivating subunits of NF kappa B . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| While the transcription of CEF 4 was strongly stimulated , that of NF kappaB 1 , c rel , p 53 or IkappaB alpha was activated more modestly by pp60v src . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| All three Rel family members p 65 , c Rel , p 50 , but not their precursors and IkB alpha inhibitory protein were shown to co precipitate with the stress protein and anti Hsp 70 antibodies from both heated and non heated cells . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| The NF kappa B family members p 50 , p 65 , p 52 , c Rel , and RelB as well as the inhibitor proteins 1 kappa B alpha , 1 kappa B beta , and p 105 were present in uninjured arteries as determined by immunoblotting . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Although AP 1 levels were not modified during cisplatin exposure , electrophoretic mobility shift assays demonstrated an increase in NF kappa B DNA binding activity that correlated with a decrease of the inhibitory protein 1 kappa B alpha and a specific relocalization of c Rel , as assessed by immunoblotting and immunofluorescence . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| In mammalian cells , 1 kappa B alpha and 1 kappa B beta proteins have been purified and shown to be the inhibitors of NF kappa B through their association with the p 65 or c Rel subunits . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Using a two step microaffinity isolation / Western immunoblot DNA binding assay , we observe that the NF kappaB subunits Rel A , NF kappaB 1 , and c Rel inducibly bind the TNF response element ; these proteins undergo rapid TNFalpha inducible increases in nuclear abundance as a consequence of IkappaBalpha proteolysis . ^^^ Dependence on nuclear abundance of Rel A , NF kappaB 1 , and c Rel transcription factors . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Distinct domains of IkappaBalpha regulate c Rel in the cytoplasm and in the nucleus . ^^^ In this study , we show that IkappaBalpha regulates the transcriptional activity of c Rel in the nuclear compartment . ^^^ We also demonstrate that discrete functional domains of IkappaBalpha are responsible for the cytoplasmic and nuclear regulation of c Rel . ^^^ We show that the determinants for the cytoplasmic regulation of c Rel reside in the N terminal and central ankyrin regions of IkappaBalpha and that the N terminal domain of IkappaBalpha is required to mask the c Rel nuclear localization signal . ^^^ Importantly , IkappaBalpha sequences necessary to regulate c Rel in the nucleus map to its central ankyrin domain and to a few negatively charged amino acids that immediately follow in the C terminal IkappaBalpha PEST domain . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| The CD28RE in the IL 8 promoter was characterized as a low affinity NF kappaB binding site recognized by the transcription factors p 50 ( NF kappaB 1 ) , p 65 ( RelA ) and c rel . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Both the PTK inhibitors blocked the degradation of IkappaBalpha , the inhibitory subunit of NF kappaB , and the consequent translocation of the p 65 subunit without any significant effect on p 50 or on c Rel . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| In response to either costimulus , c Rel selectively translocated to the nucleus as a result of induced c Rel expression and the continued production of c Rel IkappaBalpha complexes , which turn over rapidly due to the high rate of IkappaBalpha degradation in the cytosol during the second phase of the response . ^^^ Cyclosporine ( CsA ) , which inhibits stimulus induced NF kappaB transcriptional activity , selectively inhibits the stimulus induced c Rel nuclear localization and the rapid formation and degradation of c Rel IkappaBalpha complexes in the cytosol . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| The cytoplasmic localization of c Rel in antigen presenting cells correlates with a high expression of IkappaBalpha , whereas the nuclear localization of c Rel in lymphocyte precursor cells correlates with a much lower expression of IkappaBalpha . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| We found proteolysis of the cytoplasmic inhibitory protein IkappaBalpha and nuclear translocation of the NFkappaB / Rel family proteins p 65 and c Rel , corresponding to the transient binding of a p65 / c Rel heterodimer to the kappaB like site of the LRE . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| To understand the role of NF kappa B complexes in T cell development and activation , we have generated transgenic mice in which RelA and c Rel complexes were selectively inhibited in the T lineage cells by specific expression of a trans dominant form of 1 kappa B alpha . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| To investigate whether transcription factors of the NF kappa B family could play a role in early mammalian development , we have analyzed the expression of nfkb 1 , nfkb 2 , c Rel , RelA , RelB , and bcl 3 from 6 . 