| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| Mice lacking RelB or 1 kappa B alpha , as well as both mice and humans with heterozygous NEMO mutations , develop skin lesions . ^^^ |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| The RelB p 52 heterodimers display a much lower affinity for 1 kappa B alpha than RelB p 50 heterodimers or p 65 complexes . ^^^ However , similarly to the other Rel NF kappa B complexes , RelB p 52 can upregulate the synthesis of 1 kappa B alpha leading to the cytoplasmic trapping of dimers which have a higher affinity for the inhibitor . ^^^ |
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| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| We have therefore analyzed the interaction of RelB complexes with the 1 kappa B alpha inhibitor protein . ^^^ Our results show that RelB containing complexes present in lymphoid extracts are much less susceptible to inhibition by 1 kappa B alpha than RelA or RelB containing complexes from non lymphoid cells . ^^^ |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| Only antibody to RelA ( p 65 ) , but not to NFKB 1 ( p 50 ) , NFKB 2 ( p50B ) , c Rel , or RelB was able to abolish binding , suggesting that RelA is a major component in these kappa B binding complexes . ^^^ |
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| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| NF kappa B is composed of distinct subunits ; five independent genes , NFKB 1 ( p 105 ) , NFKB 2 ( p 100 ) , RelA ( p 65 ) , c rel and relB , that encode related proteins that bind to kappa B DNA elements have been isolated . ^^^ |
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| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| Overexpression of RelB in transgenic mice does not affect 1 kappa B alpha levels : differential regulation of RelA and RelB by the inhibitor protein . ^^^ Interestingly , 1 kappa B alpha protein levels are not altered in the RelB transgenic animals , indicating that within the same cell type RelA and RelB complexes are differentially regulated by 1 kappa B alpha . . ^^^ |
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| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| In contrast to RelA containing complexes , RelB containing complexes are only weakly inhibited in their activity by 1 kappa B alpha . ^^^ Furthermore , in lymphoid tissues RelB is not associated with 1 kappa B alpha . ^^^ |
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| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| The NF kappa B family members p 50 , p 65 , p 52 , c Rel , and RelB as well as the inhibitor proteins 1 kappa B alpha , 1 kappa B beta , and p 105 were present in uninjured arteries as determined by immunoblotting . ^^^ |
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| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| Discrimination between RelA and RelB transcriptional regulation by a dominant negative mutant of IkappaBalpha . ^^^ In resting cells , RelB is found mostly in the nucleus , whereas RelA is sequestered in the cytosol by protein inhibitors , among which IkappaBalpha is the dominant form in lymphocytes . ^^^ To study the selectivity of gene regulation by RelA and RelB , we generated T cell lines stably expressing a dominant negative mutant of IkappaBalpha . ^^^ Wild type IkappaBalpha expression was concomitant with RelB up regulation , suggesting that RelB could be involved in transcription of IkappaBalpha through binding to an alternative site . ^^^ |
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| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| To investigate whether transcription factors of the NF kappa B family could play a role in early mammalian development , we have analyzed the expression of nfkb 1 , nfkb 2 , c Rel , RelA , RelB , and bcl 3 from 6 . 5 to 10 . 5 day mouse embryo implantation sites . ^^^ |
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| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| RelB modulation of IkappaBalpha stability as a mechanism of transcription suppression of interleukin 1alpha ( IL 1alpha ) , IL 1beta , and tumor necrosis factor alpha in fibroblasts . ^^^ Here we show that RelB is an important transcription suppressor in fibroblasts which limits the expression of proinflammatory mediators and may exert its function by modulating the stability of IkappaBalpha protein . ^^^ The increased kappaB binding activity and cytokine overexpression was suppressed by introducing RelB cDNA or a dominant negative IkappaBalpha into relb ( / ) fibroblasts . ^^^ |
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| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| In this study , we report that RelB deficient ( relB ( / ) ) mice , in contrast to nfkb 1 ( / ) , but similar to nfkb 2 ( / ) mice , are unable to form GCs and follicular dendritic cell networks upon Ag challenge in the spleen . ^^^ |
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| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| In this study , it is demonstrated that RelB is associated in the cytosol with p 100 but not with IkappaBalpha , IkappaBbeta , IkappaBepsilon , nor p 105 . ^^^ Its cytosolic control is not affected by stimuli that lead to RelA nuclear translocation , and RelB nuclear localization is prevented by p 100 , but not by p 105 or IkappaBalpha . ^^^ |
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| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| Inhibition of the constitutive nuclear pool of NF kappaB ( RelA and RelB ) in the promonocytic U 937 cell line using dominant negative IkappaBalpha significantly decreases HIV replication . ^^^ |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| This LMP 1 mediated effect was blocked following expression of either dominant negative 1 kappa B alpha S32 / 36A , an NF kappa B inhibitor , or antisense RelB . ^^^ |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| This effect was associated with the inhibition of the nuclear translocation of selective nuclear factor ( NF ) kappaB subunits : NF kappaB 1 ( p 50 ) , RelA ( p 65 ) , RelB ( p 68 ) and c Rel ( p 75 ) , but not NF kappaB 2 ( p 52 ) . ^^^ |
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| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| METHODS : Forty three frozen sections including 30 bladder cancer and 13 non cancer bladder mucosa were subjected to immunohistochemistry and nucleus staining for determining levels of NF kappa B family and 1 kappa B alpha ; Five paired cancer and non cancer specimens were subjected to Western blot for analysis p 65 , an important subtype of NF kappa B ; Thirteen paired specimens were subjected to RT PCR for determination mRNA levels of p 50 , p 52 , p 65 , c Rel , RelB , 1 kappa B alpha , CyclinD 1 , IL 8 . ^^^ RESULTS : Expressions of p 50 , p 52 , p 65 , c Rel , RelB , 1 kappa B alpha , CyclinD 1 , IL 8 mRNAs in bladder cancer were higher than that in non cancer bladder mucosa ( P < 0 . 01 , P < 0 . 05 , P < 0 . 01 , P < 0 . 01 , P < 0 . 05 , P < 0 . 05 , P < 0 . 05 and P < 0 . 05 , respectively ) . ^^^ |
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| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| However , IkappaBalpha primarily targets RelA and c Rel containing complexes , leaving other NF kappaB / Rel protein complexes , such as p 50 and p 52 homodimers , and RelB heterodimers uninhibited . ^^^ |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| RelB inhibition markedly differed from classical NF kappaB signaling inhibition because IkappaBalpha superrepressor ( IkappaBalpha SR ) , but not p100DeltaN , impaired LC / DC differentiation , DC adhesion , and progenitor cell proliferation . ^^^ |
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| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| ATRA increased the expression of RelA ( p 65 ) , RelB , nuclear factor ( NF ) kappaB 2 ( p 52 ) , and NF kappaB 1 ( p 50 ) , and elevated the DNA binding activity of p 65 and phosphorylation of inhibitor kappaB ( IkappaB ) alpha . ^^^ |
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| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| These data provide evidence that both Rac 1 and Rac1b activate the canonical RelA IkappaBalpha pathway , whereas Rac 1 further stimulates NF kappaB by inducing the RelB NF kappaB2 / p100 pathway . ^^^ |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|