| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| The MyD 118 ( Gadd45beta ) protein is a member of a family of structurally related proteins , including Gadd 45 ( Gadd45alpha ) and CR 6 ( Gadd45gamma ) , that have critical roles in regulating growth arrest and apoptosis . ^^^ |
|
| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| Moreover , Gadd45a can complex with the two other members of the Gadd 45 family of stress induced proteins , human Gadd45b ( MyD 118 ) and Gadd45g ( CR 6 ) . ^^^ |
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| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| Gadd45a ( Gadd 45 ) , Gadd45b ( MyD 118 ) , and Gadd45g ( CR 6 ) constitute a family of evolutionarily conserved , small , acidic , nuclear proteins , which have been implicated in terminal differentiation , growth suppression , and apoptosis . ^^^ Gadd45a ( Gadd 45 ) , Gadd45b ( MyD 118 ) , and Gadd45g ( CR 6 ) constitute a family of evolutionarily conserved , small , acidic , nuclear proteins , which have been implicated in terminal differentiation , growth suppression , and apoptosis . ^^^ Data also has been obtained that Gadd45b and Gadd45g , as well as GADD45a , interact with both Cdk 1 and cyclinB 1 , resulting in inhibition of the kinase activity of the Cdk1 / cyclinB1 complex . ^^^ Inhibition of Cdk1 / cyclinB1 kinase activity by Gadd45b and Gadd45a was found to involve disruption of the complex , whereas Gadd45g did not disrupt the complex . ^^^ |
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| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| The down regulated elements included the tumor suppressor TP 53 , genes related to apoptosis such as GADD 34 , GADD45A , GADD45B and PIG 11 , and the gene encoding OVGP 1 , a protein involved in maintenance of early pregnancy . ^^^ |
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| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| Gadd45g / CR6 , Gadd45b / MyD118 , and Gadd45a / Gadd45 are members of a gene family that displays distinct patterns of gene expression in response to stimuli that induce differentiation , growth arrest , and / or apoptosis . ^^^ A comparison of the putative transcription factor binding sites found in the sequences of the gene family members suggests , that like Gadd45b , NF kappaB and STATs may be responsible for the differences in regulation of expression observed between Gadd45g and Gadd45a . ^^^ |
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| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| We show that Egr 1 contributes to the regulation of the Gadd45a and Gadd45b genes , which are involved in the control of cell cycle , DNA repair and apoptosis , by direct binding to their promoter . ^^^ |
|
| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| We found that a variety of stress regulated genes were differentially expressed , including seven genes that have not been reported previously as being regulated by hemorrhagic shock : ATF 2 , alphaB crystallin , GADD 45 , GADD45beta , Mdm 2 , p21Waf1 , and TRPM 2 . ^^^ |
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| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| However , unlike GADD 45 , neither GADD45beta nor GADD45gamma inhibited the Cdc 2 kinase or induced G ( 2 ) / M arrest . ^^^ |
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| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| Both gadd45a and gadd45b deficient BM cells also displayed defective G2 / M arrest following exposure to UVC and VP 16 , but not to DNR , indicating the existence of different G2 / M checkpoints that are either dependent or independent of gadd 45 . ^^^ Hematopoietic cells from Gadd45a and Gadd45b deficient mice are sensitized to genotoxic stress induced apoptosis . ^^^ Gadd45a , gadd45b and gadd45g ( Gadd45 / MyD118 / CR6 ) are genes that are rapidly induced by genotoxic stress . ^^^ Here , advantage was taken of gadd45a and gadd45b deficient mice to determine the role gadd45a and gadd45b play in the response of bone marrow ( BM ) cells to genotoxic stress . ^^^ BM cells from gadd45a and gadd45b deficient mice were observed to be more sensitive to ultraviolet radiation chemotherapy ( UVC ) , VP 16 and daunorubicin ( DNR ) induced apoptosis compared to wild type ( wt ) cells . ^^^ |
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| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| Acutely elevating NaCl ( and / or urea ) reduces Gadd45a , but increases Gadd45b and Gadd45g mRNA , depending on the mix of NaCl and urea and the rate of increase of osmolality . ^^^ |
