| Interacting proteins: P24522 and O95257 |
Pubmed |
SVM Score :0.0 |
| Using a yeast two hybrid method , three related proteins , GADD45alpha ( = GADD 45 ) , GADD 45 , ( = MyD 118 ) , and GADD45gamma , were identified that bound to an N terminal domain of MTK 1 . ^^^ |
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| Interacting proteins: P24522 and O95257 |
Pubmed |
SVM Score :0.0 |
| We cloned the cDNA of rat GADD45gamma , the third member of the GADD 45 family . ^^^ |
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| Interacting proteins: P24522 and O95257 |
Pubmed |
SVM Score :0.0 |
| CR 6 : A third member in the MyD 118 and Gadd 45 gene family which functions in negative growth control . ^^^ Analysis of CR 6 expression during hematopoietic cell development associated with growth arrest and apoptotic cell death , upon exposure of hematopoietic cells to a variety of growth arrest and apoptotic stimuli , and in a variety of murine tissues , has revealed that CR 6 expression differs significantly from the expression of the related MyD 118 and Gadd 45 genes . ^^^ Nevertheless , CR 6 , like MyD 118 and Gadd 45 , suppressed colony formation of human lung carcinoma H 1299 cells . ^^^ These data suggest that CR 6 plays similar , but not identical , roles to MyD 118 and Gadd 45 in negative control of cell growth . . ^^^ |
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| Interacting proteins: P24522 and O95257 |
Pubmed |
SVM Score :0.0 |
| Molecular cloning , expression , and mapping of a novel human cDNA , GRP 17 , highly homologous to human gadd 45 and murine MyD 118 . ^^^ |
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| Interacting proteins: P24522 and O95257 |
Pubmed |
SVM Score :0.0 |
| Cytokine response gene # 6 ( CR 6 ) , cloned from interleukin 2 stimulated T lymphocytes , is homologous to GADD 45 and MyD 118 , genes which promote cell cycle arrest and apoptosis . ^^^ By comparison , when CR 6 , GADD 45 , and MyD 118 genes were expressed ectopically in proliferating pRb+ cells , either G1 / S or G2 / M transition was effectively blocked , so that there was no endoreduplication . ^^^ |
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| Interacting proteins: P24522 and O95257 |
Pubmed |
SVM Score :0.0 |
| Gadd 45 family genes encode nuclear acidic proteins composed of Gadd 45 , MyD 118 , and CR 6 . ^^^ Sequence analysis showed that Gadd 45 family proteins ( Gadd 45 , MyD 118 , and CR 6 ) contain LXXLL signature motifs considered necessary and sufficient for the binding of several coactivators to nuclear receptors . ^^^ Interaction between Gadd 45 or CR 6 and RXR alpha was confirmed by a two hybrid test in yeast . ^^^ When fused to DNA binding domain of GAL 4 , Gadd 45 and CR 6 activated the UAS mediated transcription in mammalian cells . ^^^ |
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| Interacting proteins: P24522 and O95257 |
Pubmed |
SVM Score :0.0 |
| In addition , GADD 45 inhibition of Cdc 2 kinase activity was compared with Myd 118 and CR 6 , two other members of the GADD 45 family . ^^^ |
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| Interacting proteins: P24522 and O95257 |
Pubmed |
SVM Score :0.0 |
| However , unlike GADD 45 , neither GADD45beta nor GADD45gamma inhibited the Cdc 2 kinase or induced G ( 2 ) / M arrest . ^^^ |
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| Interacting proteins: P24522 and O95257 |
Pubmed |
SVM Score :0.0 |
| GADD 45 , MyD 118 , and CR 6 ( also termed GADD45alpha , beta , and gamma ) comprise a family of genes that encode for related proteins playing important roles in negative growth control , including growth suppression . ^^^ The MyD 118 , CR 6 , and GADD 45 proteins were shown to predominantly localize within the cell nucleus . ^^^ Moreover , it is shown that CR 6 interacts with PCNA via a domain that also mediates interaction of both GADD 45 and MyD 118 with PCNA . ^^^ |
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| Interacting proteins: P24522 and O95257 |
Pubmed |
SVM Score :0.0 |
| Thus , to further explore the effects of these genes on cell growth and cell viability , either in the presence or absence of extrinsic stress , we have established M 1 myeloblastic leukemia and H 1299 lung carcinoma cell lines , where high level ectopic expression of MyD 118 , Gadd 45 , or CR 6 can be induced by isopropyl beta D thiogalactopyranoside ( IPTG ) . ^^^ By taking advantage of these cell lines , it was observed that in the absence of genotoxic stress , inducible expression of MyD 118 , Gadd 45 and / or CR 6 resulted in retardation of cellular proliferation and accumulation of cells in the G 1 phase of the cell cycle . ^^^ |
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| Interacting proteins: P24522 and O95257 |
Pubmed |
SVM Score :0.0 |
| Gadd45gamma , a family member of the growth arrest and DNA damage inducible gene family 45 ( Gadd 45 ) , is strongly induced by interleukin 2 ( IL 2 ) in peripheral T cells . ^^^ While in most tissues all Gadd 45 family members are expressed , Gadd45gamma is the only member that is induced by IL 2 . ^^^ These data demonstrate that Gadd45gamma is not essential for normal mouse development and hematopoiesis , possibly due to functional redundancy among the Gadd 45 family members . ^^^ |
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| Interacting proteins: P24522 and O95257 |
Pubmed |
SVM Score :0.0 |
| The MyD 118 ( Gadd45beta ) protein is a member of a family of structurally related proteins , including Gadd 45 ( Gadd45alpha ) and CR 6 ( Gadd45gamma ) , that have critical roles in regulating growth arrest and apoptosis . ^^^ |
