| Interacting proteins: P23511 and P49715 |
Pubmed |
SVM Score :0.0 |
| CBFB SMMHC is correlated with increased calreticulin expression and suppresses the granulocytic differentiation factor CEBPA in AML with inv ( 16 ) . ^^^ Here , we found that conditional expression of core binding factor beta ( CBFB ) SMMHC in U 937 cells suppresses CEBPA protein expression and binding activity . ^^^ No differences were detected in CEBPA mRNA levels in patients with inv ( 16 ) AML M4Eo ( n = 12 ) compared to patients with AML with a normal karyotype and M 4 subtype ( n = 6 ) , whereas CEBPA protein and binding activity were significantly reduced in patients with CBFB SMMHC . ^^^ Furthermore , calreticulin , an inhibitor of CEBPA translation , was induced on mRNA and protein level in CBFB SMMHC patients with AML and after expression of CBFB SMMHC in the U 937 cell system . ^^^ Our results suggest that modulation of CEBPA by calreticulin represents a novel mechanism involved in the differentiation block in CBFB SMMHC AML . . ^^^ |
|
| Interacting proteins: P23511 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23511 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23511 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23511 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23511 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|