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| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| Gadd45a and Gadd45b protect hematopoietic cells from UV induced apoptosis via distinct signaling pathways , including p 38 activation and JNK inhibition . ^^^ Gadd45a , Gadd45b , and Gadd45g ( Gadd45 / MyD118 / CR6 ) are genes that are rapidly induced by genotoxic stress and have been implicated in genotoxic stress induced responses , notably in apoptosis . ^^^ Recently , using myeloid enriched bone marrow ( BM ) cells obtained from wild type ( WT ) , Gadd45a deficient , and Gadd45b deficient mice , we have shown that in hematopoietic cells Gadd45a and Gadd45b play a survival function to protect hematopoietic cells from DNA damaging agents , including ultra violet ( UV ) induced apoptosis . ^^^ The present study was undertaken to decipher the molecular paths that mediate the survival functions of Gadd45a and Gadd45b against genotoxic stress induced by UV radiation . ^^^ It is shown that in hematopoietic cells exposed to UV radiation Gaddd45a and Gadd45b cooperate to promote cell survival via two distinct signaling pathways involving activation of the GADD45a p 38 NF kappaB mediated survival pathway and GADD45b mediated inhibition of the stress response MKK 4 JNK pathway . . ^^^ |
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| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| MyD 118 , a protein induced by terminal differentiation sharing 57 % homology with Gadd 45 , does not cross react with any of the antibodies produced . ^^^ |
|
| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| Finally , evidence has been accumulating to indicate that the novel MyD genes MyD 116 , MyD 118 and gadd 45 ( a member in the MyD 118 gene family ) play a role in growth arrest and apoptosis of hematopoietic cells , as well as other cell types . ^^^ |
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| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| The MyD 116 gene was found to be the murine homolog of the hamster gadd 34 gene , whereas MyD 118 and gadd 45 were found to represent two separate but closely related genes . ^^^ Furthermore , gadd34 / MyD116 , gadd 45 , MyD 118 , and gadd 153 encode acidic proteins with very similar and unusual charge characteristics ; both this property and a similar pattern of induction are shared with mdm 2 , whic , like gadd 45 , has been shown previously to be regulated by the tumor suppressor p 53 . ^^^ |
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| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| Unlike GADD 45 , the response of other DNA damage inducible genes to IR is not dependent on p 53 based on the observation that induction in a panel of cell lines did not correlate with a normal p 53 status ; this included human GADD 153 , another member of the gadd ( growth arrest and DNA damage inducible ) group ; MyD 118 , a gene related to GADD 45 ; and the protooncogenes c jun and c fos . ^^^ |
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| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| Hematopoietic cells from gadd45a deficient and gadd45b deficient mice exhibit impaired stress responses to acute stimulation with cytokines , myeloablation and inflammation . ^^^ Using bone marrow ( BM ) from gadd45a / , gadd45b / and wild type ( wt ) mice , we investigated their role in stress responses of myeloid cells to acute stimulation with differentiating cytokines , myelotoxic agents and inflammatory substances . ^^^ Bone marrow cells from gadd45a / and gadd45b / mice displayed compromised myeloid differentiation and higher apoptosis in vitro , following acute stimulation with a variety of differentiating cytokines . ^^^ Intriguingly , gadd45a / and gadd45b / colony forming units granulocyte / macrophage progenitors displayed prolonged proliferation capacity compared to wt controls upon re plating in methylcellulose supplemented with interleukin 3 . ^^^ The recovery of the BM myeloid compartment following 5 Fluorouracil induced myelo ablation was much slower in gadd45a / and gadd45b / mice compared to wt controls . ^^^ |
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| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| These include Plcgamma 2 , Cdk 6 , CD 25 , Tox , Gadd45a , Gadd45b , Gfi 1 , Gfi1b , Socs 1 , Socs 3 , Id 2 , Eto 2 , and Xbp 1 . ^^^ |
