| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Guanylin is a mammalian peptide homologue of heat stable enterotoxins that acts on intestinal guanylate cyclase to elicit an increase in cyclic GMP . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Guanylin : an endogenous activator of intestinal guanylate cyclase . ^^^ Based on these data , we propose that guanylin is an activator of intestinal guanylate cyclase and that it stimulates this enzyme through the same receptor binding region as the heat stable enterotoxins . . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Rat guanylin cDNA : characterization of the precursor of an endogenous activator of intestinal guanylate cyclase . ^^^ Guanylin is a recently discovered endogenous activator of intestinal guanylate cyclase that was purified from intestinal tissue . ^^^ Guanylin may serve a paracrine function to regulate intestinal guanylate cyclase activity , cyclic GMP levels , and thereby , fluid and electrolyte absorption . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND & AIMS : Guanylin activates an intestinal guanylate cyclase ( GCC ) and stimulates electrolyte movement across the gut epithelium . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Guanylin is a 15 amino acid peptide that acts on intestinal guanylate cyclase , thereby regulating intestinal fluid and electrolyte transport through the second messenger , cyclic GMP . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Uroguanylin , a member of the guanylin peptide family , is an endogenous activator of intestinal guanylate cyclase ( GC C ) . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Guanylin is a recently discovered peptide hormone that activates intestinal guanylate cyclase ( GC C ) and thereby stimulates intestinal chloride secretion . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Guanylin may have paracrine action on neighboring enterocytes , activating intestinal guanylate cyclase and thereby regulating intestinal fluid as well as electrolyte transport through the second messenger , cyclic GMP . . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Guanylin , a 15 amino acid peptide , activates intestinal guanylate cyclase C receptor , thereby regulating intestinal fluid and electrolyte transport through the second messenger , cyclic GMP . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Intestinal guanylate cyclase C is activated by guanylin , an endogenous peptide . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Guanylin is an endogenous mammalian ligand which binds to guanylate cyclase C ( GC C ) , the Escherichia coli heat stable enterotoxin receptor . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| The guanylin receptor is a member of the guanylate cyclase ( GC C ) family of proteins . ^^^ Proguanylin is found in the circulation and GC C occurs in other epithelia , suggesting that guanylin plays an endocrine role by regulating the function of tissues such as the kidney and liver . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Although GC C , the STa receptor , may also be a receptor for guanylin , other receptors may exist that may be more specific for guanylin . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Guanylate cyclase C ( GC C ) is a transmembrane protein that serves as a receptor for the recently characterized endogenous ligand guanylin and for Escherichia coli heat stable toxin ( STa ) . ^^^ Binding of either guanylin or STa to intestinal GC C results in net chloride secretion . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Guanylin , a peptide homologue of the bacterial heat stable enterotoxins ( ST ) , is an endogenous activator of guanylate cyclase C ( GC C ) . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Guanylyl cyclase C ( GC C ) , a transmembrane receptor for E . coli heat stable enterotoxin ( STa ) and for the endogenous peptides guanylin and uroguanylin , catalyzes formation of cGMP and influences fluid and electrolyte flux in the gut . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| The polypeptide guanylin is an endogenous activator of small intestinal guanylate cyclase . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Guanylin is a peptide isolated from rat intestine that stimulates intestinal guanylate cyclase . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Guanylin , a bioactive peptide , has recently been isolated from the intestine ; this peptide activates intestinal guanylate cyclase ( i . e . , guanylate cyclase C ) and thus is potentially involved in the regulation of water / electrolyte transport in the gastrointestinal mucosa . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Guanylyl cyclase C ( GC C ) is the receptor for the heat stable enterotoxin produced by bacteria as well as for the newly discovered mammalian hormones guanylin and uroguanylin . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Uroguanylin and guanylin are structurally related peptides that activate an intestinal form of membrane guanylate cyclase ( GC C ) . