| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| On the basis of this , we used an efficient age , sex and area matched case control scheme to test the association of the polymorphisms in the human alpha1A adrenergic receptor ( ADRA1A ) gene , located on chromosome 8p21 p11 . 2 , with essential hypertension in a northern Han Chinese population . ^^^ |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| Localization of the mouse alpha1A adrenergic receptor ( AR ) in the brain : alpha1AAR is expressed in neurons , GABAergic interneurons , and NG 2 oligodendrocyte progenitors . alpha ( 1 ) Adrenergic receptors ( ARs ) are not well defined in the central nervous system . ^^^ |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| However , at a subtype level alpha 1a adrenergic receptor expression is down regulated and not detectable by ribonuclease protection assays or radioligand binding , while alpha 1b and alpha 1d adrenergic receptor expression is enhanced . ^^^ |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| The effects of intrathecal injection of tamsulosin ( an alpha 1A adrenergic receptor antagonist ) and naftopidil ( an alpha 1D adrenergic receptor antagonist ) on isovolumetric bladder contraction were investigated in rats under urethane anesthesia . ^^^ |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| The data suggest the following . 1 ) mRNA for the novel alpha 1D adrenoceptor is localized in vascular smooth muscle . 2 ) Definitive identification of expression of this receptor was not possible ; this may be related to coexpression of other subtypes of alpha 1 adrenoceptors . 3 ) mRNA for the alpha 1C adrenoceptor was detected in rat peripheral vasculature . 4 ) The alpha 1A adrenoceptor is also localized in the vasculature . 5 ) Three and possibly four alpha 1 adrenoceptors participate in vascular smooth muscle regulation . . ^^^ |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| The high affinity constant for WB 4101 ( 1 . 4 nM ) in 1 month old aorta was consistent with that for alpha 1d adrenoceptor subtype , whereas the high affinity constants ( 0 . 03 nM ) in 6 and 24 month old aortas were consistent with those for the alpha 1a adrenoceptor subtype . ^^^ |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| In several tissues from rat and cloned adrenoceptors , RS 17053 displayed high affinity for the alpha 1A adrenoceptor ( pKi and pA 2 estimates of 9 . 1 9 . 9 ) and a 30 100 fold selectivity over the alpha 1B and the alpha 1D adrenoceptor subtypes ( pK 1 and pA 2 estimates of 7 . 7 7 . 8 ) . ^^^ |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| Correlation coefficients comparing the clonal alpha 1d adrenoceptor binding affinity to in vitro contractile responses were 0 . 03 and 0 . 10 for the rat vas deferens and canine prostate alpha 1A adrenoceptor responses , respectively , 0 . 09 for the rat spleen alpha 1B and as noted , 0 . 94 for the rat aorta . ^^^ |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| The pA 2 values for the antagonist blockade of norepinephrine mediated interneuron excitation were significantly correlated to literature values for the pKi values of antagonist binding to the alpha 1B adrenoceptor ( r = 0 . 919 ) and the cloned alpha 1b adrenoceptor ( r = 0 . 849 ) but were not correlated to the pKi values of antagonist binding to the alpha 1A adrenoceptor or the cloned alpha 1a and alpha 1d adrenoceptor . ^^^ |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| These studies evaluated the effect of a selective alpha 1D adrenoceptor antagonist , BMY 7378 ( 8 [ 2 [ 4 ( 2 methoxyphenyl ) 1 piperazinyl ] ethyl ] 8 azaspirol [ 4 , 5 ] decane 7 , 9 dio ne 2HCl ) , on the pressor effect to i . v . phenylephrine ( alpha 1A / B / D adrenoceptor agonist ) and ( R ) A 61603 ( alpha 1A adrenoceptor agonist ; N [ 5 ( 4 , 5 dihydro 1 H imidazol 2yl ) 2 hydroxy 5 , 6 , 7 , 8 tetrahydronaphthalen l yl ] methanesulfonamide HBr ) in pithed rats . ^^^ |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| The results indicate that significant heterogeneity exists among alpha 1 adrenoceptor in the rabbit hypogastric artery ( alpha 1D adrenoceptor ) and the prostate ( alpha 1A adrenoceptor ) . . ^^^ |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| At higher concentrations ( 100 nM to 1 microM ) BMY 7378 antagonized the functional and biochemical response via a presumed interaction mainly with the alpha 1D adrenoceptor and partially with the alpha 1A adrenoceptor . . ^^^ |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| Two selective alpha 1A adrenoceptor antagonists , WB 4101 and 5 methyl urapidil , were potent and competitive antagonists of alpha 1 adrenoceptor induced contraction ( pA 2 10 . 67 and 8 . 90 , respectively ) and the selective alpha 1D adrenoceptor antagonist BMY 7378 had a low affinity ( pA 2 6 . 06 ) . ^^^ |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| The present results demonstrate that the alpha 1D adrenoceptor subtype plays an important role in the pressor response to sympathetic nerve stimulation in the pithed rat , and confirm the participation of the alpha 1A adrenoceptor subtype in the same response . . ^^^ |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| The potency of the selective alpha 1D adrenoceptor antagonist BMY 7378 against noradrenaline ( pA 2 = 6 . 16 + / 0 . 13 ) and of the selective alpha 1A adrenoceptor antagonist RS 17053 against noradrenaline ( pKB = 8 . 35 + / 0 . 10 ) and against the selective alpha 1A adrenoceptor agonist A 61603 ( pKB = 8 . 40 + / 0 . 09 ) were too low to account for alpha 1D and alpha 1A adrenoceptor involvement . 4 . ^^^ |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| Here , we evaluate the origins of haplotype block structure in the three genes for alpha 1 adrenergic receptors ( alpha 1 AR ) in the human genome ( ADRA1A , ADRA1B and ADRA1D ) by genotyping dense single nucleotide polymorphism ( SNP ) marker maps , and show that LD signals between distant markers are due to the presence of extended haplotype superblocks in individuals with ancient chromosomes which have escaped historic recombination . ^^^ |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25100 and P35348 |
Pubmed |
SVM Score :0.0 |
| NA |
|