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| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| In addition to p15INK4b and p21CIP1 , these genes include mediators of stress responses ( GADD45A , GADD45B , and IER 1 ) and adaptive cell signaling responses ( CTGF , JAG 1 , LEMD 3 , SGK , CDC42EP3 , and OVOL 1 ) . ^^^ |
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| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| The differentiation primary response gene MyD 118 , related to GADD 45 , encodes for a nuclear protein which interacts with PCNA and p21WAF1 / CIP1 . ^^^ The MyD 118 encoded protein was observed to be remarkably similar to the protein encoded by Gadd 45 , a growth arrest and DNA damage induced gene , regulated in part by the tumor suppressor p 53 . ^^^ To better understand the role ( s ) of MyD 118 in negative growth control , we have analysed the expression and biological characteristics of the MyD 118 protein , compared to the Gadd 45 protein , in distinct pathways of growth arrest and apoptosis , including p 53 dependent and independent pathways either coupled or uncoupled from differentiation . ^^^ It is shown that MyD 118 and Gadd 45 differentially accumulated upon induction of distinct pathways of growth arrest and apoptosis ; notably , MyD 118 , but not Gadd 45 , was induced by TGF beta , whereas Gadd 45 , but not MyD 118 , was induced by activating wild type ( wt ) p 53 function . ^^^ Finally , it is demonstrated that MyD 118 , Gadd 45 and p 21 synergized in the suppression of colony formation by NIH3T3 cells . ^^^ |
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| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| Cell cycle and apoptosis : possible roles of Gadd 45 and MyD 118 proteins inferred from their homology to ribosomal proteins . ^^^ |
|
| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| Association with the growth arrest and DNA damage inducible proteins gadd 45 and MyD 118 , further demonstrates the role of PCNA as a component of the cell cycle control apparatus . . ^^^ |
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| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| Using a yeast two hybrid method , three related proteins , GADD45alpha ( = GADD 45 ) , GADD 45 , ( = MyD 118 ) , and GADD45gamma , were identified that bound to an N terminal domain of MTK 1 . ^^^ |
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| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| Post transcriptional regulation of MyD 118 and GADD 45 in human lung carcinoma cells during 6 [ 3 ( 1 adamantyl ) 4 hydroxyphenyl ] 2 naphthalene carboxylic acid induced apoptosis . ^^^ The sequence of one of these genes was highly homologous to mouse MyD 118 , a gene closely related to GADD 45 . ^^^ Our results support a role for MyD 118 and GADD 45 in the negative growth control by AHPN . . ^^^ |
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| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| A novel oncostatin M inducible gene OIG 37 forms a gene family with MyD 118 and GADD 45 and negatively regulates cell growth . ^^^ Here we describe the novel OSM inducible gene OIG 37 that is related to MyD 118 and GADD 45 . ^^^ The MyD 118 gene has been described as an immediate early gene induced by IL 6 in M 1 monocytic cells , and GADD 45 was identified as a gene induced by UV or gamma ray irradiation . ^^^ Although the expression of OIG 37 , MyD 118 , and GADD 45 was rather ubiquitous , it was differentially regulated . ^^^ |
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| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| Cytokine response gene # 6 ( CR 6 ) , cloned from interleukin 2 stimulated T lymphocytes , is homologous to GADD 45 and MyD 118 , genes which promote cell cycle arrest and apoptosis . ^^^ By comparison , when CR 6 , GADD 45 , and MyD 118 genes were expressed ectopically in proliferating pRb+ cells , either G1 / S or G2 / M transition was effectively blocked , so that there was no endoreduplication . ^^^ |
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| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| Characterization of MyD 118 , Gadd 45 , and proliferating cell nuclear antigen ( PCNA ) interacting domains . ^^^ PCNA impedes MyD 118 AND Gadd 45 mediated negative growth control . ^^^ MyD 118 and Gadd 45 are related genes encoding for proteins that play important roles in negative growth control , including growth suppression and apoptosis . ^^^ MyD 118 and Gadd 45 are related proteins that previously were shown to interact with proliferating cell nuclear antigen ( PCNA ) , implicated in DNA replication , DNA repair , and cell cycle progression . ^^^ To establish the role of MyD 118 and Gadd 45 interactions with PCNA , in this work we sought to identify the interacting domains and analyze the significance of this interaction in negative growth control . ^^^ |
