| Interacting proteins: P12980 and P25791 |
Pubmed |
SVM Score :0.0 |
| We have found that RBTN 1 and RBTN 2 have the ability to interact with each of the leukemogenic bHLH proteins ( TAL 1 , TAL 2 and LYL 1 ) . ^^^ The LIM bHLH interactions are highly specific in that RBTN 1 and RBTN 2 will associate with TAL 1 , TAL 2 and LYL 1 , but not with other bHLH proteins , including E 12 , E 47 , Id 1 , NHLH 1 , AP 4 , MAX , MYC and MyoD 1 . ^^^ |
|
| Interacting proteins: P12980 and P25791 |
Pubmed |
SVM Score :0.0 |
| Here we show that five different T cell oncogenes ( HOX 11 , TAL 1 , LYL 1 , LMO 1 , and LMO 2 ) are often aberrantly expressed in the absence of chromosomal abnormalities . ^^^ |
|
| Interacting proteins: P12980 and P25791 |
Pubmed |
SVM Score :0.0 |
| High expression of LYL 1 , LMO 2 , or TAL 1 was observed mainly in samples negative for HOX11L2 expression . ^^^ |
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| Interacting proteins: P12980 and P25791 |
Pubmed |
SVM Score :0.0 |
| Five different multistep molecular pathways have been identified that lead to T ALL , involving activation of different T ALL oncogenes : ( 1 ) HOX 11 , ( 2 ) HOX11L2 , ( 3 ) TAL 1 plus LMO1 / 2 , ( 4 ) LYL 1 plus LMO 2 , and ( 5 ) MLL ENL . ^^^ Gene expression studies indicate activation of a subset of these genes HOX 11 , TAL 1 , LYL 1 , LMO 1 , and LMO 2 in a much larger fraction of T ALL cases than those harboring activating chromosomal translocations . ^^^ |
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| Interacting proteins: P12980 and P25791 |
Pubmed |
SVM Score :0.0 |
| Aberrant expression of transcription factor oncogenes such as HOX 11 , HOX11L2 , TAL1 / SCL , LYL 1 , LMO 1 , and LMO 2 can be detected in lymphoblasts from up to 80 % of patients with acute T cell lymphoblastic leukemia ( T ALL ) . ^^^ |
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| Interacting proteins: P12980 and P25791 |
Pubmed |
SVM Score :0.0 |
| We investigated the prognostic effect of the expression levels of eight oncogenic transcription factors TLX 1 ( HOX 11 ) , TLX 3 ( HOX11L2 ) , TAL 1 , TAL 2 , LYL 1 , OLIG 2 ( BHLHB 1 ) , LMO 1 , and LMO 2 in 52 adults with T cell acute lymphoblastic leukaemia . ^^^ |
|
| Interacting proteins: P12980 and P25791 |
Pubmed |
SVM Score :0.0 |
| LMO 2 was more frequently coexpressed with LYL 1 , predominantly in IM0 / delta / gamma adult cases , than with TAL 1 . ^^^ |
|
| Interacting proteins: P12980 and P25791 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12980 and P25791 |
Pubmed |
SVM Score :0.0 |
| NA |
|