| Interacting proteins: P23769 and P25791 |
Pubmed |
SVM Score :0.0 |
| VYS erythropoiesis is decreased or abrogated by targeted disruption of the hematopoietic transcription factors tal 1 , rbtn 2 , GATA 1 , and GATA 2 . ^^^ This VYS expression occurred in a defined temporal sequence : tal 1 and rbtn 2 transcripts were detected earlier than the others , followed by GATA 2 and GATA 1 , and then by betaH 1 globin . ^^^ We conclude that primitive mammalian erythropoiesis arises during gastrulation through the ordered temporal expression of tal 1 , rbtn 2 , GATA 2 , and GATA 1 in a subset of extraembryonic mesoderm cells . ^^^ During the stages analyzed , tal 1 and rbtn 2 expression was also present in posterior embryonic mesoderm , while GATA 1 and GATA 2 expression was evident in extraembryonic tissues of ectodermal origin . . ^^^ |
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| Interacting proteins: P23769 and P25791 |
Pubmed |
SVM Score :0.0 |
| Likewise , the level of expression of the erythroid transcription factors GATA 1 , GATA 2 , NF E 2 , SCL and RBTN 2 , all expressed in untreated K 562 cells , did not increase during sodium phenylacetate induced erythroid differentiation . ^^^ |
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| Interacting proteins: P23769 and P25791 |
Pubmed |
SVM Score :0.0 |
| Additionally , most cells coexpress the stem cell associated transcriptional regulators AML 1 , PU . 1 , GATA 2 and Lmo 2 , as well as the granulocyte colony stimulating factor receptor ( G CSF R ) . ^^^ |
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| Interacting proteins: P23769 and P25791 |
Pubmed |
SVM Score :0.0 |
| ES cell derived hematopoietic precursor cells express the cell surface antigen CD 34 and the hematopoietic transcription factors TAL 1 , LMO 2 , and GATA 2 . ^^^ |
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| Interacting proteins: P23769 and P25791 |
Pubmed |
SVM Score :0.0 |
| Commitment of hematopoietic cells to the erythroid lineage involves the actions of several transcription factors , including TAL 1 , LMO 2 , and GATA 2 . ^^^ |
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| Interacting proteins: P23769 and P25791 |
Pubmed |
SVM Score :0.0 |
| Several findings were unexpected . ( 1 ) Two distinct patterns were revealed for GATA 2 , first : low expression , ubiquitous in all mesodermal cells , as soon as cells ingress through the primitive streak ; secondly : high , blood island specific expression . ( 2 ) VEGF R 2 is coexpressed with GATA 2 at the level of the primitive streak . ( 3 ) SCL and Lmo 2 expression is restricted to presumptive hemangioblasts . ( 4 ) The up regulation of GATA 2 in newly formed blood islands is shortly followed by GATA 1 expression . ( 5 ) Lmo 2 is up regulated in blood island angioblasts thus appearing as one of the earliest markers for endothelial cell commitment . ^^^ VEGF R 2 is down regulated in hemopoietic cells prior to GATA 2 , SCL / tal 1 , Lmo 2 and GATA 1 in erythroblasts . . ^^^ |
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| Interacting proteins: P23769 and P25791 |
Pubmed |
SVM Score :0.0 |
| It has not yet been elucidated how the BMP 4 signaling promotes the differentiation of blood cells , but it is likely that transcription factors such as GATA 2 , SCL , LMO 2 , biklf and GATA 1 are at least involved in the initial blood program . ^^^ |
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| Interacting proteins: P23769 and P25791 |
Pubmed |
SVM Score :0.0 |
| Levels of Scl , Rbtn 2 , GATA 1 , and Ldb 1 expression were comparable in AML and APL blasts , while the levels of expression of Rbtn 1 , GATA 2 , and GATA 3 were absent or markedly lower in APL cells . ^^^ |
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| Interacting proteins: P23769 and P25791 |
Pubmed |
SVM Score :0.0 |
| However , the expression of early hematopoietic genes , gata 2 and lmo 2 , was unaffected , suggesting that hematopoietic cells were present but unable to further differentiate . ^^^ |
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| Interacting proteins: P23769 and P25791 |
Pubmed |
SVM Score :0.0 |
| We assigned the expression of GATA 2 , GATA 3 , and lmo 2 to AGM HSC , whereas erythromyeloid progenitors express only GATA 2 . ^^^ |
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| Interacting proteins: P23769 and P25791 |
Pubmed |
SVM Score :0.0 |
| SCL , GATA 2 and Lmo 2 expression in neurogenesis . ^^^ Here , we show that neural cells in the early embryonic chick mid and hindbrain express SCL and GATA 2 , while Lmo 2 is expressed only in vascular elements . ^^^ The lack of Lmo 2 transcripts in neural cells demonstrated that SCL and GATA 2 can not form common complexes with Lmo 2 in the developing brain . ^^^ While overlapping expression of GATA 2 / 3 and SCL was detected , Lmo 2 activation could not be demonstrated in neural cells in the investigated period of neuronal development . . ^^^ |
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| Interacting proteins: P23769 and P25791 |
Pubmed |
SVM Score :0.0 |
| Quantitative real time polymerase chain reaction showed that Scl null platelets lacked NF E 2 , and chromatin immunoprecipitation analysis demonstrated Scl binding to the NF E 2 promoter in the human megakaryoblastic cell line Meg 01 , along with its binding partners E 47 , Lmo 2 , and the cofactors Ldb 1 and GATA 2 . ^^^ |
|
| Interacting proteins: P23769 and P25791 |
Pubmed |
SVM Score :0.0 |
| NA |
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