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| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| Gadd 45 family genes encode nuclear acidic proteins composed of Gadd 45 , MyD 118 , and CR 6 . ^^^ Sequence analysis showed that Gadd 45 family proteins ( Gadd 45 , MyD 118 , and CR 6 ) contain LXXLL signature motifs considered necessary and sufficient for the binding of several coactivators to nuclear receptors . ^^^ |
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| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| In addition , GADD 45 inhibition of Cdc 2 kinase activity was compared with Myd 118 and CR 6 , two other members of the GADD 45 family . ^^^ |
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| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| CR 6 : A third member in the MyD 118 and Gadd 45 gene family which functions in negative growth control . ^^^ MyD 118 and Gadd 45 are two related genes which encode for proteins that play important roles in negative growth control , including both growth suppression and apoptosis . ^^^ A strategy was employed to clone new members of the MyD 118 and Gadd 45 family of genes . ^^^ Analysis of CR 6 expression during hematopoietic cell development associated with growth arrest and apoptotic cell death , upon exposure of hematopoietic cells to a variety of growth arrest and apoptotic stimuli , and in a variety of murine tissues , has revealed that CR 6 expression differs significantly from the expression of the related MyD 118 and Gadd 45 genes . ^^^ Nevertheless , CR 6 , like MyD 118 and Gadd 45 , suppressed colony formation of human lung carcinoma H 1299 cells . ^^^ |
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| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| Molecular cloning , expression , and mapping of a novel human cDNA , GRP 17 , highly homologous to human gadd 45 and murine MyD 118 . ^^^ From a human placenta cDNA library , we isolated a novel gene whose predicted product is highly homologous in amino acid sequence to human gadd 45 and murine MyD 118 proteins ( about 55 % and 52 % identity , respectively ) . ^^^ |
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| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| GADD 45 , MyD 118 , and CR 6 ( also termed GADD45alpha , beta , and gamma ) comprise a family of genes that encode for related proteins playing important roles in negative growth control , including growth suppression . ^^^ The MyD 118 , CR 6 , and GADD 45 proteins were shown to predominantly localize within the cell nucleus . ^^^ Recently , we have shown that both MyD 118 and GADD 45 interact with proliferating cell nuclear antigen ( PCNA ) , a protein that plays a central role in DNA replication , DNA repair , and cell cycle progression , as well as with the universal cyclin dependent kinase inhibitor p 21 . ^^^ Moreover , it is shown that CR 6 interacts with PCNA via a domain that also mediates interaction of both GADD 45 and MyD 118 with PCNA . ^^^ |
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| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| Thus , to further explore the effects of these genes on cell growth and cell viability , either in the presence or absence of extrinsic stress , we have established M 1 myeloblastic leukemia and H 1299 lung carcinoma cell lines , where high level ectopic expression of MyD 118 , Gadd 45 , or CR 6 can be induced by isopropyl beta D thiogalactopyranoside ( IPTG ) . ^^^ By taking advantage of these cell lines , it was observed that in the absence of genotoxic stress , inducible expression of MyD 118 , Gadd 45 and / or CR 6 resulted in retardation of cellular proliferation and accumulation of cells in the G 1 phase of the cell cycle . ^^^ |
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| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| The PCNA gene is induced by p 53 , while PCNA protein interacts with p 53 controlled proteins Gadd 45 , MyD 118 , CR 6 and , most importantly , p 21 , in the process of deciding cell fate . ^^^ |
|
| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75293 and P24522 |
Pubmed |
SVM Score :0.0 |
| NA |
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