5 to 10 . 5 day mouse embryo implantation sites . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Primary human mesangial cells contained in addition to p 50 ( NF kappaB 1 ) and p 65 ( Rel A ) NF kappaB proteins , the oncoprotein c rel , and Rel B , but not p 52 ( NF kappaB 2 ) . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Both neuropeptides prevent the activation induced nuclear translocation of the NF kappaB components p 65 and c Rel by inhibiting the reduction in cytoplasmic IkappaBalpha . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| In vascular endothelial cells , 1 kappa B epsilon associates predominantly with the NF kappa B subunit Rel A and to a lesser extent with c Rel , whereas 1 kappa B alpha and 1 kappa B beta associate with Rel A only . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| N terminal determinants of 1 kappa B alpha necessary for the cytoplasmic regulation of c Rel . 1 kappa B alpha is a dual regulator of Rel / NF kappa B transcription factors . 1 kappa B alpha retains inactive NF kappa B dimers in the cytoplasm , and inhibits their DNA binding and transcriptional activities in the nucleus . ^^^ Our previous studies identified discrete functional domains in 1 kappa B alpha responsible for the cytoplasmic and nuclear regulation of c Rel . ^^^ Determinants necessary for regulating c Rel in the nucleus mapped to the central ankyrin domain of 1 kappa B alpha and a few negatively charged amino acids that follow in the C terminal PEST region . ^^^ In contrast , sequences involved in the cytoplasmic regulation of c Rel reside in the N terminal and central ankyrin domains of 1 kappa B alpha . ^^^ Here , we present a refined mapping of the N terminal determinants of 1 kappa B alpha necessary for the cytoplasmic regulation of c Rel homodimers . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Distinct roles for the NF kappaB 1 ( p 50 ) and c Rel transcription factors in inflammatory arthritis . ^^^ To assess this , mice with null mutations in c rel or nfkb 1 were used to examine directly the roles of c Rel and p 50 in models of acute and chronic inflammatory arthritis . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| However , both the LPS induced degradation of the cytoplasmic NF kappaB inhibitor IkappaBalpha and the nuclear translocation of the NF kappaB p 50 , p 65 , and c Rel peptides were unaffected by treatment of the cells with the nucleoside . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Nuclear Factor kB ( NF kB ) , is a transcription factor composed of dimeric complexes of p 50 ( NF kB 1 ) or p 52 ( NF kB 2 ) usually associated with members of the Rel family ( p 65 , c Rel , Rel B ) which have potent transactivation domains . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| As inhibitory S ODN did not directly interfere with the NF kappaB DNA binding but prevented CpG induced NF kappaB nuclear translocation of p 50 , p 65 , and c Rel and blocked p 105 , IkappaBalpha , and IkappaBbeta degradation , we concluded that their putative target must lie upstream of inhibitory kinase ( IKK ) activation . . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Transcription factors NF kappaB 1 and c Rel , individually dispensable during embryogenesis , serve similar , yet distinct , roles in the function of mature hemopoietic cells . ^^^ Redundancy among Rel / NF kappaB family members prompted an examination of the combined roles of c Rel and NF kappaB 1 by using mice that lack both proteins . ^^^ Embryonic development and the maturation of hemopoietic progenitors were unaffected in nfkb 1 ( / ) c rel ( / ) mice . ^^^ In culture , a failure of mitogen stimulated nfkb 1 ( / ) c rel ( / ) B cells to proliferate was caused by a cell cycle defect in early G ( 1 ) that prevented growth . ^^^ In vivo , defects in humoral immunity and splenic architecture seen in nfkb 1 ( / ) and c rel ( / ) mice were exacerbated in the double mutant mice . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| In 5 Rel transformed cells , 5 Rel exists as homodimers or heterodimers with the endogenous Rel / NF kappaB proteins c Rel , NF kappaB 1 , NF kappaB 2 , and RelA . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Thus , unlike NF kappaB 1 , which selectively regulates Th 2 cell differentiation , c Rel is essential for Th 1 cell differentiation and Th 1 cell mediated autoimmune inflammation . . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Here we investigated the requirement for NF kappaB 1 , NF kappaB 2 , and c Rel in the expression of Th 2 cytokine responses , development of host protective immunity , and regulation of intestinal inflammation following infection with the gut dwelling helminth parasite Trichuris muris . ^^^ While mice deficient in c Rel mounted sufficient Th 2 responses to expel infection , NF kappaB 1 knockout ( KO ) and NF kappaB 2 KO mice developed chronic infections associated with elevated production of Ag specific IFN gamma . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| This effect was associated with the inhibition of the nuclear translocation of selective nuclear factor ( NF ) kappaB subunits : NF kappaB 1 ( p 50 ) , RelA ( p 65 ) , RelB ( p 68 ) and c Rel ( p 75 ) , but not NF kappaB 2 ( p 52 ) . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| METHODS : Forty three frozen sections including 30 bladder cancer and 13 non cancer bladder mucosa were subjected to immunohistochemistry and nucleus staining for determining levels of NF kappa B family and 1 kappa B alpha ; Five paired cancer and non cancer specimens were subjected to Western blot for analysis p 65 , an important subtype of NF kappa B ; Thirteen paired specimens were subjected to RT PCR for determination mRNA levels of p 50 , p 52 , p 65 , c Rel , RelB , 1 kappa B alpha , CyclinD 1 , IL 8 . ^^^ RESULTS : Expressions of p 50 , p 52 , p 65 , c Rel , RelB , 1 kappa B alpha , CyclinD 1 , IL 8 mRNAs in bladder cancer were higher than that in non cancer bladder mucosa ( P < 0 . 01 , P < 0 . 05 , P < 0 . 01 , P < 0 . 01 , P < 0 . 05 , P < 0 . 05 , P < 0 . 05 and P < 0 . 05 , respectively ) . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Here we show that B cells lacking NF kappaB 1 and c Rel fail to increase in size upon mitogenic stimulation due to a reduction in induced c myc expression . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| To determine the roles of the Rel / NF kappaB family in type 1 diabetes , we studied multiple low dose streptozotocin induced diabetes in mice deficient in either c Rel or NF kappaB 1 . ^^^ Deficiency in c Rel selectively reduced Th 1 , but not Th 2 responses , whereas NF kappaB 1 deficiency had little effect on T cell responses to anti CD 3 stimulation . ^^^ Death of dendritic cells was accelerated in the absence of NF kappaB 1 , whereas death of macrophages and granulocytes was affected primarily by c Rel deficiency . ^^^ Furthermore , Stat 1 expression was significantly reduced in macrophages deficient in NF kappaB 1 , but not c Rel . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Neither the expression of c Rel nor that of its 1 kappa B alpha inhibitor are grossly modified in talpid 3 limb buds , suggesting that the talpid 3 mutation does not affect any of these genes . ^^^ The only slight difference between control and talpid 3 limbs lies in the perichondrium which is not fully differentiated in talpid 3 embryos : c Rel and 1 kappa B alpha are only faintly expressed in talpid 3 perichondrial cells , whereas they are both detected in control perichondrial cells . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Supershift studies revealed that the RANKL induced DNA binding of NF kappaB complexes consisted of C Rel , NF kappaB 1 ( p 50 ) , and RelA ( p 65 ) . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Discreet mutations from c Rel to 5 Rel alter kappaB DNA recognition , IkappaBalpha binding , and dimerization : implications for 5 Rel oncogenicity . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Cell growth during the G 1 stage of the cell cycle is partly controlled by inducing c myc expression , which in B cells is regulated by the NF kappaB 1 and c Rel transcription factors . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical evaluation included members of the NF kappaB ( p 50 , p 65 , p 52 , c Rel , Rel B ) and the IkappaB ( IkappaBalpha , IkappaBbeta , IkappaBepsilon , Bcl 3 ) families , as well as putative targets of NF kappaB such as Flip , Bcl xL , Cyclin D 1 , and oestrogen and progesterone receptors . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Whereas NFATc 1 expression was increased significantly at days 3 and 5 following RANK L exposure , there were no significant increases in the expression of NFkappaB subunits , namely p 65 , p 50 , c Rel , IkappaBalpha , and IkappaBbeta . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| IkB alpha specific transcript regulation by the C terminal end of c Rel . ^^^ At the same time , this mutation dramatically reduced c Rel activity in induction of IkB alpha mRNA expression . ^^^ Moreover , ectopic expression of IkB alpha , along with the C terminal truncated c Rel , abrogates hyperactivity of this mutant . ^^^ IkB alpha co expression did not affect the function of wild type c Rel . ^^^ The data demonstrate that the C terminal end of c Rel has specific activity for IkB alpha mRNA expression and is dispensable for IL 2 gene expression . . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Decreased nuclear c rel was associated with a reduction in phosphorylation of inhibitory kappa B alpha ( IkappaBalpha ) in the cytoplasm , indicating that IL 10 prevents degradation of IkappaBalpha and the subsequent translocation of c rel into the nucleus . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Furthermore , induction of Nur 77 expression by LPS was severely compromised in fibroblasts lacking the three NF kappaB subunits , Nfkb 1 , c Rel , and RelA . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Distinct roles for the NF kappaB 1 and c Rel transcription factors in the differentiation and survival of plasmacytoid and conventional dendritic cells activated by TLR 9 signals . ^^^ Here we show that NF kappaB 1 and C Rel , Rel / NF kappaB proteins induced in conventional dendritic cells ( cDCs ) and plasmacytoid dendritic cells ( pDCs ) by cytosine phosphate guanosine ( CpG ) DNA , a TLR 9 ligand , serve markedly different functions in these DC subsets . ^^^ With the exception of impaired interleukin 12 ( IL 12 ) production , cultured Nfkb 1 ( / ) C Rel ( / ) cDCs responded relatively normally to CpG DNA . ^^^ In contrast , CpG treated Nfkb 1 ( / ) C Rel ( / ) pDCs , which were still able to produce type 1 interferon and regulated on activation normal T cell expressed and secreted ( RANTES ) , but not IL 6 or IL 12 , failed to acquire an activated dendritic phenotype and underwent apoptosis . ^^^ Although the TLR 9 mediated death of Nfkb 1 ( / ) C Rel ( / ) pDCs , which coincided with a failure to up regulate the prosurvival proteins B cell lymphoma apoptosis regulator xL ( Bcl 10 ( L ) ) and A 1 , was blocked by Bcl 2 transgene expression , this inhibition of apoptosis still failed to rescue the differentiation defects . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Using gene deficient and transgenic mouse models , we establish that NF kappaB 1 , and not c Rel , is the critical signaling molecule downstream of the PI3K PTEN PKB signaling axis that regulates lymphocyte homeostasis . . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Scoparone dose dependently inhibited the phosphorylation of IkappaBalpha and nuclear translocation of NF kappaB 1 p50 , RelA p 65 , and c Rel p 75 . ^^^ These data suggest that scoparone may inhibit the expression of chemokines ( IL 8 and MCP 1 ) in PMA stimulated U 937 cells and a potential mechanism of scoparone may be inhibition of NF kappaB activation , which is linked to inhibition of NF kappaB subunits ( NF kappaB 1 p50 , RelA p 65 , and c Rel p 75 ) translocation via suppression of IkappaBalpha phosphorylation . . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| A human 37 kD protein ( 1 kappa B alpha ) , identified previously as a member of the 1 kappa B family , is also unable to inhibit DNA binding activity of the Rel protein . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Additionally , 1 kappa B beta , but not 1 kappa B alpha , also prevented the binding of Rel to the kappa B site . 1 kappa B beta and pp 40 are related proteins because ( 1 ) they share a number of common tryptic peptides , ( 2 ) their inhibitory effect on DNA binding can be abolished by preincubation with pp 40 specific antiserum , and ( 3 ) labeled 1 kappa B beta can be immunoprecipitated with pp 40 antibodies . pp 40 is part of the Rel complex present in the cytoplasm and nuclear extracts of WEHI 231 cells . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Binding sites for the NF kappa B transcription factor complex , composed of two subunits , p 50 ( NFKB 1 ) and p 65 ( rel A ) , are present in many cell adhesion molecules , cytokines , and growth factor receptors . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| However , the in vivo induction of 1 kappa B alpha phosphorylation did not cause the inhibitory subunit to dissociate from the Rel complex . ^^^ In the presence of these inhibitors , phosphorylated 1 kappa B alpha remained bound to the Rel complex in the cytoplasm for an extended period of time , whereas NF kappa B activation was abolished . ^^^ It appears that activation of NF kappa B requires degradation of 1 kappa B alpha while it is a part of the Rel cytoplasmic complex , with inducible phosphorylation of the inhibitory subunit influencing the rate of degradation . . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| The 5 Rel oncoprotein blocks apoptosis and proteolysis of 1 kappa B alpha in transformed chicken spleen cells . ^^^ However , the chicken 1 kappa B alpha protein ( also called p 40 ) , which is in a complex with 5 Rel in transformed cells , is degraded when ts 5 Rel transformed cells are shifted to the nonpermissive temperature . ^^^ The results reported here indicate that 5 Rel blocks a normal pathway of programmed cell death and that 1 kappa B alpha can undergo multiple degradative pathways , which can be induced by alterations in the structure of the Rel protein to which it is bound . . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| The Rel / NF kappa B proteins and 1 kappa B alpha in thymus and spleen were also analysed by Western blotting and electrophoretic mobility shift assays . ^^^ We have studied the expression of members of the rel family of transcription factors and ikba in mouse thymus and spleen by in situ hybridization . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| These studies demonstrate : ( 1 ) distinct compartmentalization of NF kappa B precursors and products , ( 2 ) differential induction of the endogenous 1 kappa B alpha protein by transfected NF kappa B subunits , ( 3 ) subcellular relocalization of Tax to the cytoplasm or nucleus depending on the coexpressed NF kappa B subunit , and ( 4 ) Tax interaction with the Rel homology domain region of NFKB 2 . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| The NFKB 2 gene ( previously LYT 10 , NF kappa Bp 100 or NF kappa Bp 97 ) codes for a NF kappa B / rel related protein which is highly homologous to NFKB 1 ( previously NF kappa Bp 105 ) within its rel , poly glycine and ankyrin domains . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| We found that expression of 1 kappa B alpha and p 105 , members of the 1 kappa B family , and Rel , a member of the NF kappa B family , is augmented in mature B cells . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| The ankyrin repeat motif identified 1 kappa B family members , which include 1 kappa B alpha ( pp40 / MAD 3 ) , 1 kappa B gamma , and bcl 3 , directly associated with kappa B site binding proteins , resulting in specific DNA binding inhibition of rel , p 50 , or p 65 dimers . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| The candidate proto oncogene bcl 3 encodes a protein that shares structural features with 1 kappa B alpha and other proteins that bind to members of the Rel protein family . ^^^ |
|
| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| The vertebrate NF kappa B / c rel inhibitors MAD 3 / I kappa B alpha , 1 kappa B gamma / pdI and bcl 3 all share a conserved ankyrin repeat domain ( ARD ) consisting of six complete repeats , a short acidic motif and / or an incomplete seventh repeat . ^^^ We present here a detailed analysis of the domain in p105 / pdI and MAD 3 / I kappa B involved in inhibition of DNA binding and in protein interaction with rel factors . ^^^ Both pdI and MAD 3 associate with rel proteins by forming heterotrimeric complexes , as shown by native gel analysis and by cross linking . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Combined , these results indicate that 1 kappa B alpha interaction with the RXXRXRXXC motif is required for inhibition of 5 Rel DNA binding and suggest that nuclear 1 kappa B factors may be critical for regulating transcription by Rel family proteins . . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| GAL 4 1 kappa B alpha and GAL 4 1 kappa B gamma activate transcription by different mechanisms . 1 kappa B proteins regulate Rel / NF kappa B transcription complexes through a direct protein protein interaction . ^^^ We now show that a mutant chicken 1 kappa B alpha protein that can not interact with Rel proteins in vitro did not activate transcription when fused to GAL 4 in chicken embryo fibroblasts ( CEF ) and Saccharomyces cerevisiae , and did not inhibit growth in yeast ; in contrast , an 1 kappa B alpha mutant that can still interact in vitro with Rel proteins activated transcription in both CEF and yeast and inhibited growth in yeast . ^^^ Therefore , it appears that GAL 4 1 kappa B alpha activates transcription by interacting with an endogenous Rel family protein in CEF . ^^^ Since transcription activation and growth inhibition by GAL 4 1 kappa B alpha mutants in yeast correlated with their ability to interact with vertebrate Rel proteins , our results suggest that these activities of GAL 4 1 kappa B alpha are mediated through interaction with a Rel like protein in yeast , which is important for cell growth . . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| We conclude that Rel A : NF kappaB 1 is a crucial cytokine inducible transcription factor complex regulating angiotensinogen gene synthesis in hepatocytes and may be involved in controlling the activity of the renin angiotensin system . . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Mutant 5 delta NLS , which has a deletion of the primary 5 Rel nuclear localizing sequence , does not interact efficiently with 1 kappa B alpha but still transforms chicken spleen cells approximately as well as wild type 5 Rel , indicating that interaction with 1 kappa B alpha is not essential for the 5 Rel transforming function . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| The nuclear activity of Rel / NFkappaB transcription factors is tightly regulated from the cytoplasmic compartment by an inhibitory subunit called IkappaBalpha . ^^^ Furthermore , the ankyrin repeats , which are essential for forming a complex with Rel and RelA , are required for TNFalpha induced degradation suggesting that the putative IkappaB protease could interact with IkappaBalpha in complex with RelA or could recognize the structure of ankyrin repeats . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| IkappaBalpha belongs to a gene family whose members are characterized by their 6 7 Ankyrin repeats , which allow them to interact with members of the Rel family of transcription factors . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Bcl 2 and CrmA have different effects on transformation , apoptosis and the stability of 1 kappa B alpha in chicken spleen cells transformed by temperature sensitive 5 Rel oncoproteins . ^^^ However , co expression of Bcl 2 in these cells does not affect ts functions of 5 Rel , such as DNA binding and stabilization of 1 kappa B alpha . ^^^ In addition , CrmA can block cycloheximide induced amino terminal processing of 1 kappa B alpha in spleen cells transformed by wild type 5 Rel . ^^^ In summary , these results suggest that 5 Rel immortalizes chicken spleen cells through a pathway that involves the Bcl 2 family of proteins , and suggest that one pathway of proteolysis of 1 kappa B alpha involves an ICE like protease . . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| The 60 min nadir is due to a rapid IkappaBalpha resynthesis that reassociates with Rel A and completely inhibits its DNA binding activity ; the 60 min nadir is not observed when IkappaBalpha resynthesis is prevented by cycloheximide treatment . ^^^ In this study , we examine the kinetics of TNFalpha activated translocation of the 65 kDa ( Rel A ) and 50 kDa ( NF kappaB 1 ) NF kappaB subunits mediated by inhibitor ( IkappaB ) proteolysis in HepG 2 hepatoblastoma cells . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| CsA does not interfere with the synthesis of Rel proteins , but prevents the inducible degradation of cytosolic NF kappa B inhibitors 1 kappa B alpha and 1 kappa B beta upon T cell activation . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Nuclear factor kappaB ( NF kappaB ) is a eukaryotic member of the Rel family of transcription factors whose biological activity is post translationally regulated by its assembly with various ankyrin rich cytoplasmic inhibitors , including IkappaBalpha . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Mouse IkappaBepsilon contains 6 ankyrin repeats required for its interaction with the Rel proteins and is expressed in different cell types where we found that it is up regulated by NF kappaB inducers , as is the case for IkappaBalpha and human IkappaBepsilon . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| B lymphocytes differentially use the Rel and nuclear factor kappaB 1 ( NF kappaB 1 ) transcription factors to regulate cell cycle progression and apoptosis in quiescent and mitogen activated cells . ^^^ Using mice with inactivated Rel or NF kappaB 1 genes , we show that these transcription factors differentially regulate cell cycle progression and apoptosis in B lymphocytes . ^^^ Consistent with an increased rate of mature B cell turnover in naive nfkb 1 / mice , the level of apoptosis in cultures of quiescent nfkb 1 / , but not c rel / , B cells is higher . ^^^ The failure of c rel / or nfkb 1 / B cells to proliferate in response to particular mitogens coincides with a cell cycle block early in G 1 and elevated cell death . ^^^ Expression of a bcl 2 transgene prevents apoptosis in resting and activated c rel / and nfkb 1 / B cells , but does not overcome the block in cell cycle progression , suggesting that the impaired proliferation is not simply a consequence of apoptosis and that Rel / NF kappaB proteins regulate cell survival and cell cycle control through independent mechanisms . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Supershift analysis revealed that these complexes were comprised principally of the RelA ( p 65 ) and NF kappaB 1 ( p 50 ) Rel family members . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Sar 1 Ang 2 induced cytoplasmic to nuclear translocation of the NF kappaB subunits Rel A and NF kappaB 1 with parallel changes in DNA binding activity in a biphasic manner , which produced an early peak at 15 minutes followed by a nadir 1 to 6 hours later and a later peak at 24 hours . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| We assessed accumulation of fluorescence stained NF kappaB into propidium iodide stained nuclei using laser scanning cytometry . `` Activity specific ' ' antibodies to the Rel A ( p 65 ) and NF kappaB 1 ( p 50 ) subunits of NF kappaB were detected in the nuclei of A 549 cells ( an immortalized human type 2 alveolar epithelial cell line ) . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| The gel supershift assay with Nfkb 1 , Rela and / or Rel antibodies revealed that the specific molecular forms of NF kappaB activated by radiation in the spleen were Nfkb 1 homodimers and Nfkb1 / Rela heterodimers . ^^^ In bone marrow , an NF kappaB like binding factor was induced that may be Nfkb1 / Rela and Rel / Rela like heterodimers , but it exhibited a higher mobility than Nfkb 1 homodimers . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| High levels of CAT activity were seen with HIV LTR derived reporters that contained kappaB and TAR elements in response to transfected Tat in the absence of either transfected Rel A or exogenous TNF alpha , and overexpression of IkappaBalpha with Tat inhibited CAT activity by 60 % to 80 % , suggesting that some activation of NF kappaB by Tat was occurring . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| The potent oncogenicity of 5 Rel is the consequence of a number of mutations that have altered its activity and regulation : for example , certain mutations decrease its ability to be regulated by IkappaBalpha , change its DNA binding site specificity , and endow it with new transactivation properties . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Previously , we showed that the APRE is a cytokine [ tumor necrosis factor alpha ( TNFalpha ) ] inducible enhancer by binding the heterodimeric nuclear factor kappaB ( NF kappaB ) complex Rel A 10 NF kappaB 1 . ^^^ In contrast to the TNFalpha mechanism , which strongly induces Rel A 10 NF kappaB 1 binding , Sar 1 AII selectively activates a heterogenous pattern of NF kappaB 1 binding . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| We have applied these principles in order to form crystals of the Rel homology region of transcription factor NF kappaB in complex with its inhibitors IkappaBalpha and IkappaBbeta . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Cotranslational dimerization of the Rel homology domain of NF kappaB 1 generates p 50 p105 heterodimers and is required for effective p 50 production . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Through the use of mutant mice that lack one or more of these proteins , we have begun to examine the individual and combined roles of Rel , RelA and NF kappaB 1 in B cell development and function . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| IkappaBalpha does this by shifting the balance between nuclear import of Rel proteins and their export from the nucleus . ^^^ Here we show that , unlike IkappaBalpha , IkappaBbeta and IkappaBepsilon appear to sequester p 65 or c Rel in the cytoplasm by inhibiting nuclear import . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| NF kappa B 1 induces the resynthesis of 1 kappa B alpha recapturing nuclear Rel A back into the cytoplasm within 1 h of stimulation . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Here we suggest a mechanism for the cell specificity and the subunit composition of constitutive B cell NF kappaB based on the observed properties of Rel homo and heterodimers and IkappaBalpha . ^^^ Second , the nuclear import potential of p 65 and c Rel homodimers but not p 50 associated heterodimers was attenuated when they were complexed to IkappaBalpha , leading to a greater propensity of heterodimers to be nuclear . ^^^ Cell specificity may be a consequence of c Rel IkappaBalpha complexes being present only in mature B cells , which leads to nuclear c Rel due to IkappaBalpha turnover and shuttling of the complex . . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| DNA binding studies using NF kappaB subunit specific binding ELISA demonstrated that RSV and TNFalpha induced different NF kappaB binding complexes containing Rel A ( p 65 ) and NF kappaB 1 ( p 50 ) . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Stimulation of cells with tumor necrosis factor alpha ( TNFalpha ) triggers NF kappaB 1 p105 proteolysis , releasing associated Rel subunits to translocate into the nucleus and modulate target gene expression . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Cerulein induces NF kappaB / Rel via activation of IkappaB kinase ( IKK ) , which causes degradation of IkappaBalpha but not IkappaBbeta . ^^^ In contrast , oxidative stress induced by H ( 2 ) O ( 2 ) activates NF kappaB / Rel independent of IKK activation and IkappaBalpha degradation ; instead IkappaBalpha is phosphorylated on tyrosine . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| In vitro , IkappaBalpha can block the DNA binding activity of wild type REL homodimers but not REL NRG homodimers . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| The NF kappa B transcription factor p 50 and the Rel protein specific transcription inhibitor p 105 are both encoded by the nfkb 1 gene . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| Two members of the NF kappaB ( nuclear factor kappaB ) / Rel transcription factor family , NF kappaB 1 and NF kappaB 2 , are produced as precursor proteins , NF kappaB 1 p105 and NF kappaB 2 p100 respectively . ^^^ |
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| Interacting proteins: Q04864 and P25963 |
Pubmed |
SVM Score :0.0 |
| In the splenic B cells , however , the down regulation of NF kappaB rel A was associated with decreased PCNA expression as well as IkappaBalpha and phosphorylated IkappaBalpha . ^^^ |
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