| Interaction between Gadd 45 or CR 6 and RXR alpha was confirmed by a two hybrid test in yeast . ^^^ Results from a series of GST pulldown assays showed that these Gadd 45 family proteins interact with several nuclear hormone receptors including RXR alpha , RAR alpha , ER alpha , PPAR alpha , PPAR beta , and PPAR gamma 2 in vitro . ^^^ |