| Interacting proteins: P24863 and P49336 |
Pubmed |
SVM Score :0.0 |
| Colocalization of cyclin C and its preferred binding partner , Cdk 8 , was only observed in astrocytes but not in neurons . ^^^ |
|
| Interacting proteins: P24863 and P49336 |
Pubmed |
SVM Score :0.76912367 |
| The cyclin C protein has recently been shown to associate with a unique cyclin dependent protein kinase ( cdk 8 ) and it has been proposed that this complex may regulate RNA transcription during the cell cycle . 0.76912367^^^ |
|
| Interacting proteins: P24863 and P49336 |
Pubmed |
SVM Score :0.71731335 |
| Cyclin C binds the cyclin dependent kinases CDK 8 and CDK 3 , which regulate mRNA transcription and the cell cycle , respectively . 0.71731335^^^ |
|
| Interacting proteins: P24863 and P49336 |
Pubmed |
SVM Score :0.0 |
| Here we report the identification of a human protein kinase , K 35 [ cyclin dependent kinase 8 ( CDK 8 ) ] , that is likely to be a physiological partner of cyclin C . ^^^ Hence , we propose that human K 35 ( CDK 8 ) cyclin C might be functionally associated with the mammalian transcription apparatus , perhaps involved in relaying growth regulatory signals . . ^^^ |
|
| Interacting proteins: P24863 and P49336 |
Pubmed |
SVM Score :0.0 |
| Drosophila Cdk 8 , a kinase partner of cyclin C that interacts with the large subunit of RNA polymerase 2 . ^^^ Based on these observations and sequence similarity to the kinase / cyclin pair Srb10 / Srb11 in S . cerevisiae , we suggest that cyclin C and Cdk 8 control RNA polymerase 2 function . . ^^^ |
|
| Interacting proteins: P24863 and P49336 |
Pubmed |
SVM Score :0.0 |
| Gel filtration chromatography indicates that the E1A and VP 16 associated CTD kinase activity has a molecular size of approximately 1 . 5 MDa and contains cyclin C and the human homolog of SRB 7 in addition to CDK 8 . ^^^ |
|
| Interacting proteins: P24863 and P49336 |
Pubmed |
SVM Score :0.0 |
| Identified as the catalytic partner of cyclin C , Cdk 8 is a novel protein kinase of the Cdk family structurally related to the yeast Srb 10 kinase . ^^^ Cyclin C , Cdk 8 and RNA polymerase 2 are found in a large multi protein complex that shows structural as well as functional homologies with the yeast polymerase 2 holoenzyme . ^^^ These observations and the sequence similarity to the kinase / cyclin pair Srb10 / Srb11 in S . cerevisiae , suggest that cyclin C and Cdk 8 control RNA polymerase 2 function . . ^^^ |
|
| Interacting proteins: P24863 and P49336 |
Pubmed |
SVM Score :0.0 |
| Our data define a novel role for cyclin C in the regulation of both the G1 / S and G2 / M phases of the cell cycle , and this effect appears to be independent of the activity of CDK 8 in the control of transcription . . ^^^ |
|
| Interacting proteins: P24863 and P49336 |
Pubmed |
SVM Score :0.0 |
| Furthermore , regulation of cell adhesion appears to be a feature unique to cyclin C , but not other G 1 cyclins , E and D 3 , and its regulatory function is independent of CDK 8 kinase activity . ^^^ |
|
| Interacting proteins: P24863 and P49336 |
Pubmed |
SVM Score :0.0 |
| Furthermore , this substrate specificity is reflected in vivo where cyclin C / CDK 8 and cyclin H / CDK7 / p36 can differentially phosphorylate an endogenous RNA polymerase 2 substrate . ^^^ |
|
| Interacting proteins: P24863 and P49336 |
Pubmed |
SVM Score :0.0 |
| Mammalian cdk 8 and cyclin C , and their respective yeast homologues , Srb 10 and Srb 11 , are components of the RNA polymerase 2 holoenzyme complex where they function as a protein kinase that phosphorylates the carboxy terminal domain ( CTD ) of the largest subunit of RNA polymerase 2 ( ref . 7 ) . ^^^ Here we show that cdk8 / cyclin C can regulate transcription by targeting the cdk7 / cyclin H subunits of the general transcription initiation factor IIH ( TFIIH ) . cdk 8 phosphorylates mammalian cyclin H in the vicinity of its functionally unique amino terminal and carboxy terminal alpha helical domains . ^^^ |
|
| Interacting proteins: P24863 and P49336 |
Pubmed |
SVM Score :0.0 |
| Human cyclin C protein is stabilized by its associated kinase cdk 8 , independently of its catalytic activity . ^^^ However , there is as yet no evidence for any role of cyclin C and its partner , cdk 8 , in cell cycle regulation . ^^^ Rather , the cyclin C cdk 8 complex was found associated with the RNA polymerase 2 transcription machinery . ^^^ In stark contrast to data reported for other members of the cyclin family , both catalytically active and inactive cdk 8 induce cyclin C stabilization . ^^^ |
|
| Interacting proteins: P24863 and P49336 |
Pubmed |
SVM Score :0.0 |
| Immunoprecipitation of the approximately 2 MDa fraction with anti Cdk 8 antibody indicated that at least two classes of Mediator complexes occur , one containing CDK 8 and cyclin C and one lacking this CDK cyclin pair . ^^^ |
|
| Interacting proteins: P24863 and P49336 |
Pubmed |
SVM Score :0.0 |
| Other proteins identified in IGCs include transcription factors , the large subunit of RNA polymerase 2 ( Pol 2 ) , and cyclin dependent kinase 8 ( cdk 8 ) . cdk 8 is the kinase partner of cyclin C and a component of the mediator complex , associated with the Pol 2 holoenzyme . cdk 8 and cyclin C can regulate transcription via phosphorylation of cyclin H and the carboxy terminal domain of Pol 2 . ^^^ Coprecipitation of OrfA with anti cyclin C demonstrated that it was included in complexes with OrfA and cdk 8 . ^^^ |
|
| Interacting proteins: P24863 and P49336 |
Pubmed |
SVM Score :0.92074069 |
| Cyclin C associates with a novel cyclin dependent kinase , CDK 8 , and we demonstrate that this complex is associated with kinase activity towards the carboxy terminal domain ( CTD ) of RNA polymerase 2 . 0.92074069^^^ |
|