| Interacting proteins: P23771 and P17947 |
Pubmed |
SVM Score :0.5040328 |
| PU . 1 regulates the Th 2 phenotype by interfering with GATA 3 DNA binding without altering GATA 3 protein levels . 0.5040328^^^ |
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| Interacting proteins: P23771 and P17947 |
Pubmed |
SVM Score :0.0 |
| Gene inactivation studies on the PU . 1 , Ikaros and GATA 3 genes have revealed that their encoded factors are essential for the earliest commitment step into the B and T lymphoid lineages . . ^^^ |
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| Interacting proteins: P23771 and P17947 |
Pubmed |
SVM Score :0.0 |
| Maximal PD beta activity requires a TATA element situated within the D beta 1 recombination signal sequences and consensus binding sites for the ubiquitous SP 1 and the T cell specific GATA 3 transcription factors . ^^^ |
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| Interacting proteins: P23771 and P17947 |
Pubmed |
SVM Score :0.0 |
| The present paper analyzes these components and the participation of some of them such as PU . 1 , Ikaros , Aiolos , GATA 3 , Egf 1 , E2A , EBF 1 , PAX 5 ( BSAP ) , TFE 3 , Oct 1 , Oct 2 , and Nf kappa B in the regulation of the differentiation stages of cells belonging to the B and T lymphoid lineages . . ^^^ |
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| Interacting proteins: P23771 and P17947 |
Pubmed |
SVM Score :0.0 |
| To ascertain whether maintenance of GATA 2 is required for the Notch induced inhibition of differentiation , the dominant negative form of GATA 3 ( DN GATA ) , which acted also against GATA 2 , or transcription factor PU . 1 , which was recently shown to be the repressor of GATA 2 , was introduced into aNotch 1 expressing 32D ( 32D / aNotch1 ) cells that do not express GATA family proteins other than GATA 2 . ^^^ |
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| Interacting proteins: P23771 and P17947 |
Pubmed |
SVM Score :0.0 |
| Here , the operation of such a network is addressed through a focus on murine T cell development , where we have recently established regulatory linkages between GATA 3 and PU . 1 and multiple other factors essential to this differentiation pathway . ^^^ |
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| Interacting proteins: P23771 and P17947 |
Pubmed |
SVM Score :0.0 |
| Potential and known interactions between early thymic transcription factors such as GATA 3 , SCL , PU . 1 , Erg , and Spi B are explored . ^^^ |
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| Interacting proteins: P23771 and P17947 |
Pubmed |
SVM Score :0.0 |
| CD 34 ( + ) CD 43 ( + ) CD 45 ( + ) Lin ( ) cells were largely devoid of VE cadherin and KDR expression and had a distinct FLT 3 ( high ) GATA 3 ( low ) RUNX 1 ( low ) PU 1 ( high ) MPO ( high ) IL7RA ( high ) gene expression profile . . ^^^ |
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| Interacting proteins: P23771 and P17947 |
Pubmed |
SVM Score :0.0 |
| Definition of regulatory network elements for T cell development by perturbation analysis with PU . 1 and GATA 3 . ^^^ PU . 1 and GATA 3 are transcription factors that are required for development of T cell progenitors from the earliest stages . ^^^ When expressed at elevated levels at early stages of T cell development , each of these transcription factors blocks T cell development within a different , characteristic time window , with GATA 3 overexpression initially inhibiting at an earlier stage than PU . 1 . ^^^ Both transcription factors can interfere with expression of the Rag 1 and Rag 2 recombinases , while GATA 3 notably blocks PU . 1 and IL 7Ralpha expression , and PU . 1 reduces expression of HES 1 and c Myb . ^^^ The target genes identified here provide insight into the basis of the effects of GATA 3 or PU . 1 overexpression and into the regulatory changes that distinguish the developmental time windows for these effects . . ^^^ |
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| Interacting proteins: P23771 and P17947 |
Pubmed |
SVM Score :0.0 |
| Roles for PU . 1 , GATA 3 , and their target genes are highlighted . . ^^^ |
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| Interacting proteins: P23771 and P17947 |
Pubmed |
SVM Score :0.0 |
| The present study analyzed the expression of the following 13 TFs : AML 1 , CEBPA , E2A , ETS 1 , GATA 1 , GATA 2 , GATA 3 , IKAROS , IRF 1 , PAX 5 , PU 1 , TBET and TCF 1 in 7 malignant NK cell lines together with 5 malignant NKT cell lines , 5 T cell acute lymphoblastic leukemia ( ALL ) cell lines including 3 gamma / delta T cell receptor ( TCR ) type and 2 alpha / beta TCR type , and 3 B cell precursor ( BCP ) leukemia cell lines . ^^^ |
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| Interacting proteins: P23771 and P17947 |
Pubmed |
SVM Score :0.0 |
| Results demonstrated an interaction between Tax and the GATA 3 promoter via the transcription factor Sp 1 and a role for Tax in the negative regulation of GATA 3 expression , through its interaction with the repressor ZEB . ^^^ |
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| Interacting proteins: P23771 and P17947 |
Pubmed |
SVM Score :0.0 |
| Overexpression of SP 1 ( Sp 1 transcription factor ) and GATA 2 ( GATA binding protein 2 ) and GATA 3 induced syncytin promoter activity but had little or no effect on the activities of syncytin promoter fragments containing mutations in the SP 1 and GATA binding sites . ^^^ |
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| Interacting proteins: P23771 and P17947 |
Pubmed |
SVM Score :0.0 |
| To investigate the roles of TFs in human B cell precursors ( BCPs ) , the present study analyzed the expression of the following 16 hematopoietic TFs : AML 1 , C / EBPalpha , C / EBPbeta , C / EBPgamma , C / EBPepsilon , E2A , Ets 1 , GATA 1 , GATA 2 , GATA 3 , Ikaros , IRF 1 , Pax 5 , PU . 1 , T bet and TCF 1 in 30 human BCP leukemia cell lines . ^^^ |
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| Interacting proteins: P23771 and P17947 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23771 and P17947 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23771 and P17947 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23771 and P17947 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23771 and P17947 |
Pubmed |
SVM Score :0.0 |
| NA |
|