| Interacting proteins: P23771 and P17542 |
Pubmed |
SVM Score :0.0 |
| Testing the susceptibility of PEST motif bearing and non bearing transcription factors including GATA 1 , GATA 3 , Myo D , c erbA , Tal 1 and Sry , demonstrates that PEST sequences are neither necessary nor sufficient for specifying degradation of other proteins by calpains . ^^^ |
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| Interacting proteins: P23771 and P17542 |
Pubmed |
SVM Score :0.0 |
| In this context , we carried out preliminary evaluation of a potential role of the T cell specific GATA binding protein , GATA 3 , in the transcriptional activity of TAL 1 and RBTN . ^^^ Collectively , ectopic TAL 1 and RBTN 1 or 2 , together with some endogenous T cell specific cofactors like GATA 3 , constitute a highly collaborative set of transcription factors whose aberrant activity in T cells may lead to leukemogenesis by modulating expression of downstream genes such as TALLA1 . . ^^^ |
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| Interacting proteins: P23771 and P17542 |
Pubmed |
SVM Score :0.0 |
| TAL 1 and LIM only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T cell acute lymphoblastic leukemia by acting as cofactors for GATA 3 . ^^^ Promoter analysis revealed that a GATA site in a cryptic promoter in the second intron was essential and sufficient for the TAL 1 and LMO dependent transcriptional activation , and GATA 3 binds to this site . ^^^ In addition , forced expression of GATA 3 potentiated the induction of RALDH 2 by TAL 1 and LMO , and these three factors formed a complex in vivo . ^^^ Furthermore , a TAL 1 mutant not binding to DNA also activated the transcription of RALDH 2 in the presence of LMO and GATA 3 . ^^^ In this case , TAL 1 and LMO act as cofactors for GATA 3 to activate the transcription of RALDH2 . . ^^^ |
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| Interacting proteins: P23771 and P17542 |
Pubmed |
SVM Score :0.0 |
| Moreover , GATA 1 but not GATA 2 or GATA 3 was able to transactivate SCL promoter 1a in a T cell environment . ^^^ |
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| Interacting proteins: P23771 and P17542 |
Pubmed |
SVM Score :0.0 |
| SCL , GATA 1 , GATA 2 and GATA 3 encode lineage restricted haemopoietic transcription factors . ^^^ We have therefore analysed the regulation of SCL , GATA 1 , GATA 2 and GATA 3 in cell hybrids formed by the fusion of cell lines representing different haemopoietic lineages . ^^^ |
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| Interacting proteins: P23771 and P17542 |
Pubmed |
SVM Score :0.0 |
| Coexpression of SCL and GATA 3 in the V 2 interneurons of the developing mouse spinal cord . ^^^ These experiments revealed that SCL is expressed in a medially restricted subpopulation of GATA 3 producing cells , suggesting a possible role for this factor in the differentiation of the GATA population of V 2 interneurons . . ^^^ |
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| Interacting proteins: P23771 and P17542 |
Pubmed |
SVM Score :0.0 |
| Levels of Scl , Rbtn 2 , GATA 1 , and Ldb 1 expression were comparable in AML and APL blasts , while the levels of expression of Rbtn 1 , GATA 2 , and GATA 3 were absent or markedly lower in APL cells . ^^^ |
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| Interacting proteins: P23771 and P17542 |
Pubmed |
SVM Score :0.0 |
| Up regulated genes include vasculogenic growth factors such as VEGFA , VEGFC , FIGF ( VEGFD ) , ANG 1 , ANG 2 , TGFbeta 3 , and PDGFB , as well as the related receptors FLT 1 , FLT 4 , PDGFRB , TGFbetaR 2 , and TGFbetaR 3 , other markers such as CD 34 , VCAM 1 , PECAM 1 , VE CAD , and transcription factors TAL 1 , GATA 2 , and GATA 3 . ^^^ |
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| Interacting proteins: P23771 and P17542 |
Pubmed |
SVM Score :0.0 |
| The overlapping expression of SCL with GATA 2 and GATA 3 in the developing brain indicated that these factors might collaborate also in the course of neural tissue differentiation . ^^^ Similarly to the hematopoietic differentiation , GATA 2 expression precedes the activation of both SCL and GATA 3 , and may play roles in the activation of the SCL gene in neuronal development . ^^^ |
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| Interacting proteins: P23771 and P17542 |
Pubmed |
SVM Score :0.0 |
| Potential and known interactions between early thymic transcription factors such as GATA 3 , SCL , PU . 1 , Erg , and Spi B are explored . ^^^ |
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| Interacting proteins: P23771 and P17542 |
Pubmed |
SVM Score :0.0 |
| NA |
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