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| Interacting proteins: P24522 and O95257 |
Pubmed |
SVM Score :0.0 |
| Moreover , Gadd45a can complex with the two other members of the Gadd 45 family of stress induced proteins , human Gadd45b ( MyD 118 ) and Gadd45g ( CR 6 ) . ^^^ |
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| Interacting proteins: P24522 and O95257 |
Pubmed |
SVM Score :0.0 |
| The PCNA gene is induced by p 53 , while PCNA protein interacts with p 53 controlled proteins Gadd 45 , MyD 118 , CR 6 and , most importantly , p 21 , in the process of deciding cell fate . ^^^ |
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| Interacting proteins: P24522 and O95257 |
Pubmed |
SVM Score :0.0 |
| Gadd45a ( Gadd 45 ) , Gadd45b ( MyD 118 ) , and Gadd45g ( CR 6 ) constitute a family of evolutionarily conserved , small , acidic , nuclear proteins , which have been implicated in terminal differentiation , growth suppression , and apoptosis . ^^^ |
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| Interacting proteins: P24522 and O95257 |
Pubmed |
SVM Score :0.0 |
| We report that three growth arrest and DNA damage inducible 45 ( GADD 45 ) isoforms ( GADD45alpha , GADDD45beta , and GADD45gamma ) are induced by acute hypertonicity in murine IM cells . ^^^ GADD 45 induction patterns in IM cells exposed to 10 different stresses suggest isoform specificity , but similar functions , of individual isoforms during hypertonicity , heat shock , and heavy metal stress , when GADD45gamma induction is strongest ( 17 fold ) . ^^^ |
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| Interacting proteins: P24522 and O95257 |
Pubmed |
SVM Score :0.0 |
| The Gadd 45 family of proteins includes Gadd45alpha , MyD118 / Gadd45beta , and CR6 / OIG37 / Gadd45gamma . ^^^ |
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| Interacting proteins: P24522 and O95257 |
Pubmed |
SVM Score :0.0 |
| We further demonstrated that , following Ol Gadd45gamma overexpression , cells are proliferation arrested before both G1 / S and G2 / M cell cycle checkpoints , while in the MO Ol Gadd 45 loss of function experiments cells are engaged in apoptosis rather than prevented from proliferating . ^^^ |
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| Interacting proteins: P24522 and O95257 |
Pubmed |
SVM Score :0.0 |
| Same as other GADD 45 members , GADD45G is ubiquitously expressed in all normal adult and fetal tissues . ^^^ |
|
| Interacting proteins: P24522 and O95257 |
Pubmed |
SVM Score :0.0 |
| Gadd45g / CR6 , Gadd45b / MyD118 , and Gadd45a / Gadd45 are members of a gene family that displays distinct patterns of gene expression in response to stimuli that induce differentiation , growth arrest , and / or apoptosis . ^^^ A comparison of the putative transcription factor binding sites found in the sequences of the gene family members suggests , that like Gadd45b , NF kappaB and STATs may be responsible for the differences in regulation of expression observed between Gadd45g and Gadd45a . ^^^ |
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| Interacting proteins: P24522 and O95257 |
Pubmed |
SVM Score :0.0 |
| Myeloid differentiation ( MyD ) primary response and growth arrest DNA damage ( Gadd ) genes comprise a set of overlapping genes , including known ( IRF 1 , EGR 1 , Jun ) and novel ( MyD 88 , Gadd45a MyD118 / Gadd45b , GADD45g , MyD116 / Gadd34 ) genes , that have been cloned by virtue of being coordinately induced upon the onset of terminal myeloid differentiation . ^^^ |
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| Interacting proteins: P24522 and O95257 |
Pubmed |
SVM Score :0.0 |
| Gadd45a , gadd45b and gadd45g ( Gadd45 / MyD118 / CR6 ) are genes that are rapidly induced by genotoxic stress . ^^^ |
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| Interacting proteins: P24522 and O95257 |
Pubmed |
SVM Score :0.0 |
| Acutely elevating NaCl ( and / or urea ) reduces Gadd45a , but increases Gadd45b and Gadd45g mRNA , depending on the mix of NaCl and urea and the rate of increase of osmolality . ^^^ |
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| Interacting proteins: P24522 and O95257 |
Pubmed |
SVM Score :0.0 |
| Gadd45a , Gadd45b , and Gadd45g ( Gadd45 / MyD118 / CR6 ) are genes that are rapidly induced by genotoxic stress and have been implicated in genotoxic stress induced responses , notably in apoptosis . ^^^ |
|
| Interacting proteins: P24522 and O95257 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24522 and O95257 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24522 and O95257 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24522 and O95257 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24522 and O95257 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24522 and O95257 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24522 and O95257 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24522 and O95257 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24522 and O95257 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24522 and O95257 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24522 and O95257 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24522 and O95257 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24522 and O95257 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24522 and O95257 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24522 and O95257 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24522 and O95257 |
Pubmed |
SVM Score :0.0 |
| NA |
|