| Interacting proteins: Q16559 and P25791 |
Pubmed |
SVM Score :0.0 |
| We have found that RBTN 1 and RBTN 2 have the ability to interact with each of the leukemogenic bHLH proteins ( TAL 1 , TAL 2 and LYL 1 ) . ^^^ The LIM bHLH interactions are highly specific in that RBTN 1 and RBTN 2 will associate with TAL 1 , TAL 2 and LYL 1 , but not with other bHLH proteins , including E 12 , E 47 , Id 1 , NHLH 1 , AP 4 , MAX , MYC and MyoD 1 . ^^^ |
|
| Interacting proteins: Q16559 and P25791 |
Pubmed |
SVM Score :0.0 |
| Our data support the involvement of 2 distinct mechanisms : translocations involving LMO 2 , TAL 2 , and TAL 1 in T cell acute lymphoblastic leukemia ( T ALL ) , are compatible with illegitimate 5 ( D ) J recombination between a TCR locus and a proto oncogene locus bearing a fortuitous but functional recombination site ( type 1 ) ; in contrast , translocations involving BCL 1 and BCL 2 in B cell non Hodgkin ' s lymphomas ( B NHL ) , are compatible with a process in which only the IgH locus breaks are mediated by 5 ( D ) J recombination ( type 2 ) . ^^^ |
|
| Interacting proteins: Q16559 and P25791 |
Pubmed |
SVM Score :0.0 |
| We investigated the prognostic effect of the expression levels of eight oncogenic transcription factors TLX 1 ( HOX 11 ) , TLX 3 ( HOX11L2 ) , TAL 1 , TAL 2 , LYL 1 , OLIG 2 ( BHLHB 1 ) , LMO 1 , and LMO 2 in 52 adults with T cell acute lymphoblastic leukaemia . ^^^ |
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