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND / AIMS : Guanylyl cyclase C ( GC C ) is an intestinal transmembrane receptor which binds both guanylin , an endogenous ligand , and Escherichia coli heat stable enterotoxin ( STa ) resulting in 5 ' cyclic guanosine monophosphate ( cGMP ) accumulation and chloride secretion . ^^^ The expression of this receptor in hepatocytes , combined with the recent demonstration of circulating guanylin , is consistent with a functional role for GC C in the liver . . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Thus , GC C may be involved in the fluid regulation by typical ligands ( e . g . , the peptide hormone guanylin or the toxins causing travellers ' diarrhea ) , not only in the intestine but also in the organs responsible for hearing and gravitational orientation . . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Recently , the peptides guanylin and uroguanylin were identified as endogenous ligands of the membrane bound guanylate cyclase C ( GC C ) that is mainly expressed in the intestinal epithelium . ^^^ The presence of the amino terminally neighboring residues of Cys 104 for guanylin and Cys 100 for uroguanylin has been found to be essential for GC C stimulation . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Both uroguanylin and the related peptide ligand guanylin bind to GC C and stimulate an increase in cyclic GMP , inducing chloride secretion via the cystic fibrosis transmembrane conductance regulator . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Binding of STa , or of the mammalian endogenous ligands guanylin and uroguanylin , activates the guanylyl cyclase C receptor ( GC C ) ; the resulting elevation of cGMP levels stimulates chloride secretion via CFTR . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Uroguanylin and guanylin are isolated mainly from the gastrointestinal tract and are activators of guanylyl cyclase C receptor ( GC C ) , which mediates the production of intracellular cyclic guanosine 3 ' , 5 ' monophosphate ( cyclic GMP ) . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Heat stable enterotoxins produced by pathogenic bacteria have close structural similarities to guanylin and uroguanylin , and they use this mimicry to act on GC C , causing life threatening secretory diarrhea . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Uroguanylin , a member of the guanylin peptide family , acts on guanylyl cyclase C ( GC C ) to regulate intestinal and renal fluid and electrolyte transport through the second messenger , cGMP . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| To investigate the importance of amino acid residues in the central region between the inner cysteines and at the carboxy terminus for this isomerism , synthetic derivatives of guanylin were compared by HPLC , 2D1H NMR spectroscopy and by their guanylyl cyclase C ( GC C ) activating potency . ^^^ Because only one of the stabilized guanylin isomers activates guanylyl cyclase C , the three dimensional structure of the GC C activating guanylin isomer is now defined . ^^^ The stabilized isoforms of guanylin described in this study represent suitable tools for the separate functional investigation of the GC C agonistic isomer of guanylin as well as of its isomeric counterpart . . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| The role of carbohydrate moieties at the N linked glycosylation sites of guanylate cyclase C ( GC C ) , a receptor protein for guanylin , uroguanylin and heat stable enterotoxin , in ligand binding and structural stability was examined using site directed mutagenesis of the putative N linked glycosylation sites in the extracellular domain ( ECD ) of porcine GC C . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| GC C is an intestinal receptor GC for guanylin and uroguanylin , but GC C may not be involved in renal cGMP pathways . ^^^ Guanylin and uroguanylin are highly expressed in intestinal mucosa to regulate intestinal salt and water transport via paracrine actions on GC C . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Uroguanylin and guanylin are newly discovered endogenous heat stable peptides that bind to and activate a membrane bound guanylyl cyclase signaling receptor ( termed guanylyl cyclase C ; GC C ) . ^^^ Thus , uroguanylin and guanylin seem to serve as intestinal and renal natriuretic peptide hormones influencing salt and water transport in the kidney through GC C dependent and independent pathways . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Uroguanylin ( UGN ) and guanylin ( GN ) are the endogenous intestinal ligands for guanylyl cyclase C ( GC C ) . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Two receptor GC signaling molecules have been identified that are highly expressed in the intestine ( GC C ) and / or the kidney ( OK GC ) and are selectively activated by the guanylin peptides . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Expression of GC C , a receptor guanylate cyclase , and its endogenous ligands uroguanylin and guanylin along the rostrocaudal axis of the intestine . ^^^ We establish that 1 ) uroguanylin is essentially restricted to small bowel ; 2 ) guanylin is very low in proximal small bowel , increasing to prominent levels in distal small bowel and throughout colon ; 3 ) GC C messenger RNA and STa binding sites are uniformly expressed throughout the intestine ; and 4 ) GC C mediated cGMP synthesis peaks at the proximal and distal extremes of the intestine ( duodenum and colon ) , but is nearly absent in the middle ( ileum ) . ^^^ These observations suggest that GC C ' s activity may be posttranslationally regulated , demonstrate that the distribution of GC C is appropriate to mediate the actions of both uroguanylin and guanylin , and help to refine current hypotheses about the physiological role ( s ) of these peptides . . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| ATP regulates the activity of guanylyl cyclase C ( GC C ) , the receptor for the guanylin and stable toxin family of peptides , presumably as a result of binding to the kinase homology domain ( KHD ) . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Guanylyl cyclase C ( GC C ) is the receptor for the hormones guanylin and uroguanylin . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Northern and / or Western analysis was used to determine the levels of guanylin , uroguanylin , and GC C in mice with osmotic diarrhea . ^^^ Although they did not develop diarrhea , GC C sufficient and deficient mice on the lactose diet responded with elevated levels of guanylin and uroguanylin RNA and protein . ^^^ A polyethylene glycol drinking water solution resulted in diarrhea , higher gut to carcass ratios , and induction of guanylin and uroguanylin in both GC C heterozygous and null animals . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Human colonic cancer cells are known to express guanylate cyclase C ( GC C ) receptors for guanylin and uroguanylin . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| So far two endogenous ligands of mammalian GC C have been identified i . e . the small cysteine rich peptides guanylin and uroguanylin . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| AIMS : Because CFTR is essentially involved in the electrolyte secretion of the pancreatic duct cells , the rat pancreas was investigated for expression and cell specific localization of guanylin and uroguanylin ; expression of major components of the guanylin signaling pathway , i . e . , the guanylin / uroguanylin receptor guanylate cyclase C ( GC C ) , cGMP dependent protein kinase 2 , and CFTR ; and expression of the epithelial Cl / HCO3 exchanger AE 2 . ^^^ The guanylin / uroguanylin receptor GC C , cGKII , CFTR , and AE 2 were all found in the same segments of the ductal system , where they were confined to the apical membrane of centroacinar cells and proximal duct epithelial cells , a circumstance suggesting that both peptides may act through the ductal lumen . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Guanylyl cyclase C ( GC C ) , a member of membrane bound guanylyl cyclases , is a receptor protein for guanylin and uroguanylin . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Guanylyl cyclase C ( GC C ) is a membrane associated form of guanylyl cyclase and serves as the receptor for the heat stable enterotoxin ( ST ) peptide and endogenous ligands guanylin , uroguanylin , and lymphoguanylin . ^^^ Using reverse transcriptase and the polymerase chain reaction , we demonstrated the presence of GC C , uroguanylin , and guanylin mRNA in both male and female reproductive organs . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Both STa and guanylin , a peptide structurally similar to STa , increase intracellular cGMP levels after binding to the same intestinal receptor , guanylate cyclase C ( GC C ) . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Guanylin and uroguanylin are peptides that activate guanylyl cyclase C ( GC C ) receptors in the intestine and kidney , which causes an increase in the excretion of salt and water . ^^^ The Spinifex hopping mouse , Notomys alexis , is a desert rodent that can survive for extended periods without free access to water and it was hypothesised that to conserve water , the expression of guanylin , uroguanylin , and GC C would be down regulated to reduce the excretion of water in urine and faeces . ^^^ Accordingly , this study examined the expression of guanylin , uroguanylin , and GC C mRNA in Notomys under normal ( access to water ) and water deprived conditions . ^^^ Subsequently , a semi quantitative PCR method showed that water deprivation in Notomys caused a significant increase in guanylin and uroguanylin mRNA expression in the distal colon , and in guanylin and GC C mRNA expression in the proximal colon . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| ST , guanylin or uroguanylin binding to GC C results in increased cGMP , phosphorylation of the CFTR Cl channel and secretion . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Previous studies in the rat and human duodenum have shown that guanylin and Escherichia coli heat stable toxin , both ligands of the transmembrane guanylyl cyclase receptor [ guanylate cyclase C ( GC C ) ] , are potent stimulators for duodenal HCO 3 secretion . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| GC C mediates the effects of guanylin and uroguanylin on intestinal electrolyte and water transport and on epithelial cell growth and differentiation . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| However , it did not affect membrane bound guanylate cyclase GC C stimulated by guanylin or Escherichia coli heat stable toxin STa . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| The ultracytochemical localization of adenylate cyclase ( AC ) and guanylate cyclase B ( GC B ) and C ( GC C ) activity was studied after stimulation with pituitary adenylate cyclase activating peptide , C type natriuretic peptide and guanylin , respectively , in normal human respiratory nasal mucosa and mucosa of nasal polyps . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| The peptide hormones guanylin and uroguanylin are ligands of the intestinal guanylyl cyclase C ( GC C ) that is involved in the regulation of epithelial water and electrolyte transport . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| GC C is a receptor protein , i . e . specifically stimulated by the endogenous peptides guanylin , uroguanylin , lymphoguanylin , and the exogenous peptide heat stable enterotoxin ( ST ( a ) ) , secreted by pathogenic Escherichia coli and acting on the intestinal brush border membranes . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| One cyclase , GC C or StaR , is predominantly found in the intestinal epithelium and is the receptor for guanylin and uroguanylin , as well as for the bacterial pathogen , heat stable enterotoxin ( Sta ) . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Cells depolarized upon guanylin or uroguanylin ( each 10 nmol / L ) by 3 . 3 + / 0 . 8 mV ( N= 12 ) and 3 . 4 + / 0 . 5 mV ( N= 18 ) , respectively , but were hyperpolarized by 8Br cyclic guanosine monophosphate ( cGMP ) ( 100 micromol / L ) ( 3 . 0 + / 0 . 2 mV ) ( N= 4 ) . mRNA for GC C was not detected in CCD . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Guanylyl cyclase C ( GC C ) , a transmembrane receptor for bacterial heat stable enterotoxin and the mammalian peptides guanylin and uroguanylin , mediates intestinal ion secretion and affects intestinal cell growth via cyclic GMP signaling . ^^^ In intestinal tumors , GC C expression is maintained while guanylin and uroguanylin expression is lost , suggesting a role for GC C activation in tumor formation or growth . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| The enterotoxin / guanylin receptor type membrane GC ( designated as GC C in mammals ) is activated by exogenous ligands such as heat stable enterotoxins ( STa ) , small peptides secreted by some pathogenic strains of Escherichia coli which cause severe secretory diarrhea and also activated by endogenous ligands such as guanylin and uroguanylin . ^^^ In mammals , only a single membrane GC ( GC C ) is known to be the STa / guanylin receptor . ^^^ Furthermore , the transcriptional regulatory mechanism of the OlGC 9 gene is different from those of both the OlGC 6 and human GC C genes , indicating that the study on these two medaka fish GCs will be useful for further understanding of the STa / guanylin receptor type membrane GC in the vertebrates . . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Guanylyl cyclase C ( GC C ) is a single transmembrane receptor that is specifically activated by endogenous ligands , including guanylin , and the exogenous ligand , heat stable enterotoxin . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Guanylin , and endogenous ligand for the Escherichia coli heat stable enterotoxin receptor , is a recently characterized intestinal peptide . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Guanylin generated by either trypsin or acid treatment of proguanylin was purified and found to bind to , and activate , STaR . ^^^ These results demonstrate that guanylin is an endogenous activator of STaR . . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| These findings fill a major gap in our knowledge of talpid sensory biology and suggest ( 1 ) how Eimer ' s organs evolved , ( 2 ) how the unusual appendages of the star nosed mole evolved , ( 3 ) that the evolution of Eimer ' s organ is convergent with the mechanosensory push rod of monotremes . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| The presence of apoptotic cells ( TUNEL method ) and the expression of proliferating cell nuclear antigen ( PCNA ) , gap junction protein ( Cx 43 ) , steroidogenic acute regulatory protein ( StAR ) , aromatase and synaptosome associated protein of 25 kDa ( SNAP 25 ) were determined by immunocytochemistry . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Oscillating fluid flow regulates gap junction communication in osteocytic MLO Y 4 cells by an ERK1 / 2 MAP kinase dependent mechanism small star , filled . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| Case of hemorrhagic fever in Star a Zagora . ] . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| The protein has a sterile alpha motif ( SAM ) , a distinct GAP domain , and a conserved START ( StAR related lipid transfer ) domain . ^^^ |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25092 and Q02747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| These findings fill a major gap in our knowledge of talpid sensory biology and suggest ( 1 ) how Eimer ' s organs evolved , ( 2 ) how the unusual appendages of the star nosed mole evolved , ( 3 ) that the evolution of Eimer ' s organ is convergent with the mechanosensory push rod of monotremes . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| The presence of apoptotic cells ( TUNEL method ) and the expression of proliferating cell nuclear antigen ( PCNA ) , gap junction protein ( Cx 43 ) , steroidogenic acute regulatory protein ( StAR ) , aromatase and synaptosome associated protein of 25 kDa ( SNAP 25 ) were determined by immunocytochemistry . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Oscillating fluid flow regulates gap junction communication in osteocytic MLO Y 4 cells by an ERK1 / 2 MAP kinase dependent mechanism small star , filled . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| The protein has a sterile alpha motif ( SAM ) , a distinct GAP domain , and a conserved START ( StAR related lipid transfer ) domain . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Guanylin is a mammalian peptide homologue of heat stable enterotoxins that acts on intestinal guanylate cyclase to elicit an increase in cyclic GMP . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Guanylin : an endogenous activator of intestinal guanylate cyclase . ^^^ Based on these data , we propose that guanylin is an activator of intestinal guanylate cyclase and that it stimulates this enzyme through the same receptor binding region as the heat stable enterotoxins . . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Rat guanylin cDNA : characterization of the precursor of an endogenous activator of intestinal guanylate cyclase . ^^^ Guanylin is a recently discovered endogenous activator of intestinal guanylate cyclase that was purified from intestinal tissue . ^^^ Guanylin may serve a paracrine function to regulate intestinal guanylate cyclase activity , cyclic GMP levels , and thereby , fluid and electrolyte absorption . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Guanylin generated by either trypsin or acid treatment of proguanylin was purified and found to bind to , and activate , STaR . ^^^ These results demonstrate that guanylin is an endogenous activator of STaR . . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND & AIMS : Guanylin activates an intestinal guanylate cyclase ( GCC ) and stimulates electrolyte movement across the gut epithelium . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Guanylin is an endogenous mammalian ligand which binds to guanylate cyclase C ( GC C ) , the Escherichia coli heat stable enterotoxin receptor . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| The guanylin receptor is a member of the guanylate cyclase ( GC C ) family of proteins . ^^^ Proguanylin is found in the circulation and GC C occurs in other epithelia , suggesting that guanylin plays an endocrine role by regulating the function of tissues such as the kidney and liver . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Guanylin is a 15 amino acid peptide that acts on intestinal guanylate cyclase , thereby regulating intestinal fluid and electrolyte transport through the second messenger , cyclic GMP . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Although GC C , the STa receptor , may also be a receptor for guanylin , other receptors may exist that may be more specific for guanylin . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^ Recently an endogenous ligand called guanylin has been extracted from mammalian intestine and shown to bind the STa receptor . ^^^ It is likely that guanylin and uroguanylin are indeed endogenous ligands for the STa receptor and may be modulators of Cl secretion in the intestine , kidney , and perhaps in other organs . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Guanylate cyclase C ( GC C ) is a transmembrane protein that serves as a receptor for the recently characterized endogenous ligand guanylin and for Escherichia coli heat stable toxin ( STa ) . ^^^ Binding of either guanylin or STa to intestinal GC C results in net chloride secretion . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| The polypeptide guanylin is an endogenous activator of small intestinal guanylate cyclase . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Guanylin is a peptide isolated from rat intestine that stimulates intestinal guanylate cyclase . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Guanylin , a peptide homologue of the bacterial heat stable enterotoxins ( ST ) , is an endogenous activator of guanylate cyclase C ( GC C ) . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Guanylin , a bioactive peptide , has recently been isolated from the intestine ; this peptide activates intestinal guanylate cyclase ( i . e . , guanylate cyclase C ) and thus is potentially involved in the regulation of water / electrolyte transport in the gastrointestinal mucosa . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Guanylin , and endogenous ligand for the Escherichia coli heat stable enterotoxin receptor , is a recently characterized intestinal peptide . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Uroguanylin , a member of the guanylin peptide family , is an endogenous activator of intestinal guanylate cyclase ( GC C ) . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Guanylin is a recently discovered peptide hormone that activates intestinal guanylate cyclase ( GC C ) and thereby stimulates intestinal chloride secretion . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Guanylyl cyclase C ( GC C ) , a transmembrane receptor for E . coli heat stable enterotoxin ( STa ) and for the endogenous peptides guanylin and uroguanylin , catalyzes formation of cGMP and influences fluid and electrolyte flux in the gut . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Guanylin may have paracrine action on neighboring enterocytes , activating intestinal guanylate cyclase and thereby regulating intestinal fluid as well as electrolyte transport through the second messenger , cyclic GMP . . ^^^ Guanylin , a peptide homologue of the bacterial heat stable enterotoxins , is an endogenous activator of guanylate cyclase C ( GC C ) . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Guanylyl cyclase C ( GC C ) is the receptor for the heat stable enterotoxin produced by bacteria as well as for the newly discovered mammalian hormones guanylin and uroguanylin . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Uroguanylin and guanylin are structurally related peptides that activate an intestinal form of membrane guanylate cyclase ( GC C ) . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Guanylin , a 15 amino acid peptide , activates intestinal guanylate cyclase C receptor , thereby regulating intestinal fluid and electrolyte transport through the second messenger , cyclic GMP . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND / AIMS : Guanylyl cyclase C ( GC C ) is an intestinal transmembrane receptor which binds both guanylin , an endogenous ligand , and Escherichia coli heat stable enterotoxin ( STa ) resulting in 5 ' cyclic guanosine monophosphate ( cGMP ) accumulation and chloride secretion . ^^^ The expression of this receptor in hepatocytes , combined with the recent demonstration of circulating guanylin , is consistent with a functional role for GC C in the liver . . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Thus , GC C may be involved in the fluid regulation by typical ligands ( e . g . , the peptide hormone guanylin or the toxins causing travellers ' diarrhea ) , not only in the intestine but also in the organs responsible for hearing and gravitational orientation . . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Recently , the peptides guanylin and uroguanylin were identified as endogenous ligands of the membrane bound guanylate cyclase C ( GC C ) that is mainly expressed in the intestinal epithelium . ^^^ The presence of the amino terminally neighboring residues of Cys 104 for guanylin and Cys 100 for uroguanylin has been found to be essential for GC C stimulation . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Both uroguanylin and the related peptide ligand guanylin bind to GC C and stimulate an increase in cyclic GMP , inducing chloride secretion via the cystic fibrosis transmembrane conductance regulator . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Binding of STa , or of the mammalian endogenous ligands guanylin and uroguanylin , activates the guanylyl cyclase C receptor ( GC C ) ; the resulting elevation of cGMP levels stimulates chloride secretion via CFTR . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Uroguanylin and guanylin are isolated mainly from the gastrointestinal tract and are activators of guanylyl cyclase C receptor ( GC C ) , which mediates the production of intracellular cyclic guanosine 3 ' , 5 ' monophosphate ( cyclic GMP ) . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Heat stable enterotoxins produced by pathogenic bacteria have close structural similarities to guanylin and uroguanylin , and they use this mimicry to act on GC C , causing life threatening secretory diarrhea . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Uroguanylin , a member of the guanylin peptide family , acts on guanylyl cyclase C ( GC C ) to regulate intestinal and renal fluid and electrolyte transport through the second messenger , cGMP . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| To investigate the importance of amino acid residues in the central region between the inner cysteines and at the carboxy terminus for this isomerism , synthetic derivatives of guanylin were compared by HPLC , 2D1H NMR spectroscopy and by their guanylyl cyclase C ( GC C ) activating potency . ^^^ Because only one of the stabilized guanylin isomers activates guanylyl cyclase C , the three dimensional structure of the GC C activating guanylin isomer is now defined . ^^^ The stabilized isoforms of guanylin described in this study represent suitable tools for the separate functional investigation of the GC C agonistic isomer of guanylin as well as of its isomeric counterpart . . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| The role of carbohydrate moieties at the N linked glycosylation sites of guanylate cyclase C ( GC C ) , a receptor protein for guanylin , uroguanylin and heat stable enterotoxin , in ligand binding and structural stability was examined using site directed mutagenesis of the putative N linked glycosylation sites in the extracellular domain ( ECD ) of porcine GC C . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| GC C is an intestinal receptor GC for guanylin and uroguanylin , but GC C may not be involved in renal cGMP pathways . ^^^ Guanylin and uroguanylin are highly expressed in intestinal mucosa to regulate intestinal salt and water transport via paracrine actions on GC C . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Uroguanylin ( UGN ) and guanylin ( GN ) are the endogenous intestinal ligands for guanylyl cyclase C ( GC C ) . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Two receptor GC signaling molecules have been identified that are highly expressed in the intestine ( GC C ) and / or the kidney ( OK GC ) and are selectively activated by the guanylin peptides . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Intestinal guanylate cyclase C is activated by guanylin , an endogenous peptide . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Uroguanylin and guanylin are newly discovered endogenous heat stable peptides that bind to and activate a membrane bound guanylyl cyclase signaling receptor ( termed guanylyl cyclase C ; GC C ) . ^^^ Thus , uroguanylin and guanylin seem to serve as intestinal and renal natriuretic peptide hormones influencing salt and water transport in the kidney through GC C dependent and independent pathways . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Expression of GC C , a receptor guanylate cyclase , and its endogenous ligands uroguanylin and guanylin along the rostrocaudal axis of the intestine . ^^^ We establish that 1 ) uroguanylin is essentially restricted to small bowel ; 2 ) guanylin is very low in proximal small bowel , increasing to prominent levels in distal small bowel and throughout colon ; 3 ) GC C messenger RNA and STa binding sites are uniformly expressed throughout the intestine ; and 4 ) GC C mediated cGMP synthesis peaks at the proximal and distal extremes of the intestine ( duodenum and colon ) , but is nearly absent in the middle ( ileum ) . ^^^ These observations suggest that GC C ' s activity may be posttranslationally regulated , demonstrate that the distribution of GC C is appropriate to mediate the actions of both uroguanylin and guanylin , and help to refine current hypotheses about the physiological role ( s ) of these peptides . . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| ATP regulates the activity of guanylyl cyclase C ( GC C ) , the receptor for the guanylin and stable toxin family of peptides , presumably as a result of binding to the kinase homology domain ( KHD ) . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Guanylyl cyclase C ( GC C ) is the receptor for the hormones guanylin and uroguanylin . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Northern and / or Western analysis was used to determine the levels of guanylin , uroguanylin , and GC C in mice with osmotic diarrhea . ^^^ Although they did not develop diarrhea , GC C sufficient and deficient mice on the lactose diet responded with elevated levels of guanylin and uroguanylin RNA and protein . ^^^ A polyethylene glycol drinking water solution resulted in diarrhea , higher gut to carcass ratios , and induction of guanylin and uroguanylin in both GC C heterozygous and null animals . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Human colonic cancer cells are known to express guanylate cyclase C ( GC C ) receptors for guanylin and uroguanylin . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| So far two endogenous ligands of mammalian GC C have been identified i . e . the small cysteine rich peptides guanylin and uroguanylin . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| AIMS : Because CFTR is essentially involved in the electrolyte secretion of the pancreatic duct cells , the rat pancreas was investigated for expression and cell specific localization of guanylin and uroguanylin ; expression of major components of the guanylin signaling pathway , i . e . , the guanylin / uroguanylin receptor guanylate cyclase C ( GC C ) , cGMP dependent protein kinase 2 , and CFTR ; and expression of the epithelial Cl / HCO3 exchanger AE 2 . ^^^ The guanylin / uroguanylin receptor GC C , cGKII , CFTR , and AE 2 were all found in the same segments of the ductal system , where they were confined to the apical membrane of centroacinar cells and proximal duct epithelial cells , a circumstance suggesting that both peptides may act through the ductal lumen . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Guanylyl cyclase C ( GC C ) , a member of membrane bound guanylyl cyclases , is a receptor protein for guanylin and uroguanylin . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Guanylyl cyclase C ( GC C ) is a membrane associated form of guanylyl cyclase and serves as the receptor for the heat stable enterotoxin ( ST ) peptide and endogenous ligands guanylin , uroguanylin , and lymphoguanylin . ^^^ Using reverse transcriptase and the polymerase chain reaction , we demonstrated the presence of GC C , uroguanylin , and guanylin mRNA in both male and female reproductive organs . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Both STa and guanylin , a peptide structurally similar to STa , increase intracellular cGMP levels after binding to the same intestinal receptor , guanylate cyclase C ( GC C ) . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Guanylin and uroguanylin are peptides that activate guanylyl cyclase C ( GC C ) receptors in the intestine and kidney , which causes an increase in the excretion of salt and water . ^^^ The Spinifex hopping mouse , Notomys alexis , is a desert rodent that can survive for extended periods without free access to water and it was hypothesised that to conserve water , the expression of guanylin , uroguanylin , and GC C would be down regulated to reduce the excretion of water in urine and faeces . ^^^ Accordingly , this study examined the expression of guanylin , uroguanylin , and GC C mRNA in Notomys under normal ( access to water ) and water deprived conditions . ^^^ Subsequently , a semi quantitative PCR method showed that water deprivation in Notomys caused a significant increase in guanylin and uroguanylin mRNA expression in the distal colon , and in guanylin and GC C mRNA expression in the proximal colon . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| ST , guanylin or uroguanylin binding to GC C results in increased cGMP , phosphorylation of the CFTR Cl channel and secretion . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Previous studies in the rat and human duodenum have shown that guanylin and Escherichia coli heat stable toxin , both ligands of the transmembrane guanylyl cyclase receptor [ guanylate cyclase C ( GC C ) ] , are potent stimulators for duodenal HCO 3 secretion . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| GC C mediates the effects of guanylin and uroguanylin on intestinal electrolyte and water transport and on epithelial cell growth and differentiation . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| However , it did not affect membrane bound guanylate cyclase GC C stimulated by guanylin or Escherichia coli heat stable toxin STa . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| The ultracytochemical localization of adenylate cyclase ( AC ) and guanylate cyclase B ( GC B ) and C ( GC C ) activity was studied after stimulation with pituitary adenylate cyclase activating peptide , C type natriuretic peptide and guanylin , respectively , in normal human respiratory nasal mucosa and mucosa of nasal polyps . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| The peptide hormones guanylin and uroguanylin are ligands of the intestinal guanylyl cyclase C ( GC C ) that is involved in the regulation of epithelial water and electrolyte transport . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| GC C is a receptor protein , i . e . specifically stimulated by the endogenous peptides guanylin , uroguanylin , lymphoguanylin , and the exogenous peptide heat stable enterotoxin ( ST ( a ) ) , secreted by pathogenic Escherichia coli and acting on the intestinal brush border membranes . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| One cyclase , GC C or StaR , is predominantly found in the intestinal epithelium and is the receptor for guanylin and uroguanylin , as well as for the bacterial pathogen , heat stable enterotoxin ( Sta ) . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Cells depolarized upon guanylin or uroguanylin ( each 10 nmol / L ) by 3 . 3 + / 0 . 8 mV ( N= 12 ) and 3 . 4 + / 0 . 5 mV ( N= 18 ) , respectively , but were hyperpolarized by 8Br cyclic guanosine monophosphate ( cGMP ) ( 100 micromol / L ) ( 3 . 0 + / 0 . 2 mV ) ( N= 4 ) . mRNA for GC C was not detected in CCD . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Guanylyl cyclase C ( GC C ) , a transmembrane receptor for bacterial heat stable enterotoxin and the mammalian peptides guanylin and uroguanylin , mediates intestinal ion secretion and affects intestinal cell growth via cyclic GMP signaling . ^^^ In intestinal tumors , GC C expression is maintained while guanylin and uroguanylin expression is lost , suggesting a role for GC C activation in tumor formation or growth . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| The enterotoxin / guanylin receptor type membrane GC ( designated as GC C in mammals ) is activated by exogenous ligands such as heat stable enterotoxins ( STa ) , small peptides secreted by some pathogenic strains of Escherichia coli which cause severe secretory diarrhea and also activated by endogenous ligands such as guanylin and uroguanylin . ^^^ In mammals , only a single membrane GC ( GC C ) is known to be the STa / guanylin receptor . ^^^ Furthermore , the transcriptional regulatory mechanism of the OlGC 9 gene is different from those of both the OlGC 6 and human GC C genes , indicating that the study on these two medaka fish GCs will be useful for further understanding of the STa / guanylin receptor type membrane GC in the vertebrates . . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Guanylyl cyclase C ( GC C ) is a single transmembrane receptor that is specifically activated by endogenous ligands , including guanylin , and the exogenous ligand , heat stable enterotoxin . ^^^ |
|
| Interacting proteins: Q02747 and P25092 |
Pubmed |
SVM Score :0.0 |
| Case of hemorrhagic fever in Star a Zagora . ] . ^^^ |
|